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Items: 1 to 50 of 58

1.

Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease.

Santos E Sousa P, Ciré S, Conlan T, Jardine L, Tkacz C, Ferrer IR, Lomas C, Ward S, West H, Dertschnig S, Blobner S, Means TK, Henderson S, Kaplan DH, Collin M, Plagnol V, Bennett CL, Chakraverty R.

JCI Insight. 2018 Mar 8;3(5). pii: 97011. doi: 10.1172/jci.insight.97011.

2.

Redirection to the bone marrow improves T cell persistence and antitumor functions.

Khan AB, Carpenter B, Santos E Sousa P, Pospori C, Khorshed R, Griffin J, Velica P, Zech M, Ghorashian S, Forrest C, Thomas S, Gonzalez Anton S, Ahmadi M, Holler A, Flutter B, Ramirez-Ortiz Z, Means TK, Bennett CL, Stauss H, Morris E, Lo Celso C, Chakraverty R.

J Clin Invest. 2018 May 1;128(5):2010-2024. doi: 10.1172/JCI97454. Epub 2018 Apr 9.

3.

Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.

Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL.

Sci Immunol. 2017 Mar 3;2(9). pii: eaag3160. doi: 10.1126/sciimmunol.aag3160. Epub 2017 Mar 3.

4.

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.

PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J.

J Immunol. 2017 May 15;198(10):3775-3789. doi: 10.4049/jimmunol.1700373.

5.

Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys.

Dehnadi A, Benedict Cosimi A, Neal Smith R, Li X, Alonso JL, Means TK, Arnaout MA.

Nat Commun. 2017 Jan 10;8:13899. doi: 10.1038/ncomms13899.

6.

Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes.

Iram T, Ramirez-Ortiz Z, Byrne MH, Coleman UA, Kingery ND, Means TK, Frenkel D, El Khoury J.

J Neurosci. 2016 May 11;36(19):5185-92. doi: 10.1523/JNEUROSCI.3850-15.2016.

7.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Cao Z, Conway KL, Heath RJ, Rush JS, Leshchiner ES, Ramirez-Ortiz ZG, Nedelsky NB, Huang H, Ng A, Gardet A, Cheng SC, Shamji AF, Rioux JD, Wijmenga C, Netea MG, Means TK, Daly MJ, Xavier RJ.

Immunity. 2015 Oct 20;43(4):715-26. doi: 10.1016/j.immuni.2015.10.005.

8.

Depletion of CD11c⁺ cells in the CD11c.DTR model drives expansion of unique CD64⁺ Ly6C⁺ monocytes that are poised to release TNF-α.

Sivakumaran S, Henderson S, Ward S, Sousa PS, Manzo T, Zhang L, Conlan T, Means TK, D'Aveni M, Hermine O, Rubio MT, Chakraverty R, Bennett CL.

Eur J Immunol. 2016 Jan;46(1):192-203. doi: 10.1002/eji.201545789. Epub 2015 Nov 30.

9.

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.

Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK.

Nat Immunol. 2015 May;16(5):495-504. doi: 10.1038/ni.3143. Epub 2015 Apr 6.

10.

AGS, SLE, and RNASEH2 mutations: translating insights into therapeutic advances.

Pendergraft WF 3rd, Means TK.

J Clin Invest. 2015 Jan;125(1):102-4. doi: 10.1172/JCI78533. Epub 2014 Dec 15.

11.

Standardizing scavenger receptor nomenclature.

Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J.

J Immunol. 2014 Mar 1;192(5):1997-2006. doi: 10.4049/jimmunol.1490003. Review.

12.

The microglial sensome revealed by direct RNA sequencing.

Hickman SE, Kingery ND, Ohsumi TK, Borowsky ML, Wang LC, Means TK, El Khoury J.

Nat Neurosci. 2013 Dec;16(12):1896-905. doi: 10.1038/nn.3554. Epub 2013 Oct 27.

13.

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity.

Ramirez-Ortiz ZG, Pendergraft WF 3rd, Prasad A, Byrne MH, Iram T, Blanchette CJ, Luster AD, Hacohen N, El Khoury J, Means TK.

Nat Immunol. 2013 Sep;14(9):917-26. doi: 10.1038/ni.2670. Epub 2013 Jul 28.

14.

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression.

Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J.

