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Items: 1 to 50 of 131

1.

Human mesenchymal stromal cells do not promote recurrence of soft tissue sarcomas in mouse xenografts after radiation and surgery.

Filomeno PA, Kim KP, Yoon N, Rashedi I, Dayan V, Kandel RA, Wang XH, Felizardo TC, Berinstein E, Jelveh S, Filomeno A, Medin JA, Ferguson PC, Keating A.

Cytotherapy. 2018 Aug;20(8):1001-1012. doi: 10.1016/j.jcyt.2018.05.011. Epub 2018 Jul 31.

PMID:
30076069
2.

Acid ceramidase deficiency: Farber disease and SMA-PME.

Yu FPS, Amintas S, Levade T, Medin JA.

Orphanet J Rare Dis. 2018 Jul 20;13(1):121. doi: 10.1186/s13023-018-0845-z. Review.

3.

A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice.

Oishi H, Juvet SC, Martinu T, Sato M, Medin JA, Liu M, Keshavjee S.

J Thorac Cardiovasc Surg. 2018 Sep;156(3):1305-1315. doi: 10.1016/j.jtcvs.2018.05.003. Epub 2018 May 29.

PMID:
29937159
4.

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Fougerat A, Pan X, Smutova V, Heveker N, Cairo CW, Issad T, Larrivée B, Medin JA, Pshezhetsky AV.

Mol Metab. 2018 Jun;12:76-88. doi: 10.1016/j.molmet.2018.03.017. Epub 2018 Apr 21.

5.

ASAH1-Related Disorders.

Dyment DA, Bennett SAL, Medin JA, Levade T.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2018 Mar 29.

6.

Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.

Yu FPS, Dworski S, Medin JA.

Sci Rep. 2018 Jan 29;8(1):1808. doi: 10.1038/s41598-018-20052-6.

7.

Yin and Yang of mesenchymal stem cells and aplastic anemia.

Broglie L, Margolis D, Medin JA.

World J Stem Cells. 2017 Dec 26;9(12):219-226. doi: 10.4252/wjsc.v9.i12.219. Review.

8.

Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.

Yu FPS, Islam D, Sikora J, Dworski S, Gurka J, López-Vásquez L, Liu M, Kuebler WM, Levade T, Zhang H, Medin JA.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L406-L420. doi: 10.1152/ajplung.00223.2017. Epub 2017 Nov 22.

PMID:
29167126
9.

Sphingolipid pathway enzymes modulate cell fate and immune responses.

Molino S, Tate E, McKillop WM, Medin JA.

Immunotherapy. 2017 Nov;9(14):1185-1198. doi: 10.2217/imt-2017-0089. Review.

PMID:
29067886
10.

Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system.

Nomura R, Sato T, Sato Y, Medin JA, Kushimoto S, Yanagisawa T.

Redox Biol. 2017 Oct;13:407-417. doi: 10.1016/j.redox.2017.06.011. Epub 2017 Jun 29.

11.

Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34+ Cells for Correction of Fabry Disease.

Huang J, Khan A, Au BC, Barber DL, López-Vásquez L, Prokopishyn NL, Boutin M, Rothe M, Rip JW, Abaoui M, Nagree MS, Dworski S, Schambach A, Keating A, West ML, Klassen J, Turner PV, Sirrs S, Rupar CA, Auray-Blais C, Foley R, Medin JA.

Mol Ther Methods Clin Dev. 2017 May 12;5:241-258. doi: 10.1016/j.omtm.2017.05.003. eCollection 2017 Jun 16.

12.

Practical considerations for chimeric antigen receptor design and delivery.

Oldham RAA, Medin JA.

Expert Opin Biol Ther. 2017 Aug;17(8):961-978. doi: 10.1080/14712598.2017.1339687. Epub 2017 Jun 16. Review.

PMID:
28586264
13.

Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.

Sikora J, Dworski S, Jones EE, Kamani MA, Micsenyi MC, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Dunn CK, Xuan ICY, Casas J, Fabrias G, Hampson DR, Levade T, Drake RR, Medin JA, Walkley SU.

Am J Pathol. 2017 Apr;187(4):864-883. doi: 10.1016/j.ajpath.2016.12.005.

14.

Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.

He X, Dworski S, Zhu C, DeAngelis V, Solyom A, Medin JA, Simonaro CM, Schuchman EH.

BBA Clin. 2017 Feb 13;7:85-96. doi: 10.1016/j.bbacli.2017.02.001. eCollection 2017 Jun.

15.

Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion.

Kamani MA, Provençal P, Boutin M, Pacienza N, Fan X, Novak A, Huang TC, Binnington B, Au BC, Auray-Blais C, Lingwood CA, Medin JA.

Future Sci OA. 2016 Oct 13;2(4):FSO147. doi: 10.4155/fsoa-2016-0027. eCollection 2016 Dec.

16.

Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.

Huang J, Liu Y, Au BC, Barber DL, Arruda A, Schambach A, Rothe M, Minden MD, Paige CJ, Medin JA.

