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Items: 1 to 50 of 89

1.

Development of prednisone resistance in naïve canine lymphoma: Longitudinal evaluation of NR3C1α, ABCB1, and 11β-HSD mRNA expression.

Hanot CC, Mealey KL, Fidel JL, Burke NS, White LA, Sellon RK.

J Vet Pharmacol Ther. 2020 Mar;43(2):231-236. doi: 10.1111/jvp.12837. Epub 2020 Jan 14.

PMID:
31943234
2.

Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding.

Costa AP, Court MH, Burke NS, Zhu Z, Mealey KL, Villarino NF.

Drug Metab Dispos. 2019 Oct;47(10):1024-1031. doi: 10.1124/dmd.119.087304. Epub 2019 Sep 3.

3.

Personalized medicine: going to the dogs?

Mealey KL, Martinez SE, Villarino NF, Court MH.

Hum Genet. 2019 May;138(5):467-481. doi: 10.1007/s00439-019-02020-w. Epub 2019 Apr 28. Review.

PMID:
31032534
4.

Evaluation of Transdermal Administration of Phenobarbital in Healthy Cats.

Krull DP, Thomovsky SA, Chen AV, Mealey KL, Papich MG.

J Am Anim Hosp Assoc. 2019 Jan/Feb;55(1):1-7. doi: 10.5326/JAAHA-MS-6670. Epub 2018 Nov 14.

PMID:
30427717
5.

Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs.

Perez Jimenez TE, Kukanich B, Joo H, Mealey KL, Grubb TL, Greene SA, Court MH.

Drug Metab Dispos. 2019 Jan;47(1):15-25. doi: 10.1124/dmd.118.083444. Epub 2018 Oct 26.

6.

Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.

Perez Jimenez TE, Mealey KL, Schnider D, Grubb TL, Greene SA, Court MH.

J Vet Pharmacol Ther. 2018 Dec;41(6):815-824. doi: 10.1111/jvp.12706. Epub 2018 Aug 16.

7.

Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.

Martinez MN, Court MH, Fink-Gremmels J, Mealey KL.

J Vet Pharmacol Ther. 2018 Aug;41(4):E57-E67. doi: 10.1111/jvp.12670. Epub 2018 Jun 19. Review.

PMID:
29917248
8.

Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.

Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA.

Vet Anaesth Analg. 2017 Mar;44(2):370-374. doi: 10.1016/j.vaa.2016.05.003. Epub 2017 Jan 11.

9.

Establishment of a cell line for assessing drugs as canine P-glycoprotein substrates: proof of principle.

Mealey KL, Dassanayake S, Burke NS.

J Vet Pharmacol Ther. 2017 Oct;40(5):545-551. doi: 10.1111/jvp.12390. Epub 2017 Jan 17.

PMID:
28093773
10.

Adverse reaction to apomorphine in a Collie homozygous for the ABCB1-1∆ (MDR1) mutation.

Campbell O, de Lorimier LP, Mealey KL.

J Small Anim Pract. 2017 Feb;58(2):119. doi: 10.1111/jsap.12618. Epub 2017 Jan 9. No abstract available.

PMID:
28066884
11.

Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs).

Perez Jimenez TE, Mealey KL, Grubb TL, Greene SA, Court MH.

Drug Metab Dispos. 2016 Dec;44(12):1963-1972. doi: 10.1124/dmd.116.071902. Epub 2016 Oct 6. Erratum in: Drug Metab Dispos. 2017 Jul;45(7):706.

12.

The Effect of the Canine ABCB1-1Δ Mutation on Sedation after Intravenous Administration of Acepromazine.

Deshpande D, Hill KE, Mealey KL, Chambers JP, Gieseg MA.

J Vet Intern Med. 2016 Mar-Apr;30(2):636-41. doi: 10.1111/jvim.13827. Epub 2016 Jan 29.

13.

Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2.

Lewis RS, Fidel J, Dassanayake S, Court MH, Burke NS, Mealey KL.

Vet Comp Oncol. 2017 Jun;15(2):411-420. doi: 10.1111/vco.12177. Epub 2015 Oct 14.

PMID:
26464002
14.

Impact of the canine double-deletion β1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a β1-selective β-blocker.

Meurs KM, Stern JA, Reina-Doreste Y, Maran BA, Chdid L, Lahmers S, Keene BW, Mealey KL.

Pharmacogenet Genomics. 2015 Sep;25(9):427-31. doi: 10.1097/FPC.0000000000000152.

PMID:
26065525
15.

Polymorphisms in the canine glucocorticoid receptor alpha gene (NR3C1α).

Costa A, Sellon RK, Court M, Burke NS, Mealey KL.

J Vet Pharmacol Ther. 2016 Feb;39(1):16-21. doi: 10.1111/jvp.12241. Epub 2015 May 18.

PMID:
25989385
16.

Determination of optimal storage temperature and duration for analysis of total and isoenzyme lactate dehydrogenase activities in canine serum and cerebrospinal fluid.

