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Items: 47

1.

Biomarkers and sustainable innovation in cardiovascular drug development: lessons from near and far afield.

Medford RM, Dagi TF, Rosenson RS, Offermann MK.

Curr Atheroscler Rep. 2013 May;15(5):321. doi: 10.1007/s11883-013-0321-0. Review.

PMID:
23512605
3.

Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow.

Chen XL, Grey JY, Thomas S, Qiu FH, Medford RM, Wasserman MA, Kunsch C.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1452-8. Epub 2004 Jun 10.

4.

Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent.

Kunsch C, Luchoomun J, Grey JY, Olliff LK, Saint LB, Arrendale RF, Wasserman MA, Saxena U, Medford RM.

J Pharmacol Exp Ther. 2004 Mar;308(3):820-9. Epub 2003 Nov 14.

PMID:
14617690
5.

Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase.

Chen XL, Zhang Q, Zhao R, Medford RM.

Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1001-7. Epub 2003 Oct 23.

6.

Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease.

Wasserman MA, Sundell CL, Kunsch C, Edwards D, Meng CQ, Medford RM.

Am J Cardiol. 2003 Feb 6;91(3A):34A-40A. Review.

PMID:
12645642
7.

AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.

Sundell CL, Somers PK, Meng CQ, Hoong LK, Suen KL, Hill RR, Landers LK, Chapman A, Butteiger D, Jones M, Edwards D, Daugherty A, Wasserman MA, Alexander RW, Medford RM, Saxena U.

J Pharmacol Exp Ther. 2003 Jun;305(3):1116-23. Epub 2003 Mar 6.

PMID:
12626663
8.

Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells.

Chen XL, Zhang Q, Zhao R, Ding X, Tummala PE, Medford RM.

J Pharmacol Exp Ther. 2003 May;305(2):573-80. Epub 2003 Feb 11.

PMID:
12606638
9.

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism.

Chen XL, Varner SE, Rao AS, Grey JY, Thomas S, Cook CK, Wasserman MA, Medford RM, Jaiswal AK, Kunsch C.

J Biol Chem. 2003 Jan 10;278(2):703-11. Epub 2002 Oct 4.

10.

Dithiocarbamates: effects on lipid hydroperoxides and vascular inflammatory gene expression.

Somers PK, Medford RM, Saxena U.

Free Radic Biol Med. 2000 May 15;28(10):1532-7.

PMID:
10927178
12.

Decreased secretion of ApoB follows inhibition of ApoB-MTP binding by a novel antagonist.

Bakillah A, Nayak N, Saxena U, Medford RM, Hussain MM.

Biochemistry. 2000 Apr 25;39(16):4892-9.

PMID:
10769147
13.

Oxidative stress as a regulator of gene expression in the vasculature.

Kunsch C, Medford RM.

Circ Res. 1999 Oct 15;85(8):753-66. Review.

PMID:
10521248
14.

Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis.

Tummala PE, Chen XL, Sundell CL, Laursen JB, Hammes CP, Alexander RW, Harrison DG, Medford RM.

Circulation. 1999 Sep 14;100(11):1223-9.

PMID:
10484544
15.

Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells.

Yerneni KK, Bai W, Khan BV, Medford RM, Natarajan R.

Diabetes. 1999 Apr;48(4):855-64.

PMID:
10102704
16.

Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells.

Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM.

Circ Res. 1998 Nov 2;83(9):952-9.

PMID:
9797345
17.

The study of the influence of flow on vascular endothelial biology.

Nerem RM, Alexander RW, Chappell DC, Medford RM, Varner SE, Taylor WR.

Am J Med Sci. 1998 Sep;316(3):169-75. Review.

PMID:
9749558
18.

Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium.

Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW.

Circ Res. 1998 Mar 23;82(5):532-9.

PMID:
9529157
19.
20.

Alpha 1T can support Na+,K(+)-ATPase: Na+ pump functions in expression systems.

Allen JC, Zhao X, Odebunmi T, Jemelka S, Medford RM, Pressley TA, Mercer RW.

Ann N Y Acad Sci. 1997 Nov 3;834:457-8. No abstract available.

PMID:
9405844
21.

E-selectin gene expression in vascular smooth muscle cells. Evidence for a tissue-specific repressor protein.

Chen XL, Tummala PE, Olliff L, Medford RM.

Circ Res. 1997 Mar;80(3):305-11.

PMID:
9048649
22.

Generation of a polyclonal antibody against lipid peroxide-modified proteins.

Kim JG, Sabbagh F, Santanam N, Wilcox JN, Medford RM, Parthasarathy S.

Free Radic Biol Med. 1997;23(2):251-9.

PMID:
9199887
23.

Antioxidant-sensitive regulation of inflammatory-response genes in Kaposi's sarcoma cells.

Offermann MK, Lin JC, Mar EC, Shaw R, Yang J, Medford RM.

