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Items: 1 to 50 of 295

1.

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.

2.

Evaluating intimal hyperplasia under clinical conditions.

Mylonaki I, Allain E, Strano F, Allémann E, Corpataux JM, Meda P, Jordan O, Delie F, Rougemont AL, Haefliger JA, Saucy F.

Interact Cardiovasc Thorac Surg. 2018 Mar 30. doi: 10.1093/icvts/ivy101. [Epub ahead of print]

PMID:
29617792
3.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

4.

Targeting Cx40 (Connexin40) Expression or Function Reduces Angiogenesis in the Developing Mouse Retina.

Haefliger JA, Allagnat F, Hamard L, Le Gal L, Meda P, Nardelli-Haefliger D, Génot E, Alonso F.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2136-2146. doi: 10.1161/ATVBAHA.117.310072. Epub 2017 Oct 5.

PMID:
28982669
5.

αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation.

Jimenez-Caliani AJ, Pillich R, Yang W, Diaferia GR, Meda P, Crisa L, Cirulli V.

Cell Rep. 2017 Aug 8;20(6):1295-1306. doi: 10.1016/j.celrep.2017.07.035.

6.

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.

Berchtold LA, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, Størling J.

Mol Cell Endocrinol. 2017 Jun 15;448:108-121. doi: 10.1016/j.mce.2017.04.001. Epub 2017 Apr 5.

PMID:
28390953
7.

Orthodontically induced cervical root resorption in humans is associated with the amount of tooth movement.

Dudic A, Giannopoulou C, Meda P, Montet X, Kiliaridis S.

Eur J Orthod. 2017 Oct 1;39(5):534-540. doi: 10.1093/ejo/cjw087.

PMID:
28339612
8.

Gap junction proteins are key drivers of endocrine function.

Meda P.

Biochim Biophys Acta. 2018 Jan;1860(1):124-140. doi: 10.1016/j.bbamem.2017.03.005. Epub 2017 Mar 8. Review.

PMID:
28284720
9.

Glibenclamide Prevents Diabetes in NOD Mice.

Lamprianou S, Gysemans C, Bou Saab J, Pontes H, Mathieu C, Meda P.

PLoS One. 2016 Dec 22;11(12):e0168839. doi: 10.1371/journal.pone.0168839. eCollection 2016.

10.

Connexins and pannexins: from biology towards clinical targets.

Meda P, Haefliger JA.

Swiss Med Wkly. 2016 Dec 5;146:w14365. doi: 10.4414/smw.2016.14365. eCollection 2016. Review.

11.

A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.

Cigliola V, Populaire C, Pierri CL, Deutsch S, Haefliger JA, Fadista J, Lyssenko V, Groop L, Rueedi R, Thorel F, Herrera PL, Meda P.

PLoS One. 2016 Mar 9;11(3):e0150880. doi: 10.1371/journal.pone.0150880. eCollection 2016.

12.

Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion.

Alonso F, Domingos-Pereira S, Le Gal L, Derré L, Meda P, Jichlinski P, Nardelli-Haefliger D, Haefliger JA.

Oncotarget. 2016 Mar 22;7(12):14015-28. doi: 10.18632/oncotarget.7370.

13.

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.

Mellado-Gil JM, Jiménez-Moreno CM, Martin-Montalvo A, Alvarez-Mercado AI, Fuente-Martin E, Cobo-Vuilleumier N, Lorenzo PI, Bru-Tari E, Herrera-Gómez Ide G, López-Noriega L, Pérez-Florido J, Santoyo-López J, Spyrantis A, Meda P, Boehm BO, Quesada I, Gauthier BR.

Diabetologia. 2016 Apr;59(4):755-65. doi: 10.1007/s00125-016-3864-0. Epub 2016 Jan 26.

14.

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection.

Sommerstein R, Flatz L, Remy MM, Malinge P, Magistrelli G, Fischer N, Sahin M, Bergthaler A, Igonet S, Ter Meulen J, Rigo D, Meda P, Rabah N, Coutard B, Bowden TA, Lambert PH, Siegrist CA, Pinschewer DD.

