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Biomarkers and sustainable innovation in cardiovascular drug development: lessons from near and far afield.
Medford RM, Dagi TF, Rosenson RS, Offermann MK.
Curr Atheroscler Rep. 2013 May;15(5):321. doi: 10.1007/s11883-013-0321-0. Review.
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Activation of RelA homodimers by tumour necrosis factor alpha: a possible transcriptional activator in human vascular endothelial cells.
Marui N, Medford RM, Ahmad M.
Biochem J. 2005 Aug 15;390(Pt 1):317-24.
Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow.
Chen XL, Grey JY, Thomas S, Qiu FH, Medford RM, Wasserman MA, Kunsch C.
Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1452-8. Epub 2004 Jun 10.
Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent.
Kunsch C, Luchoomun J, Grey JY, Olliff LK, Saint LB, Arrendale RF, Wasserman MA, Saxena U, Medford RM.
J Pharmacol Exp Ther. 2004 Mar;308(3):820-9. Epub 2003 Nov 14.
Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase.
Chen XL, Zhang Q, Zhao R, Medford RM.
Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1001-7. Epub 2003 Oct 23.
Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease.
Wasserman MA, Sundell CL, Kunsch C, Edwards D, Meng CQ, Medford RM.
Am J Cardiol. 2003 Feb 6;91(3A):34A-40A. Review.
AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.
Sundell CL, Somers PK, Meng CQ, Hoong LK, Suen KL, Hill RR, Landers LK, Chapman A, Butteiger D, Jones M, Edwards D, Daugherty A, Wasserman MA, Alexander RW, Medford RM, Saxena U.
J Pharmacol Exp Ther. 2003 Jun;305(3):1116-23. Epub 2003 Mar 6.
Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells.
Chen XL, Zhang Q, Zhao R, Ding X, Tummala PE, Medford RM.
J Pharmacol Exp Ther. 2003 May;305(2):573-80. Epub 2003 Feb 11.
Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism.
Chen XL, Varner SE, Rao AS, Grey JY, Thomas S, Cook CK, Wasserman MA, Medford RM, Jaiswal AK, Kunsch C.
J Biol Chem. 2003 Jan 10;278(2):703-11. Epub 2002 Oct 4.
Dithiocarbamates: effects on lipid hydroperoxides and vascular inflammatory gene expression.
Somers PK, Medford RM, Saxena U.
Free Radic Biol Med. 2000 May 15;28(10):1532-7.
NF- kappa B independent suppression of endothelial vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 gene expression by inhibition of flavin binding proteins and superoxide production.
Tummala PE, Chen XL, Medford RM.
J Mol Cell Cardiol. 2000 Aug;32(8):1499-508.
Decreased secretion of ApoB follows inhibition of ApoB-MTP binding by a novel antagonist.
Bakillah A, Nayak N, Saxena U, Medford RM, Hussain MM.
Biochemistry. 2000 Apr 25;39(16):4892-9.
Oxidative stress as a regulator of gene expression in the vasculature.
Kunsch C, Medford RM.
Circ Res. 1999 Oct 15;85(8):753-66. Review.
Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis.
Tummala PE, Chen XL, Sundell CL, Laursen JB, Hammes CP, Alexander RW, Harrison DG, Medford RM.
Circulation. 1999 Sep 14;100(11):1223-9.
Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells.
Yerneni KK, Bai W, Khan BV, Medford RM, Natarajan R.
Diabetes. 1999 Apr;48(4):855-64.
Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells.
Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM.
Circ Res. 1998 Nov 2;83(9):952-9.
The study of the influence of flow on vascular endothelial biology.
Nerem RM, Alexander RW, Chappell DC, Medford RM, Varner SE, Taylor WR.
Am J Med Sci. 1998 Sep;316(3):169-75. Review.
Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium.
Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW.
Circ Res. 1998 Mar 23;82(5):532-9.
Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha.
Ahmad M, Theofanidis P, Medford RM.
J Biol Chem. 1998 Feb 20;273(8):4616-21.
Alpha 1T can support Na+,K(+)-ATPase: Na+ pump functions in expression systems.
Allen JC, Zhao X, Odebunmi T, Jemelka S, Medford RM, Pressley TA, Mercer RW.
Ann N Y Acad Sci. 1997 Nov 3;834:457-8. No abstract available.
E-selectin gene expression in vascular smooth muscle cells. Evidence for a tissue-specific repressor protein.
Chen XL, Tummala PE, Olliff L, Medford RM.
Circ Res. 1997 Mar;80(3):305-11.
Generation of a polyclonal antibody against lipid peroxide-modified proteins.
Kim JG, Sabbagh F, Santanam N, Wilcox JN, Medford RM, Parthasarathy S.
Free Radic Biol Med. 1997;23(2):251-9.
Antioxidant-sensitive regulation of inflammatory-response genes in Kaposi's sarcoma cells.
Offermann MK, Lin JC, Mar EC, Shaw R, Yang J, Medford RM.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Sep;13(1):1-11.
Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.
Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM.
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9114-9.
Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.
