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Items: 48

1.

Central nicotine induces browning through hypothalamic κ opioid receptor.

Seoane-Collazo P, Liñares-Pose L, Rial-Pensado E, Romero-Picó A, Moreno-Navarrete JM, Martínez-Sánchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-García JL, Nogueiras R, Domingos AI, Fernández-Real JM, Rahmouni K, Diéguez C, López M.

Nat Commun. 2019 Sep 6;10(1):4037. doi: 10.1038/s41467-019-12004-z.

2.

The risk of jiggly fat in aging.

Corrales P, Martín-Taboada M, Medina-Gomez G.

Aging (Albany NY). 2019 Aug 6;11(15):5298-5299. doi: 10.18632/aging.102147. Epub 2019 Aug 6. No abstract available.

3.

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.

Keiran N, Ceperuelo-Mallafré V, Calvo E, Hernández-Alvarez MI, Ejarque M, Núñez-Roa C, Horrillo D, Maymó-Masip E, Rodríguez MM, Fradera R, de la Rosa JV, Jorba R, Megia A, Zorzano A, Medina-Gómez G, Serena C, Castrillo A, Vendrell J, Fernández-Veledo S.

Nat Immunol. 2019 May;20(5):581-592. doi: 10.1038/s41590-019-0372-7. Epub 2019 Apr 8.

PMID:
30962591
4.

Long-term caloric restriction ameliorates deleterious effects of aging on white and brown adipose tissue plasticity.

Corrales P, Vivas Y, Izquierdo-Lahuerta A, Horrillo D, Seoane-Collazo P, Velasco I, Torres L, Lopez Y, Martínez C, López M, Ros M, Obregon MJ, Medina-Gomez G.

Aging Cell. 2019 Jun;18(3):e12948. doi: 10.1111/acel.12948. Epub 2019 Mar 28.

5.

Chronic mercury at low doses impairs white adipose tissue plasticity.

Rizzetti DA, Corrales P, Piagette JT, Uranga-Ocio JA, Medina-Gomez G, Peçanha FM, Vassallo DV, Miguel M, Wiggers GA.

Toxicology. 2019 Apr 15;418:41-50. doi: 10.1016/j.tox.2019.02.013. Epub 2019 Feb 23.

PMID:
30807803
6.

Insulin action is severely impaired in adipocytes of apparently healthy overweight and obese subjects.

Rydén M, Petrus P, Andersson DP, Medina-Gómez G, Escasany E, Corrales Cordón P, Dahlman I, Kulyté A, Arner P.

J Intern Med. 2019 May;285(5):578-588. doi: 10.1111/joim.12887. Epub 2019 Mar 14.

PMID:
30758089
7.

Underlying Mechanisms of Renal Lipotoxicity in Obesity.

Escasany E, Izquierdo-Lahuerta A, Medina-Gomez G.

Nephron. 2019;143(1):28-32. doi: 10.1159/000494694. Epub 2019 Jan 9. Review.

8.

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.

Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M.

Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069.

9.

Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice.

Sevillano J, Sánchez-Alonso MG, Zapatería B, Calderón M, Alcalá M, Limones M, Pita J, Gramage E, Vicente-Rodríguez M, Horrillo D, Medina-Gómez G, Obregón MJ, Viana M, Valladolid-Acebes I, Herradón G, Ramos-Álvarez MP.

Diabetologia. 2019 Jan;62(1):123-135. doi: 10.1007/s00125-018-4746-4. Epub 2018 Oct 16.

PMID:
30327824
10.

PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity.

Corrales P, Vidal-Puig A, Medina-Gómez G.

Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review.

11.

Maintenance of Kidney Metabolic Homeostasis by PPAR Gamma.

Corrales P, Izquierdo-Lahuerta A, Medina-Gómez G.

Int J Mol Sci. 2018 Jul 16;19(7). pii: E2063. doi: 10.3390/ijms19072063. Review.

12.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

13.

Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic β-Cell Growth During Early Life in Male Mice Offspring.

García-Arévalo M, Alonso-Magdalena P, Servitja JM, Boronat-Belda T, Merino B, Villar-Pazos S, Medina-Gómez G, Novials A, Quesada I, Nadal A.

