Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 345

1.

Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine.

Rock EM, Ayoub SM, Limebeer CL, Gene A, Wills KL, DeVuono MV, Smoum R, Di Marzo V, Lichtman AH, Mechoulam R, Parker LA.

Psychopharmacology (Berl). 2019 Nov 11. doi: 10.1007/s00213-019-05373-2. [Epub ahead of print]

PMID:
31712968
2.

Cannabidiol partially blocks the sleepiness in hypocretin-deficient rats. Preliminary data.

Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Morales-Lara D, Mechoulam R, Drucker-Colín R.

CNS Neurol Disord Drug Targets. 2019 Oct 21. doi: 10.2174/1871527318666191021143300. [Epub ahead of print]

PMID:
31642794
3.

HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity.

Baraghithy S, Smoum R, Attar-Namdar M, Mechoulam R, Bab I, Tam J.

Molecules. 2019 Oct 16;24(20). pii: E3719. doi: 10.3390/molecules24203719.

4.

Beyond THC and Endocannabinoids.

Pacher P, Kogan NM, Mechoulam R.

Annu Rev Pharmacol Toxicol. 2019 Oct 3. doi: 10.1146/annurev-pharmtox-010818-021441. [Epub ahead of print]

PMID:
31580774
5.

Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.

Petrie GN, Wills KL, Piscitelli F, Smoum R, Limebeer CL, Rock EM, Humphrey AE, Sheppard-Perkins M, Lichtman AH, Mechoulam R, Di Marzo V, Parker LA.

Psychopharmacology (Berl). 2019 Sep;236(9):2623-2633. doi: 10.1007/s00213-019-05237-9. Epub 2019 Apr 16.

PMID:
30993360
6.

Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy.

Bar-Lev Schleider L, Mechoulam R, Saban N, Meiri G, Novack V.

Sci Rep. 2019 Jan 17;9(1):200. doi: 10.1038/s41598-018-37570-y.

7.

Effects of cannabidiol in males and females in two different rat models of depression.

Shbiro L, Hen-Shoval D, Hazut N, Rapps K, Dar S, Zalsman G, Mechoulam R, Weller A, Shoval G.

Physiol Behav. 2019 Mar 15;201:59-63. doi: 10.1016/j.physbeh.2018.12.019. Epub 2018 Dec 17.

PMID:
30571957
8.

Antimicrobial potential of endocannabinoid and endocannabinoid-like compounds against methicillin-resistant Staphylococcus aureus.

Feldman M, Smoum R, Mechoulam R, Steinberg D.

Sci Rep. 2018 Dec 6;8(1):17696. doi: 10.1038/s41598-018-35793-7.

9.

Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia.

Stark T, Ruda-Kucerova J, Iannotti FA, D'Addario C, Di Marco R, Pekarik V, Drazanova E, Piscitelli F, Bari M, Babinska Z, Giurdanella G, Di Bartolomeo M, Salomone S, Sulcova A, Maccarrone M, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V.

Neuropharmacology. 2019 Mar 1;146:212-221. doi: 10.1016/j.neuropharm.2018.11.035. Epub 2018 Nov 26.

PMID:
30496751
10.

Role of CB2 Receptor in the Recovery of Mice after Traumatic Brain Injury.

Magid L, Heymann S, Elgali M, Avram L, Cohen Y, Liraz-Zaltsman S, Mechoulam R, Shohami E.

J Neurotrauma. 2019 Jun;36(11):1836-1846. doi: 10.1089/neu.2018.6063. Epub 2019 Feb 7.

PMID:
30489198
11.

Magel2 Modulates Bone Remodeling and Mass in Prader-Willi Syndrome by Affecting Oleoyl Serine Levels and Activity.

Baraghithy S, Smoum R, Drori A, Hadar R, Gammal A, Hirsch S, Attar-Namdar M, Nemirovski A, Gabet Y, Langer Y, Pollak Y, Schaaf CP, Rech ME, Gross-Tsur V, Bab I, Mechoulam R, Tam J.