Offermann MK, Zimring J, Mellits KH, Hagan MK, Shaw R, Medford RM, Mathews MB, Goodbourn S, Jagus R.
Eur J Biochem. 1995 Aug 15;232(1):28-36.
Cell type-specific transactivation of the VCAM-1 promoter through an NF-kappa B enhancer motif.
Ahmad M, Marui N, Alexander RW, Medford RM.
J Biol Chem. 1995 Apr 14;270(15):8976-83.
Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells.
Khan BV, Parthasarathy SS, Alexander RW, Medford RM.
J Clin Invest. 1995 Mar;95(3):1262-70.
Regulation of Na+,K(+)-ATPase alpha-subunit isoforms in rat tissues during hypertension.
Sahin-Erdemli I, Medford RM, Songu-Mize E.
Eur J Pharmacol. 1995 Jan 13;292(2):163-71.
Evidence for the regulation of Na+, K(+)-ATPase alpha 1 gene expression through the interaction of aldosterone and cAMP-inducible transcriptional factors.
Ahmad M, Medford RM.
Steroids. 1995 Jan;60(1):147-52.
Na pump defects in chronic uremia cannot be attributed to changes in Na-K-ATPase mRNA or protein.
Greiber S, England BK, Price SR, Medford RM, Ebb RG, Mitch WE.
Am J Physiol. 1994 Apr;266(4 Pt 2):F536-42.
Expression of Na-K-ATPase alpha- and beta-subunit mRNA and protein isoforms in the rat nephron.
Tumlin JA, Hoban CA, Medford RM, Sands JM.
Am J Physiol. 1994 Feb;266(2 Pt 2):F240-5.
Tissue specific membrane association of alpha 1T, a truncated form of the alpha 1 subunit of the Na pump.
Allen JC, Pressley TA, Odebunmi T, Medford RM.
FEBS Lett. 1994 Jan 17;337(3):285-8.
Antioxidants and atherosclerosis: a molecular perspective.
Offermann MK, Medford RM.
Heart Dis Stroke. 1994 Jan-Feb;3(1):52-7. Review.
Regulation of Na-K-ATPase gene expression by aldosterone in vascular smooth muscle cells.
Oguchi A, Ikeda U, Kanbe T, Tsuruya Y, Yamamoto K, Kawakami K, Medford RM, Shimada K.
Am J Physiol. 1993 Oct;265(4 Pt 2):H1167-72.
Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.
Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM.
J Clin Invest. 1993 Oct;92(4):1866-74.
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.
Middleton JP, Khan WA, Collinsworth G, Hannun YA, Medford RM.
J Biol Chem. 1993 Jul 25;268(21):15958-64.
Digitalis and the Na+,K(+)-ATPase.
Medford RM.
Heart Dis Stroke. 1993 May-Jun;2(3):250-5. Review.
Vascular smooth muscle expresses a truncated Na+, K(+)-ATPase alpha-1 subunit isoform.
Medford RM, Hyman R, Ahmad M, Allen JC, Pressley TA, Allen PD, Nadal-Ginard B.
J Biol Chem. 1991 Sep 25;266(27):18308-12.
Disproportionate alpha- and beta-mRNA sodium pump subunit content in canine vascular smooth muscle.
Allen JC, Medford RM, Zhao X, Pressley TA.
Circ Res. 1991 Jul;69(1):39-44.
Aldosterone-mediated regulation of Na+, K(+)-ATPase gene expression in adult and neonatal rat cardiocytes.
Ikeda U, Hyman R, Smith TW, Medford RM.
J Biol Chem. 1991 Jun 25;266(18):12058-66.
Augmented Na,K-ATPase gene expression in spontaneously hypertensive rat hearts.
Tsuruya Y, Ikeda U, Kawakami K, Nagano K, Kamitani T, Oguchi A, Ebata H, Shimada K, Medford RM.
Clin Exp Hypertens A. 1991;13(6-7):1213-22.
Properties of adult rat ventricular cells in long-term culture.
Ikeda U, Briggs GM, Allen PD, Sen L, Medford RM, Smith TW.
Cardioscience. 1990 Sep;1(3):225-33.
Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene.
Breitbart RE, Nguyen HT, Medford RM, Destree AT, Mahdavi V, Nadal-Ginard B.
Cell. 1985 May;41(1):67-82.
A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene.
Medford RM, Nguyen HT, Destree AT, Summers E, Nadal-Ginard B.
Cell. 1984 Sep;38(2):409-21.
Transcriptional and cell cycle-mediated regulation of myosin heavy chain gene expression during muscle cell differentiation.
Medford RM, Nguyen HT, Nadal-Ginard B.
J Biol Chem. 1983 Sep 25;258(18):11063-73.
Reversibility of muscle differentiation in the absence of commitment: analysis of a myogenic cell line temperature-sensitive for commitment.
Nguyen HT, Medford RM, Nadal-Ginard B.
Cell. 1983 Aug;34(1):281-93.
Cytoplasmic processing of myosin heavy chain messenger RNA: evidence provided by using a recombinant DNA plasmid.
Medford RM, Wydro RM, Nguyen HT, Nadal-Ginard B.
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5749-53.
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