Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 84

1.

Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power.

Opuu V, Nigro G, Gaillard T, Schmitt E, Mechulam Y, Simonson T.

PLoS Comput Biol. 2020 Jan 9;16(1):e1007600. doi: 10.1371/journal.pcbi.1007600. [Epub ahead of print]

2.

Use of β3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase.

Nigro G, Bourcier S, Lazennec-Schurdevin C, Schmitt E, Marlière P, Mechulam Y.

J Struct Biol. 2019 Dec 17:107435. doi: 10.1016/j.jsb.2019.107435. [Epub ahead of print]

3.

Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex.

Heddi B, Cheong VV, Schmitt E, Mechulam Y, Phan AT.

J Struct Biol. 2020 Jan 1;209(1):107399. doi: 10.1016/j.jsb.2019.10.001. Epub 2019 Oct 3.

PMID:
31586599
4.

SponGee: A Genetic Tool for Subcellular and Cell-Specific cGMP Manipulation.

Ros O, Zagar Y, Ribes S, Baudet S, Loulier K, Couvet S, Ladarre D, Aghaie A, Louail A, Petit C, Mechulam Y, Lenkei Z, Nicol X.

Cell Rep. 2019 Jun 25;27(13):4003-4012.e6. doi: 10.1016/j.celrep.2019.05.102.

5.

NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes.

Winnerdy FR, Bakalar B, Maity A, Vandana JJ, Mechulam Y, Schmitt E, Phan AT.

Nucleic Acids Res. 2019 Sep 5;47(15):8272-8281. doi: 10.1093/nar/gkz349.

6.

Start Codon Recognition in Eukaryotic and Archaeal Translation Initiation: A Common Structural Core.

Schmitt E, Coureux PD, Monestier A, Dubiez E, Mechulam Y.

Int J Mol Sci. 2019 Feb 21;20(4). pii: E939. doi: 10.3390/ijms20040939. Review.

7.

A Minimal Sequence for Left-Handed G-Quadruplex Formation.

Bakalar B, Heddi B, Schmitt E, Mechulam Y, Phan AT.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2331-2335. doi: 10.1002/anie.201812628. Epub 2019 Jan 21.

PMID:
30481397
8.

Role of aIF1 in Pyrococcus abyssi translation initiation.

Monestier A, Lazennec-Schurdevin C, Coureux PD, Mechulam Y, Schmitt E.

Nucleic Acids Res. 2018 Nov 16;46(20):11061-11074. doi: 10.1093/nar/gky850.

9.

The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at centrosomes.

Visweshwaran SP, Thomason PA, Guerois R, Vacher S, Denisov EV, Tashireva LA, Lomakina ME, Lazennec-Schurdevin C, Lakisic G, Lilla S, Molinie N, Henriot V, Mechulam Y, Alexandrova AY, Cherdyntseva NV, Bièche I, Schmitt E, Insall RH, Gautreau A.

EMBO J. 2018 Jul 2;37(13). pii: e97706. doi: 10.15252/embj.201797706. Epub 2018 May 29.

10.

Structural basis for partition of the cyclodipeptide synthases into two subfamilies.

Bourgeois G, Seguin J, Babin M, Belin P, Moutiez M, Mechulam Y, Gondry M, Schmitt E.

J Struct Biol. 2018 Jul;203(1):17-26. doi: 10.1016/j.jsb.2018.03.001. Epub 2018 Mar 2.

PMID:
29505829
11.

The structure of an E. coli tRNAfMet A1-U72 variant shows an unusual conformation of the A1-U72 base pair.

Monestier A, Aleksandrov A, Coureux PD, Panvert M, Mechulam Y, Schmitt E.

RNA. 2017 May;23(5):673-682. doi: 10.1261/rna.057877.116. Epub 2017 Jan 31.

12.

Cryo-EM study of start codon selection during archaeal translation initiation.

Coureux PD, Lazennec-Schurdevin C, Monestier A, Larquet E, Cladière L, Klaholz BP, Schmitt E, Mechulam Y.

Nat Commun. 2016 Nov 7;7:13366. doi: 10.1038/ncomms13366.

13.

Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features.

Panvert M, Dubiez E, Arnold L, Perez J, Mechulam Y, Seufert W, Schmitt E.

Structure. 2015 Sep 1;23(9):1596-1608. doi: 10.1016/j.str.2015.06.014. Epub 2015 Jul 23.

14.

Structure of a left-handed DNA G-quadruplex.

Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2729-33. doi: 10.1073/pnas.1418718112. Epub 2015 Feb 18.

15.

Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2.

Dubiez E, Aleksandrov A, Lazennec-Schurdevin C, Mechulam Y, Schmitt E.