Nat Commun. 2013;4:2030. doi: 10.1038/ncomms3030.

15.

The role of dendritic cells in the innate recognition of pathogenic fungi (A. fumigatus, C. neoformans and C. albicans).

Ramirez-Ortiz ZG, Means TK.

Virulence. 2012 Nov 15;3(7):635-46. doi: 10.4161/viru.22295. Epub 2012 Oct 17. Review.

16.

Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin.

Bennett CL, Fallah-Arani F, Conlan T, Trouillet C, Goold H, Chorro L, Flutter B, Means TK, Geissmann F, Chakraverty R.

Blood. 2011 Jun 30;117(26):7063-9. doi: 10.1182/blood-2011-01-329185. Epub 2011 May 12.

17.

Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans.

Lin Y, Zhang L, Cai AX, Lee M, Zhang W, Neuberg D, Canning CM, Soiffer RJ, Alyea EP, Ritz J, Hacohen N, Means TK, Wu CJ.

J Clin Invest. 2011 Apr;121(4):1574-84. doi: 10.1172/JCI44581. Epub 2011 Mar 14.

18.

Fungal pathogen recognition by scavenger receptors in nematodes and mammals.

Means TK.

Virulence. 2010 Jan-Feb;1(1):37-41. doi: 10.4161/viru.1.1.10228.

19.

Models to study ancient host-pathogen interactions: lessons from Crete.

Means TK, Aballay A.

EMBO Rep. 2011 Jan;12(1):5-7. doi: 10.1038/embor.2010.205. Epub 2010 Dec 17.

20.

Integrins limit the Toll.

Means TK, Luster AD.

Nat Immunol. 2010 Aug;11(8):691-3. doi: 10.1038/ni0810-691. No abstract available.

PMID:
20644576
21.

Synaptotagmin-mediated vesicle fusion regulates cell migration.

Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD.

Nat Immunol. 2010 Jun;11(6):495-502. doi: 10.1038/ni.1878. Epub 2010 May 16.

22.

Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.

Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J.

J Exp Med. 2009 Mar 16;206(3):637-53. doi: 10.1084/jem.20082109. Epub 2009 Feb 23.

23.

CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.

Menke J, Zeller GC, Kikawada E, Means TK, Huang XR, Lan HY, Lu B, Farber J, Luster AD, Kelley VR.

J Am Soc Nephrol. 2008 Jun;19(6):1177-89. doi: 10.1681/ASN.2007111179. Epub 2008 Mar 12.

24.

Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis.

Jones KL, Muellegger RR, Means TK, Lee M, Glickstein LJ, Damle N, Sikand VK, Luster AD, Steere AC.

Clin Infect Dis. 2008 Jan 1;46(1):85-92. doi: 10.1086/524022.

PMID:
18171218
25.

Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma.

Müllegger RR, Means TK, Shin JJ, Lee M, Jones KL, Glickstein LJ, Luster AD, Steere AC.

Infect Immun. 2007 Sep;75(9):4621-8. Epub 2007 Jul 2.

26.

Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine.

Shaffer J, Villard J, Means TK, Alexander S, Dombkowski D, Dey BR, McAfee S, Ballen KK, Saidman S, Preffer FI, Sachs DH, Spitzer TR, Sykes M.

Exp Hematol. 2007 Jul;35(7):1140-52.

27.

CCR4-dependent regulatory T cell function in inflammatory bowel disease.

Yuan Q, Bromley SK, Means TK, Jones KJ, Hayashi F, Bhan AK, Luster AD.

J Exp Med. 2007 Jun 11;204(6):1327-34. Epub 2007 Jun 4.

28.

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD.

Nat Med. 2007 Apr;13(4):432-8. Epub 2007 Mar 11.

PMID:
17351623
29.

Bacterial c-di-GMP is an immunostimulatory molecule.

Karaolis DK, Means TK, Yang D, Takahashi M, Yoshimura T, Muraille E, Philpott D, Schroeder JT, Hyodo M, Hayakawa Y, Talbot BG, Brouillette E, Malouin F.

J Immunol. 2007 Feb 15;178(4):2171-81.

30.

Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells.

Yuan Q, Campanella GS, Colvin RA, Hamilos DL, Jones KJ, Mathew A, Means TK, Luster AD.

