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Items: 1 to 50 of 387

1.

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.

Racioppi L, Nelson ER, Huang W, Mukherjee D, Lawrence SA, Lento W, Masci AM, Jiao Y, Park S, York B, Liu Y, Baek AE, Drewry DH, Zuercher WJ, Bertani FR, Businaro L, Geradts J, Hall A, Means AR, Chao N, Chang CY, McDonnell DP.

Nat Commun. 2019 Jun 4;10(1):2450. doi: 10.1038/s41467-019-10424-5.

2.

Catalyzing NTD gender and equity research: A call for papers.

Means AR, Krentel A, Theobald S, Dean L, Mbabazi PS, Elphick-Pooley T, Fleming FM, Jacobson J, Simpson S, Ducker C.

PLoS Negl Trop Dis. 2018 Oct 18;12(10):e0006681. doi: 10.1371/journal.pntd.0006681. eCollection 2018 Oct. No abstract available.

3.

Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults.

Means AR, van Lieshout L, Brienen E, Yuhas K, Hughes JP, Ndungu P, Singa B, Walson JL.

PLoS Negl Trop Dis. 2018 Jan 18;12(1):e0005955. doi: 10.1371/journal.pntd.0005955. eCollection 2018 Jan.

4.

Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol.

Ásbjörnsdóttir KH, Ajjampur SSR, Anderson RM, Bailey R, Gardiner I, Halliday KE, Ibikounle M, Kalua K, Kang G, Littlewood DTJ, Luty AJF, Means AR, Oswald W, Pullan RL, Sarkar R, Schär F, Szpiro A, Truscott JE, Werkman M, Yard E, Walson JL; DeWorm3 Trials Team.

PLoS Negl Trop Dis. 2018 Jan 18;12(1):e0006166. doi: 10.1371/journal.pntd.0006166. eCollection 2018 Jan. Erratum in: PLoS Negl Trop Dis. 2018 Jan 31;12 (1):e0006253.

5.

Evaluating the sustainability, scalability, and replicability of an STH transmission interruption intervention: The DeWorm3 implementation science protocol.

Means AR, Ajjampur SSR, Bailey R, Galactionova K, Gwayi-Chore MC, Halliday K, Ibikounle M, Juvekar S, Kalua K, Kang G, Lele P, Luty AJF, Pullan R, Sarkar R, Schär F, Tediosi F, Weiner BJ, Yard E, Walson J; DeWorm3 Implementation Science Team.

PLoS Negl Trop Dis. 2018 Jan 18;12(1):e0005988. doi: 10.1371/journal.pntd.0005988. eCollection 2018 Jan. Erratum in: PLoS Negl Trop Dis. 2018 Jan 31;12 (1):e0006252.

6.

Testing for soil-transmitted helminth transmission elimination: Analysing the impact of the sensitivity of different diagnostic tools.

Werkman M, Wright JE, Truscott JE, Easton AV, Oliveira RG, Toor J, Ower A, Ásbjörnsdóttir KH, Means AR, Farrell SH, Walson JL, Anderson RM.

PLoS Negl Trop Dis. 2018 Jan 18;12(1):e0006114. doi: 10.1371/journal.pntd.0006114. eCollection 2018 Jan.

7.

Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.

York B, Li F, Lin F, Marcelo KL, Mao J, Dean A, Gonzales N, Gooden D, Maity S, Coarfa C, Putluri N, Means AR.

Sci Rep. 2017 Sep 18;7(1):11793. doi: 10.1038/s41598-017-12139-3.

8.

Prospects for elimination of soil-transmitted helminths.

Ásbjörnsdóttir KH, Means AR, Werkman M, Walson JL.

Curr Opin Infect Dis. 2017 Oct;30(5):482-488. doi: 10.1097/QCO.0000000000000395. Review.

9.

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation.

O'Brien MT, Oakhill JS, Ling NX, Langendorf CG, Hoque A, Dite TA, Means AR, Kemp BE, Scott JW.

