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Items: 48


Genetic Simulation Resources and the GSR Certification Program.

Peng B, Leong MC, Chen HS, Rotunno M, Brignole KR, Clarke J, Mechanic LE.

Bioinformatics. 2019 Feb 15;35(4):709-710. doi: 10.1093/bioinformatics/bty666. No abstract available.


Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.

McAllister K, Mechanic LE, Amos C, Aschard H, Blair IA, Chatterjee N, Conti D, Gauderman WJ, Hsu L, Hutter CM, Jankowska MM, Kerr J, Kraft P, Montgomery SB, Mukherjee B, Papanicolaou GJ, Patel CJ, Ritchie MD, Ritz BR, Thomas DC, Wei P, Witte JS.

Am J Epidemiol. 2017 Oct 1;186(7):753-761. doi: 10.1093/aje/kwx227.


Lessons Learned From Past Gene-Environment Interaction Successes.

Ritz BR, Chatterjee N, Garcia-Closas M, Gauderman WJ, Pierce BL, Kraft P, Tanner CM, Mechanic LE, McAllister K.

Am J Epidemiol. 2017 Oct 1;186(7):778-786. doi: 10.1093/aje/kwx230. Review.


Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology.

Mechanic LE, Lindström S, Daily KM, Sieberts SK, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, Schildkraut J, Schumacher F, Witte JS, Wang W, Williams SM; U4C Challenge Participants; U4C Challenge Data Contributors, Gillanders EM.

PLoS Genet. 2017 Sep 28;13(9):e1006945. doi: 10.1371/journal.pgen.1006945. eCollection 2017 Sep. No abstract available.


Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies.

Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teitelbaum SL, Amos CI.

Cancer Epidemiol Biomarkers Prev. 2017 Sep;26(9):1370-1380. doi: 10.1158/1055-9965.EPI-17-0459. Epub 2017 Jul 14. Review.


Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach.

Samimi G, Bernardini MQ, Brody LC, Caga-Anan CF, Campbell IG, Chenevix-Trench G, Couch FJ, Dean M, de Hullu JA, Domchek SM, Drapkin R, Spencer Feigelson H, Friedlander M, Gaudet MM, Harmsen MG, Hurley K, James PA, Kwon JS, Lacbawan F, Lheureux S, Mai PL, Mechanic LE, Minasian LM, Myers ER, Robson ME, Ramus SJ, Rezende LF, Shaw PA, Slavin TP, Swisher EM, Takenaka M, Bowtell DD, Sherman ME.

J Clin Oncol. 2017 Jul 10;35(20):2329-2337. doi: 10.1200/JCO.2016.70.3439. Epub 2017 Apr 11.


Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know?

Simonds NI, Ghazarian AA, Pimentel CB, Schully SD, Ellison GL, Gillanders EM, Mechanic LE.

Genet Epidemiol. 2016 Jul;40(5):356-65. doi: 10.1002/gepi.21967. Epub 2016 Apr 7. Review.


Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans.

Pine SR, Mechanic LE, Enewold L, Bowman ED, Ryan BM, Cote ML, Wenzlaff AS, Loffredo CA, Olivo-Marston S, Chaturvedi A, Caporaso NE, Schwartz AG, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):488-97. doi: 10.1158/1055-9965.EPI-15-0378. Epub 2015 Dec 28.


Robustness of Next Generation Sequencing on Older Formalin-Fixed Paraffin-Embedded Tissue.

Carrick DM, Mehaffey MG, Sachs MC, Altekruse S, Camalier C, Chuaqui R, Cozen W, Das B, Hernandez BY, Lih CJ, Lynch CF, Makhlouf H, McGregor P, McShane LM, Phillips Rohan J, Walsh WD, Williams PM, Gillanders EM, Mechanic LE, Schully SD.

PLoS One. 2015 Jul 29;10(7):e0127353. doi: 10.1371/journal.pone.0127353. eCollection 2015.