J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Sep;13(1):1-11.

PMID:
8797679
24.

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM.

Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9114-9.

25.

Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.

Offermann MK, Zimring J, Mellits KH, Hagan MK, Shaw R, Medford RM, Mathews MB, Goodbourn S, Jagus R.

Eur J Biochem. 1995 Aug 15;232(1):28-36.

26.

Cell type-specific transactivation of the VCAM-1 promoter through an NF-kappa B enhancer motif.

Ahmad M, Marui N, Alexander RW, Medford RM.

J Biol Chem. 1995 Apr 14;270(15):8976-83.

28.

Regulation of Na+,K(+)-ATPase alpha-subunit isoforms in rat tissues during hypertension.

Sahin-Erdemli I, Medford RM, Songu-Mize E.

Eur J Pharmacol. 1995 Jan 13;292(2):163-71.

PMID:
7720789
30.

Na pump defects in chronic uremia cannot be attributed to changes in Na-K-ATPase mRNA or protein.

Greiber S, England BK, Price SR, Medford RM, Ebb RG, Mitch WE.

Am J Physiol. 1994 Apr;266(4 Pt 2):F536-42.

PMID:
8184885
31.

Expression of Na-K-ATPase alpha- and beta-subunit mRNA and protein isoforms in the rat nephron.

Tumlin JA, Hoban CA, Medford RM, Sands JM.

Am J Physiol. 1994 Feb;266(2 Pt 2):F240-5.

PMID:
8141325
32.

Tissue specific membrane association of alpha 1T, a truncated form of the alpha 1 subunit of the Na pump.

Allen JC, Pressley TA, Odebunmi T, Medford RM.

FEBS Lett. 1994 Jan 17;337(3):285-8.

33.

Antioxidants and atherosclerosis: a molecular perspective.

Offermann MK, Medford RM.

Heart Dis Stroke. 1994 Jan-Feb;3(1):52-7. Review.

PMID:
7511030
34.

Regulation of Na-K-ATPase gene expression by aldosterone in vascular smooth muscle cells.

Oguchi A, Ikeda U, Kanbe T, Tsuruya Y, Yamamoto K, Kawakami K, Medford RM, Shimada K.

Am J Physiol. 1993 Oct;265(4 Pt 2):H1167-72.

PMID:
8238401
35.

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM.

J Clin Invest. 1993 Oct;92(4):1866-74.

36.

Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.

Middleton JP, Khan WA, Collinsworth G, Hannun YA, Medford RM.

J Biol Chem. 1993 Jul 25;268(21):15958-64.

37.

Digitalis and the Na+,K(+)-ATPase.

Medford RM.

Heart Dis Stroke. 1993 May-Jun;2(3):250-5. Review.

PMID:
8137034
38.

Vascular smooth muscle expresses a truncated Na+, K(+)-ATPase alpha-1 subunit isoform.

Medford RM, Hyman R, Ahmad M, Allen JC, Pressley TA, Allen PD, Nadal-Ginard B.

J Biol Chem. 1991 Sep 25;266(27):18308-12.

39.

Disproportionate alpha- and beta-mRNA sodium pump subunit content in canine vascular smooth muscle.

Allen JC, Medford RM, Zhao X, Pressley TA.

Circ Res. 1991 Jul;69(1):39-44.

PMID:
1647279
40.

Aldosterone-mediated regulation of Na+, K(+)-ATPase gene expression in adult and neonatal rat cardiocytes.

Ikeda U, Hyman R, Smith TW, Medford RM.

J Biol Chem. 1991 Jun 25;266(18):12058-66.

41.

Augmented Na,K-ATPase gene expression in spontaneously hypertensive rat hearts.

Tsuruya Y, Ikeda U, Kawakami K, Nagano K, Kamitani T, Oguchi A, Ebata H, Shimada K, Medford RM.

Clin Exp Hypertens A. 1991;13(6-7):1213-22.

PMID:
1662123
42.

Properties of adult rat ventricular cells in long-term culture.

Ikeda U, Briggs GM, Allen PD, Sen L, Medford RM, Smith TW.

Cardioscience. 1990 Sep;1(3):225-33.

PMID:
2102811
43.

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene.

Breitbart RE, Nguyen HT, Medford RM, Destree AT, Mahdavi V, Nadal-Ginard B.

Cell. 1985 May;41(1):67-82.

PMID:
2986851
44.

A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene.

Medford RM, Nguyen HT, Destree AT, Summers E, Nadal-Ginard B.

Cell. 1984 Sep;38(2):409-21.

PMID:
6205765
45.
47.

Cytoplasmic processing of myosin heavy chain messenger RNA: evidence provided by using a recombinant DNA plasmid.

Medford RM, Wydro RM, Nguyen HT, Nadal-Ginard B.

Proc Natl Acad Sci U S A. 1980 Oct;77(10):5749-53.

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