J Bone Miner Res. 2019 Jan;34(1):93-105. doi: 10.1002/jbmr.3591. Epub 2018 Oct 22.

PMID:
30347474
12.

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test.

Linares IM, Zuardi AW, Pereira LC, Queiroz RH, Mechoulam R, Guimarães FS, Crippa JA.

Braz J Psychiatry. 2019 Jan-Feb;41(1):9-14. doi: 10.1590/1516-4446-2017-0015. Epub 2018 Oct 11.

13.

Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes.

Chiurchiù V, Leuti A, Smoum R, Mechoulam R, Maccarrone M.

FASEB J. 2018 Oct;32(10):5716-5723. doi: 10.1096/fj.201800107R. Epub 2018 Jun 7.

PMID:
29879374
14.

Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression.

Hen-Shoval D, Amar S, Shbiro L, Smoum R, Haj CG, Mechoulam R, Zalsman G, Weller A, Shoval G.

Behav Brain Res. 2018 Oct 1;351:1-3. doi: 10.1016/j.bbr.2018.05.027. Epub 2018 May 31.

PMID:
29860002
15.

N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.

Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R.

Neuropharmacology. 2019 Apr;148:320-331. doi: 10.1016/j.neuropharm.2018.03.020. Epub 2018 Mar 19.

PMID:
29567093
16.

Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer.

Bar-Lev Schleider L, Mechoulam R, Lederman V, Hilou M, Lencovsky O, Betzalel O, Shbiro L, Novack V.

Eur J Intern Med. 2018 Mar;49:37-43. doi: 10.1016/j.ejim.2018.01.023.

PMID:
29482741
17.

Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly.

Abuhasira R, Schleider LB, Mechoulam R, Novack V.

Eur J Intern Med. 2018 Mar;49:44-50. doi: 10.1016/j.ejim.2018.01.019.

PMID:
29398248
18.

Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats.

Pertwee RG, Rock EM, Guenther K, Limebeer CL, Stevenson LA, Haj C, Smoum R, Parker LA, Mechoulam R.

Br J Pharmacol. 2018 Jan;175(1):100-112. doi: 10.1111/bph.14073. Epub 2017 Dec 5.

19.

Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury.

Wang Y, Mukhopadhyay P, Cao Z, Wang H, Feng D, Haskó G, Mechoulam R, Gao B, Pacher P.

Sci Rep. 2017 Sep 21;7(1):12064. doi: 10.1038/s41598-017-10924-8.

20.

Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative.

Silva NR, Gomes FV, Fonseca MD, Mechoulam R, Breuer A, Cunha TM, Guimarães FS.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):369-377. doi: 10.1016/j.pnpbp.2017.07.012. Epub 2017 Jul 15.

PMID:
28720466
21.

Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats.

Rock EM, Limebeer CL, Petrie GN, Williams LA, Mechoulam R, Parker LA.

Psychopharmacology (Berl). 2017 Jul;234(14):2207-2217. doi: 10.1007/s00213-017-4626-5. Epub 2017 Apr 20.

PMID:
28424834
22.

HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.

Večeřa J, Bártová E, Krejčí J, Legartová S, Komůrková D, Rudá-Kučerová J, Štark T, Dražanová E, Kašpárek T, Šulcová A, Dekker FJ, Szymanski W, Seiser C, Weitzer G, Mechoulam R, Micale V, Kozubek S.

J Cell Physiol. 2018 Jan;233(1):530-548. doi: 10.1002/jcp.25914. Epub 2017 May 3.

PMID:
28300292
23.

Cannabis and epilepsy.

Mechoulam R.

Epilepsy Behav. 2017 May;70(Pt B):278-279. doi: 10.1016/j.yebeh.2017.01.014. Epub 2017 Feb 21. No abstract available.

PMID:
28254349
24.

Correction: Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.

Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, Del Bel EA, Hallak JC, Crippa JA, Zuardi AW, Mechoulam R, Guimarães FS.

PLoS One. 2016 Aug 25;11(8):e0162087. doi: 10.1371/journal.pone.0162087. eCollection 2016.

25.

Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.

Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, Del Bel EA, Hallak JC, Crippa JA, Zuardi AW, Mechoulam R, Guimarães FS.

PLoS One. 2016 Jul 14;11(7):e0158779. doi: 10.1371/journal.pone.0158779. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0162087.

26.

Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats.

Rock EM, Boulet N, Limebeer CL, Mechoulam R, Parker LA.

Eur J Pharmacol. 2016 Sep 5;786:94-99. doi: 10.1016/j.ejphar.2016.06.001. Epub 2016 Jun 2.

PMID:
27263826
27.

In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma.

Fisher T, Golan H, Schiby G, PriChen S, Smoum R, Moshe I, Peshes-Yaloz N, Castiel A, Waldman D, Gallily R, Mechoulam R, Toren A.

Curr Oncol. 2016 Mar;23(2):S15-22. doi: 10.3747/co.23.2893. Epub 2016 Mar 16.

28.

Prohedonic Effect of Cannabidiol in a Rat Model of Depression.

Shoval G, Shbiro L, Hershkovitz L, Hazut N, Zalsman G, Mechoulam R, Weller A.

Neuropsychobiology. 2016;73(2):123-9. doi: 10.1159/000443890. Epub 2016 Mar 25.

PMID:
27010632
29.

Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation.

Lee WS, Erdelyi K, Matyas C, Mukhopadhyay P, Varga ZV, Liaudet L, Haskú G, Čiháková D, Mechoulam R, Pacher P.

Mol Med. 2016 Sep;22:136-146. doi: 10.2119/molmed.2016.00007. Epub 2016 Jan 8.

30.

The Endocannabinoid System: A Look Back and Ahead.

Mechoulam R.

Handb Exp Pharmacol. 2015;231:vii-ix. No abstract available.

PMID:
26618208
31.

Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury?

Mann A, Cohen-Yeshurun A, Trembovler V, Mechoulam R, Shohami E.

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):209-16. doi: 10.1515/jbcpp-2015-0092. Review.

32.

Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells.

Juknat A, Kozela E, Kaushansky N, Mechoulam R, Vogel Z.

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):289-96. doi: 10.1515/jbcpp-2015-0071.

33.

Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists.

Maslov LN, Khaliulin I, Zhang Y, Krylatov AV, Naryzhnaya NV, Mechoulam R, De Petrocellis L, Downey JM.

J Cardiovasc Pharmacol Ther. 2016 May;21(3):262-72. doi: 10.1177/1074248415612593. Epub 2015 Oct 19. Review.

PMID:
26487546
34.

Cannabis - the Israeli perspective.

Mechoulam R.

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):181-7. doi: 10.1515/jbcpp-2015-0091. Review.

35.

HU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid.

Haj CG, Sumariwalla PF, Hanuš L, Kogan NM, Yektin Z, Mechoulam R, Feldmann M, Gallily R.

J Pharmacol Exp Ther. 2015 Oct;355(1):66-75. doi: 10.1124/jpet.115.226100. Epub 2015 Aug 13.

36.

Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi.

Soni D, Smoum R, Breuer A, Mechoulam R, Steinberg D.

BMC Microbiol. 2015 Aug 12;15:159. doi: 10.1186/s12866-015-0499-0.

37.

HU-446 and HU-465, Derivatives of the Non-psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells.

Kozela E, Haj C, Hanuš L, Chourasia M, Shurki A, Juknat A, Kaushansky N, Mechoulam R, Vogel Z.

Chem Biol Drug Des. 2016 Jan;87(1):143-53. doi: 10.1111/cbdd.12637. Epub 2015 Sep 16.

PMID:
26259697
38.

CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency.

Smoum R, Baraghithy S, Chourasia M, Breuer A, Mussai N, Attar-Namdar M, Kogan NM, Raphael B, Bolognini D, Cascio MG, Marini P, Pertwee RG, Shurki A, Mechoulam R, Bab I.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8774-9. doi: 10.1073/pnas.1503395112. Epub 2015 Jun 29.

39.

Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study.