Sci Rep. 2017 Feb 23;7:43264. doi: 10.1038/srep43264.

10.

Correction: Impact of Age and Sex on CD4+ Cell Count Trajectories following Treatment Initiation: An Analysis of the Tanzanian HIV Treatment Database.

Means AR, Risher KA, Ujeneza EL, Maposa I, Nondi J, Bellan SE.

PLoS One. 2017 Jan 6;12(1):e0170155. doi: 10.1371/journal.pone.0170155. eCollection 2017.

11.

The role of implementation science training in global health: from the perspective of graduates of the field's first dedicated doctoral program.

Means AR, Phillips DE, Lurton G, Njoroge A, Furere SM, Liu R, Hassan WM, Dai X, Augusto O, Cherutich P, Ikilezi G, Soi C, Xu D, Kemp CG.

Glob Health Action. 2016 Nov 14;9:31899. doi: 10.3402/gha.v9.31899. eCollection 2016.

12.

Integrated Healthcare Delivery: A Qualitative Research Approach to Identifying and Harmonizing Perspectives of Integrated Neglected Tropical Disease Programs.

Means AR, Jacobson J, Mosher AW, Walson JL.

PLoS Negl Trop Dis. 2016 Oct 24;10(10):e0005085. doi: 10.1371/journal.pntd.0005085. eCollection 2016 Oct.

13.

Impact of Age and Sex on CD4+ Cell Count Trajectories following Treatment Initiation: An Analysis of the Tanzanian HIV Treatment Database.

Means AR, Risher KA, Ujeneza EL, Maposa I, Nondi J, Bellan SE.

PLoS One. 2016 Oct 7;11(10):e0164148. doi: 10.1371/journal.pone.0164148. eCollection 2016. Erratum in: PLoS One. 2017 Jan 6;12 (1):e0170155.

14.
15.

The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft.

Marcelo KL, Means AR, York B.

Trends Endocrinol Metab. 2016 Oct;27(10):706-718. doi: 10.1016/j.tem.2016.06.001. Epub 2016 Jul 20. Review.

16.

Sustaining Progress towards NTD Elimination: An Opportunity to Leverage Lymphatic Filariasis Elimination Programs to Interrupt Transmission of Soil-Transmitted Helminths.

Means AR, Ásbjörnsdóttir K, Mwandawiro C, Rollinson D, Jacobson J, Littlewood T, Walson JL.

PLoS Negl Trop Dis. 2016 Jul 14;10(7):e0004737. doi: 10.1371/journal.pntd.0004737. eCollection 2016 Jul. No abstract available.

17.

Integrating Neglected Tropical Disease and Immunization Programs: The Experiences of the Tanzanian Ministry of Health.

Mwingira UJ, Means AR, Chikawe M, Kilembe B, Lyimo D, Crowley K, Rusibamayila N, Nshala A, Mphuru A.

Am J Trop Med Hyg. 2016 Sep 7;95(3):505-507. doi: 10.4269/ajtmh.15-0724. Epub 2016 May 31.

18.

Antihelminthics in helminth-endemic areas: effects on HIV disease progression.

Means AR, Burns P, Sinclair D, Walson JL.

Cochrane Database Syst Rev. 2016 Apr 14;4:CD006419. doi: 10.1002/14651858.CD006419.pub4. Review.

19.

Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism.

Marcelo KL, Ribar T, Means CR, Tsimelzon A, Stevens RD, Ilkayeva O, Bain JR, Hilsenbeck SG, Newgard CB, Means AR, York B.

Mol Endocrinol. 2016 May;30(5):557-72. doi: 10.1210/me.2016-1021. Epub 2016 Mar 22.

20.

Deciphering hepatocellular responses to metabolic and oncogenic stress.

Marcelo KL, Lin F, Rajapakshe K, Dean A, Gonzales N, Coarfa C, Means AR, Goldie LC, York B.

