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Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens.

Grillová L, Oppelt J, Mikalová L, Nováková M, Giacani L, Niesnerová A, Noda AA, Mechaly AE, Pospíšilová P, Čejková D, Grange PA, Dupin N, Strnadel R, Chen M, Denham I, Arora N, Picardeau M, Weston C, Forsyth RA, Šmajs D.

Front Microbiol. 2019 Jul 31;10:1691. doi: 10.3389/fmicb.2019.01691. eCollection 2019.


Inhibition of Francisella tularensis phagocytosis using a novel anti-LPS scFv antibody fragment.

Mechaly A, Elia U, Alcalay R, Cohen H, Epstein E, Cohen O, Mazor O.

Sci Rep. 2019 Aug 6;9(1):11418. doi: 10.1038/s41598-019-47931-w.


Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish.

Mechaly AS, Tovar Bohórquez MO, Mechaly AE, Suku E, Pérez MR, Giorgetti A, Ortí G, Viñas J, Somoza GM.

Front Endocrinol (Lausanne). 2018 Oct 17;9:604. doi: 10.3389/fendo.2018.00604. eCollection 2018.


Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.

Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM.

J Struct Biol. 2018 Nov;204(2):165-171. doi: 10.1016/j.jsb.2018.08.001. Epub 2018 Aug 4.


Structural insights into the signalling mechanisms of two-component systems.

Jacob-Dubuisson F, Mechaly A, Betton JM, Antoine R.

Nat Rev Microbiol. 2018 Oct;16(10):585-593. doi: 10.1038/s41579-018-0055-7. Review.


Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira.

Adhikarla H, Wunder EA Jr, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI.

Front Cell Infect Microbiol. 2018 Feb 23;8:45. doi: 10.3389/fcimb.2018.00045. eCollection 2018.


Novel Phage Display-Derived Anti-Abrin Antibodies Confer Post-Exposure Protection against Abrin Intoxication.

Mechaly A, Alcalay R, Noy-Porat T, Epstein E, Gal Y, Mazor O.

Toxins (Basel). 2018 Feb 13;10(2). pii: E80. doi: 10.3390/toxins10020080.


Simultaneous Immunodetection of Anthrax, Plague, and Tularemia from Blood Cultures by Use of Multiplexed Suspension Arrays.

Mechaly A, Vitner E, Levy H, Weiss S, Bar-David E, Gur D, Koren M, Cohen H, Cohen O, Mamroud E, Fisher M.

J Clin Microbiol. 2018 Mar 26;56(4). pii: e01479-17. doi: 10.1128/JCM.01479-17. Print 2018 Apr.


Kisspeptins and their receptors in the brain-pituitary-gonadal axis of Odonthestes bonariensis: Their relationship with gametogenesis along the reproductive cycle.

Tovar Bohórquez MO, Mechaly AS, Elisio M, Chalde T, Canosa LF, Miranda LA, Somoza GM.

Gen Comp Endocrinol. 2017 Oct 1;252:209-218. doi: 10.1016/j.ygcen.2017.06.028. Epub 2017 Jun 30.


Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase.

Mechaly AE, Soto Diaz S, Sassoon N, Buschiazzo A, Betton JM, Alzari PM.

Structure. 2017 Jun 6;25(6):939-944.e3. doi: 10.1016/j.str.2017.04.011. Epub 2017 May 25.


Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values.

Rosenfeld R, Alcalay R, Mechaly A, Lapidoth G, Epstein E, Kronman C, J Fleishman S, Mazor O.

Protein Eng Des Sel. 2017 Sep 1;30(9):611-617. doi: 10.1093/protein/gzx028.


Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis.

San Martin F, Mechaly AE, Larrieux N, Wunder EA Jr, Ko AI, Picardeau M, Trajtenberg F, Buschiazzo A.

Acta Crystallogr F Struct Biol Commun. 2017 Mar 1;73(Pt 3):123-129. doi: 10.1107/S2053230X17002096. Epub 2017 Feb 21.


Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin.

Mechaly AS, Richardson E, Rinkwitz S.

