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Items: 1 to 50 of 216

1.

Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target.

Li Y, Xu Y, Benitez BA, Nagree MS, Dearborn JT, Jiang X, Guzman MA, Woloszynek JC, Giaramita A, Yip BK, Elsbernd J, Babcock MC, Lo M, Fowler SC, Wozniak DF, Vogler CA, Medin JA, Crawford BE, Sands MS.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20097-20103. doi: 10.1073/pnas.1912108116. Epub 2019 Sep 16.

PMID:
31527255
2.

MediYoga as a part of a self-management programme among patients with paroxysmal atrial fibrillation - a randomised study.

Wahlström M, Rosenqvist M, Medin J, Walfridsson U, Rydell-Karlsson M.

Eur J Cardiovasc Nurs. 2019 Sep 17:1474515119871796. doi: 10.1177/1474515119871796. [Epub ahead of print]

PMID:
31526039
3.

Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.

Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA.

Lab Invest. 2019 Oct;99(10):1572-1592. doi: 10.1038/s41374-019-0271-4. Epub 2019 Jun 11.

PMID:
31186526
4.

Sleep as a topic in nursing education programs? A mixed method study of syllabuses and nursing students' perceptions.

Gellerstedt L, Medin J, Kumlin M, Rydell Karlsson M.

Nurse Educ Today. 2019 Aug;79:168-174. doi: 10.1016/j.nedt.2019.05.030. Epub 2019 May 23.

PMID:
31132729
5.

Inherited monogenic defects of ceramide metabolism: Molecular bases and diagnoses.

Dubot P, Sabourdy F, Rybova J, Medin JA, Levade T.

Clin Chim Acta. 2019 Aug;495:457-466. doi: 10.1016/j.cca.2019.05.020. Epub 2019 May 22. Review.

PMID:
31128082
6.

Nursing care and management of patients' sleep during hospitalisation: A cross-sectional study.

Gellerstedt L, Medin J, Kumlin M, Rydell Karlsson M.

J Clin Nurs. 2019 Oct;28(19-20):3400-3407. doi: 10.1111/jocn.14915. Epub 2019 Jun 10.

PMID:
31091343
7.

An update on gene therapy for lysosomal storage disorders.

Nagree MS, Scalia S, McKillop WM, Medin JA.

Expert Opin Biol Ther. 2019 Jul;19(7):655-670. doi: 10.1080/14712598.2019.1607837. Epub 2019 May 6.

PMID:
31056978
8.

Lentiviral interleukin-10 gene therapy: Safety and questions.

Liu M, Juvet SC, Medin JA, Martinu T, Oishi H, Keshavjee S.

J Thorac Cardiovasc Surg. 2019 Feb;157(2):818-819. doi: 10.1016/j.jtcvs.2018.10.082. No abstract available.

PMID:
30669243
9.

Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells.

Neschadim A, Medin JA.

Methods Mol Biol. 2019;1895:149-163. doi: 10.1007/978-1-4939-8922-5_12.

PMID:
30539536
10.

Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury.

Islam D, Huang Y, Fanelli V, Delsedime L, Wu S, Khang J, Han B, Grassi A, Li M, Xu Y, Luo A, Wu J, Liu X, McKillop M, Medin J, Qiu H, Zhong N, Liu M, Laffey J, Li Y, Zhang H.

Am J Respir Crit Care Med. 2019 May 15;199(10):1214-1224. doi: 10.1164/rccm.201802-0356OC.

PMID:
30521764
11.

Perceptions and experiences of MediYoga among patients with paroxysmal atrial fibrillation-An interview study.

Wahlström M, Rydell Karlsson M, Medin J.

Complement Ther Med. 2018 Dec;41:29-34. doi: 10.1016/j.ctim.2018.09.002. Epub 2018 Sep 5.

PMID:
30477856
12.

Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.

Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA.

Am J Pathol. 2019 Feb;189(2):320-338. doi: 10.1016/j.ajpath.2018.10.018. Epub 2018 Nov 23.

PMID:
30472209
13.

Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the multiple sclerosis, clinical and MRI outcomes in the USA (MS-MRIUS) study.

Zivadinov R, Medin J, Khan N, Korn JR, Chitnis T, Naismith RT, Alvarez E, Dwyer MG, Bergsland N, Carl E, Silva D, Weinstock-Guttman B; MS-MRIUS Study Group.

