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Items: 44


Functionalization of sol-gel coatings with organophosphorus compounds for prosthetic devices.

Garcia-Casas A, Aguilera-Correa JJ, Mediero A, Esteban J, Jimenez-Morales A.

Colloids Surf B Biointerfaces. 2019 Sep 1;181:973-980. doi: 10.1016/j.colsurfb.2019.06.042. Epub 2019 Jun 19.


Chondrocyte enlargement is a marker of osteoarthritis severity.

Gratal P, Mediero A, Sánchez-Pernaute O, Prieto-Potin I, Lamuedra A, Herrero-Beaumont G, Largo R.

Osteoarthritis Cartilage. 2019 Aug;27(8):1229-1234. doi: 10.1016/j.joca.2019.04.013. Epub 2019 Apr 30.


Tenofovir Causes Bone Loss via Decreased Bone Formation and Increased Bone Resorption, Which Can Be Counteracted by Dipyridamole in Mice.

Conesa-Buendía FM, Llamas-Granda P, Larrañaga-Vera A, Wilder T, Largo R, Herrero-Beaumont G, Cronstein B, Mediero A.

J Bone Miner Res. 2019 May;34(5):923-938. doi: 10.1002/jbmr.3665. Epub 2019 Feb 25.


Microbiological and Cellular Evaluation of a Fluorine-Phosphorus-Doped Titanium Alloy, a Novel Antibacterial and Osteostimulatory Biomaterial with Potential Applications in Orthopedic Surgery.

Aguilera-Correa JJ, Mediero A, Conesa-Buendía FM, Conde A, Arenas MÁ, de-Damborenea JJ, Esteban J.

Appl Environ Microbiol. 2019 Jan 9;85(2). pii: e02271-18. doi: 10.1128/AEM.02271-18. Print 2019 Jan 15.


Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing.

Lopez CD, Bekisz JM, Corciulo C, Mediero A, Coelho PG, Witek L, Flores RL, Cronstein BN.

Adv Drug Deliv Rev. 2018 Jun 18. pii: S0169-409X(18)30149-2. doi: 10.1016/j.addr.2018.06.010. [Epub ahead of print]


Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis.

Naredo E, Medina JP, Pérez-Baos S, Mediero A, Herrero-Beaumont G, Largo R.

Ultrasound Med Biol. 2018 Jul;44(7):1516-1524. doi: 10.1016/j.ultrasmedbio.2018.03.018. Epub 2018 Apr 24.


The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation.

Bekisz JM, Lopez CD, Corciulo C, Mediero A, Coelho PG, Witek L, Flores RL, Cronstein BN.

Inflammation. 2018 Aug;41(4):1135-1141. doi: 10.1007/s10753-018-0781-z. Review.


Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis.

Mediero A, Wilder T, Shah L, Cronstein BN.

FASEB J. 2018 Jul;32(7):3487-3501. doi: 10.1096/fj.201700217R. Epub 2018 Feb 2.


The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin.

Feig JL, Mediero A, Corciulo C, Liu H, Zhang J, Perez-Aso M, Picard L, Wilder T, Cronstein B.

PLoS One. 2017 Nov 16;12(11):e0188135. doi: 10.1371/journal.pone.0188135. eCollection 2017.


Unexpected Bone Formation Produced by RANKL Blockade.

Portal-Núñez S, Mediero A, Esbrit P, Sánchez-Pernaute O, Largo R, Herrero-Beaumont G.

Trends Endocrinol Metab. 2017 Oct;28(10):695-704. doi: 10.1016/j.tem.2017.06.003. Epub 2017 Jul 19. Review.


The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits.

Roman-Blas JA, Mediero A, Tardío L, Portal-Nuñez S, Gratal P, Herrero-Beaumont G, Largo R.

Eur J Pharmacol. 2017 Jan 5;794:8-14. doi: 10.1016/j.ejphar.2016.11.015. Epub 2016 Nov 12.


Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism.

Mediero A, Wilder T, Reddy VS, Cheng Q, Tovar N, Coelho PG, Witek L, Whatling C, Cronstein BN.

FASEB J. 2016 Nov;30(11):3887-3900. Epub 2016 Aug 10.


Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis.

Mediero A, Wilder T, Ramkhelawon B, Moore KJ, Cronstein BN.

