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Items: 1 to 50 of 72

1.

Design of magnetic spirals in layered perovskites: Extending the stability range far beyond room temperature.

Shang T, Canévet E, Morin M, Sheptyakov D, Fernández-Díaz MT, Pomjakushina E, Medarde M.

Sci Adv. 2018 Oct 26;4(10):eaau6386. doi: 10.1126/sciadv.aau6386. eCollection 2018 Oct.

2.

Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target.

Vicente-Blázquez A, González M, Álvarez R, Del Mazo S, Medarde M, Peláez R.

Med Res Rev. 2018 Oct 25. doi: 10.1002/med.21541. [Epub ahead of print] Review.

PMID:
30362234
3.

Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells.

Álvarez R, Gajate C, Puebla P, Mollinedo F, Medarde M, Peláez R.

Eur J Med Chem. 2018 Oct 5;158:167-183. doi: 10.1016/j.ejmech.2018.08.078. Epub 2018 Aug 31.

PMID:
30216850
4.

Dipolar Spin Ice States with a Fast Monopole Hopping Rate in CdEr_{2}X_{4} (X=Se, S).

Gao S, Zaharko O, Tsurkan V, Prodan L, Riordan E, Lago J, Fåk B, Wildes AR, Koza MM, Ritter C, Fouquet P, Keller L, Canévet E, Medarde M, Blomgren J, Johansson C, Giblin SR, Vrtnik S, Luzar J, Loidl A, Rüegg C, Fennell T.

Phys Rev Lett. 2018 Mar 30;120(13):137201. doi: 10.1103/PhysRevLett.120.137201.

PMID:
29694199
5.

Tuning magnetic spirals beyond room temperature with chemical disorder.

Morin M, Canévet E, Raynaud A, Bartkowiak M, Sheptyakov D, Ban V, Kenzelmann M, Pomjakushina E, Conder K, Medarde M.

Nat Commun. 2016 Dec 16;7:13758. doi: 10.1038/ncomms13758.

6.

Pyridine Based Antitumour Compounds Acting at the Colchicine Site.

Álvarez R, Aramburu L, Puebla P, Caballero E, González M, Vicente A, Medarde M, Peláez R.

Curr Med Chem. 2016;23(11):1100-30. Review.

PMID:
27117490
7.

Pushing the limits of magnetic anisotropy in trigonal bipyramidal Ni(ii).

Marriott KER, Bhaskaran L, Wilson C, Medarde M, Ochsenbein ST, Hill S, Murrie M.

Chem Sci. 2015 Dec 1;6(12):6823-6828. doi: 10.1039/c5sc02854j. Epub 2015 Sep 8.

8.

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.

Jiménez C, Ellahioui Y, Álvarez R, Aramburu L, Riesco A, González M, Vicente A, Dahdouh A, Ibn Mansour A, Jiménez C, Martín D, Sarmiento RG, Medarde M, Caballero E, Peláez R.

Eur J Med Chem. 2015 Jul 15;100:210-22. doi: 10.1016/j.ejmech.2015.05.047. Epub 2015 Jun 4.

PMID:
26092446
9.

New ligands of the tubulin colchicine site based on X-ray structures.

Álvarez R, Medarde M, Peláez R.

Curr Top Med Chem. 2014;14(20):2231-52. Review.

PMID:
25434358
10.

p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition.

Álvarez R, López V, Mateo C, Medarde M, Peláez R.

J Org Chem. 2014 Aug 1;79(15):6840-57. doi: 10.1021/jo500798r. Epub 2014 Jul 23.

PMID:
24966024
11.

1D to 2D Na+ ion diffusion inherently linked to structural transitions in Na0.7CoO2.

Medarde M, Mena M, Gavilano JL, Pomjakushina E, Sugiyama J, Kamazawa K, Pomjakushin VY, Sheptyakov D, Batlogg B, Ott HR, Månsson M, Juranyi F.

Phys Rev Lett. 2013 Jun 28;110(26):266401. Epub 2013 Jun 26.

PMID:
23848903
12.

Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.

Álvarez R, Puebla P, Díaz JF, Bento AC, García-Navas R, de la Iglesia-Vicente J, Mollinedo F, Andreu JM, Medarde M, Peláez R.

J Med Chem. 2013 Apr 11;56(7):2813-27. doi: 10.1021/jm3015603. Epub 2013 Mar 20.

PMID:
23470139
13.

Tunable conductivity threshold at polar oxide interfaces.

Reinle-Schmitt ML, Cancellieri C, Li D, Fontaine D, Medarde M, Pomjakushina E, Schneider CW, Gariglio S, Ghosez P, Triscone JM, Willmott PR.

Nat Commun. 2012 Jul 3;3:932. doi: 10.1038/ncomms1936.

PMID:
22760631
14.

New para-para stilbenophanes: synthesis by McMurry coupling, conformational analysis and inhibition of tubulin polymerisation.

Álvarez R, López V, Mateo C, Medarde M, Peláez R.

Chemistry. 2011 Mar 14;17(12):3406-19. doi: 10.1002/chem.201002869. Epub 2011 Feb 23.

