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Items: 1 to 50 of 133

1.

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Review.

PMID:
29712883
2.

The beta secretase BACE1 regulates the expression of insulin receptor in the liver.

Meakin PJ, Mezzapesa A, Benabou E, Haas ME, Bonardo B, Grino M, Brunel JM, Desbois-Mouthon C, Biddinger SB, Govers R, Ashford MLJ, Peiretti F.

Nat Commun. 2018 Apr 3;9(1):1306. doi: 10.1038/s41467-018-03755-2.

3.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

PMID:
29590092
4.

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.

Botteri G, Salvadó L, Gumà A, Lee Hamilton D, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer X, Vázquez-Carrera M.

Metabolism. 2018 Mar 8. pii: S0026-0495(18)30071-4. doi: 10.1016/j.metabol.2018.03.005. [Epub ahead of print]

PMID:
29526536
5.

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice.

Meakin PJ, Jalicy SM, Montagut G, Allsop DJP, Cavellini DL, Irvine SW, McGinley C, Liddell MK, McNeilly AD, Parmionova K, Liu YR, Bailey CLS, Dale JK, Heisler LK, McCrimmon RJ, Ashford MLJ.

Sci Rep. 2018 Jan 8;8(1):55. doi: 10.1038/s41598-017-18388-6.

6.

Development of a novel immunochromatographic lateral flow assay specific for Mycobacterium bovis cells and its application in combination with immunomagnetic separation to test badger faeces.

Stewart LD, Tort N, Meakin P, Argudo JM, Nzuma R, Reid N, Delahay RJ, Ashford R, Montgomery WI, Grant IR.

BMC Vet Res. 2017 May 12;13(1):131. doi: 10.1186/s12917-017-1048-x.

7.

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation.

McGuire VA, Ruiz-Zorrilla Diez T, Emmerich CH, Strickson S, Ritorto MS, Sutavani RV, Weiβ A, Houslay KF, Knebel A, Meakin PJ, Phair IR, Ashford ML, Trost M, Arthur JS.

Sci Rep. 2016 Aug 8;6:31159. doi: 10.1038/srep31159.

8.

Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation.

Meakin PJ, Morrison VL, Sneddon CC, Savinko T, Uotila L, Jalicy SM, Gabriel JL, Kang L, Ashford ML, Fagerholm SC.

PLoS One. 2015 Sep 25;10(9):e0138872. doi: 10.1371/journal.pone.0138872. eCollection 2015.

9.

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome.

Rzepecka J, Pineda MA, Al-Riyami L, Rodgers DT, Huggan JK, Lumb FE, Khalaf AI, Meakin PJ, Corbet M, Ashford ML, Suckling CJ, Harnett MM, Harnett W.

J Autoimmun. 2015 Jun;60:59-73. doi: 10.1016/j.jaut.2015.04.005. Epub 2015 May 11.

10.

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.

Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, Scannevin RH, Chandran S, Hayes JD, Hardingham GE.

Nat Commun. 2015 May 13;6:7066. doi: 10.1038/ncomms8066.

11.

Evolution of a fracture network in an elastic medium with internal fluid generation and expulsion.

Kobchenko M, Hafver A, Jettestuen E, Renard F, Galland O, Jamtveit B, Meakin P, Dysthe DK.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Nov;90(5-1):052801. Epub 2014 Nov 4.

PMID:
25493828
12.

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance.

Meakin PJ, Chowdhry S, Sharma RS, Ashford FB, Walsh SV, McCrimmon RJ, Dinkova-Kostova AT, Dillon JF, Hayes JD, Ashford ML.

Mol Cell Biol. 2014 Sep;34(17):3305-20. doi: 10.1128/MCB.00677-14. Epub 2014 Jun 23.

13.

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes.

Hamilton DL, Findlay JA, Montagut G, Meakin PJ, Bestow D, Jalicy SM, Ashford ML.

Diabetologia. 2014 Aug;57(8):1684-92. doi: 10.1007/s00125-014-3269-x. Epub 2014 May 22.

14.

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

Deighton RF, Márkus NM, Al-Mubarak B, Bell KF, Papadia S, Meakin PJ, Chowdhry S, Hayes JD, Hardingham GE.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1818-20. doi: 10.1073/pnas.1402097111. Epub 2014 Apr 21. No abstract available.