PLoS Pathog. 2015 Nov 20;11(11):e1005276. doi: 10.1371/journal.ppat.1005276. eCollection 2015 Nov.

15.

Multivalent glibenclamide to generate islet specific imaging probes.

Babič A, Lamprianou S, Vinet L, Stransky-Heilkron N, Xayaphoummine C, Campo MA, Glombik H, Schulte A, Juretschke HP, Montet X, Meda P, Lange N.

Biomaterials. 2016 Jan;75:1-12. doi: 10.1016/j.biomaterials.2015.10.006. Epub 2015 Oct 9.

PMID:
26474038
16.

Role of Connexins and Pannexins in the Pancreas.

Cigliola V, Allagnat F, Berchtold LA, Lamprianou S, Haefliger JA, Meda P.

Pancreas. 2015 Nov;44(8):1234-44. doi: 10.1097/MPA.0000000000000378. Review.

PMID:
26465951
17.

Pancreatic β-cell imaging in humans: fiction or option?

Laurent D, Vinet L, Lamprianou S, Daval M, Filhoulaud G, Ktorza A, Wang H, Sewing S, Juretschke HP, Glombik H, Meda P, Boisgard R, Nguyen DL, Stasiuk GJ, Long NJ, Montet X, Hecht P, Kramer W, Rutter GA, Hecksher-Sørensen J.

Diabetes Obes Metab. 2016 Jan;18(1):6-15. doi: 10.1111/dom.12544. Epub 2015 Oct 5. Review.

18.

Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress.

Nunes P, Roth I, Meda P, Féraille E, Brown D, Hasler U.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3104-13. doi: 10.1073/pnas.1421290112. Epub 2015 Jun 4.

19.

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice.

Motterle A, Gattesco S, Caille D, Meda P, Regazzi R.

Diabetologia. 2015 Aug;58(8):1827-35. doi: 10.1007/s00125-015-3641-5. Epub 2015 Jun 3.

20.

Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells.

Lebreton F, Pirog A, Belouah I, Bosco D, Berney T, Meda P, Bornat Y, Catargi B, Renaud S, Raoux M, Lang J.

Diabetologia. 2015 Jun;58(6):1291-9. doi: 10.1007/s00125-015-3558-z. Epub 2015 Mar 19.

PMID:
25788295
21.

Interplay between connexin40 and nitric oxide signaling during hypertension.

Le Gal L, Alonso F, Mazzolai L, Meda P, Haefliger JA.

Hypertension. 2015 Apr;65(4):910-5. doi: 10.1161/HYPERTENSIONAHA.114.04775. Epub 2015 Feb 23.

PMID:
25712722
22.

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.

Vinet L, Lamprianou S, Babič A, Lange N, Thorel F, Herrera PL, Montet X, Meda P.

Diabetologia. 2015 Feb;58(2):304-12. doi: 10.1007/s00125-014-3442-2. Epub 2014 Nov 22.

23.

Restoration of connexin 40 (Cx40) in Renin-producing cells reduces the hypertension of Cx40 null mice.

Le Gal L, Alonso F, Wagner C, Germain S, Nardelli Haefliger D, Meda P, Haefliger JA.

Hypertension. 2014 Jun;63(6):1198-204. doi: 10.1161/HYPERTENSIONAHA.113.02976. Epub 2014 Mar 10.

PMID:
24614215
24.

The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins.

Longchamp A, Alonso F, Dubuis C, Allagnat F, Berard X, Meda P, Saucy F, Corpataux JM, Déglise S, Haefliger JA.

Biomaterials. 2014 Mar;35(9):2588-99. doi: 10.1016/j.biomaterials.2013.12.041. Epub 2014 Jan 13.

PMID:
24429385
25.

Protein-mediated interactions of pancreatic islet cells.

Meda P.

Scientifica (Cairo). 2013;2013:621249. doi: 10.1155/2013/621249. Epub 2013 Jan 8. Review.

26.