Mol Ther Methods Clin Dev. 2016 Dec 7;3:16074. eCollection 2016.

17.

Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.

Dworski S, Lu P, Khan A, Maranda B, Mitchell JJ, Parini R, Di Rocco M, Hugle B, Yoshimitsu M, Magnusson B, Makay B, Arslan N, Guelbert N, Ehlert K, Jarisch A, Gardner-Medwin J, Dagher R, Terreri MT, Lorenco CM, Barillas-Arias L, Tanpaiboon P, Solyom A, Norris JS, He X, Schuchman EH, Levade T, Medin JA.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):386-394. doi: 10.1016/j.bbadis.2016.11.031. Epub 2016 Dec 1.

18.

Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues.

Desnick RJ, Barton NW, Furbish S, Grabowski GA, Karlsson S, Kolodny EH, Medin JA, Murray GJ, Mistry PK, Patterson MC, Schiffmann R, Weinreb NJ.

Mol Genet Metab. 2017 Jan - Feb;120(1-2):1-7. doi: 10.1016/j.ymgme.2016.10.010. Epub 2016 Nov 12.

PMID:
27866832
19.

Roscoe Owen Brady: Passion for patients.

Medin JA.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11644-11645. Epub 2016 Oct 7. No abstract available.

20.

Development of Novel Immunotherapies for Multiple Myeloma.

Al-Hujaily EM, Oldham RA, Hari P, Medin JA.

Int J Mol Sci. 2016 Sep 8;17(9). pii: E1506. doi: 10.3390/ijms17091506. Review.

21.

Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry.

Provençal P, Boutin M, Dworski S, Au B, Medin JA, Auray-Blais C.

Bioanalysis. 2016 Sep;8(17):1793-807. doi: 10.4155/bio-2016-0116. Epub 2016 Aug 15.

22.

Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns.

Resetca D, Neschadim A, Medin JA.

J Immunother. 2016 Sep;39(7):249-59. doi: 10.1097/CJI.0000000000000134. Review.

PMID:
27488725
23.

Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques.

Au BC, Lee CJ, Lopez-Perez O, Foltz W, Felizardo TC, Wang JCM, Huang J, Fan X, Madden M, Goldstein A, Jaffray DA, Moloo B, McCart JA, Medin JA.

Biomedicines. 2016 Feb 19;4(1). pii: E6. doi: 10.3390/biomedicines4010006.

24.

Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy.

Nagree MS, López-Vásquez L, Medin JA.

World J Stem Cells. 2015 Dec 26;7(11):1233-50. doi: 10.4252/wjsc.v7.i11.1233. Review.

25.

Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis.

Sato T, Neschadim A, Nakagawa R, Yanagisawa T, Medin JA.

Methods Mol Biol. 2015;1317:55-67. doi: 10.1007/978-1-4939-2727-2_4.

PMID:
26072401
26.

Lentiviral vectors in cancer immunotherapy.

Oldham RA, Berinstein EM, Medin JA.

Immunotherapy. 2015;7(3):271-84. doi: 10.2217/imt.14.108. Review.

PMID:
25804479
27.

Markedly perturbed hematopoiesis in acid ceramidase deficient mice.

Dworski S, Berger A, Furlonger C, Moreau JM, Yoshimitsu M, Trentadue J, Au BC, Paige CJ, Medin JA.

Haematologica. 2015 May;100(5):e162-5. doi: 10.3324/haematol.2014.108530. Epub 2015 Feb 14. No abstract available.

28.

Advances in haplo-identical stem cell transplantation in adults with high-risk hematological malignancies.

Ricci MJ, Medin JA, Foley RS.

World J Stem Cells. 2014 Sep 26;6(4):380-90. doi: 10.4252/wjsc.v6.i4.380. Review.

29.

Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity.

Nelles ME, Moreau JM, Furlonger CL, Berger A, Medin JA, Paige CJ.

Cancer Immunol Res. 2014 Nov;2(11):1113-24. doi: 10.1158/2326-6066.CIR-13-0208. Epub 2014 Aug 25.

30.

On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.

Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR.

Anal Chem. 2014 Aug 19;86(16):8303-11. doi: 10.1021/ac501937d. Epub 2014 Aug 8.

31.

Localized interleukin-12 delivery for immunotherapy of solid tumours.

Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ.

J Cell Mol Med. 2013 Nov;17(11):1465-74. doi: 10.1111/jcmm.12121. Epub 2013 Nov 19.

32.

The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.

Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA.

PLoS One. 2013 Oct 23;8(10):e78711. doi: 10.1371/journal.pone.0078711. eCollection 2013.

33.

Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways.

Wang JC, Felizardo TC, Au BC, Fowler DH, Dekaban GA, Medin JA.

Virol J. 2013 Jul 20;10:240. doi: 10.1186/1743-422X-10-240.

34.

Systemic ceramide accumulation leads to severe and varied pathological consequences.

Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA.