Gen Comp Endocrinol. 2017 May 15;246:233-240. doi: 10.1016/j.ygcen.2016.12.013. Epub 2016 Dec 29.


Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action.

Trajtenberg F, Imelio JA, Machado MR, Larrieux N, Marti MA, Obal G, Mechaly AE, Buschiazzo A.

Elife. 2016 Dec 12;5. pii: e21422. doi: 10.7554/eLife.21422.


Kisspeptin system in pejerrey fish (Odontesthes bonariensis). Characterization and gene expression pattern during early developmental stages.

Tovar Bohórquez MO, Mechaly AS, Hughes LC, Campanella D, Ortí G, Canosa LF, Somoza GM.

Comp Biochem Physiol A Mol Integr Physiol. 2017 Feb;204:146-156. doi: 10.1016/j.cbpa.2016.11.014. Epub 2016 Nov 23.


Revisiting the Concept of Targeting Only Bacillus anthracis Toxins as a Treatment for Anthrax.

Glinert I, Bar-David E, Sittner A, Weiss S, Schlomovitz J, Ben-Shmuel A, Mechaly A, Altboum Z, Kobiler D, Levy H.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4878-85. doi: 10.1128/AAC.00546-16. Print 2016 Aug.


Highly Stable Lyophilized Homogeneous Bead-Based Immunoassays for On-Site Detection of Bio Warfare Agents from Complex Matrices.

Mechaly A, Marx S, Levy O, Yitzhaki S, Fisher M.

Anal Chem. 2016 Jun 21;88(12):6283-91. doi: 10.1021/acs.analchem.6b00362. Epub 2016 Jun 10.


A biolayer interferometry-based assay for rapid and highly sensitive detection of biowarfare agents.

Mechaly A, Cohen H, Cohen O, Mazor O.

Anal Biochem. 2016 Aug 1;506:22-7. doi: 10.1016/j.ab.2016.04.018. Epub 2016 May 5.


What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira.

Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA Jr, Yang XF, Zhang JJ, Vinetz JM.

PLoS Negl Trop Dis. 2016 Feb 18;10(2):e0004403. doi: 10.1371/journal.pntd.0004403. eCollection 2016 Feb.


Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis.

East A, Mechaly AE, Huysmans GHM, Bernarde C, Tello-Manigne D, Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ, Francetic O.

Structure. 2016 Jan 5;24(1):92-104. doi: 10.1016/j.str.2015.10.023. Epub 2015 Dec 10.


Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene.

Ishibashi M, Manning E, Shoubridge C, Krecsmarik M, Hawkins TA, Giacomotto J, Zhao T, Mueller T, Bader PI, Cheung SW, Stankiewicz P, Bain NL, Hackett A, Reddy CC, Mechaly AS, Peers B, Wilson SW, Lenhard B, Bally-Cuif L, Gecz J, Becker TS, Rinkwitz S.

Hum Genet. 2015 Nov;134(11-12):1163-82. doi: 10.1007/s00439-015-1594-x. Epub 2015 Sep 4.


Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation.

Trajtenberg F, Albanesi D, Ruétalo N, Botti H, Mechaly AE, Nieves M, Aguilar PS, Cybulski L, Larrieux N, de Mendoza D, Buschiazzo A.

MBio. 2014 Nov 18;5(6):e02105. doi: 10.1128/mBio.02105-14.


Characterization and epitope mapping of the polyclonal antibody repertoire elicited by ricin holotoxin-based vaccination.

Cohen O, Mechaly A, Sabo T, Alcalay R, Aloni-Grinstein R, Seliger N, Kronman C, Mazor O.

Clin Vaccine Immunol. 2014 Nov;21(11):1534-40. doi: 10.1128/CVI.00510-14. Epub 2014 Sep 10.


Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins).

Correa A, Pacheco S, Mechaly AE, Obal G, Béhar G, Mouratou B, Oppezzo P, Alzari PM, Pecorari F.

PLoS One. 2014 May 13;9(5):e97438. doi: 10.1371/journal.pone.0097438. eCollection 2014.