15.

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy.

Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P.

Antioxid Redox Signal. 2014 Jun 20;20(18):2907-22. doi: 10.1089/ars.2013.5455. Epub 2014 Feb 6.

16.

Coalescence kinetics in surfactant stabilized emulsions: evolution equations from direct numerical simulations.

Skartlien R, Grimes B, Meakin P, Sjöblom J, Sollum E.

J Chem Phys. 2012 Dec 7;137(21):214701. doi: 10.1063/1.4768243.

PMID:
23231250
17.

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.

Watterson KR, Bestow D, Gallagher J, Hamilton DL, Ashford FB, Meakin PJ, Ashford ML.

Neurosignals. 2013;21(1-2):28-41. doi: 10.1159/000334144. Epub 2012 Mar 28.

18.

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.

Meakin PJ, Harper AJ, Hamilton DL, Gallagher J, McNeilly AD, Burgess LA, Vaanholt LM, Bannon KA, Latcham J, Hussain I, Speakman JR, Howlett DR, Ashford ML.

Biochem J. 2012 Jan 1;441(1):285-96. doi: 10.1042/BJ20110512.

19.

Dissipative-particle-dynamics model of biofilm growth.

Xu Z, Meakin P, Tartakovsky A, Scheibe TD.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Jun;83(6 Pt 2):066702. Epub 2011 Jun 13.

PMID:
21797511
20.
21.

Morphological transitions in partially gas-fluidized granular mixtures.

Nermoen A, Raufaste C, deVilliers SD, Jettestuen E, Meakin P, Dysthe DK.

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jun;81(6 Pt 1):061305. Epub 2010 Jun 29.

PMID:
20866414
22.

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis.

Deldicque L, Cani PD, Philp A, Raymackers JM, Meakin PJ, Ashford ML, Delzenne NM, Francaux M, Baar K.

Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E695-705. doi: 10.1152/ajpendo.00038.2010. Epub 2010 May 25.

23.

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML, Hayes JD.

Free Radic Biol Med. 2010 Jan 15;48(2):357-71. doi: 10.1016/j.freeradbiomed.2009.11.007. Epub 2009 Nov 13.

PMID:
19914374
25.

Diffuse-interface model for smoothed particle hydrodynamics.

Xu Z, Meakin P, Tartakovsky AM.

Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Mar;79(3 Pt 2):036702. Epub 2009 Mar 9.

PMID:
19392076
26.

Simple kinetic Monte Carlo models for dissolution pitting induced by crystal defects.

Meakin P, Rosso KM.

J Chem Phys. 2008 Nov 28;129(20):204106. doi: 10.1063/1.3021478.

PMID:
19045851
27.

Stochastic langevin model for flow and transport in porous media.

Tartakovsky AM, Tartakovsky DM, Meakin P.

Phys Rev Lett. 2008 Jul 25;101(4):044502. Epub 2008 Jul 22.

PMID:
18764333
28.

Phase-field modeling of solute precipitation and dissolution.

Xu Z, Meakin P.

J Chem Phys. 2008 Jul 7;129(1):014705. doi: 10.1063/1.2948949.

PMID:
18624494
29.

Two-dimensional lattice Boltzmann simulation of colloid migration in rough-walled narrow flow channels.

Başağaoğlu H, Meakin P, Succi S, Redden GR, Ginn TR.

Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Mar;77(3 Pt 1):031405. Epub 2008 Mar 20.

PMID:
18517379
30.

Fracture patterns generated by diffusion controlled volume changing reactions.

Malthe-Sørenssen A, Jamtveit B, Meakin P.

Phys Rev Lett. 2006 Jun 23;96(24):245501. Epub 2006 Jun 20.

PMID:
16907251
31.

Fructose metabolism in the adult mouse optic nerve, a central white matter tract.

Meakin PJ, Fowler MJ, Rathbone AJ, Allen LM, Ransom BR, Ray DE, Brown AM.

J Cereb Blood Flow Metab. 2007 Jan;27(1):86-99. Epub 2006 May 3.

PMID:
16670697
32.

Energy dissipation measures in three-dimensional disordered porous media.

Başağaoğlu H, Meakin P, Succi S.