Yeshurun M, Shpilberg O, Herscovici C, Shargian L, Dreyer J, Peck A, Israeli M, Levy-Assaraf M, Gruenewald T, Mechoulam R, Raanani P, Ram R.

Biol Blood Marrow Transplant. 2015 Oct;21(10):1770-5. doi: 10.1016/j.bbmt.2015.05.018. Epub 2015 May 30.

40.

Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.

Kogan NM, Melamed E, Wasserman E, Raphael B, Breuer A, Stok KS, Sondergaard R, Escudero AV, Baraghithy S, Attar-Namdar M, Friedlander-Barenboim S, Mathavan N, Isaksson H, Mechoulam R, Müller R, Bajayo A, Gabet Y, Bab I.

J Bone Miner Res. 2015 Oct;30(10):1905-13. doi: 10.1002/jbmr.2513. Epub 2015 May 10.

41.

Endocannabinoid signaling at the periphery: 50 years after THC.

Maccarrone M, Bab I, Bíró T, Cabral GA, Dey SK, Di Marzo V, Konje JC, Kunos G, Mechoulam R, Pacher P, Sharkey KA, Zimmer A.

Trends Pharmacol Sci. 2015 May;36(5):277-96. doi: 10.1016/j.tips.2015.02.008. Epub 2015 Mar 18. Review.

42.

Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury.

Mann A, Smoum R, Trembovler V, Alexandrovich A, Breuer A, Mechoulam R, Shohami E.

J Neuroimmune Pharmacol. 2015 Jun;10(2):356-63. doi: 10.1007/s11481-015-9595-z. Epub 2015 Feb 27.

PMID:
25721934
43.

Intraperirhinal cortex administration of the synthetic cannabinoid, HU210, disrupts object recognition memory in rats.

Sticht MA, Jacklin DL, Mechoulam R, Parker LA, Winters BD.

Neuroreport. 2015 Mar 25;26(5):258-62. doi: 10.1097/WNR.0000000000000338.

PMID:
25714419
44.

CB1 cannabinoid receptors mediate endochondral skeletal growth attenuation by Δ9-tetrahydrocannabinol.

Wasserman E, Tam J, Mechoulam R, Zimmer A, Maor G, Bab I.

Ann N Y Acad Sci. 2015 Jan;1335:110-9. doi: 10.1111/nyas.12642.

PMID:
25573322
45.

Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis.

Hao E, Mukhopadhyay P, Cao Z, Erdélyi K, Holovac E, Liaudet L, Lee WS, Haskó G, Mechoulam R, Pacher P.

Mol Med. 2015 Jan 6;21:38-45. doi: 10.2119/molmed.2014.00261.

46.

Early phytocannabinoid chemistry to endocannabinoids and beyond.

Mechoulam R, Hanuš LO, Pertwee R, Howlett AC.

Nat Rev Neurosci. 2014 Nov;15(11):757-64. doi: 10.1038/nrn3811. Epub 2014 Oct 15. Review.

PMID:
25315390
47.

Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder.

Roitman P, Mechoulam R, Cooper-Kazaz R, Shalev A.

Clin Drug Investig. 2014 Aug;34(8):587-91. doi: 10.1007/s40261-014-0212-3.

PMID:
24935052
48.

N-Acyl amino acids and their impact on biological processes.

Hanuš L, Shohami E, Bab I, Mechoulam R.

Biofactors. 2014 Jul-Aug;40(4):381-8. doi: 10.1002/biof.1166. Epub 2014 Apr 21.

PMID:
24753374
49.

Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression.

Kaminitz A, Barzilay R, Segal H, Taler M, Offen D, Gil-Ad I, Mechoulam R, Weizman A.

World J Biol Psychiatry. 2014 Jan;15(1):76-82. doi: 10.3109/15622975.2013.841993. Epub 2013 Nov 13.

PMID:
24219803
50.

Towards a better cannabis drug.

Mechoulam R, Parker L.

Br J Pharmacol. 2013 Dec;170(7):1363-4. doi: 10.1111/bph.12400.

Supplemental Content

Loading ...
Support Center