Leveraging biospecimen resources for discovery or validation of markers for early cancer detection.

Schully SD, Carrick DM, Mechanic LE, Srivastava S, Anderson GL, Baron JA, Berg CD, Cullen J, Diamandis EP, Doria-Rose VP, Goddard KA, Hankinson SE, Kushi LH, Larson EB, McShane LM, Schilsky RL, Shak S, Skates SJ, Urban N, Kramer BS, Khoury MJ, Ransohoff DF.

J Natl Cancer Inst. 2015 Feb 16;107(4). pii: djv012. doi: 10.1093/jnci/djv012. Print 2015 Apr.


Genetic data simulators and their applications: an overview.

Peng B, Chen HS, Mechanic LE, Racine B, Clarke J, Gillanders E, Feuer EJ.

Genet Epidemiol. 2015 Jan;39(1):2-10. doi: 10.1002/gepi.21876. Epub 2014 Dec 13.


SEER cancer registry biospecimen research: yesterday and tomorrow.

Altekruse SF, Rosenfeld GE, Carrick DM, Pressman EJ, Schully SD, Mechanic LE, Cronin KA, Hernandez BY, Lynch CF, Cozen W, Khoury MJ, Penberthy LT.

Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2681-7. doi: 10.1158/1055-9965.EPI-14-0490. Review.


Genetic simulation tools for post-genome wide association studies of complex diseases.

Chen HS, Hutter CM, Mechanic LE, Amos CI, Bafna V, Hauser ER, Hernandez RD, Li C, Liberles DA, McAllister K, Moore JH, Paltoo DN, Papanicolaou GJ, Peng B, Ritchie MD, Rosenfeld G, Witte JS, Gillanders EM, Feuer EJ.

Genet Epidemiol. 2015 Jan;39(1):11-19. doi: 10.1002/gepi.21870. Epub 2014 Nov 4.


The use of biospecimens in population-based research: a review of the National Cancer Institute's Division of Cancer Control and Population Sciences grant portfolio.

Carrick DM, Mette E, Hoyle B, Rogers SD, Gillanders EM, Schully SD, Mechanic LE.

Biopreserv Biobank. 2014 Aug;12(4):240-5. doi: 10.1089/bio.2014.0009. Review.


Approaches to integrating germline and tumor genomic data in cancer research.

Feigelson HS, Goddard KA, Hollombe C, Tingle SR, Gillanders EM, Mechanic LE, Nelson SA.

Carcinogenesis. 2014 Oct;35(10):2157-63. doi: 10.1093/carcin/bgu165. Epub 2014 Aug 12. Review.


Pharmacogenomics in oncology care.

Filipski KK, Mechanic LE, Long R, Freedman AN.

Front Genet. 2014 Apr 8;5:73. doi: 10.3389/fgene.2014.00073. eCollection 2014. Review.


Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report.

Hutter CM, Mechanic LE, Chatterjee N, Kraft P, Gillanders EM; NCI Gene-Environment Think Tank.

Genet Epidemiol. 2013 Nov;37(7):643-57. doi: 10.1002/gepi.21756. Epub 2013 Oct 5.


NCI think tank concerning the identifiability of biospecimens and "omic" data.

Weil CJ, Mechanic LE, Green T, Kinsinger C, Lockhart NC, Nelson SA, Rodriguez LL, Buccini LD.

Genet Med. 2013 Dec;15(12):997-1003. doi: 10.1038/gim.2013.40. Epub 2013 Apr 11.


A review of NCI's extramural grant portfolio: identifying opportunities for future research in genes and environment in cancer.

Ghazarian AA, Simonds NI, Bennett K, Pimentel CB, Ellison GL, Gillanders EM, Schully SD, Mechanic LE.

Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):501-7. doi: 10.1158/1055-9965.EPI-13-0156. Epub 2013 Mar 5. Review.


Genetic Simulation Resources: a website for the registration and discovery of genetic data simulators.

