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Items: 7

1.

Molecular basis of action of a small molecule positive allosteric modulator (PAM)-agonist at the type 1 cholecystokinin holoreceptor.

Desai AJ, Mechin I, Nagarajan K, Valant C, Wootten D, Lam PCH, Orry A, Abagyan R, Nair A, Sexton PM, Christopoulos A, Miller LJ.

Mol Pharmacol. 2018 Dec 27. pii: mol.118.114082. doi: 10.1124/mol.118.114082. [Epub ahead of print]

2.

Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.

Barberis C, Moorcroft N, Arendt C, Levit M, Moreno-Mazza S, Batchelor J, Mechin I, Majid T.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4730-4734. doi: 10.1016/j.bmcl.2017.08.069. Epub 2017 Sep 18.

PMID:
28947155
3.

Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.

Gao Q, Mechin I, Kothari N, Guo Z, Deng G, Haas K, McManus J, Hoffmann D, Wang A, Wiederschain D, Rocnik J, Czechtizky W, Chen X, McLean L, Arlt H, Harper D, Liu F, Majid T, Patel V, Lengauer C, Garcia-Echeverria C, Zhang B, Cheng H, Dorsch M, Huang SM.

J Biol Chem. 2013 Oct 18;288(42):30125-38. doi: 10.1074/jbc.M113.473348. Epub 2013 Sep 3.

4.

The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle.

Banaszak K, Mechin I, Obmolova G, Oldham M, Chang SH, Ruiz T, Radermacher M, Kopperschläger G, Rypniewski W.

J Mol Biol. 2011 Mar 25;407(2):284-97. doi: 10.1016/j.jmb.2011.01.019. Epub 2011 Jan 15.

PMID:
21241708
5.

Structure of the reduced disulfide-bond isomerase DsbC from Escherichia coli.

Banaszak K, Mechin I, Frost G, Rypniewski W.

Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1747-52. Epub 2004 Sep 23.

PMID:
15388920
6.

The 10.8-A structure of Saccharomyces cerevisiae phosphofructokinase determined by cryoelectron microscopy: localization of the putative fructose 6-phosphate binding sites.

Ruiz T, Mechin I, Bär J, Rypniewski W, Kopperschläger G, Radermacher M.

J Struct Biol. 2003 Aug;143(2):124-34.

PMID:
12972349
7.

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