Rapid homogenous time-resolved fluorescence (HTRF) immunoassay for anthrax detection.

Cohen N, Mechaly A, Mazor O, Fisher M, Zahavy E.

J Fluoresc. 2014 May;24(3):795-801. doi: 10.1007/s10895-014-1354-7. Epub 2014 Feb 12.


Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation.

Mechaly AE, Sassoon N, Betton JM, Alzari PM.

PLoS Biol. 2014 Jan 28;12(1):e1001776. doi: 10.1371/journal.pbio.1001776. eCollection 2014 Jan.


Stage-specific gene expression during spermatogenesis in the Senegalese sole (Solea senegalensis), a fish with semi-cystic type of spermatogenesis, as assessed by laser capture microdissection and absolute quantitative PCR.

Marín-Juez R, Viñas J, Mechaly AS, Planas JV, Piferrer F.

Gen Comp Endocrinol. 2013 Jul 1;188:242-50. doi: 10.1016/j.ygcen.2013.04.015. Epub 2013 Apr 28.


The kisspeptin system genes in teleost fish, their structure and regulation, with particular attention to the situation in Pleuronectiformes.

Mechaly AS, Viñas J, Piferrer F.

Gen Comp Endocrinol. 2013 Jul 1;188:258-68. doi: 10.1016/j.ygcen.2013.04.010. Epub 2013 Apr 25.


Using zebrafish transgenesis to test human genomic sequences for specific enhancer activity.

Ishibashi M, Mechaly AS, Becker TS, Rinkwitz S.

Methods. 2013 Aug 15;62(3):216-25. doi: 10.1016/j.ymeth.2013.03.018. Epub 2013 Mar 27.


A novel homogeneous immunoassay for anthrax detection based on the AlphaLISA method: detection of B. anthracis spores and protective antigen (PA) in complex samples.

Mechaly A, Cohen N, Weiss S, Zahavy E.

Anal Bioanal Chem. 2013 May;405(12):3965-72. doi: 10.1007/s00216-013-6752-1. Epub 2013 Feb 7.


A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.

Mechaly A, Levy H, Epstein E, Rosenfeld R, Marcus H, Ben-Arie E, Shafferman A, Ordentlich A, Mazor O.

J Biol Chem. 2012 Sep 21;287(39):32665-73. Epub 2012 Aug 6.


The Kiss2 receptor (Kiss2r) gene in Southern Bluefin Tuna, Thunnus maccoyii and in Yellowtail Kingfish, Seriola lalandi - functional analysis and isolation of transcript variants.

Nocillado JN, Biran J, Lee YY, Levavi-Sivan B, Mechaly AS, Zohar Y, Elizur A.

Mol Cell Endocrinol. 2012 Oct 15;362(1-2):211-20. doi: 10.1016/j.mce.2012.06.024. Epub 2012 Jul 21.


Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes.

Mechaly AE, Bellomio A, Morante K, Agirre J, Gil-Cartón D, Valle M, González-Mañas JM, Guérin DM.

J Struct Biol. 2012 Nov;180(2):312-7. doi: 10.1016/j.jsb.2012.06.003. Epub 2012 Jun 21.


Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M.

FEBS Lett. 2012 Jun 4;586(11):1606-11. doi: 10.1016/j.febslet.2012.04.034. Epub 2012 May 3.


Changing the receptor specificity of anthrax toxin.

Mechaly A, McCluskey AJ, Collier RJ.

MBio. 2012 May 1;3(3). pii: e00088-12. doi: 10.1128/mBio.00088-12. Print 2012.


Sex-specific changes in the expression of kisspeptin, kisspeptin receptor, gonadotropins and gonadotropin receptors in the Senegalese sole (Solea senegalensis) during a full reproductive cycle.

Mechaly AS, Viñas J, Piferrer F.

Comp Biochem Physiol A Mol Integr Physiol. 2012 Aug;162(4):364-71. doi: 10.1016/j.cbpa.2012.04.003. Epub 2012 Apr 16.


In silico analysis of the regulatory region of the Yellowtail Kingfish and Zebrafish Kiss and Kiss receptor genes.