FASEB J. 2016 Nov;30(11):3835-3844. Epub 2016 Aug 8.


Adenosine A2A receptor promotes collagen type III synthesis via β-catenin activation in human dermal fibroblasts.

Shaikh G, Zhang J, Perez-Aso M, Mediero A, Cronstein B.

Br J Pharmacol. 2016 Dec;173(23):3279-3291. doi: 10.1111/bph.13615. Epub 2016 Oct 4.


Bone regeneration in critical bone defects using three-dimensionally printed β-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2.

Ishack S, Mediero A, Wilder T, Ricci JL, Cronstein BN.

J Biomed Mater Res B Appl Biomater. 2017 Feb;105(2):366-375. doi: 10.1002/jbm.b.33561. Epub 2015 Oct 29.


Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis.

Mediero A, Ramkhelawon B, Wilder T, Purdue PE, Goldring SR, Dewan MZ, Loomis C, Moore KJ, Cronstein BN.

Ann Rheum Dis. 2016 Sep;75(9):1706-13. doi: 10.1136/annrheumdis-2015-207593. Epub 2015 Oct 9.


Adenosine A2A receptor plays an important role in radiation-induced dermal injury.

Perez-Aso M, Mediero A, Low YC, Levine J, Cronstein BN.

FASEB J. 2016 Jan;30(1):457-65. doi: 10.1096/fj.15-280388. Epub 2015 Sep 28.


Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.

Perez-Aso M, Montesinos MC, Mediero A, Wilder T, Schafer PH, Cronstein B.

Arthritis Res Ther. 2015 Sep 15;17:249. doi: 10.1186/s13075-015-0771-6.


Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2.

Mediero A, Wilder T, Perez-Aso M, Cronstein BN.

FASEB J. 2015 Apr;29(4):1577-90. doi: 10.1096/fj.14-265066. Epub 2015 Jan 8.


Brief Report: Methotrexate Prevents Wear Particle-Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2A Receptor.

Mediero A, Perez-Aso M, Wilder T, Cronstein BN.

Arthritis Rheumatol. 2015 Mar;67(3):849-55. doi: 10.1002/art.38971.


Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation.

Mediero A, Ramkhelawon B, Perez-Aso M, Moore KJ, Cronstein BN.

J Bone Miner Res. 2015 May;30(5):837-54. doi: 10.1002/jbmr.2421.


Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements.

Mediero A, Perez-Aso M, Cronstein BN.

FASEB J. 2014 Nov;28(11):4901-13. doi: 10.1096/fj.14-255703. Epub 2014 Aug 13.


Effect of melatonin and analogues on corneal wound healing: involvement of Mt2 melatonin receptor.

Crooke A, Guzman-Aranguez A, Mediero A, Alarma-Estrany P, Carracedo G, Pelaez T, Peral A, Pintor J.

Curr Eye Res. 2015 Jan;40(1):56-65. doi: 10.3109/02713683.2014.914540. Epub 2014 Jun 3.


Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3.

Perez-Aso M, Fernandez P, Mediero A, Chan ES, Cronstein BN.

FASEB J. 2014 Feb;28(2):802-12. doi: 10.1096/fj.13-241646. Epub 2013 Nov 7.


Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance.

Perez-Aso M, Mediero A, Cronstein BN.

Purinergic Signal. 2013 Dec;9(4):573-83. doi: 10.1007/s11302-013-9368-1. Epub 2013 Jun 8.


Activation of adenosine A(2A) receptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation.

Mediero A, Perez-Aso M, Cronstein BN.

Br J Pharmacol. 2013 Jul;169(6):1372-88. doi: 10.1111/bph.12227.


Adenosine and bone metabolism.

Mediero A, Cronstein BN.

Trends Endocrinol Metab. 2013 Jun;24(6):290-300. doi: 10.1016/j.tem.2013.02.001. Epub 2013 Mar 14. Review.


Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.

Perez-Aso M, Feig JL, Mediero A, Cronstein BN.

Inflammation. 2013 Feb;36(1):152-62. doi: 10.1007/s10753-012-9530-x. Erratum in: Inflammation. 2013 Feb;36(1):163. Aránzazu, Mediero [corrected to Mediero, Aránzazu].


Adenosine A2A receptor activation prevents wear particle-induced osteolysis.

