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Items: 1 to 50 of 54

1.

TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1.

Talebian A, Robinson-Brookes K, Meakin SO.

J Mol Neurosci. 2019 Jan;67(1):97-110. doi: 10.1007/s12031-018-1214-z. Epub 2018 Dec 13.

PMID:
30547417
2.

Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors.

Wills MK, Keyvani Chahi A, Lau HR, Tilak M, Guild BD, New LA, Lu P, Jacquet K, Meakin SO, Bisson N, Jones N.

J Biol Chem. 2017 Apr 7;292(14):5748-5759. doi: 10.1074/jbc.M116.770511. Epub 2017 Feb 17.

3.

Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells.

Li C, MacDonald JI, Talebian A, Leuenberger J, Seah C, Pasternak SH, Michnick SW, Meakin SO.

Mol Cell Biol. 2016 Sep 26;36(20):2596-611. doi: 10.1128/MCB.00255-16. Print 2016 Oct 15.

4.

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes.

Tang W, Tam JH, Seah C, Chiu J, Tyrer A, Cregan SP, Meakin SO, Pasternak SH.

Mol Brain. 2015 Jul 14;8:41. doi: 10.1186/s13041-015-0129-7.

5.

Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine.

McVicar N, Li AX, Meakin SO, Bartha R.

NMR Biomed. 2015 May;28(5):566-75. doi: 10.1002/nbm.3287. Epub 2015 Mar 23.

PMID:
25808190
6.

The signaling adapter, FRS2, facilitates neuronal branching in primary cortical neurons via both Grb2- and Shp2-dependent mechanisms.

Zhou L, Talebian A, Meakin SO.

J Mol Neurosci. 2015 Mar;55(3):663-77. doi: 10.1007/s12031-014-0406-4. Epub 2014 Aug 27.

PMID:
25159185
7.

Quantitative tissue pH measurement during cerebral ischemia using amine and amide concentration-independent detection (AACID) with MRI.

McVicar N, Li AX, Gonçalves DF, Bellyou M, Meakin SO, Prado MA, Bartha R.

J Cereb Blood Flow Metab. 2014 Apr;34(4):690-8. doi: 10.1038/jcbfm.2014.12. Epub 2014 Feb 5.

8.

Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells.

Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR.

J Biol Chem. 2013 Aug 16;288(33):23807-13. doi: 10.1074/jbc.M112.436279. Epub 2013 Jun 7.

9.

Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.

Talebian A, Robinson-Brookes K, MacDonald JI, Meakin SO.

J Mol Neurosci. 2013 Jan;49(1):38-51. doi: 10.1007/s12031-012-9847-9. Epub 2012 Jun 29.

PMID:
22744634
10.

Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.

MacDonald JI, Dietrich A, Gamble S, Hryciw T, Grant RI, Meakin SO.

J Neurochem. 2012 Jun;121(6):861-80. doi: 10.1111/j.1471-4159.2012.07729.x. Epub 2012 Apr 2.

11.

The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.

Hryciw T, MacDonald JI, Phillips R, Seah C, Pasternak S, Meakin SO.

J Neurochem. 2010 Feb;112(4):924-39. doi: 10.1111/j.1471-4159.2009.06503.x. Epub 2009 Nov 24.

12.

Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells.

Li C, Macdonald JI, Hryciw T, Meakin SO.

J Neurochem. 2010 Feb;112(4):882-99. doi: 10.1111/j.1471-4159.2009.06507.x. Epub 2009 Nov 24.

13.

Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cells.

Woronowicz A, Amith SR, Davis VW, Jayanth P, De Vusser K, Laroy W, Contreras R, Meakin SO, Szewczuk MR.

Glycobiology. 2007 Jul;17(7):725-34. Epub 2007 Mar 27.

PMID:
17389653
14.

Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3.

Dixon SJ, MacDonald JI, Robinson KN, Kubu CJ, Meakin SO.

Biochim Biophys Acta. 2006 Apr;1763(4):366-80. Epub 2006 Mar 21.

15.

Nerve growth factor increases connexin43 phosphorylation and gap junctional intercellular communication.

Cushing P, Bhalla R, Johnson AM, Rushlow WJ, Meakin SO, Belliveau DJ.

J Neurosci Res. 2005 Dec 15;82(6):788-801.

PMID:
16302187
16.