Nocillado JN, Mechaly AS, Elizur A.

Fish Physiol Biochem. 2013 Feb;39(1):59-63. doi: 10.1007/s10695-012-9642-0. Epub 2012 Apr 12.


Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins.

Mechaly AE, Bellomio A, Gil-Cartón D, Morante K, Valle M, González-Mañas JM, Guérin DM.

Structure. 2011 Feb 9;19(2):181-91. doi: 10.1016/j.str.2010.11.013.


The search for early markers of plague: evidence for accumulation of soluble Yersinia pestis LcrV in bubonic and pneumonic mouse models of disease.

Flashner Y, Fisher M, Tidhar A, Mechaly A, Gur D, Halperin G, Zahavy E, Mamroud E, Cohen S.

FEMS Immunol Med Microbiol. 2010 Jul 1;59(2):197-206. doi: 10.1111/j.1574-695X.2010.00687.x. Epub 2010 Apr 19.


Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: insights into the evolution and regulation of Kiss1r genes.

Mechaly AS, Viñas J, Murphy C, Reith M, Piferrer F.

Mol Cell Endocrinol. 2010 Apr 12;317(1-2):78-89. doi: 10.1016/j.mce.2009.11.005. Epub 2009 Nov 17.


Isolation and chimerization of a highly neutralizing antibody conferring passive protection against lethal Bacillus anthracis infection.

Rosenfeld R, Marcus H, Ben-Arie E, Lachmi BE, Mechaly A, Reuveny S, Gat O, Mazor O, Ordentlich A.

PLoS One. 2009 Jul 24;4(7):e6351. doi: 10.1371/journal.pone.0006351.


Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea.

Mechaly AE, Bellomio A, Morante K, González-Mañas JM, Guérin DM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Apr 1;65(Pt 4):357-60. doi: 10.1107/S1744309109007064. Epub 2009 Mar 21.


A combined immunomagnetic separation and lateral flow method for a sensitive on-site detection of Bacillus anthracis spores--assessment in water and dairy products.

Fisher M, Atiya-Nasagi Y, Simon I, Gordin M, Mechaly A, Yitzhaki S.

Lett Appl Microbiol. 2009 Apr;48(4):413-8. doi: 10.1111/j.1472-765X.2008.02542.x. Epub 2009 Feb 2.


Identification of two isoforms of the Kisspeptin-1 receptor (kiss1r) generated by alternative splicing in a modern teleost, the Senegalese sole (Solea senegalensis).

Mechaly AS, Viñas J, Piferrer F.

Biol Reprod. 2009 Jan;80(1):60-9. doi: 10.1095/biolreprod.108.072173. Epub 2008 Sep 24.


A plate holder for non-destructive testing of mesophase crystallization assays.

Agirre J, Mechaly A, Cabo-Bilbao A, Guérin DM.

Eur Biophys J. 2008 Jul;37(6):871-7. doi: 10.1007/s00249-008-0296-x. Epub 2008 Mar 11.


Development and implementation of a single-chain Fv antibody for specific detection of Bacillus anthracis spores.

Mechaly A, Zahavy E, Fisher M.

Appl Environ Microbiol. 2008 Feb;74(3):818-22. Epub 2007 Oct 26.


Protective antigen as a correlative marker for anthrax in animal models.

Kobiler D, Weiss S, Levy H, Fisher M, Mechaly A, Pass A, Altboum Z.

Infect Immun. 2006 Oct;74(10):5871-6.


Crystal structure of the temperature-sensitive and allosteric-defective chaperonin GroELE461K.

Cabo-Bilbao A, Spinelli S, Sot B, Agirre J, Mechaly AE, Muga A, Guérin DM.

J Struct Biol. 2006 Sep;155(3):482-92. Epub 2006 Jul 8.


Matching fusion protein systems for affinity analysis of two interacting families of proteins: the cohesin-dockerin interaction.

Barak Y, Handelsman T, Nakar D, Mechaly A, Lamed R, Shoham Y, Bayer EA.

J Mol Recognit. 2005 Nov-Dec;18(6):491-501.


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