Glucose-stimulated insulin secretion: the hierarchy of its multiple cellular and subcellular mechanisms.

Meda P, Schuit F.

Diabetologia. 2013 Dec;56(12):2552-5. doi: 10.1007/s00125-013-3073-z. Epub 2013 Oct 11.

PMID:
24114115
27.

Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.

Allagnat F, Klee P, Cardozo AK, Meda P, Haefliger JA.

Cell Death Differ. 2013 Dec;20(12):1742-52. doi: 10.1038/cdd.2013.134. Epub 2013 Oct 4.

28.

Atorvastatin-loaded hydrogel affects the smooth muscle cells of human veins.

Dubuis C, May L, Alonso F, Luca L, Mylonaki I, Meda P, Delie F, Jordan O, Déglise S, Corpataux JM, Saucy F, Haefliger JA.

J Pharmacol Exp Ther. 2013 Dec;347(3):574-81. doi: 10.1124/jpet.113.208769. Epub 2013 Sep 26.

29.

Lipotoxicity disrupts incretin-regulated human β cell connectivity.

Hodson DJ, Mitchell RK, Bellomo EA, Sun G, Vinet L, Meda P, Li D, Li WH, Bugliani M, Marchetti P, Bosco D, Piemonti L, Johnson P, Hughes SJ, Rutter GA.

J Clin Invest. 2013 Oct;123(10):4182-94. doi: 10.1172/JCI68459. Epub 2013 Sep 9.

30.

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, Meda P, Langer T, Maechler P.

Diabetes. 2013 Oct;62(10):3488-99. doi: 10.2337/db13-0152. Epub 2013 Jul 17.

31.

Promises and pitfalls of a Pannexin1 transgenic mouse line.

Hanstein R, Negoro H, Patel NK, Charollais A, Meda P, Spray DC, Suadicani SO, Scemes E.

Front Pharmacol. 2013 May 9;4:61. doi: 10.3389/fphar.2013.00061. eCollection 2013.

32.

Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ.

Haefliger JA, Rohner-Jeanrenaud F, Caille D, Charollais A, Meda P, Allagnat F.

J Mol Endocrinol. 2013 May 17;51(1):49-58. doi: 10.1530/JME-13-0054. Print 2013.

PMID:
23613279
33.

Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles.

Haefliger JA, Martin D, Favre D, Petremand Y, Mazzolai L, Abderrahmani A, Meda P, Waeber G, Allagnat F.

PLoS One. 2013;8(1):e55198. doi: 10.1371/journal.pone.0055198. Epub 2013 Jan 30.

34.

Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters.

Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Féraille E, Brown D, Hasler U.

Autophagy. 2013 Apr;9(4):550-67. doi: 10.4161/auto.23662. Epub 2013 Feb 4.

35.

Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin.

Wakae-Takada N, Xuan S, Watanabe K, Meda P, Leibel RL.

Diabetologia. 2013 Apr;56(4):856-66. doi: 10.1007/s00125-012-2824-6. Epub 2013 Jan 26.

36.

Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins.

Berard X, Déglise S, Alonso F, Saucy F, Meda P, Bordenave L, Corpataux JM, Haefliger JA.

J Vasc Surg. 2013 May;57(5):1371-82. doi: 10.1016/j.jvs.2012.09.041. Epub 2013 Jan 23.

37.

Improved protocol for laser microdissection of human pancreatic islets from surgical specimens.

Sturm D, Marselli L, Ehehalt F, Richter D, Distler M, Kersting S, Grützmann R, Bokvist K, Froguel P, Liechti R, Jörns A, Meda P, Baretton GB, Saeger HD, Schulte AM, Marchetti P, Solimena M.

J Vis Exp. 2013 Jan 6;(71). pii: 50231. doi: 10.3791/50231.

38.

Embryonic stem cell-based cardiopatches improve cardiac function in infarcted rats.

Vallée JP, Hauwel M, Lepetit-Coiffé M, Bei W, Montet-Abou K, Meda P, Gardier S, Zammaretti P, Kraehenbuehl TP, Herrmann F, Hubbell JA, Jaconi ME.