Houle JC, Chen AV, Brenna AC, Mealey KL, Kiszonas AM.

Vet Clin Pathol. 2015 Jun;44(2):253-61. doi: 10.1111/vcp.12263. Epub 2015 May 11.

PMID:
25964061
17.

Identification of a nonsense mutation in feline ABCB1.

Mealey KL, Burke NS.

J Vet Pharmacol Ther. 2015 Oct;38(5):429-33. doi: 10.1111/jvp.12212. Epub 2015 Feb 9.

PMID:
25660379
18.

P-glycoprotein mediated drug interactions in animals and humans with cancer.

Mealey KL, Fidel J.

J Vet Intern Med. 2015 Jan;29(1):1-6. doi: 10.1111/jvim.12525. Review.

19.

Tyrosine kinase inhibitors enhance ciprofloxacin-induced phototoxicity by inhibiting ABCG2.

Mealey KL, Dassanayake S, Burke NS.

Oncology. 2014;87(6):364-70. doi: 10.1159/000366132. Epub 2014 Sep 6.

PMID:
25227759
20.

Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs.

Cullen JM, Willson CJ, Minch JD, Kimbrough CL, Mealey KL.

J Vet Diagn Invest. 2014 May;26(3):434-436. Epub 2014 Apr 23.

PMID:
24760133
21.

Clinical pharmacology and therapeutics.

Mealey KL.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):xi-xiii. doi: 10.1016/j.cvsm.2013.05.004. Epub 2013 May 31. No abstract available.

PMID:
23890246
22.

Adverse drug reactions in veterinary patients associated with drug transporters.

Mealey KL.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1067-78. doi: 10.1016/j.cvsm.2013.04.004. Epub 2013 Jun 2.

PMID:
23890239
23.

Identification of DNA variants in the canine beta-1 adrenergic receptor gene.

Maran BA, Mealey KL, Lahmers SM, Nelson OL, Meurs KM.

Res Vet Sci. 2013 Aug;95(1):238-40. doi: 10.1016/j.rvsc.2013.02.021. Epub 2013 Apr 6.

PMID:
23566791
24.

Evaluation of vincristine-associated myelosuppression in Border Collies.

Lind DL, Fidel JL, Gay JM, Mealey KL.

Am J Vet Res. 2013 Feb;74(2):257-61. doi: 10.2460/ajvr.74.2.257.

PMID:
23363351
25.

Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.

Muñana KR, Nettifee-Osborne JA, Bergman RL Jr, Mealey KL.

J Vet Intern Med. 2012 Nov-Dec;26(6):1358-64. doi: 10.1111/j.1939-1676.2012.01006.x. Epub 2012 Sep 24.

26.

Frequency of the mutant MDR1 allele in dogs in the UK.

Tappin SW, Goodfellow MR, Peters IR, Day MJ, Hall EJ, Mealey KL.

Vet Rec. 2012 Jul 21;171(3):72. doi: 10.1136/vr.100633. Epub 2012 Jun 26. No abstract available.

PMID:
22735986
27.

Evaluation of the biliary and brain distribution of technetium Tc 99m sestamibi in healthy dogs with the ABCB1 wildtype genotype before and after treatment with spinosad.

MacKay CS, Mattoon JS, Roberts GD, Tucker RL, Morimoto TR, Mealey KL.

Am J Vet Res. 2012 Jun;73(6):814-20. doi: 10.2460/ajvr.73.6.814.

PMID:
22620695
28.

Intravenous fat emulsion as treatment for ivermectin toxicosis in three dogs homozygous for the ABCB1-1Δ gene mutation.

Wright HM, Chen AV, Talcott PA, Poppenga RH, Mealey KL.

J Vet Emerg Crit Care (San Antonio). 2011 Dec;21(6):666-72. doi: 10.1111/j.1476-4431.2011.00687.x.

PMID:
22316260
29.

Vincristine-induced central neurotoxicity in a collie homozygous for the ABCB1Δ mutation.

Krugman L, Bryan JN, Mealey KL, Chen A.

J Small Anim Pract. 2012 Mar;53(3):185-7. doi: 10.1111/j.1748-5827.2011.01155.x. Epub 2011 Nov 28.

PMID:
22122243
30.

Normal dogs treated with famotidine for 14 days have only transient increases in serum gastrin concentrations.

Mordecai A, Sellon RK, Mealey KL.

J Vet Intern Med. 2011 Nov-Dec;25(6):1248-52. doi: 10.1111/j.1939-1676.2011.00826.x. Epub 2011 Nov 1.

31.

ABCG2 transporter: therapeutic and physiologic implications in veterinary species.

Mealey KL.

J Vet Pharmacol Ther. 2012 Apr;35(2):105-12. doi: 10.1111/j.1365-2885.2011.01313.x. Epub 2011 Jun 6. Review.

PMID:
21645015
32.

Molecular genetic basis for fluoroquinolone-induced retinal degeneration in cats.

