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Items: 1 to 50 of 63

1.

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers.

Fasciano AC, Blutt SE, Estes MK, Mecsas J.

J Vis Exp. 2019 Jul 26;(149). doi: 10.3791/59894.

2.

Unraveling neutrophil- Yersinia interactions during tissue infection.

Mecsas J.

F1000Res. 2019 Jul 11;8. pii: F1000 Faculty Rev-1046. doi: 10.12688/f1000research.18940.1. eCollection 2019. Review.

3.

Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions.

Nguyen GT, McCabe AL, Fasciano AC, Mecsas J.

Methods Mol Biol. 2019;2010:117-139. doi: 10.1007/978-1-4939-9541-7_9.

PMID:
31177435
4.

Amino Acid Biosynthetic Pathways Are Required for Klebsiella pneumoniae Growth in Immunocompromised Lungs and Are Druggable Targets during Infection.

Silver RJ, Paczosa MK, McCabe AL, Balada-Llasat JM, Baleja JD, Mecsas J.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e02674-18. doi: 10.1128/AAC.02674-18. Print 2019 Aug.

PMID:
31109974
5.

New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems.

Fasciano AC, Mecsas J, Isberg RR.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.BAI-0013-2019. Review.

6.

Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target.

Fasciano AC, Shaban L, Mecsas J.

EcoSal Plus. 2019 Feb;8(2). doi: 10.1128/ecosalplus.ESP-0032-2018. Review.

7.

Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection.

Markey L, Shaban L, Green ER, Lemon KP, Mecsas J, Kumamoto CA.

Gut Microbes. 2018 Nov 2;9(6):497-509. doi: 10.1080/19490976.2018.1465158. Epub 2018 May 30.

8.

Editorial overview: Host-pathogen interactions shaped through evolutionary and regulatory processes.

Buchrieser C, Mecsas J.

Curr Opin Microbiol. 2018 Feb;41:v-viii. doi: 10.1016/j.mib.2018.02.001. No abstract available.

PMID:
29559085
9.

A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage.

Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J.

Anaerobe. 2018 Apr;50:85-92. doi: 10.1016/j.anaerobe.2018.02.006. Epub 2018 Feb 17.

10.

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.

Nguyen GT, Green ER, Mecsas J.

Front Cell Infect Microbiol. 2017 Aug 25;7:373. doi: 10.3389/fcimb.2017.00373. eCollection 2017. Review.

11.

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.

Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A.

J Immunol. 2017 Jun 1;198(11):4435-4447. doi: 10.4049/jimmunol.1601717. Epub 2017 May 1.

12.

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E.

PLoS Pathog. 2016 Dec 2;12(12):e1006035. doi: 10.1371/journal.ppat.1006035. eCollection 2016 Dec.

13.

Fis Is Essential for Yersinia pseudotuberculosis Virulence and Protects against Reactive Oxygen Species Produced by Phagocytic Cells during Infection.

Green ER, Clark S, Crimmins GT, Mack M, Kumamoto CA, Mecsas J.

PLoS Pathog. 2016 Sep 30;12(9):e1005898. doi: 10.1371/journal.ppat.1005898. eCollection 2016 Sep.

14.

Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation.

Anantharajah A, Faure E, Buyck JM, Sundin C, Lindmark T, Mecsas J, Yahr TL, Tulkens PM, Mingeot-Leclercq MP, Guery B, Van Bambeke F.

J Infect Dis. 2016 Oct 1;214(7):1105-16. doi: 10.1093/infdis/jiw295. Epub 2016 Jul 13.

PMID:
27412581
15.

Klebsiella pneumoniae: Going on the Offense with a Strong Defense.

Paczosa MK, Mecsas J.

Microbiol Mol Biol Rev. 2016 Jun 15;80(3):629-61. doi: 10.1128/MMBR.00078-15. Print 2016 Sep. Review.

16.

Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.

Hauser AR, Mecsas J, Moir DT.

Clin Infect Dis. 2016 Jul 1;63(1):89-95. doi: 10.1093/cid/ciw200. Epub 2016 Mar 29.

17.

Bacterial Secretion Systems: An Overview.

Green ER, Mecsas J.

Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.VMBF-0012-2015. Review.

18.

A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.

Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC.

Cell Host Microbe. 2015 Dec 9;18(6):682-93. doi: 10.1016/j.chom.2015.11.006.

19.

Robust bioengineered 3D functional human intestinal epithelium.

Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, Isberg RR, Kumamoto CA, Mecsas J, Kaplan DL.

Sci Rep. 2015 Sep 16;5:13708. doi: 10.1038/srep13708.

20.

Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain.

Yang Y, Millán JL, Mecsas J, Guillemin K.

Infect Immun. 2015 Jan;83(1):247-58. doi: 10.1128/IAI.02520-14. Epub 2014 Oct 27.

21.

Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system.

Bowlin NO, Williams JD, Knoten CA, Torhan MC, Tashjian TF, Li B, Aiello D, Mecsas J, Hauser AR, Peet NP, Bowlin TL, Moir DT.

Antimicrob Agents Chemother. 2014;58(4):2211-20. doi: 10.1128/AAC.02795-13. Epub 2014 Jan 27.

22.

Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection.

Paczosa MK, Fisher ML, Maldonado-Arocho FJ, Mecsas J.

Cell Microbiol. 2014 Feb;16(2):247-68. doi: 10.1111/cmi.12219. Epub 2013 Nov 3.

23.

Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.

Rolán HG, Durand EA, Mecsas J.