Nucleic Acids Res. 2015 Mar 11;43(5):2946-57. doi: 10.1093/nar/gkv053. Epub 2015 Feb 17.

16.

Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases.

Moutiez M, Schmitt E, Seguin J, Thai R, Favry E, Belin P, Mechulam Y, Gondry M.

Nat Commun. 2014 Oct 6;5:5141. doi: 10.1038/ncomms6141.

PMID:
25284085
17.

Capturing the mutational landscape of the beta-lactamase TEM-1.

Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13067-72. doi: 10.1073/pnas.1215206110. Epub 2013 Jul 22.

18.

Roles of yeast eIF2α and eIF2β subunits in the binding of the initiator methionyl-tRNA.

Naveau M, Lazennec-Schurdevin C, Panvert M, Dubiez E, Mechulam Y, Schmitt E.

Nucleic Acids Res. 2013 Jan;41(2):1047-57. doi: 10.1093/nar/gks1180. Epub 2012 Nov 27.

19.

Structure of the ternary initiation complex aIF2-GDPNP-methionylated initiator tRNA.

Schmitt E, Panvert M, Lazennec-Schurdevin C, Coureux PD, Perez J, Thompson A, Mechulam Y.

Nat Struct Mol Biol. 2012 Mar 25;19(4):450-4. doi: 10.1038/nsmb.2259.

PMID:
22447243
20.

Translation Initiation.

Mechulam Y, Blanquet S, Schmitt E.

EcoSal Plus. 2011 Dec;4(2). doi: 10.1128/ecosalplus.4.2.2.

PMID:
26442511
21.

Intrinsic resistance to aminoglycosides in Enterococcus faecium is conferred by the 16S rRNA m5C1404-specific methyltransferase EfmM.

Galimand M, Schmitt E, Panvert M, Desmolaize B, Douthwaite S, Mechulam Y, Courvalin P.

RNA. 2011 Feb;17(2):251-62. doi: 10.1261/rna.2233511. Epub 2010 Dec 15.

22.

tRNA binding properties of eukaryotic translation initiation factor 2 from Encephalitozoon cuniculi.

Naveau M, Lazennec-Schurdevin C, Panvert M, Mechulam Y, Schmitt E.

Biochemistry. 2010 Oct 12;49(40):8680-8. doi: 10.1021/bi1009166. Epub 2010 Sep 15.

PMID:
20822097
23.

Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.

Schmitt E, Naveau M, Mechulam Y.

FEBS Lett. 2010 Jan 21;584(2):405-12. doi: 10.1016/j.febslet.2009.11.002. Review.

24.

Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.

Schmitt E, Tanrikulu IC, Yoo TH, Panvert M, Tirrell DA, Mechulam Y.

J Mol Biol. 2009 Dec 18;394(5):843-51. doi: 10.1016/j.jmb.2009.10.016. Epub 2009 Oct 23.

25.

Discovery of Escherichia coli methionyl-tRNA synthetase mutants for efficient labeling of proteins with azidonorleucine in vivo.

Tanrikulu IC, Schmitt E, Mechulam Y, Goddard WA 3rd, Tirrell DA.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15285-90. doi: 10.1073/pnas.0905735106. Epub 2009 Aug 17.

26.

Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases.

Schmitt E, Galimand M, Panvert M, Courvalin P, Mechulam Y.

J Mol Biol. 2009 May 8;388(3):570-82. doi: 10.1016/j.jmb.2009.03.034. Epub 2009 Mar 20.

PMID:
19303884
27.

A unique conformation of the anticodon stem-loop is associated with the capacity of tRNAfMet to initiate protein synthesis.

Barraud P, Schmitt E, Mechulam Y, Dardel F, Tisné C.

Nucleic Acids Res. 2008 Sep;36(15):4894-901. doi: 10.1093/nar/gkn462. Epub 2008 Jul 24.

28.

Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states.

Yatime L, Mechulam Y, Blanquet S, Schmitt E.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18445-50. Epub 2007 Nov 13.

29.

Protection-based assays to measure aminoacyl-tRNA binding to translation initiation factors.

Mechulam Y, Guillon L, Yatime L, Blanquet S, Schmitt E.

Methods Enzymol. 2007;430:265-81.

PMID:
17913642
30.

Structural basis of RNA-dependent recruitment of glutamine to the genetic code.

Oshikane H, Sheppard K, Fukai S, Nakamura Y, Ishitani R, Numata T, Sherrer RL, Feng L, Schmitt E, Panvert M, Blanquet S, Mechulam Y, Söll D, Nureki O.

Science. 2006 Jun 30;312(5782):1950-4.

31.

Structural switch of the gamma subunit in an archaeal aIF2 alpha gamma heterodimer.