Endocrinology. 2016 Nov;157(11):4158-4171. Epub 2016 Sep 13.

PMID:
27623287
14.

Peroxisome proliferator activated receptor gamma 2 modulates late pregnancy homeostatic metabolic adaptations.

Vivas Y, Díez-Hochleitner M, Izquierdo-Lahuerta A, Corrales P, Horrillo D, Velasco I, Martínez-García C, Campbell M, Sevillano J, Ricote M, Ros M, Ramos MP, Medina-Gomez G.

Mol Med. 2016 Dec;22:724-736. doi: 10.2119/molmed.2015.00262. Epub 2016 Oct 19.

15.

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT.

Contreras C, Nogueiras R, Diéguez C, Medina-Gómez G, López M.

Mol Cell Endocrinol. 2016 Dec 15;438:107-115. doi: 10.1016/j.mce.2016.08.002. Epub 2016 Aug 4. Review.

PMID:
27498420
16.

Lipotoxicity as a trigger factor of renal disease.

Izquierdo-Lahuerta A, Martínez-García C, Medina-Gómez G.

J Nephrol. 2016 Oct;29(5):603-10. doi: 10.1007/s40620-016-0278-5. Epub 2016 Mar 8. Review.

PMID:
26956132
17.

Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes.

Martínez-García C, Izquierdo-Lahuerta A, Vivas Y, Velasco I, Yeo TK, Chen S, Medina-Gomez G.

PLoS One. 2015 Nov 6;10(11):e0142291. doi: 10.1371/journal.pone.0142291. eCollection 2015.

18.

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.

Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.

Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28.

19.

DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.

Charalambous M, Da Rocha ST, Radford EJ, Medina-Gomez G, Curran S, Pinnock SB, Ferrón SR, Vidal-Puig A, Ferguson-Smith AC.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16088-93. doi: 10.1073/pnas.1406119111. Epub 2014 Oct 27.

20.

Obesity and type 2 diabetes in renal pathology.

Medina-Gómez G.

Endocrinol Nutr. 2013;60 Suppl 1:23-5. No abstract available.

PMID:
24490221
21.

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.

Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.

Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6.

22.

Mitochondria and endocrine function of adipose tissue.

Medina-Gómez G.

Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):791-804. doi: 10.1016/j.beem.2012.06.002. Epub 2012 Jul 26. Review.

PMID:
23168280
23.

Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.

Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A.

PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5.

24.

Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model.

Martínez-García C, Izquierdo A, Velagapudi V, Vivas Y, Velasco I, Campbell M, Burling K, Cava F, Ros M, Oresic M, Vidal-Puig A, Medina-Gomez G.

Dis Model Mech. 2012 Sep;5(5):636-48. doi: 10.1242/dmm.009266. Epub 2012 Jul 5.

25.

Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass.

Vivas Y, Martínez-García C, Izquierdo A, Garcia-Garcia F, Callejas S, Velasco I, Campbell M, Ros M, Dopazo A, Dopazo J, Vidal-Puig A, Medina-Gomez G.

BMC Med Genomics. 2011 Dec 30;4:86. doi: 10.1186/1755-8794-4-86.

26.

Metabolomic and Lipidomic Analysis of the Heart of Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-β Knock Out Mice on a High Fat Diet.

McCombie G, Medina-Gomez G, Lelliott CJ, Vidal-Puig A, Griffin JL.

Metabolites. 2012 Jun 18;2(2):366-81. doi: 10.3390/metabo2020366.

27.

PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.

Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED.

Circ Res. 2011 Sep 16;109(7):783-93. doi: 10.1161/CIRCRESAHA.111.243964. Epub 2011 Jul 28.

28.

[Obesity, adipogenesis and insulin resistance].

Ros Pérez M, Medina-Gómez G.

Endocrinol Nutr. 2011 Aug-Sep;58(7):360-9. doi: 10.1016/j.endonu.2011.05.008. Epub 2011 Jul 22. Review. Spanish.

PMID:
21778123
29.

Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia.

Gurung IS, Medina-Gomez G, Kis A, Baker M, Velagapudi V, Neogi SG, Campbell M, Rodriguez-Cuenca S, Lelliott C, McFarlane I, Oresic M, Grace AA, Vidal-Puig A, Huang CL.