J Biol Methods. 2015;2(3). pii: e28. Epub 2015 Oct 8.

21.

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.

Scott JW, Park E, Rodriguiz RM, Oakhill JS, Issa SM, O'Brien MT, Dite TA, Langendorf CG, Wetsel WC, Means AR, Kemp BE.

Sci Rep. 2015 Sep 23;5:14436. doi: 10.1038/srep14436.

22.

The camKK2/camKIV relay is an essential regulator of hepatic cancer.

Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York B.

Hepatology. 2015 Aug;62(2):505-20. doi: 10.1002/hep.27832. Epub 2015 May 9.

23.

Prioritizing countries for interventions to reduce child mortality: tools for maximizing the impact of mass drug administration of azithromycin.

Matheson AI, Manhart LE, Pavlinac PB, Means AR, Akullian A, Levine GA, Jacobson J, Shutes E, Walson JL.

PLoS One. 2014 May 16;9(5):e96658. doi: 10.1371/journal.pone.0096658. eCollection 2014.

24.

Correlates of inappropriate prescribing of antibiotics to patients with malaria in Uganda.

Means AR, Weaver MR, Burnett SM, Mbonye MK, Naikoba S, McClelland RS.

PLoS One. 2014 Feb 28;9(2):e90179. doi: 10.1371/journal.pone.0090179. eCollection 2014.

25.

Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.

Racioppi L, Means AR.

J Biol Chem. 2012 Sep 14;287(38):31658-65. doi: 10.1074/jbc.R112.356485. Epub 2012 Jul 9. Review.

26.

Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.

Racioppi L, Noeldner PK, Lin F, Arvai S, Means AR.

J Biol Chem. 2012 Mar 30;287(14):11579-91. doi: 10.1074/jbc.M111.336032. Epub 2012 Feb 14.

27.

Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.

Anderson KA, Lin F, Ribar TJ, Stevens RD, Muehlbauer MJ, Newgard CB, Means AR.

Mol Endocrinol. 2012 Feb;26(2):281-91. doi: 10.1210/me.2011-1299. Epub 2012 Jan 12.

28.

The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice.

Barberi TJ, Dunkle A, He YW, Racioppi L, Means AR.

PLoS One. 2012;7(1):e29808. doi: 10.1371/journal.pone.0029808. Epub 2012 Jan 4.

29.

The Ca2+/calmodulin-dependent protein kinase kinase, CaMKK2, inhibits preadipocyte differentiation.

Lin F, Ribar TJ, Means AR.

Endocrinology. 2011 Oct;152(10):3668-79. doi: 10.1210/en.2011-1107. Epub 2011 Aug 23.

30.

A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation.

Teng EC, Racioppi L, Means AR.

J Leukoc Biol. 2011 Nov;90(5):897-909. doi: 10.1189/jlb.0311152. Epub 2011 Aug 4.

31.

Characterization of the CaMKKβ-AMPK signaling complex.

Green MF, Anderson KA, Means AR.

Cell Signal. 2011 Dec;23(12):2005-12. doi: 10.1016/j.cellsig.2011.07.014. Epub 2011 Jul 23.

32.

Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma.

Teng BL, Hacker KE, Chen S, Means AR, Rathmell WK.

Mol Oncol. 2011 Oct;5(5):465-74. doi: 10.1016/j.molonc.2011.06.002. Epub 2011 Jun 28.

33.

Systems biology of vaccination for seasonal influenza in humans.

Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li GM, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R, Pulendran B.

Nat Immunol. 2011 Jul 10;12(8):786-95. doi: 10.1038/ni.2067.

34.

A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.

Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, Capaci V, Jordan L, Quinlan P, Thompson A, Mano M, Rosato A, Crook T, Scanziani E, Means AR, Lozano G, Schneider C, Del Sal G.

Cancer Cell. 2011 Jul 12;20(1):79-91. doi: 10.1016/j.ccr.2011.06.004.

35.

Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation.

Green MF, Scott JW, Steel R, Oakhill JS, Kemp BE, Means AR.

J Biol Chem. 2011 Aug 12;286(32):28066-79. doi: 10.1074/jbc.M111.251504. Epub 2011 Jun 13.

36.

Gfer is a critical regulator of HSC proliferation.

Sankar U, Means AR.

Cell Cycle. 2011 Jul 15;10(14):2263-8. Epub 2011 Jul 15.

37.

Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells.

Teng EC, Todd LR, Ribar TJ, Lento W, Dimascio L, Means AR, Sankar U.

Mol Biol Cell. 2011 Apr 15;22(8):1312-20. doi: 10.1091/mbc.E10-08-0723. Epub 2011 Feb 23.

38.

CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.

Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP.

Cancer Res. 2011 Jan 15;71(2):528-37. doi: 10.1158/0008-5472.CAN-10-2581. Epub 2010 Nov 22.

39.

CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.

Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, Karsenty G.

Genes Dev. 2010 Oct 15;24(20):2330-42. doi: 10.1101/gad.1977210.

40.

Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase.

Cipolletta E, Monaco S, Maione AS, Vitiello L, Campiglia P, Pastore L, Franchini C, Novellino E, Limongelli V, Bayer KU, Means AR, Rossi G, Trimarco B, Iaccarino G, Illario M.

Endocrinology. 2010 Jun;151(6):2747-59. doi: 10.1210/en.2009-1248. Epub 2010 Apr 14.

41.

Identification and inhibitory properties of a novel Ca(2+)/calmodulin antagonist.

Colomer J, Schmitt AA, Toone EJ, Means AR.

Biochemistry. 2010 May 18;49(19):4244-54. doi: 10.1021/bi1001213.

42.

Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells.

Todd LR, Damin MN, Gomathinayagam R, Horn SR, Means AR, Sankar U.

Mol Biol Cell. 2010 Apr 1;21(7):1225-36. doi: 10.1091/mbc.E09-11-0937. Epub 2010 Feb 10.

43.

BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.

Kokubo M, Nishio M, Ribar TJ, Anderson KA, West AE, Means AR.

J Neurosci. 2009 Jul 15;29(28):8901-13. doi: 10.1523/JNEUROSCI.0040-09.2009.

44.

Central control of feeding.

Anderson KA, Means AR.

F1000 Biol Rep. 2009 Jan 21;1:10. doi: 10.3410/B1-10.

45.

Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.

Racioppi L, Means AR.

Trends Immunol. 2008 Dec;29(12):600-7. doi: 10.1016/j.it.2008.08.005. Epub 2008 Oct 17. Review.

PMID:
18930438
46.

MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.

Swenson-Fields KI, Sandquist JC, Rossol-Allison J, Blat IC, Wennerberg K, Burridge K, Means AR.

Mol Cell. 2008 Oct 10;32(1):43-56. doi: 10.1016/j.molcel.2008.09.007.

47.

The Year in Basic Science: calmodulin kinase cascades.

Means AR.

Mol Endocrinol. 2008 Dec;22(12):2759-65. doi: 10.1210/me.2008-0312. Epub 2008 Oct 9. Review.

48.

The C-terminal tail region of nonmuscle myosin II directs isoform-specific distribution in migrating cells.

Sandquist JC, Means AR.

Mol Biol Cell. 2008 Dec;19(12):5156-67. doi: 10.1091/mbc.E08-05-0533. Epub 2008 Oct 8.

49.

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT.

Stanya KJ, Liu Y, Means AR, Kao HY.

J Cell Biol. 2008 Oct 6;183(1):49-61. doi: 10.1083/jcb.200806172.

50.

Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages.

Zhang X, Wheeler D, Tang Y, Guo L, Shapiro RA, Ribar TJ, Means AR, Billiar TR, Angus DC, Rosengart MR.

J Immunol. 2008 Oct 1;181(7):5015-23.

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