Mediero A, Frenkel SR, Wilder T, He W, Mazumder A, Cronstein BN.

Sci Transl Med. 2012 May 23;4(135):135ra65. doi: 10.1126/scitranslmed.3003393.


Adenosine A(2A) receptor ligation inhibits osteoclast formation.

Mediero A, Kara FM, Wilder T, Cronstein BN.

Am J Pathol. 2012 Feb;180(2):775-86. doi: 10.1016/j.ajpath.2011.10.017. Epub 2011 Nov 30.


Phospholipase C/Protein Kinase C pathway is essential for corneal re-epithelialization induced by Ap(4)A.

Mediero A, Crooke A, Guzmán-Aránguez A, Pintor J.

Curr Eye Res. 2011 Dec;36(12):1108-15. doi: 10.3109/02713683.2011.614371. Epub 2011 Oct 11.


[Tuberculosis-related hospitalization in Spain: a cost analysis].

Montes-Santiago J, Fernández C, Rey G, Mediero A.

Enferm Infecc Microbiol Clin. 2010 Jun-Jul;28(6):358-61. doi: 10.1016/j.eimc.2009.03.009. Epub 2009 Aug 15. Spanish.


Silencing of P2Y2 receptor delays Ap4A-corneal re-epithelialization process.

Crooke A, Mediero A, Guzmán-Aránguez A, Pintor J.

Mol Vis. 2009 Jun 11;15:1169-78.


New treatments for ocular hypertension.

Mediero A, Alarma-Estrany P, Pintor J.

Auton Neurosci. 2009 May 11;147(1-2):14-9. doi: 10.1016/j.autneu.2008.12.009. Epub 2009 Jan 26. Review.


Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbits.

Alarma-Estrany P, Crooke A, Mediero A, Peláez T, Pintor J.

J Pineal Res. 2008 Nov;45(4):468-75. doi: 10.1111/j.1600-079X.2008.00618.x. Epub 2008 Jul 31.


Corneal re-epithelialization stimulated by diadenosine polyphosphates recruits RhoA/ROCK and ERK1/2 pathways.

Mediero A, Guzmán-Aranguez A, Crooke A, Peral A, Pintor J.

Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4982-92. doi: 10.1167/iovs.07-1583. Epub 2008 Jul 18.


Immunolocalisation of P2Y receptors in the rat eye.

Pintor J, Sánchez-Nogueiro J, Irazu M, Mediero A, Peláez T, Peral A.

Purinergic Signal. 2004 Dec;1(1):83-90. doi: 10.1007/s11302-004-5072-5.


Dual roles of diadenosine polyphosphates in corneal epithelial cell migration.

Mediero A, Peral A, Pintor J.

Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4500-6.


[Home versus inpatient therapy for deep venous thrombosis. A cost-comparative analysis].

Montes J, González L, Amador L, Novo A, Enero M, Rey G, Mediero A.

An Med Interna. 2005 Aug;22(8):369-72. Spanish.


Immunoreactive ET-1 in the vitreous humor and epiretinal membranes of patients with proliferative vitreoretinopathy.

Roldán-Pallarés M, Rollín R, Mediero A, Martínez-Montero JC, Fernández-Cruz A, Bravo-Llata C, Fernández-Durango R.

Mol Vis. 2005 Jul 7;11:461-71.


Atrial natriuretic peptide in the vitreous humor and epiretinal membranes of patients with proliferative diabetic retinopathy.

Rollin R, Mediero A, Martínez-Montero JC, Roldán-Pallarés M, Suárez-Leoz M, Vidal-Fernández P, Cortés-Valdés C, Fernández-Cruz A, Fernández-Durango R.

Mol Vis. 2004 Jul 15;10:450-7.


Natriuretic peptide system in the human retina.

Rollín R, Mediero A, Roldán-Pallarés M, Fernández-Cruz A, Fernández-Durango R.

Mol Vis. 2004 Jan 9;10:15-22.


Localization of endothelin-1 mRNA expression and immunoreactivity in the anterior segment of human eye: expression of ETA and ETB receptors.

Fernández-Durango R, Rollín R, Mediero A, Roldán-Pallares M, García Feijo J, García Sánchez J, Fernández-Cruz A, Rípodas A.

Mol Vis. 2003 Apr 9;9:103-9.

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