Human tumorous imaginal disc 1 (TID1) associates with Trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-TrkA cells.

Liu HY, MacDonald JI, Hryciw T, Li C, Meakin SO.

J Biol Chem. 2005 May 20;280(20):19461-71. Epub 2005 Mar 7.

17.

Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.

Robinson KN, Manto K, Buchsbaum RJ, MacDonald JI, Meakin SO.

J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.

19.

Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation.

Woronowicz A, De Vusser K, Laroy W, Contreras R, Meakin SO, Ross GM, Szewczuk MR.

Glycobiology. 2004 Nov;14(11):987-98. Epub 2004 Jul 7.

PMID:
15240558
20.
22.

Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection.

Melchior B, Nerrière-Daguin V, Laplaud DA, Rémy S, Wiertlewski S, Neveu I, Naveilhan P, Meakin SO, Brachet P.

Exp Neurol. 2003 Oct;183(2):367-78.

PMID:
14552878
23.

Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes.

Zhou L, McDougall K, Kubu CJ, Verdi JM, Meakin SO.

Mol Biol Rep. 2003 Mar;30(1):15-25.

PMID:
12688531
24.

The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.

Ranzi V, Meakin SO, Miranda C, Mondellini P, Pierotti MA, Greco A.

Endocrinology. 2003 Mar;144(3):922-8.

PMID:
12586769
25.
26.

Central mechanisms for autonomic dysreflexia after spinal cord injury.

Weaver LC, Marsh DR, Gris D, Meakin SO, Dekaban GA.

Prog Brain Res. 2002;137:83-95. Review. No abstract available.

PMID:
12440361
28.

ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.

Liu HY, Meakin SO.

J Biol Chem. 2002 Jul 19;277(29):26046-56. Epub 2002 May 2.

29.
30.

p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains.

Zaccaro MC, Ivanisevic L, Perez P, Meakin SO, Saragovi HU.

J Biol Chem. 2001 Aug 17;276(33):31023-9. Epub 2001 Jun 25.

31.

Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis.

McDougall K, Kubu C, Verdi JM, Meakin SO.

Mech Dev. 2001 May;103(1-2):145-8.

32.

A differential role of extracellular signal-regulated kinase in stimulated PC12 pheochromocytoma cell movement.

Ho W, Uniyal S, Meakin SO, Morris VL, Chan BM.

Exp Cell Res. 2001 Feb 15;263(2):254-64.

PMID:
11161724
33.
35.
37.

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.

Verdi JM, Bashirullah A, Goldhawk DE, Kubu CJ, Jamali M, Meakin SO, Lipshitz HD.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10472-6.

38.

Neutralizing intraspinal nerve growth factor blocks autonomic dysreflexia caused by spinal cord injury.

Krenz NR, Meakin SO, Krassioukov AV, Weaver LC.

J Neurosci. 1999 Sep 1;19(17):7405-14.

39.
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43.

Tissue-specific alternative splicing generates two isoforms of the trkA receptor.

Barker PA, Lomen-Hoerth C, Gensch EM, Meakin SO, Glass DJ, Shooter EM.

J Biol Chem. 1993 Jul 15;268(20):15150-7.

44.

The nerve growth factor family of receptors.

Meakin SO, Shooter EM.

Trends Neurosci. 1992 Sep;15(9):323-31. Review.

PMID:
1382329
45.

The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.

Meakin SO, Suter U, Drinkwater CC, Welcher AA, Shooter EM.

Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2374-8.

46.

Isolation of transcriptionally regulated sequences associated with neuronal and non-neuronal cell interactions.

Welcher AA, De Leon M, Suter U, Snipes GJ, Meakin SO, Shooter EM.

Prog Brain Res. 1992;94:163-76. Review. No abstract available.

PMID:
1287719
47.

Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.

Meakin SO, Shooter EM.

Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5862-6.

48.

Molecular investigations on the high-affinity nerve growth factor receptor.

Meakin SO, Shooter EM.

Neuron. 1991 Jan;6(1):153-63.

PMID:
1702649
49.
50.

Relationship between proteins encoded by three human gamma-crystallin genes and distinct polypeptides in the eye lens.

Russell P, Meakin SO, Hohman TC, Tsui LC, Breitman ML.

Mol Cell Biol. 1987 Sep;7(9):3320-3.

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