Ramirez CJ, Minch JD, Gay JM, Lahmers SM, Guerra DJ, Haldorson GJ, Schneider T, Mealey KL.

Pharmacogenet Genomics. 2011 Feb;21(2):66-75. doi: 10.1097/FPC.0b013e3283425f44.

PMID:
21150813
33.

Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.

Mealey KL, Waiting D, Raunig DL, Schmidt KR, Nelson FR.

J Vet Pharmacol Ther. 2010 Oct;33(5):453-60. doi: 10.1111/j.1365-2885.2010.01170.x.

PMID:
20840389
34.

An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs.

Mealey KL, Minch JD, White SN, Snekvik KR, Mattoon JS.

Comp Hepatol. 2010 Jul 3;9:6. doi: 10.1186/1476-5926-9-6.

35.

Canine ABCB4: Tissue expression and cDNA structure.

Spencer ES, Minch J, Lahmers KK, Haldorson GJ, Mealey KL.

Res Vet Sci. 2010 Aug;89(1):65-71. doi: 10.1016/j.rvsc.2010.01.012. Epub 2010 Feb 12.

PMID:
20153493
36.

Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1Delta mutation) and extrinsic (ketoconazole treated) P-glycoprotein deficiency.

Coelho JC, Tucker R, Mattoon J, Roberts G, Waiting DK, Mealey KL.

J Vet Pharmacol Ther. 2009 Oct;32(5):417-21. doi: 10.1111/j.1365-2885.2009.01068.x.

PMID:
19754906
37.

ABCB1-1 Delta (MDR1-1 Delta) genotype is associated with adverse reactions in dogs treated with milbemycin oxime for generalized demodicosis.

Barbet JL, Snook T, Gay JM, Mealey KL.

Vet Dermatol. 2009 Apr;20(2):111-4. doi: 10.1111/j.1365-3164.2008.00725.x. Epub 2008 Dec 18.

PMID:
19171022
38.

Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics.

Mealey KL.

Vet Parasitol. 2008 Dec 10;158(3):215-22. doi: 10.1016/j.vetpar.2008.09.009. Epub 2008 Sep 7. Review.

PMID:
18922637
39.

Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.

Mealey KL, Jabbes M, Spencer E, Akey JM.

Xenobiotica. 2008 Oct;38(10):1305-12. doi: 10.1080/00498250802446146 .

PMID:
18841518
40.

Breed distribution of the ABCB1-1Delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping.

Mealey KL, Meurs KM.

J Am Vet Med Assoc. 2008 Sep 15;233(6):921-4. doi: 10.2460/javma.233.6.921.

PMID:
18795852
41.

Evaluation of the flanking nucleotide sequences of sarcomeric hypertrophic cardiomyopathy substitution mutations.

Meurs KM, Mealey KL.

Mutat Res. 2008 Jul 3;642(1-2):86-9. doi: 10.1016/j.mrfmmm.2008.04.005. Epub 2008 Apr 24.

PMID:
18539302
42.

ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine.

Mealey KL, Fidel J, Gay JM, Impellizeri JA, Clifford CA, Bergman PJ.

J Vet Intern Med. 2008 Jul-Aug;22(4):996-1000. doi: 10.1111/j.1939-1676.2008.0122.x.

43.

P-glycoprotein contributes to the blood-brain, but not blood-cerebrospinal fluid, barrier in a spontaneous canine p-glycoprotein knockout model.

Mealey KL, Greene S, Bagley R, Gay J, Tucker R, Gavin P, Schmidt K, Nelson F.

Drug Metab Dispos. 2008 Jun;36(6):1073-9. doi: 10.1124/dmd.107.018978. Epub 2008 Mar 10.

PMID:
18332085
44.

Assessment of antiepileptic drugs as substrates for canine P-glycoprotein.

West CL, Mealey KL.

Am J Vet Res. 2007 Oct;68(10):1106-10.

PMID:
17916018
45.

Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogs.

Martin LG, Behrend EN, Mealey KL, Carpenter DM, Hickey KC.

Am J Vet Res. 2007 May;68(5):555-60.

PMID:
17472457
46.

Pharmacogenetics.

Mealey KL.

Vet Clin North Am Small Anim Pract. 2006 Sep;36(5):961-73, v. Review.

PMID:
16984822
47.

Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys.

Sinclair MD, Mealey KL, Matthews NS, Peck KE, Taylor TS, Bennett BS.

Am J Vet Res. 2006 Jun;67(6):1082-5.

PMID:
16740106
48.

Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation.

Henik RA, Kellum HB, Bentjen SA, Mealey KL.

J Vet Intern Med. 2006 Mar-Apr;20(2):415-7. No abstract available.

49.

The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs.

Kukanich B, Lascelles BD, Aman AM, Mealey KL, Papich MG.

J Vet Pharmacol Ther. 2005 Oct;28(5):461-6.

PMID:
16207309
50.

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