Cardiovasc Res. 2011 Oct 1;92(1):29-38. doi: 10.1093/cvr/cvr155. Epub 2011 Jun 1.

30.

[Adipose tissue as a therapeutic target in obesity].

Medina-Gómez G, Vidal-Puig A.

Endocrinol Nutr. 2009 Oct;56(8):404-11. doi: 10.1016/S1575-0922(09)72710-X. Review. Spanish.

PMID:
19959150
31.

Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome.

Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A.

Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. doi: 10.1242/dmm.003251. Epub 2009 Oct 19.

32.

Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.

Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK.

Diabetes. 2009 Mar;58(3):609-19. doi: 10.2337/db08-1180. Epub 2008 Dec 10.

33.

Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.

Liesa M, Borda-d'Agua B, Medina-Gómez G, Lelliott CJ, Paz JC, Rojo M, Palacín M, Vidal-Puig A, Zorzano A.

PLoS One. 2008;3(10):e3613. doi: 10.1371/journal.pone.0003613. Epub 2008 Oct 31.

34.

Thermogenic effect of triiodothyroacetic acid at low doses in rat adipose tissue without adverse side effects in the thyroid axis.

Medina-Gomez G, Calvo RM, Obregon MJ.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E688-97. doi: 10.1152/ajpendo.00417.2007. Epub 2008 Feb 19.

35.

The metabolic profile of early Huntington's disease--a combined human and transgenic mouse study.

Goodman AO, Murgatroyd PR, Medina-Gomez G, Wood NI, Finer N, Vidal-Puig AJ, Morton AJ, Barker RA.

Exp Neurol. 2008 Apr;210(2):691-8. doi: 10.1016/j.expneurol.2007.12.026. Epub 2008 Jan 19.

PMID:
18284928
36.

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.

Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O'Rahilly S, DePaoli-Roach AA.

PLoS Med. 2008 Jan 29;5(1):e27. doi: 10.1371/journal.pmed.0050027. Erratum in: PLoS Med. 2008 Dec;5(12):e246.. Solanky, Bhavana [added]; Deelchand, Dinesh [added].

37.

Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1).

Medina-Gomez G, Gray S, Vidal-Puig A.

Public Health Nutr. 2007 Oct;10(10A):1132-7. Review.

PMID:
17903321
38.

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.

PLoS Genet. 2007 Apr 27;3(4):e64.

39.

Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.

Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M.

BMC Syst Biol. 2007 Feb 15;1:12.

40.

IGF-binding protein-2 protects against the development of obesity and insulin resistance.

Wheatcroft SB, Kearney MT, Shah AM, Ezzat VA, Miell JR, Modo M, Williams SC, Cawthorn WP, Medina-Gomez G, Vidal-Puig A, Sethi JK, Crossey PA.

Diabetes. 2007 Feb;56(2):285-94.

41.

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

PLoS Biol. 2006 Nov;4(11):e369.

42.

Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice.

Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O'Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A.

Diabetes. 2006 Oct;55(10):2669-77.

43.

Gateway to the metabolic syndrome.

Medina-Gomez G, Vidal-Puig A.

Nat Med. 2005 Jun;11(6):602-3. No abstract available.

PMID:
15937471
44.

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.

Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A.

Diabetes. 2005 Jun;54(6):1706-16.

45.

The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro.

Jitrapakdee S, Slawik M, Medina-Gomez G, Campbell M, Wallace JC, Sethi JK, O'rahilly S, Vidal-Puig AJ.

J Biol Chem. 2005 Jul 22;280(29):27466-76. Epub 2005 May 25.

46.

T3 and Triac inhibit leptin secretion and expression in brown and white rat adipocytes.

Medina-Gomez G, Calvo RM, Obregón MJ.

Biochim Biophys Acta. 2004 Jun 1;1682(1-3):38-47.

PMID:
15158754
47.

Nuclear receptor corepressor RIP140 regulates fat accumulation.

Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG.

Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8437-42. Epub 2004 May 20.

48.

Potent thermogenic action of triiodothyroacetic acid in brown adipocytes.

Medina-Gomez G, Hernàndez A, Calvo RM, Martin E, Obregón MJ.

Cell Mol Life Sci. 2003 Sep;60(9):1957-67.

PMID:
14523556

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