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Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development.

Lin CJ, Staiculescu MC, Hawes JZ, Cocciolone AJ, Hunkins BM, Roth RA, Lin CY, Mecham R, Wagenseil JE.

Circ Res. 2019 Oct 8. doi: 10.1161/CIRCRESAHA.119.315348. [Epub ahead of print]


Sodium-activated potassium channels moderate excitability in vascular smooth muscle.

Li P, Halabi CM, Stewart R, Butler A, Brown B, Xia X, Santi C, England S, Ferreira J, Mecham RP, Salkoff L.

J Physiol. 2019 Aug 24. doi: 10.1113/JP278279. [Epub ahead of print]


Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.

Kim J, Cocciolone AJ, Staiculescu MC, Mecham RP, Wagenseil JE.

Biomech Model Mechanobiol. 2019 Jul 3. doi: 10.1007/s10237-019-01198-2. [Epub ahead of print]


Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.

Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP.

JCI Insight. 2019 Jun 18;5. pii: 127748. doi: 10.1172/jci.insight.127748.


Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy.

Kim D, Mecham RP, Nguyen NH, Roy S.

Exp Eye Res. 2019 Jul;184:221-226. doi: 10.1016/j.exer.2019.04.019. Epub 2019 May 6.


Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.

Huang LH, Zinselmeyer BH, Chang CH, Saunders BT, Elvington A, Baba O, Broekelmann TJ, Qi L, Rueve JS, Swartz MA, Kim BS, Mecham RP, Wiig H, Thomas MJ, Sorci-Thomas MG, Randolph GJ.

Cell Metab. 2019 Feb 5;29(2):475-487.e7. doi: 10.1016/j.cmet.2018.10.006. Epub 2018 Nov 8.


MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations.

Villain G, Lelievre E, Broekelmann T, Gayet O, Havet C, Werkmeister E, Mecham R, Dusetti N, Soncin F, Mattot V.

FEBS J. 2018 Dec;285(23):4394-4412. doi: 10.1111/febs.14680. Epub 2018 Nov 1.


Cardiovascular consequences of KATP overactivity in Cantu syndrome.

Huang Y, McClenaghan C, Harter TM, Hinman K, Halabi CM, Matkovich SJ, Zhang H, Brown GS, Mecham RP, England SK, Kovacs A, Remedi MS, Nichols CG.

JCI Insight. 2018 Aug 9;3(15). pii: 121153. doi: 10.1172/jci.insight.121153. eCollection 2018 Aug 9.


Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis.

Mecham RP, Ramirez F.

Curr Top Dev Biol. 2018;130:193-216. doi: 10.1016/bs.ctdb.2018.02.001. Review.


Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development.

Luo Y, Li N, Chen H, Fernandez GE, Warburton D, Moats R, Mecham RP, Krenitsky D, Pryhuber GS, Shi W.

Sci Rep. 2018 May 29;8(1):8334. doi: 10.1038/s41598-018-26673-1.


Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis.

Kabir AU, Lee TJ, Pan H, Berry JC, Krchma K, Wu J, Liu F, Kang HK, Hinman K, Yang L, Hamilton S, Zhou Q, Veis DJ, Mecham RP, Wickline SA, Miller MJ, Choi K.

JCI Insight. 2018 Apr 19;3(8). pii: 97349. doi: 10.1172/jci.insight.97349. eCollection 2018 Apr 19.


Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.

Craft CS, Broekelmann TJ, Mecham RP.

Matrix Biol. 2018 Oct;71-72:100-111. doi: 10.1016/j.matbio.2018.03.006. Epub 2018 Mar 7. Review.


Contribution of metabolic disease to bone fragility in MAGP1-deficient mice.

Turecamo SE, Walji TA, Broekelmann TJ, Williams JW, Ivanov S, Wee NK, Procknow JD, McManus MR, Randolph GJ, Scheller EL, Mecham RP, Craft CS.

Matrix Biol. 2018 Apr;67:1-14. doi: 10.1016/j.matbio.2018.02.022. Epub 2018 Mar 5.


Elastin in lung development and disease pathogenesis.

Mecham RP.

Matrix Biol. 2018 Nov;73:6-20. doi: 10.1016/j.matbio.2018.01.005. Epub 2018 Jan 11. Review.



Mecham RP.

Methods Cell Biol. 2018;143:xix-xxi. doi: 10.1016/S0091-679X(17)30166-8. No abstract available.


Elastin purification and solubilization.

Halabi CM, Mecham RP.

Methods Cell Biol. 2018;143:207-222. doi: 10.1016/bs.mcb.2017.08.012. Epub 2017 Nov 6.