Mult Scler Relat Disord. 2019 Jan;27:65-73. doi: 10.1016/j.msard.2018.09.037. Epub 2018 Oct 3.

PMID:
30342416
14.

Human mesenchymal stromal cells do not promote recurrence of soft tissue sarcomas in mouse xenografts after radiation and surgery.

Filomeno PA, Kim KP, Yoon N, Rashedi I, Dayan V, Kandel RA, Wang XH, Felizardo TC, Berinstein E, Jelveh S, Filomeno A, Medin JA, Ferguson PC, Keating A.

Cytotherapy. 2018 Aug;20(8):1001-1012. doi: 10.1016/j.jcyt.2018.05.011. Epub 2018 Jul 31.

PMID:
30076069
15.

Acid ceramidase deficiency: Farber disease and SMA-PME.

Yu FPS, Amintas S, Levade T, Medin JA.

Orphanet J Rare Dis. 2018 Jul 20;13(1):121. doi: 10.1186/s13023-018-0845-z. Review.

16.

A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice.

Oishi H, Juvet SC, Martinu T, Sato M, Medin JA, Liu M, Keshavjee S.

J Thorac Cardiovasc Surg. 2018 Sep;156(3):1305-1315. doi: 10.1016/j.jtcvs.2018.05.003. Epub 2018 May 29.

PMID:
29937159
17.

Fingolimod's Impact on MRI Brain Volume Measures in Multiple Sclerosis: Results from MS-MRIUS.

Zivadinov R, Medin J, Khan N, Korn JR, Bergsland N, Dwyer MG, Chitnis T, Naismith RT, Alvarez E, Kinkel P, Cohan S, Hunter SF, Silva D, Weinstock-Guttman B; MS-MRIUS investigators.

J Neuroimaging. 2018 Jul;28(4):399-405. doi: 10.1111/jon.12518. Epub 2018 May 11.

PMID:
29749661
18.

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Fougerat A, Pan X, Smutova V, Heveker N, Cairo CW, Issad T, Larrivée B, Medin JA, Pshezhetsky AV.

Mol Metab. 2018 Jun;12:76-88. doi: 10.1016/j.molmet.2018.03.017. Epub 2018 Apr 21.

19.

No evidence of disease activity in patients receiving fingolimod at private or academic centers in clinical practice: a retrospective analysis of the multiple sclerosis, clinical, and magnetic resonance imaging outcomes in the USA (MS-MRIUS) study.

Zivadinov R, Khan N, Korn JR, Lathi E, Silversteen J, Calkwood J, Kolodny S, Silva D, Medin J, Weinstock-Guttman B; MS-MRIUS study group.

Curr Med Res Opin. 2018 Aug;34(8):1431-1440. doi: 10.1080/03007995.2018.1458708. Epub 2018 Apr 12.

PMID:
29648900
20.

ASAH1-Related Disorders.

Dyment DA, Bennett SAL, Medin JA, Levade T.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2018 Mar 29.

21.

Establishing pathological cut-offs for lateral ventricular volume expansion rates.

Dwyer MG, Hagemeier J, Bergsland N, Horakova D, Korn JR, Khan N, Uher T, Medin J, Silva D, Vaneckova M, Havrdova EK, Zivadinov R.

Neuroimage Clin. 2018 Feb 7;18:494-501. doi: 10.1016/j.nicl.2018.02.009. eCollection 2018.

22.

Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.

Yu FPS, Dworski S, Medin JA.

Sci Rep. 2018 Jan 29;8(1):1808. doi: 10.1038/s41598-018-20052-6.

23.

Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells.

Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S.

J Vis Exp. 2018 Jan 15;(131). doi: 10.3791/55063.

24.

Yin and Yang of mesenchymal stem cells and aplastic anemia.

Broglie L, Margolis D, Medin JA.

World J Stem Cells. 2017 Dec 26;9(12):219-226. doi: 10.4252/wjsc.v9.i12.219. Review.

25.

Clinical and Demographic Profile of Patients Receiving Fingolimod in Clinical Practice in Germany and the Benefit-Risk Profile of Fingolimod After 1 Year of Treatment: Initial Results From the Observational, Noninterventional Study PANGAEA.