EMBO Mol Med. 2013 Jun;5(6):827-42. doi: 10.1002/emmm.201202301. Epub 2013 May 16.

35.

Harnessing autophagy for cell fate control gene therapy.

Felizardo TC, Foley J, Steed K, Dropulic B, Amarnath S, Medin JA, Fowler DH.

Autophagy. 2013 Jul;9(7):1069-79. doi: 10.4161/auto.24639. Epub 2013 Apr 17.

36.

Lentivirus IL-10 gene therapy down-regulates IL-17 and attenuates mouse orthotopic lung allograft rejection.

Hirayama S, Sato M, Loisel-Meyer S, Matsuda Y, Oishi H, Guan Z, Saito T, Yeung J, Cypel M, Hwang DM, Medin JA, Liu M, Keshavjee S.

Am J Transplant. 2013 Jun;13(6):1586-93. doi: 10.1111/ajt.12230. Epub 2013 Apr 19.

37.

Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity.

Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC.

Brain Behav Immun. 2013 May;30:103-14. doi: 10.1016/j.bbi.2013.01.079. Epub 2013 Jan 29.

PMID:
23369732
38.

Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia.

Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA.

Hum Gene Ther. 2012 Dec;23(12):1280-9. doi: 10.1089/hum.2012.063. Epub 2012 Nov 23.

PMID:
22998370
39.

Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer.

Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T.

Mol Cell Proteomics. 2012 Dec;11(12):1870-84. doi: 10.1074/mcp.M112.017889. Epub 2012 Sep 17.

40.

Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice.

Pacienza N, Yoshimitsu M, Mizue N, Au BC, Wang JC, Fan X, Takenaka T, Medin JA.

Mol Ther. 2012 Jul;20(7):1454-61. doi: 10.1038/mt.2012.64. Epub 2012 Apr 3.

41.

Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.

Neschadim A, Wang JC, Lavie A, Medin JA.

Cancer Gene Ther. 2012 May;19(5):320-7. doi: 10.1038/cgt.2012.4. Epub 2012 Mar 2.

PMID:
22388453
42.

Identification of prostate-enriched proteins by in-depth proteomic analyses of expressed prostatic secretions in urine.

Principe S, Kim Y, Fontana S, Ignatchenko V, Nyalwidhe JO, Lance RS, Troyer DA, Alessandro R, Semmes OJ, Kislinger T, Drake RR, Medin JA.

J Proteome Res. 2012 Apr 6;11(4):2386-96. doi: 10.1021/pr2011236. Epub 2012 Feb 29.

43.

Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase.

Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA.

Mol Ther. 2012 May;20(5):1002-13. doi: 10.1038/mt.2011.298. Epub 2012 Jan 24.

44.

Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model.

Swift BE, Williams BA, Kosaka Y, Wang XH, Medin JA, Viswanathan S, Martinez-Lopez J, Keating A.

Haematologica. 2012 Jul;97(7):1020-8. doi: 10.3324/haematol.2011.054254. Epub 2012 Jan 22.

45.

Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes.

Scaife M, Pacienza N, Au BC, Wang JC, Devine S, Scheid E, Lee CJ, Lopez-Perez O, Neschadim A, Fowler DH, Foley R, Medin JA.

Gene Ther. 2013 Jan;20(1):24-34. doi: 10.1038/gt.2011.210. Epub 2012 Jan 12.

PMID:
22241175
46.

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.

Amarnath S, Mangus CW, Wang JC, Wei F, He A, Kapoor V, Foley JE, Massey PR, Felizardo TC, Riley JL, Levine BL, June CH, Medin JA, Fowler DH.

Sci Transl Med. 2011 Nov 30;3(111):111ra120. doi: 10.1126/scitranslmed.3003130.

47.

Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro.

Berthod F, Symes J, Tremblay N, Medin JA, Auger FA.

J Cell Physiol. 2012 May;227(5):2130-7. doi: 10.1002/jcp.22943.

PMID:
21769871
48.

Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways.

Hirayama S, Sato M, Liu M, Loisel-Meyer S, Yeung JC, Wagnetz D, Cypel M, Zehong G, Medin JA, Keshavjee S.

Hum Gene Ther. 2011 Nov;22(11):1453-60. doi: 10.1089/hum.2010.225. Epub 2011 Jul 12.

PMID:
21568692
49.

Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model.

Felizardo TC, Wang JC, McGray RA, Evelegh C, Spaner DE, Fowler DH, Bramson JL, Medin JA.

Gene Ther. 2011 Oct;18(10):986-95. doi: 10.1038/gt.2011.53. Epub 2011 Apr 14.

PMID:
21490686
50.

A novel tissue-engineered approach to problems of the postpneumonectomy space.

Tsunooka N, Hirayama S, Medin JA, Liles WC, Keshavjee S, Waddell TK.

Ann Thorac Surg. 2011 Mar;91(3):880-6. doi: 10.1016/j.athoracsur.2010.11.039.

PMID:
21353020

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