Cell Host Microbe. 2013 Sep 11;14(3):306-17. doi: 10.1016/j.chom.2013.08.013.

24.

Adhesins and host serum factors drive Yop translocation by yersinia into professional phagocytes during animal infection.

Maldonado-Arocho FJ, Green C, Fisher ML, Paczosa MK, Mecsas J.

PLoS Pathog. 2013;9(6):e1003415. doi: 10.1371/journal.ppat.1003415. Epub 2013 Jun 20.

25.
26.

Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes.

Crimmins GT, Mohammadi S, Green ER, Bergman MA, Isberg RR, Mecsas J.

PLoS Pathog. 2012;8(8):e1002828. doi: 10.1371/journal.ppat.1002828. Epub 2012 Aug 2.

27.

The NLRP12 inflammasome recognizes Yersinia pestis.

Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JE, Burbage JJ, Proulx MK, Liu Q, Reed G, Mecsas JC, Iwakura Y, Bertin J, Goguen JD, Fitzgerald KA, Lien E.

Immunity. 2012 Jul 27;37(1):96-107. doi: 10.1016/j.immuni.2012.07.006. Erratum in: Immunity. 2012 Sep 21;37(3):588.

28.

Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence.

Lister IM, Raftery C, Mecsas J, Levy SB.

Antimicrob Agents Chemother. 2012 Feb;56(2):1120-3. doi: 10.1128/AAC.05338-11. Epub 2011 Nov 14.

29.

Development of a vaccinia virus based reservoir-targeted vaccine against Yersinia pestis.

Bhattacharya D, Mecsas J, Hu LT.

Vaccine. 2010 Nov 10;28(48):7683-9. doi: 10.1016/j.vaccine.2010.09.039. Epub 2010 Sep 25.

30.

Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model.

Garrity-Ryan LK, Kim OK, Balada-Llasat JM, Bartlett VJ, Verma AK, Fisher ML, Castillo C, Songsungthong W, Tanaka SK, Levy SB, Mecsas J, Alekshun MN.

Infect Immun. 2010 Nov;78(11):4683-90. doi: 10.1128/IAI.01305-09. Epub 2010 Sep 7.

31.

Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis.

Harmon DE, Davis AJ, Castillo C, Mecsas J.

Antimicrob Agents Chemother. 2010 Aug;54(8):3241-54. doi: 10.1128/AAC.00364-10. Epub 2010 May 24.

32.

The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence.

McCoy MW, Marré ML, Lesser CF, Mecsas J.

Infect Immun. 2010 Jun;78(6):2584-98. doi: 10.1128/IAI.00141-10. Epub 2010 Apr 5.

33.

A dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia.

Davis AJ, Díaz DA, Mecsas J.

Mol Microbiol. 2010 Apr;76(1):236-59. doi: 10.1111/j.1365-2958.2010.07096.x. Epub 2010 Feb 28.

34.

ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice.

Songsungthong W, Higgins MC, Rolán HG, Murphy JL, Mecsas J.

Cell Microbiol. 2010 Jul;12(7):988-1001. doi: 10.1111/j.1462-5822.2010.01448.x. Epub 2010 Feb 9.

35.

The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.

Durand EA, Maldonado-Arocho FJ, Castillo C, Walsh RL, Mecsas J.

Cell Microbiol. 2010 Aug;12(8):1064-82. doi: 10.1111/j.1462-5822.2010.01451.x. Epub 2010 Feb 9.

36.

Effect of MarA-like proteins on antibiotic resistance and virulence in Yersinia pestis.

Lister IM, Mecsas J, Levy SB.

Infect Immun. 2010 Jan;78(1):364-71. doi: 10.1128/IAI.00904-09. Epub 2009 Oct 19.

37.

CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells.

Bergman MA, Loomis WP, Mecsas J, Starnbach MN, Isberg RR.

PLoS Pathog. 2009 Sep;5(9):e1000573. doi: 10.1371/journal.ppat.1000573. Epub 2009 Sep 4.

38.

Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice.

Ren Z, Gay R, Thomas A, Pae M, Wu D, Logsdon L, Mecsas J, Meydani SN.

J Med Microbiol. 2009 Dec;58(Pt 12):1559-67. doi: 10.1099/jmm.0.013250-0. Epub 2009 Sep 3.

39.

Self-regulation of Candida albicans population size during GI colonization.

White SJ, Rosenbach A, Lephart P, Nguyen D, Benjamin A, Tzipori S, Whiteway M, Mecsas J, Kumamoto CA.

PLoS Pathog. 2007 Dec;3(12):e184.

40.
41.
44.

A non-invasive quantitative assay to measure murine intestinal inflammation using the neutrophil marker lactoferrin.

Logsdon LK, Mecsas J.

J Immunol Methods. 2006 Jun 30;313(1-2):183-90. Epub 2006 Jun 12.

PMID:
16806255
45.

Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine.

Barnes PD, Bergman MA, Mecsas J, Isberg RR.

J Exp Med. 2006 Jun 12;203(6):1591-601. Epub 2006 Jun 5. Erratum in: J Exp Med. 2006 Jul 10;203(7):1829.

47.

Evolutionary genetics: CCR5 mutation and plague protection.

Mecsas J, Franklin G, Kuziel WA, Brubaker RR, Falkow S, Mosier DE.

Nature. 2004 Feb 12;427(6975):606.

PMID:
14961112
49.

Use of signature-tagged mutagenesis in pathogenesis studies.

Mecsas J.

Curr Opin Microbiol. 2002 Feb;5(1):33-7. Review.

PMID:
11834366

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