Yatime L, Mechulam Y, Blanquet S, Schmitt E.

Structure. 2006 Jan;14(1):119-28.

32.

Initiator tRNA binding by e/aIF5B, the eukaryotic/archaeal homologue of bacterial initiation factor IF2.

Guillon L, Schmitt E, Blanquet S, Mechulam Y.

Biochemistry. 2005 Nov 29;44(47):15594-601.

PMID:
16300409
33.

Structural basis for tRNA-dependent amidotransferase function.

Schmitt E, Panvert M, Blanquet S, Mechulam Y.

Structure. 2005 Oct;13(10):1421-33.

34.

Structure-function relationships of the intact aIF2alpha subunit from the archaeon Pyrococcus abyssi.

Yatime L, Schmitt E, Blanquet S, Mechulam Y.

Biochemistry. 2005 Jun 21;44(24):8749-56.

PMID:
15952781
35.

Crystal structure at 1.8 A resolution and identification of active site residues of Sulfolobus solfataricus peptidyl-tRNA hydrolase.

Fromant M, Schmitt E, Mechulam Y, Lazennec C, Plateau P, Blanquet S.

Biochemistry. 2005 Mar 22;44(11):4294-301.

PMID:
15766258
36.

Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi.

Crepin T, Schmitt E, Blanquet S, Mechulam Y.

Biochemistry. 2004 Mar 9;43(9):2635-44.

PMID:
14992601
37.

Functional molecular mapping of archaeal translation initiation factor 2.

Yatime L, Schmitt E, Blanquet S, Mechulam Y.

J Biol Chem. 2004 Apr 16;279(16):15984-93. Epub 2004 Feb 3.

38.

Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.

Crepin T, Schmitt E, Mechulam Y, Sampson PB, Vaughan MD, Honek JF, Blanquet S.

J Mol Biol. 2003 Sep 5;332(1):59-72.

PMID:
12946347
39.

Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: gene disruption and tRNA substrate specificity.

Vial L, Gomez P, Panvert M, Schmitt E, Blanquet S, Mechulam Y.

Biochemistry. 2003 Feb 4;42(4):932-9.

PMID:
12549912
40.

Structure and function of the C-terminal domain of methionyl-tRNA synthetase.

Crepin T, Schmitt E, Blanquet S, Mechulam Y.

Biochemistry. 2002 Oct 29;41(43):13003-11.

PMID:
12390027
41.
42.

Structure of crystalline D-Tyr-tRNA(Tyr) deacylase. A representative of a new class of tRNA-dependent hydrolases.

Ferri-Fioni ML, Schmitt E, Soutourina J, Plateau P, Mechulam Y, Blanquet S.

J Biol Chem. 2001 Dec 14;276(50):47285-90. Epub 2001 Sep 21.

43.

Recognition of tRNAs by Methionyl-tRNA transformylase from mammalian mitochondria.

Takeuchi N, Vial L, Panvert M, Schmitt E, Watanabe K, Mechulam Y, Blanquet S.

J Biol Chem. 2001 Jun 8;276(23):20064-8. Epub 2001 Mar 23.

44.

The many routes of bacterial transfer RNAs after aminoacylation.

Blanquet S, Mechulam Y, Schmitt E.

Curr Opin Struct Biol. 2000 Feb;10(1):95-101. Review.

PMID:
10679458
45.

Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features.

Mechulam Y, Schmitt E, Maveyraud L, Zelwer C, Nureki O, Yokoyama S, Konno M, Blanquet S.

J Mol Biol. 1999 Dec 17;294(5):1287-97.

PMID:
10600385
46.

Receptor site for the 5'-phosphate of elongator tRNAs governs substrate selection by peptidyl-tRNA hydrolase.

Fromant M, Plateau P, Schmitt E, Mechulam Y, Blanquet S.

Biochemistry. 1999 Apr 20;38(16):4982-7.

PMID:
10213600
47.

Crystallization and preliminary X-ray analysis of Escherichia coli methionyl-tRNAMet(f) formyltransferase complexed with formyl-methionyl-tRNAMet(f).

Schmitt E, Blanquet S, Mechulam Y.

Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):332-4. Epub 1999 Jan 1.

PMID:
10089442
48.
49.

Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase.

Schmitt E, Mechulam Y, Fromant M, Plateau P, Blanquet S.

EMBO J. 1997 Aug 1;16(15):4760-9.

50.

General structure/function properties of microbial methionyl-tRNA synthetases.

Schmitt E, Panvert M, Mechulam Y, Blanquet S.

Eur J Biochem. 1997 Jun 1;246(2):539-47.

Supplemental Content

Loading ...
Support Center