PMID:
21344518
15.

Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins.

Alvarez C, Alvarez R, Corchete P, Pérez-Melero C, Peláez R, Medarde M.

Eur J Med Chem. 2010 Feb;45(2):588-97. doi: 10.1016/j.ejmech.2009.10.047. Epub 2009 Nov 3.

PMID:
19939521
16.

Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.

Alvarez R, Alvarez C, Mollinedo F, Sierra BG, Medarde M, Peláez R.

Bioorg Med Chem. 2009 Sep 1;17(17):6422-31. doi: 10.1016/j.bmc.2009.07.012. Epub 2009 Jul 9.

PMID:
19647439
17.

LaBaNiO(4): a Fermi glass.

Schilling A, Dell'amore R, Karpinski J, Bukowski Z, Medarde M, Pomjakushina E, Müller KA.

J Phys Condens Matter. 2009 Jan 7;21(1):015701. doi: 10.1088/0953-8984/21/1/015701. Epub 2008 Dec 1.

PMID:
21817228
18.

Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.

Alvarez C, Alvarez R, Corchete P, Pérez-Melero C, Peláez R, Medarde M.

Bioorg Med Chem. 2008 Oct 1;16(19):8999-9008. doi: 10.1016/j.bmc.2008.08.040. Epub 2008 Aug 26.

PMID:
18790642
19.

Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.

Alvarez C, Alvarez R, Corchete P, López JL, Pérez-Melero C, Peláez R, Medarde M.

Bioorg Med Chem. 2008 Jun 1;16(11):5952-61. doi: 10.1016/j.bmc.2008.04.054. Epub 2008 Apr 26.

PMID:
18502133
20.

[Fulminant pseudomembranous colitis].

Medarde M, Espin E, Sánchez JL, Armengol M.

Cir Esp. 2007 Dec;82(6):368. Spanish. No abstract available.

21.

Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.

Figueroa J, Caballero E, Puebla P, Tomé F, Medarde M.

Molecules. 2006 Nov 30;11(11):929-39.

22.

Conformationally restricted macrocyclic analogues of combretastatins.

Mateo C, Alvarez R, Pérez-Melero C, Peláez R, Medarde M.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6316-20. Epub 2007 Sep 4.

PMID:
17889536
23.

Synthesis and conformational analysis of macrocyclic dihydroxystilbenes linked between the para-para positions.

Mateo C, López V, Medarde M, Peláez R.

Chemistry. 2007;13(25):7246-56.

PMID:
17566133
24.

Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins.

Alvarez C, Alvarez R, Corchete P, Pérez-Melero C, Peláez R, Medarde M.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3417-20. Epub 2007 Mar 30.

PMID:
17434303
25.

Spin-state transition in LaCoO3: direct neutron spectroscopic evidence of excited magnetic states.

Podlesnyak A, Streule S, Mesot J, Medarde M, Pomjakushina E, Conder K, Tanaka A, Haverkort MW, Khomskii DI.

Phys Rev Lett. 2006 Dec 15;97(24):247208. Epub 2006 Dec 15.

PMID:
17280319
26.

Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.

Vicens M, Medarde M, Macias RI, Larena MG, Villafaina A, Serrano MA, Marin JJ.

Bioorg Med Chem. 2007 Mar 15;15(6):2359-67. Epub 2007 Jan 19.

PMID:
17276074
27.

Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases.

Vallejo M, Castro MA, Medarde M, Macias RI, Romero MR, El-Mir MY, Monte MJ, Briz O, Serrano MA, Marin JJ.

Biochem Pharmacol. 2007 May 1;73(9):1394-404. Epub 2006 Dec 28.

PMID:
17257589
28.

Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions.

Vicens M, Macias RI, Briz O, Rodriguez A, El-Mir MY, Medarde M, Marin JJ.

Biochem Pharmacol. 2007 Feb 1;73(3):394-404. Epub 2006 Oct 20.

PMID:
17134679
29.

Stilbenophane analogues of deoxycombretastatin A-4.

Mateo C, Pérez-Melero C, Peláez R, Medarde M.

J Org Chem. 2005 Aug 5;70(16):6544-7.

PMID:
16050729
30.

Intrinsically fluorescent cytotoxic cisplatin analogues as DNA marker molecules.

Criado JJ, Fernández ER, Manzano JL, Alonso A, Barrena S, Medarde M, Pelaez R, Tabernero MD, Orfao A.

Bioconjug Chem. 2005 Mar-Apr;16(2):275-82.

PMID:
15769080
31.

New naphthylcombretastatins. Modifications on the ethylene bridge.

Sánchez Maya AB, Pérez-Melero C, Salvador N, Peláez R, Caballero E, Medarde M.

Bioorg Med Chem. 2005 Mar 15;13(6):2097-107.

PMID:
15727863
32.

Naphthalene combretastatin analogues: synthesis, cytotoxicity and antitubulin activity.

Medarde M, Maya AB, Pérez-Melero C.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):521-40. Review.

PMID:
15662956
33.