Stem Cells Transl Med. 2012 Mar;1(3):248-60. doi: 10.5966/sctm.2011-0028. Epub 2012 Mar 7.

39.

Connexins and β-cell functions.

Cigliola V, Chellakudam V, Arabieter W, Meda P.

Diabetes Res Clin Pract. 2013 Mar;99(3):250-9. doi: 10.1016/j.diabres.2012.10.016. Epub 2012 Nov 20. Review.

PMID:
23176806
40.

Early metabolic defects in dexamethasone-exposed and undernourished intrauterine growth restricted rats.

Somm E, Vauthay DM, Guérardel A, Toulotte A, Cettour-Rose P, Klee P, Meda P, Aubert ML, Hüppi PS, Schwitzgebel VM.

PLoS One. 2012;7(11):e50131. doi: 10.1371/journal.pone.0050131. Epub 2012 Nov 16.

41.

Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.

Martin D, Allagnat F, Gesina E, Caille D, Gjinovci A, Waeber G, Meda P, Haefliger JA.

PLoS One. 2012;7(9):e45844. doi: 10.1371/journal.pone.0045844. Epub 2012 Sep 20.

42.

The intercellular synchronization of Ca2+ oscillations evaluates Cx36-dependent coupling.

Bavamian S, Pontes H, Cancela J, Charollais A, Startchik S, Van de Ville D, Meda P.

PLoS One. 2012;7(7):e41535. doi: 10.1371/journal.pone.0041535. Epub 2012 Jul 25.

43.

Cx36 is a target of Beta2/NeuroD1, which associates with prenatal differentiation of insulin-producing β cells.

Nlend RN, Aït-Lounis A, Allagnat F, Cigliola V, Charollais A, Reith W, Haefliger JA, Meda P.

J Membr Biol. 2012 Jun;245(5-6):263-73. doi: 10.1007/s00232-012-9447-1. Epub 2012 Jun 23.

PMID:
22729650
44.

The in vivo β-to-β-cell chat room: connexin connections matter.

Meda P.

Diabetes. 2012 Jul;61(7):1656-8. doi: 10.2337/db12-0336. No abstract available.

45.

Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients.

Botsikas D, Terraz S, Vinet L, Lamprianou S, Becker CD, Bosco D, Meda P, Montet X.

Islets. 2012 May-Jun;4(3):243-8. doi: 10.4161/isl.20857. Epub 2012 May 1.

46.

Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice.

Carvalho CP, Oliveira RB, Britan A, Santos-Silva JC, Boschero AC, Meda P, Collares-Buzato CB.

Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E144-51. doi: 10.1152/ajpendo.00489.2011. Epub 2012 May 8.

47.

Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice.

Roggli E, Gattesco S, Caille D, Briet C, Boitard C, Meda P, Regazzi R.

Diabetes. 2012 Jul;61(7):1742-51. doi: 10.2337/db11-1086. Epub 2012 Apr 26.

48.

Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity.

Li Y, Mouche S, Sajic T, Veyrat-Durebex C, Supale R, Pierroz D, Ferrari S, Negro F, Hasler U, Feraille E, Moll S, Meda P, Deffert C, Montet X, Krause KH, Szanto I.

Int J Obes (Lond). 2012 Dec;36(12):1503-13. doi: 10.1038/ijo.2011.279. Epub 2012 Mar 20.

PMID:
22430302
49.

Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis.

Andralojc K, Srinivas M, Brom M, Joosten L, de Vries IJ, Eizirik DL, Boerman OC, Meda P, Gotthardt M.

Diabetologia. 2012 May;55(5):1247-57. doi: 10.1007/s00125-012-2491-7. Epub 2012 Feb 23. Review.

50.

[Connexin signaling: a new mechanism for protection of insulin-producing cells against apoptosis].

Klee P, Meda P.

Med Sci (Paris). 2012 Jan;28(1):41-4. doi: 10.1051/medsci/2012281015. Epub 2012 Jan 27. French. No abstract available.

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