Ziemssen T, Lang M, Tackenberg B, Schmidt S, Albrecht H, Klotz L, Haas J, Lassek C, Medin J, Cornelissen C; PANGAEA study group.

Neurotherapeutics. 2018 Jan;15(1):190-199. doi: 10.1007/s13311-017-0595-y.

26.
27.

Feasibility of Brain Atrophy Measurement in Clinical Routine without Prior Standardization of the MRI Protocol: Results from MS-MRIUS, a Longitudinal Observational, Multicenter Real-World Outcome Study in Patients with Relapsing-Remitting MS.

Zivadinov R, Bergsland N, Korn JR, Dwyer MG, Khan N, Medin J, Price JC, Weinstock-Guttman B, Silva D; MS-MRIUS Study Group.

AJNR Am J Neuroradiol. 2018 Feb;39(2):289-295. doi: 10.3174/ajnr.A5442. Epub 2017 Nov 23.

28.

Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.

Yu FPS, Islam D, Sikora J, Dworski S, Gurka J, López-Vásquez L, Liu M, Kuebler WM, Levade T, Zhang H, Medin JA.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L406-L420. doi: 10.1152/ajplung.00223.2017. Epub 2017 Nov 22.

29.

Sphingolipid pathway enzymes modulate cell fate and immune responses.

Molino S, Tate E, McKillop WM, Medin JA.

Immunotherapy. 2017 Nov;9(14):1185-1198. doi: 10.2217/imt-2017-0089. Review.

PMID:
29067886
30.

Patient-reported outcomes in multiple sclerosis: a systematic comparison of available measures.

Khurana V, Sharma H, Afroz N, Callan A, Medin J.

Eur J Neurol. 2017 Sep;24(9):1099-1107. doi: 10.1111/ene.13339. Epub 2017 Jul 11. Review.

PMID:
28695634
31.

Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system.

Nomura R, Sato T, Sato Y, Medin JA, Kushimoto S, Yanagisawa T.

Redox Biol. 2017 Oct;13:407-417. doi: 10.1016/j.redox.2017.06.011. Epub 2017 Jun 29.

32.

Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34+ Cells for Correction of Fabry Disease.

Huang J, Khan A, Au BC, Barber DL, López-Vásquez L, Prokopishyn NL, Boutin M, Rothe M, Rip JW, Abaoui M, Nagree MS, Dworski S, Schambach A, Keating A, West ML, Klassen J, Turner PV, Sirrs S, Rupar CA, Auray-Blais C, Foley R, Medin JA.

Mol Ther Methods Clin Dev. 2017 May 12;5:241-258. doi: 10.1016/j.omtm.2017.05.003. eCollection 2017 Jun 16.

33.

Practical considerations for chimeric antigen receptor design and delivery.

Oldham RAA, Medin JA.

Expert Opin Biol Ther. 2017 Aug;17(8):961-978. doi: 10.1080/14712598.2017.1339687. Epub 2017 Jun 16. Review.

PMID:
28586264
34.

Two studies in one: A propensity-score-matched comparison of fingolimod versus interferons and glatiramer acetate using real-world data from the independent German studies, PANGAEA and PEARL.

Alsop J, Medin J, Cornelissen C, Vormfelde SV, Ziemssen T.

PLoS One. 2017 May 5;12(5):e0173353. doi: 10.1371/journal.pone.0173353. eCollection 2017.

35.

The psychosocial work environment is associated with risk of stroke at working age.

Jood K, Karlsson N, Medin J, Pessah-Rasmussen H, Wester P, Ekberg K.

Scand J Work Environ Health. 2017 Jul 1;43(4):367-374. doi: 10.5271/sjweh.3636. Epub 2017 Mar 27.

36.

Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.

Sikora J, Dworski S, Jones EE, Kamani MA, Micsenyi MC, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Dunn CK, Xuan ICY, Casas J, Fabrias G, Hampson DR, Levade T, Drake RR, Medin JA, Walkley SU.

Am J Pathol. 2017 Apr;187(4):864-883. doi: 10.1016/j.ajpath.2016.12.005.

37.

Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.

He X, Dworski S, Zhu C, DeAngelis V, Solyom A, Medin JA, Simonaro CM, Schuchman EH.