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Oct;72(4 Pt 2):046705. Epub 2005 Oct 4.

PMID:
16383565
33.

Application of stereolithographic custom models for studying the impact of biofilms and mineral precipitation on fluid flow.

Stoner DL, Watson SM, Stedtfeld RD, Meakin P, Griffel LK, Tyler TL, Pegram LM, Barnes JM, Deason VA.

Appl Environ Microbiol. 2005 Dec;71(12):8721-8.

34.

Modeling of surface tension and contact angles with smoothed particle hydrodynamics.

Tartakovsky A, Meakin P.

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Aug;72(2 Pt 2):026301. Epub 2005 Aug 9.

PMID:
16196705
35.

Fructose supports energy metabolism of some, but not all, axons in adult mouse optic nerve.

Allen L, Anderson S, Wender R, Meakin P, Ransom BR, Ray DE, Brown AM.

J Neurophysiol. 2006 Mar;95(3):1917-25. Epub 2005 Sep 7.

36.

Lattice-Boltzmann simulation of coalescence-driven island coarsening.

Başağaoğlu H, Green CT, Meakin P, McCoy BJ.

J Chem Phys. 2004 Oct 22;121(16):7987-95.

PMID:
15485261
37.
38.

High-resolution measurements of pressure solution creep.

Dysthe DK, Renard F, Feder J, Jamtveit B, Meakin P, Jøssang T.

Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Jul;68(1 Pt 1):011603. Epub 2003 Jul 14.

PMID:
12935153
39.

Extended Eden model reproduces growth of an acellular slime mold.

Wagner G, Halvorsrud R, Meakin P.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 Nov;60(5 Pt B):5879-87.

PMID:
11970488
40.

Dynamics of water coning.

Farmen JE, Wagner G, Oxaal U, Meakin P, Feder J, Jøssang T.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 Oct;60(4 Pt B):4244-51.

PMID:
11970276
41.

Ultrapermeable, reverse-selective nanocomposite membranes.

Merkel TC, Freeman BD, Spontak RJ, He Z, Pinnau I, Meakin P, Hill AJ.

Science. 2002 Apr 19;296(5567):519-22.

42.

Scaling Relations for the Lengths and Widths of Fractures.

Walmann T, Malthe-Sorenssen A, Feder J, Jossang T, Meakin P, Hardy HH.

Phys Rev Lett. 1996 Dec 30;77(27):5393-5396. No abstract available.

PMID:
10062792
43.

Migration and fragmentation of invasion percolation clusters in two-dimensional porous media.

Birovljev A, Wagner G, Meakin P, Feder J, Jossang T.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1995 Jun;51(6):5911-5915. No abstract available.

PMID:
9963330
44.

Minimum energy dissipation river networks with fractal boundaries.

Sun T, Meakin P, Jossang T.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1995 Jun;51(6):5353-5359. No abstract available.

PMID:
9963266
45.

Fast, immiscible fluid-fluid displacement in three-dimensional porous media at finite viscosity contrast.

Frette V V, Feder J, Jossang T, Meakin P, Måloy KJ.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Oct;50(4):2881-2890. No abstract available.

PMID:
9962330
46.

Fractal characterization of two-dimensional aluminum corrosion fronts.

Holten T, Jossang T, Meakin P, Feder J.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Aug;50(2):754-759. No abstract available.

PMID:
9962034
47.

Minimum energy dissipation model for river basin geometry.

Sun T, Meakin P, Jossang T.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Jun;49(6):4865-4872. No abstract available.

PMID:
9961804
48.

Equivalent-circuit, scaling, random-walk simulation, and an experimental study of self-similar fractal electrodes and interfaces.

Sapoval B, Gutfraind R, Meakin P, Keddam M, Takenouti H.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 Nov;48(5):3333-3344. No abstract available.

PMID:
9960990
49.

Simple passivation and depassivation model for pitting corrosion.

Meakin P, Jossang T, Feder J.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 Oct;48(4):2906-2916. No abstract available.

PMID:
9960924
50.

Jullien, Meakin, and Pavlovitch reply.

Jullien R, Meakin P, Pavlovitch A.

Phys Rev Lett. 1993 Apr 5;70(14):2195. No abstract available.

PMID:
10053495

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