Eur J Immunol. 2006 Oct;36(10):2700-14.

31.

CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function.

Medoff BD, Wain JC, Seung E, Jackobek R, Means TK, Ginns LC, Farber JM, Luster AD.

J Immunol. 2006 Jun 1;176(11):7087-95.

32.

CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus.

Robertson P, Means TK, Luster AD, Scadden DT.

Exp Hematol. 2006 Mar;34(3):308-19.

PMID:
16543065
33.

Role of CXC chemokine receptor 3 pathway in renal ischemic injury.

Fiorina P, Ansari MJ, Jurewicz M, Barry M, Ricchiuti V, Smith RN, Shea S, Means TK, Auchincloss H Jr, Luster AD, Sayegh MH, Abdi R.

J Am Soc Nephrol. 2006 Mar;17(3):716-23. Epub 2006 Feb 15.

34.

Toll-like receptor activation in the pathogenesis of systemic lupus erythematosus.

Means TK, Luster AD.

Ann N Y Acad Sci. 2005 Dec;1062:242-51. Review.

PMID:
16461805
35.

T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction.

Eom HS, Rubio MT, Means TK, Luster AD, Sykes M.

Exp Hematol. 2005 Dec;33(12):1564-73.

PMID:
16338500
36.
37.

The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.

Islam SA, Thomas SY, Hess C, Medoff BD, Means TK, Brander C, Lilly CM, Tager AM, Luster AD.

Blood. 2006 Jan 15;107(2):444-53. Epub 2005 Sep 22.

38.

Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1.

Medoff BD, Tager AM, Jackobek R, Means TK, Wang L, Luster AD.

Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L170-8. Epub 2005 Aug 26.

39.

BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation.

Medoff BD, Seung E, Wain JC, Means TK, Campanella GS, Islam SA, Thomas SY, Ginns LC, Grabie N, Lichtman AH, Tager AM, Luster AD.

J Exp Med. 2005 Jul 4;202(1):97-110.

40.

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.

Sipkins DA, Wei X, Wu JW, Runnels JM, Côté D, Means TK, Luster AD, Scadden DT, Lin CP.

Nature. 2005 Jun 16;435(7044):969-73.

41.

Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells.

Freeman L, Hewison M, Hughes SV, Evans KN, Hardie D, Means TK, Chakraverty R.

Blood. 2005 Sep 15;106(6):2042-9. Epub 2005 Jun 7.

42.

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

Means TK, Latz E, Hayashi F, Murali MR, Golenbock DT, Luster AD.

J Clin Invest. 2005 Feb;115(2):407-17.

43.

IL-8 responsiveness defines a subset of CD8 T cells poised to kill.

Hess C, Means TK, Autissier P, Woodberry T, Altfeld M, Addo MM, Frahm N, Brander C, Walker BD, Luster AD.

Blood. 2004 Dec 1;104(12):3463-71. Epub 2004 Aug 3.

44.

Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo.

Abdi R, Means TK, Ito T, Smith RN, Najafian N, Jurewicz M, Tchipachvili V, Charo I, Auchincloss H Jr, Sayegh MH, Luster AD.

J Immunol. 2004 Jan 15;172(2):767-75.

45.

CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells.

Thomas SY, Hou R, Boyson JE, Means TK, Hess C, Olson DP, Strominger JL, Brenner MB, Gumperz JE, Wilson SB, Luster AD.

J Immunol. 2003 Sep 1;171(5):2571-80.

46.

Toll-like receptors stimulate human neutrophil function.

Hayashi F, Means TK, Luster AD.

Blood. 2003 Oct 1;102(7):2660-9. Epub 2003 Jun 26.

47.

CD36 mediates the innate host response to beta-amyloid.

El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD.

J Exp Med. 2003 Jun 16;197(12):1657-66. Epub 2003 Jun 9.

48.

Chemokines in islet allograft rejection.

Abdi R, Means TK, Luster AD.

Diabetes Metab Res Rev. 2003 May-Jun;19(3):186-90. Review.

PMID:
12789651
49.

The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.

Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.

J Immunol. 2003 May 15;170(10):5165-75.

50.

Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages.

Jones BW, Heldwein KA, Means TK, Saukkonen JJ, Fenton MJ.

Ann Rheum Dis. 2001 Nov;60 Suppl 3:iii6-12.

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