Peng B, Chen HS, Mechanic LE, Racine B, Clarke J, Clarke L, Gillanders E, Feuer EJ.

Bioinformatics. 2013 Apr 15;29(8):1101-2. doi: 10.1093/bioinformatics/btt094. Epub 2013 Feb 23.


SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.

Enewold L, Mechanic LE, Bowman ED, Platz EA, Alberg AJ.

Anticancer Res. 2012 Sep;32(9):3923-8.


Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer.

Enewold L, Mechanic LE, Bowman ED, Platz EA, Alberg AJ.

Anticancer Res. 2012 Sep;32(9):3917-22.


EGFR somatic mutations in lung tumors: radon exposure and passive smoking in former- and never-smoking U.S. women.

Taga M, Mechanic LE, Hagiwara N, Vähäkangas KH, Bennett WP, Alavanja MC, Welsh JA, Khan MA, Lee A, Diasio R, Edell E, Bungum A, Jang JS, Yang P, Jen J, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):988-92. doi: 10.1158/1055-9965.EPI-12-0166. Epub 2012 Apr 20.


Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.

Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan R, Harris EL, Jacobs K, Kraft P, Leal SM, McAllister K, Moore JH, Paltoo DN, Province MA, Ramos EM, Ritchie MD, Roeder K, Schaid DJ, Stephens M, Thomas DC, Weinberg CR, Witte JS, Zhang S, Zöllner S, Feuer EJ, Gillanders EM.

Genet Epidemiol. 2012 Jan;36(1):22-35. doi: 10.1002/gepi.20652. Epub 2011 Dec 6.


Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.

Pine SR, Mechanic LE, Enewold L, Chaturvedi AK, Katki HA, Zheng YL, Bowman ED, Engels EA, Caporaso NE, Harris CC.

J Natl Cancer Inst. 2011 Jul 20;103(14):1112-22. doi: 10.1093/jnci/djr216. Epub 2011 Jun 17.


Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.

Gill RK, Yang SH, Meerzaman D, Mechanic LE, Bowman ED, Jeon HS, Roy Chowdhuri S, Shakoori A, Dracheva T, Hong KM, Fukuoka J, Zhang JH, Harris CC, Jen J.

Oncogene. 2011 Sep 1;30(35):3784-91. doi: 10.1038/onc.2011.98. Epub 2011 May 2.


Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women.

Olivo-Marston SE, Mechanic LE, Mollerup S, Bowman ED, Remaley AT, Forman MR, Skaug V, Zheng YL, Haugen A, Harris CC.

Carcinogenesis. 2010 Oct;31(10):1778-86. doi: 10.1093/carcin/bgq156. Epub 2010 Aug 20.


Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Troy JD, Hartge P, Weissfeld JL, Oken MM, Colditz GA, Mechanic LE, Morton LM.

Am J Epidemiol. 2010 Jun 15;171(12):1270-81. doi: 10.1093/aje/kwq085. Epub 2010 May 21.


Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk.

Olivo-Marston SE, Yang P, Mechanic LE, Bowman ED, Pine SR, Loffredo CA, Alberg AJ, Caporaso N, Shields PG, Chanock S, Wu Y, Jiang R, Cunningham J, Jen J, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3375-83. doi: 10.1158/1055-9965.EPI-09-0986.


Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians.

Enewold L, Mechanic LE, Bowman ED, Zheng YL, Yu Z, Trivers G, Alberg AJ, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):215-22. doi: 10.1158/1055-9965.EPI-08-0705.


Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.

Mechanic LE, Luke BT, Goodman JE, Chanock SJ, Harris CC.

BMC Bioinformatics. 2008 Mar 6;9:146. doi: 10.1186/1471-2105-9-146.


Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene.

Pine SR, Mechanic LE, Ambs S, Bowman ED, Chanock SJ, Loffredo C, Shields PG, Harris CC.

J Natl Cancer Inst. 2007 Sep 19;99(18):1401-9. Epub 2007 Sep 11.


Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.

Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, Kumamoto K, Mechanic LE, Matsumoto S, Yokota J, Shibata T, Sugimura H, Gemma A, Kudoh S, Wang XW, Harris CC.

J Natl Cancer Inst. 2007 Aug 15;99(16):1257-69. Epub 2007 Aug 8.


Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors.

Mechanic LE, Bowman ED, Welsh JA, Khan MA, Hagiwara N, Enewold L, Shields PG, Burdette L, Chanock S, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):214-22.


The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women.

Bernig T, Boersma BJ, Howe TM, Welch R, Yadavalli S, Staats B, Mechanic LE, Chanock SJ, Ambs S.

Carcinogenesis. 2007 Apr;28(4):828-36. Epub 2006 Oct 27.


Association of MTHFR gene polymorphisms with breast cancer survival.

Martin DN, Boersma BJ, Howe TM, Goodman JE, Mechanic LE, Chanock SJ, Ambs S.

BMC Cancer. 2006 Oct 27;6:257.


Quantitative detection of p53 mutations in plasma DNA from tobacco smokers.

Hagiwara N, Mechanic LE, Trivers GE, Cawley HL, Taga M, Bowman ED, Kumamoto K, He P, Bernard M, Doja S, Miyashita M, Tajiri T, Sasajima K, Nomura T, Makino H, Takahashi K, Hussain SP, Harris CC.

Cancer Res. 2006 Aug 15;66(16):8309-17.


MDM2 SNP309 and SNP354 are not associated with lung cancer risk.

Pine SR, Mechanic LE, Bowman ED, Welsh JA, Chanock SC, Shields PG, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1559-61.


Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.

Mechanic LE, Millikan RC, Player J, de Cotret AR, Winkel S, Worley K, Heard K, Heard K, Tse CK, Keku T.

Carcinogenesis. 2006 Jul;27(7):1377-85. Epub 2006 Jan 6.


Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis.

Goodman JE, Mechanic LE, Luke BT, Ambs S, Chanock S, Harris CC.

Int J Cancer. 2006 Apr 1;118(7):1790-7.


TP53 mutation spectrum in lung cancer is not different in women and men.

Marrogi AJ, Mechanic LE, Welsh JA, Bowman ED, Khan MA, Enewold L, Shields PG, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):1031-3.


Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer.

Yang SH, Mechanic LE, Yang P, Landi MT, Bowman ED, Wampfler J, Meerzaman D, Hong KM, Mann F, Dracheva T, Fukuoka J, Travis W, Caporaso NE, Harris CC, Jen J.

Clin Cancer Res. 2005 Mar 15;11(6):2106-10. Erratum in: Clin Cancer Res. 2005 Nov 1;11(21):7960-1.


Polymorphisms in XPD and TP53 and mutation in human lung cancer.

Mechanic LE, Marrogi AJ, Welsh JA, Bowman ED, Khan MA, Enewold L, Zheng YL, Chanock S, Shields PG, Harris CC.

Carcinogenesis. 2005 Mar;26(3):597-604. Epub 2004 Nov 25.


Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.

Hussain SP, Trivers GE, Hofseth LJ, He P, Shaikh I, Mechanic LE, Doja S, Jiang W, Subleski J, Shorts L, Haines D, Laubach VE, Wiltrout RH, Djurickovic D, Harris CC.

Cancer Res. 2004 Oct 1;64(19):6849-53.


The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, Samson LD, Harris CC.

J Clin Invest. 2003 Dec;112(12):1887-94. Erratum in: J Clin Invest. 2004 Feb;113(3):490.


Escherichia coli MutL loads DNA helicase II onto DNA.

Mechanic LE, Frankel BA, Matson SW.

J Biol Chem. 2000 Dec 8;275(49):38337-46.


Escherichia coli DNA helicase II is active as a monomer.

Mechanic LE, Hall MC, Matson SW.

J Biol Chem. 1999 Apr 30;274(18):12488-98.


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