BBA Clin. 2017 Feb 13;7:85-96. doi: 10.1016/j.bbacli.2017.02.001. eCollection 2017 Jun.

38.

Multiple sclerosis in the real world: A systematic review of fingolimod as a case study.

Ziemssen T, Medin J, Couto CA, Mitchell CR.

Autoimmun Rev. 2017 Apr;16(4):355-376. doi: 10.1016/j.autrev.2017.02.007. Epub 2017 Feb 15. Review.

39.

Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion.

Kamani MA, Provençal P, Boutin M, Pacienza N, Fan X, Novak A, Huang TC, Binnington B, Au BC, Auray-Blais C, Lingwood CA, Medin JA.

Future Sci OA. 2016 Oct 13;2(4):FSO147. doi: 10.4155/fsoa-2016-0027. eCollection 2016 Dec.

40.

Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.

Huang J, Liu Y, Au BC, Barber DL, Arruda A, Schambach A, Rothe M, Minden MD, Paige CJ, Medin JA.

Mol Ther Methods Clin Dev. 2016 Dec 7;3:16074. eCollection 2016.

41.

An Observational Study to Assess Brain MRI Change and Disease Progression in Multiple Sclerosis Clinical Practice-The MS-MRIUS Study.

Zivadinov R, Khan N, Medin J, Christoffersen P, Price J, Korn JR, Bonzani I, Dwyer MG, Bergsland N, Carl E, Silva D, Weinstock-Guttman B.

J Neuroimaging. 2017 May;27(3):339-347. doi: 10.1111/jon.12411. Epub 2016 Dec 5.

42.

Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.

Dworski S, Lu P, Khan A, Maranda B, Mitchell JJ, Parini R, Di Rocco M, Hugle B, Yoshimitsu M, Magnusson B, Makay B, Arslan N, Guelbert N, Ehlert K, Jarisch A, Gardner-Medwin J, Dagher R, Terreri MT, Lorenco CM, Barillas-Arias L, Tanpaiboon P, Solyom A, Norris JS, He X, Schuchman EH, Levade T, Medin JA.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):386-394. doi: 10.1016/j.bbadis.2016.11.031. Epub 2016 Dec 1.

43.

Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues.

Desnick RJ, Barton NW, Furbish S, Grabowski GA, Karlsson S, Kolodny EH, Medin JA, Murray GJ, Mistry PK, Patterson MC, Schiffmann R, Weinreb NJ.

Mol Genet Metab. 2017 Jan - Feb;120(1-2):1-7. doi: 10.1016/j.ymgme.2016.10.010. Epub 2016 Nov 12.

PMID:
27866832
44.

Roscoe Owen Brady: Passion for patients.

Medin JA.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11644-11645. Epub 2016 Oct 7. No abstract available.

46.

Development of Novel Immunotherapies for Multiple Myeloma.

Al-Hujaily EM, Oldham RA, Hari P, Medin JA.

Int J Mol Sci. 2016 Sep 8;17(9). pii: E1506. doi: 10.3390/ijms17091506. Review.

47.

Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry.

Provençal P, Boutin M, Dworski S, Au B, Medin JA, Auray-Blais C.

Bioanalysis. 2016 Sep;8(17):1793-807. doi: 10.4155/bio-2016-0116. Epub 2016 Aug 15.

48.

Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns.

Resetca D, Neschadim A, Medin JA.

J Immunother. 2016 Sep;39(7):249-59. doi: 10.1097/CJI.0000000000000134. Review.

PMID:
27488725
49.

Effects of yoga in patients with paroxysmal atrial fibrillation - a randomized controlled study.

Wahlstrom M, Rydell Karlsson M, Medin J, Frykman V.

Eur J Cardiovasc Nurs. 2017 Jan;16(1):57-63. doi: 10.1177/1474515116637734. Epub 2016 Jul 7.

PMID:
26976659
50.

Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques.

Au BC, Lee CJ, Lopez-Perez O, Foltz W, Felizardo TC, Wang JCM, Huang J, Fan X, Madden M, Goldstein A, Jaffray DA, Moloo B, McCart JA, Medin JA.

Biomedicines. 2016 Feb 19;4(1). pii: E6. doi: 10.3390/biomedicines4010006.

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