Measurement of elastin, collagen, and total protein levels in tissues.

Stoilov I, Starcher BC, Mecham RP, Broekelmann TJ.

Methods Cell Biol. 2018;143:133-146. doi: 10.1016/bs.mcb.2017.08.008. Epub 2017 Nov 6.


Maintaining Elastogenicity of Mesenchymal Stem Cell-Derived Smooth Muscle Cells in Two-Dimensional Culture.

Dahal S, Broekelman T, Mecham RP, Ramamurthi A.

Tissue Eng Part A. 2018 Jun;24(11-12):979-989. doi: 10.1089/ten.TEA.2017.0237. Epub 2018 Feb 2.


A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension.

Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS.

Circ Res. 2017 Nov 10;121(11):1216-1218. doi: 10.1161/CIRCRESAHA.117.311703. Review. No abstract available.


FGF receptors control alveolar elastogenesis.

Li R, Herriges JC, Chen L, Mecham RP, Sun X.

Development. 2017 Dec 15;144(24):4563-4572. doi: 10.1242/dev.149443. Epub 2017 Nov 9.


Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration.

Eekhoff JD, Fang F, Kahan LG, Espinosa G, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP.

J Biomech Eng. 2017 Nov 1;139(11). doi: 10.1115/1.4037932.


Multifunctional, JNK-inhibiting nanotherapeutics for augmented elastic matrix regenerative repair in aortic aneurysms.

Camardo A, Seshadri D, Broekelmann T, Mecham R, Ramamurthi A.

Drug Deliv Transl Res. 2018 Aug;8(4):964-984. doi: 10.1007/s13346-017-0419-y.


Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta.

Kim J, Staiculescu MC, Cocciolone AJ, Yanagisawa H, Mecham RP, Wagenseil JE.

J Biomech. 2017 Aug 16;61:199-207. doi: 10.1016/j.jbiomech.2017.07.011. Epub 2017 Jul 25.


Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice.

Staiculescu MC, Kim J, Mecham RP, Wagenseil JE.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H446-H456. doi: 10.1152/ajpheart.00712.2016. Epub 2017 May 26.


Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis.

Kim D, Mecham RP, Trackman PC, Roy S.

Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2725-2731. doi: 10.1167/iovs.16-21340.


Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.

Halabi CM, Broekelmann TJ, Lin M, Lee VS, Chu ML, Mecham RP.

Sci Adv. 2017 May 3;3(5):e1602532. doi: 10.1126/sciadv.1602532. eCollection 2017 May.


Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model.

Munjal C, Jegga AG, Opoka AM, Stoilov I, Norris RA, Thomas CJ, Smith JM, Mecham RP, Bressan GM, Hinton RB.

Physiol Rep. 2017 Mar;5(5). pii: e13152. doi: 10.14814/phy2.13152.


Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency.

Jiao Y, Li G, Korneva A, Caulk AW, Qin L, Bersi MR, Li Q, Li W, Mecham RP, Humphrey JD, Tellides G.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):930-941. doi: 10.1161/ATVBAHA.117.309079. Epub 2017 Mar 2.


Magnetically-responsive, multifunctional drug delivery nanoparticles for elastic matrix regenerative repair.

Sivaraman B, Swaminathan G, Moore L, Fox J, Seshadri D, Dahal S, Stoilov I, Zborowski M, Mecham R, Ramamurthi A.

Acta Biomater. 2017 Apr 1;52:171-186. doi: 10.1016/j.actbio.2016.11.048. Epub 2016 Nov 21.


Phenotype-based selection of bone marrow mesenchymal stem cell-derived smooth muscle cells for elastic matrix regenerative repair in abdominal aortic aneurysms.

Swaminathan G, Stoilov I, Broekelmann T, Mecham R, Ramamurthi A.

J Tissue Eng Regen Med. 2018 Jan;12(1):e60-e70. doi: 10.1002/term.2349. Epub 2017 Apr 25.


Characterization of metabolic health in mouse models of fibrillin-1 perturbation.

Walji TA, Turecamo SE, DeMarsilis AJ, Sakai LY, Mecham RP, Craft CS.

Matrix Biol. 2016 Sep;55:63-76. doi: 10.1016/j.matbio.2016.02.006. Epub 2016 Feb 21.


Loss of Elastic Fiber Integrity Compromises Common Carotid Artery Function: Implications for Vascular Aging.

Ferruzzi J, Bersi MR, Mecham RP, Ramirez F, Yanagisawa H, Tellides G, Humphrey JD.

Artery Res. 2016 Jun;14:41-52. Epub 2016 Apr 22.


Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.

Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS.

Front Endocrinol (Lausanne). 2016 Jun 30;7:87. doi: 10.3389/fendo.2016.00087. eCollection 2016.


Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.

Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D; Brigham Genomic Medicine, Mecham RP, Frank NY, Stitziel NO.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8759-64. doi: 10.1073/pnas.1601442113. Epub 2016 Jul 18.


Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.

Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES.

Biomaterials. 2016 Sep;102:220-30. doi: 10.1016/j.biomaterials.2016.06.025. Epub 2016 Jun 16.


Albumin contributes to kidney disease progression in Alport syndrome.

Jarad G, Knutsen RH, Mecham RP, Miner JH.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F120-30. doi: 10.1152/ajprenal.00456.2015. Epub 2016 May 4.


Sterilization of Lung Matrices by Supercritical Carbon Dioxide.

Balestrini JL, Liu A, Gard AL, Huie J, Blatt KM, Schwan J, Zhao L, Broekelmann TJ, Mecham RP, Wilcox EC, Niklason LE.

Tissue Eng Part C Methods. 2016 Mar;22(3):260-9. doi: 10.1089/ten.TEC.2015.0449. Epub 2016 Jan 29.


Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.

Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H1008-16. doi: 10.1152/ajpheart.00288.2015. Epub 2015 Jul 31.


Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.

Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML.

J Biol Chem. 2015 Aug 28;290(35):21443-59. doi: 10.1074/jbc.M115.640425. Epub 2015 Jul 15.


Elastin Insufficiency Predisposes Mice to Impaired Glucose Metabolism.

DeMarsilis AJ, Walji TA, Maedeker JA, Stoka KV, Kozel BA, Mecham RP, Wagenseil JE, Craft CS.

J Mol Genet Med. 2014 Oct;8(3). pii: 129.


The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche.

Mecham RP, Gibson MA.

Matrix Biol. 2015 Sep;47:13-33. doi: 10.1016/j.matbio.2015.05.003. Epub 2015 May 8. Review.


Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

Hubmacher D, Wang LW, Mecham RP, Reinhardt DP, Apte SS.

Dis Model Mech. 2015 May;8(5):487-99. doi: 10.1242/dmm.017046. Epub 2015 Mar 11.


Mechanical factors direct mouse aortic remodelling during early maturation.

Le VP, Cheng JK, Kim J, Staiculescu MC, Ficker SW, Sheth SC, Bhayani SA, Mecham RP, Yanagisawa H, Wagenseil JE.

J R Soc Interface. 2015 Mar 6;12(104):20141350. doi: 10.1098/rsif.2014.1350.


Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness.

Walker AE, Henson GD, Reihl KD, Morgan RG, Dobson PS, Nielson EI, Ling J, Mecham RP, Li DY, Lesniewski LA, Donato AJ.

J Physiol. 2015 Apr 15;593(8):1931-43. doi: 10.1113/jphysiol.2014.285338. Epub 2015 Feb 20.


Pro-elastogenic effects of bone marrow mesenchymal stem cell-derived smooth muscle cells on cultured aneurysmal smooth muscle cells.

Swaminathan G, Gadepalli VS, Stoilov I, Mecham RP, Rao RR, Ramamurthi A.

J Tissue Eng Regen Med. 2017 Mar;11(3):679-693. doi: 10.1002/term.1964. Epub 2014 Nov 6.


Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.

Guzy RD, Stoilov I, Elton TJ, Mecham RP, Ornitz DM.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):116-28. doi: 10.1165/rcmb.2014-0184OC.


The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β.

Craft CS, Pietka TA, Schappe T, Coleman T, Combs MD, Klein S, Abumrad NA, Mecham RP.

Diabetes. 2014 Jun;63(6):1920-32. doi: 10.2337/db13-1604. Epub 2014 Jan 23.


Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency.

Osei-Owusu P, Knutsen RH, Kozel BA, Dietrich HH, Blumer KJ, Mecham RP.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H654-66. doi: 10.1152/ajpheart.00601.2013. Epub 2014 Jan 10.


Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

Beene LC, Wang LW, Hubmacher D, Keene DR, Reinhardt DP, Annis DS, Mosher DF, Mecham RP, Traboulsi EI, Apte SS.

Invest Ophthalmol Vis Sci. 2013 Dec 23;54(13):8337-44. doi: 10.1167/iovs.13-13121.


Ocular phenotype of Fbn2-null mice.

Shi Y, Tu Y, Mecham RP, Bassnett S.

Invest Ophthalmol Vis Sci. 2013 Nov 1;54(12):7163-73. doi: 10.1167/iovs.13-12687.

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