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

Maya AB, Pérez-Melero C, Mateo C, Alonso D, Fernández JL, Gajate C, Mollinedo F, Peláez R, Caballero E, Medarde M.

J Med Chem. 2005 Jan 27;48(2):556-68.

PMID:
15658869
34.

Anti-HIV activity of some synthetic lignanolides and intermediates.

Sancho R, Medarde M, Sánchez-Palomino S, Madrigal BM, Alcamí J, Muñoz E, San Feliciano A.

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4483-6.

PMID:
15357976
35.

A new family of quinoline and quinoxaline analogues of combretastatins.

Pérez-Melero C, Maya AB, del Rey B, Peláez R, Caballero E, Medarde M.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3771-4.

PMID:
15203159
36.

Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues.

Caballero E, Adeva M, Calderón S, Sahagún H, Tomé F, Medarde M, Fernández JL, López-Lázaro M, Ayuso MJ.

Bioorg Med Chem. 2003 Aug 5;11(16):3413-21.

PMID:
12878136
37.

Naphthalene analogues of lignans.

Madrigal B, Puebla P, Peláez R, Caballero E, Medarde M.

J Org Chem. 2003 Feb 7;68(3):854-64.

PMID:
12558407
38.

Physiological characteristics of allo-cholic acid.

Mendoza ME, Monte MJ, Serrano MA, Pastor-Anglada M, Stieger B, Meier PJ, Medarde M, Marin JJ.

J Lipid Res. 2003 Jan;44(1):84-92.

39.

Biosynthesis of podophyllotoxin in Linum album cell cultures.

Seidel V, Windhövel J, Eaton G, Alfermann AW, Arroo RR, Medarde M, Petersen M, Woolley JG.

Planta. 2002 Oct;215(6):1031-9. Epub 2002 Jul 25.

PMID:
12355164
40.

Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes.

Maya JD, Morello A, Repetto Y, Tellez R, Rodriguez A, Zelada U, Puebla P, Caballero E, Medarde M, Núñez-Vergara LJ, Squella JA, Bontá M, Bollo S, San Feliciano A.

Comp Biochem Physiol C Toxicol Pharmacol. 2000 Jan;125(1):103-9.

PMID:
11790334
41.

Inotropic activity of hydroindene amidinohydrazones.

Sevillano LG, Melero CP, Caballero E, Tomé F, Lelièvre LG, Geering K, Crambert G, Carrón R, Medarde M, San Feliciano A.

J Med Chem. 2002 Jan 3;45(1):127-36.

PMID:
11754584
42.

A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species.

Koulman A, Bos R, Medarde M, Pras N, Quax WJ.

Planta Med. 2001 Dec;67(9):858-62.

PMID:
11745025
43.

Synthesis and cytotoxic activities of analogues of thuriferic acid.

Madrigal B, Puebla P, Ramos A, Peláez R, Grávalos D, Caballero E, Medarde M.

Bioorg Med Chem. 2002 Feb;10(2):303-12.

PMID:
11741779
44.

Trypanosoma cruzi: inhibition of parasite growth and respiration by oxazolo(thiazolo)pyridine derivatives and its relationship to redox potential and lipophilicity.

Maya JD, Morello A, Repetto Y, Rodríguez A, Puebla P, Caballero E, Medarde M, Núñez-Vergara LJ, Squella JA, Ortiz ME, Fuentealba J, San Feliciano A.

Exp Parasitol. 2001 Sep;99(1):1-6.

PMID:
11708828
45.

Synthesis of imidazo[4,5-d]oxazolo[3,4-a]pyridines. New heterocyclic analogues of lignans.

Madrigal B, Puebla P, Caballero E, Peláez R, Grávalos DG, Medarde M.

Arch Pharm (Weinheim). 2001 May;334(5):177-9.

PMID:
11413825
46.

Structural characterization and cytostatic activity of chlorobischolylglycinatogold(III).

Carrasco J, Criado JJ, Macías RI, Manzano JL, Marín JJ, Medarde M, Rodríguez E.

J Inorg Biochem. 2001 Apr;84(3-4):287-92.

PMID:
11374592
47.

Cardenolides and diterpenes as a source of and model for positive ionotropic agents.

Medarde M, Caballero E, Tomé F, San Feliciano A.

Pharm Biol. 2001;39 Suppl 1:53-62. doi: 10.1076/phbi.39.s1.53.0004.

PMID:
21554171
48.

Design, synthesis and cytotoxic activities of naphthyl analogues of combretastatin A-4.

Maya AB, del Rey B, Lamamie de Clairac RP, Caballero E, Barasoain I, Andreu JM, Medarde M.

Bioorg Med Chem Lett. 2000 Nov 20;10(22):2549-51.

PMID:
11086727
49.

Open analogues of arcyriaflavin A. Synthesis through Diels-Alder reaction between maleimides and 1-aryl-3-tert-butyldimethylsiloxy-1, 3-butadienes.

Adeva M, Sahagún H, Caballero E, Peláez-Lamamié De Clairac R, Medarde M, Tomé F.

J Org Chem. 2000 Jun 2;65(11):3387-94.

PMID:
10843621
50.

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