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Insights into Pasteurellaceae carriage dynamics in the nasal passages of healthy beef calves.

Thomas AC, Bailey M, Lee MRF, Mead A, Morales-Aza B, Reynolds R, Vipond B, Finn A, Eisler MC.

Sci Rep. 2019 Aug 16;9(1):11943. doi: 10.1038/s41598-019-48007-5.


Discovery of a CD10 negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S, Elliott N, Rice S, Buck G, Fordham N, Garnett C, Godfrey L, Crump NT, Wright G, Inglott S, Hua P, Psaila B, Povinelli B, Knapp DJHF, Agraz-Doblas A, Bueno C, Varela I, Bennett P, Koohy H, Watt SM, Karadimitris A, Mead AJ, Ancliff P, Vyas P, Menendez P, Milne TA, Roberts I, Roy A.

Blood. 2019 Aug 5. pii: blood.2019001289. doi: 10.1182/blood.2019001289. [Epub ahead of print]


Legal and Regulatory Issues Governing Cannabis and Cannabis-Derived Products in the United States.

Mead A.

Front Plant Sci. 2019 Jun 14;10:697. doi: 10.3389/fpls.2019.00697. eCollection 2019. Review.


Indigenous Perspectives and Gene Editing in Aotearoa New Zealand.

Hudson M, Mead ATP, Chagné D, Roskruge N, Morrison S, Wilcox PL, Allan AC.

Front Bioeng Biotechnol. 2019 Apr 11;7:70. doi: 10.3389/fbioe.2019.00070. eCollection 2019.


Perampanel for the treatment of epilepsy; Longitudinal actuarial analysis and dose responses based on monthly outcomes.

Stavropoulos I, Louden W, Queally C, Adcock J, Tristram M, Neale M, Moran N, Flores L L, Nashef L, Richardson MP, Bell C, Slaght S, Aram J, Rayner N, Powell R, Mead A, Sen A, Elwes R.

Seizure. 2019 Jul;69:125-132. doi: 10.1016/j.seizure.2019.04.013. Epub 2019 Apr 15.


Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.

Di Genua C, Norfo R, Rodriguez-Meira A, Wen WX, Drissen R, Booth CAG, Povinelli B, Repapi E, Gray N, Carrelha J, Kettyle LM, Jamieson L, Neo WH, Thongjuea S, Nerlov C, Mead AJ.

Haematologica. 2019 Apr 11. pii: haematol.2018.205351. doi: 10.3324/haematol.2018.205351. [Epub ahead of print]


Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion.

Hua P, Kronsteiner B, van der Garde M, Ashley N, Hernandez D, Tarunina M, Hook L, Choo Y, Roberts I, Mead A, Watt SM.

Sci Rep. 2019 Mar 28;9(1):5300. doi: 10.1038/s41598-019-41803-z.


UK results from the myeloproliferative neoplasms (MPN) landmark survey on the symptom, emotional and economic burden of MPN.

Harrison C, Mathias J, Campbell-Drew M, Mead AJ, Pemberton-Whiteley Z, Ali S, Wadelin F, Taylor-Stokes G, Waller J, Taylor B.

Br J Haematol. 2019 Aug;186(3):e1-e4. doi: 10.1111/bjh.15839. Epub 2019 Mar 10. No abstract available.


Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

Rodriguez-Meira A, Buck G, Clark SA, Povinelli BJ, Alcolea V, Louka E, McGowan S, Hamblin A, Sousos N, Barkas N, Giustacchini A, Psaila B, Jacobsen SEW, Thongjuea S, Mead AJ.

Mol Cell. 2019 Mar 21;73(6):1292-1305.e8. doi: 10.1016/j.molcel.2019.01.009. Epub 2019 Feb 12.


Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation.

Psaila B, Mead AJ.

Blood. 2019 Mar 28;133(13):1427-1435. doi: 10.1182/blood-2018-11-835371. Epub 2019 Feb 6. Review.


In-hospital training in addiction medicine: A mixed-methods study of health care provider benefits and differences.

Gorfinkel L, Klimas J, Reel B, Dong H, Ahamad K, Fairgrieve C, McLean M, Mead A, Nolan S, Small W, Cullen W, Wood E, Fairbairn N.

Subst Abus. 2019 Jan 28:1-7. doi: 10.1080/08897077.2018.1561596. [Epub ahead of print]


HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma.

Fleming JC, Woo J, Moutasim K, Mellone M, Frampton SJ, Mead A, Ahmed W, Wood O, Robinson H, Ward M, Woelk CH, Ottensmeier CH, King E, Kim D, Blaydes JP, Thomas GJ.

Br J Cancer. 2019 Feb;120(3):356-367. doi: 10.1038/s41416-018-0364-7. Epub 2019 Jan 17.


Origins of ETP leukemia.

Booth CAG, Jacobsen SEW, Mead AJ.

Oncoscience. 2018 Aug 22;5(11-12):271-272. doi: 10.18632/oncoscience.456. eCollection 2018 Nov. No abstract available.


Royal College of Ophthalmologists: National Survey of ST1 Supervision.

King C, Tytko A, Spencer AF, Mead A.

Eye (Lond). 2019 Jun;33(6):866-867. doi: 10.1038/s41433-018-0325-7. Epub 2019 Jan 7. No abstract available.


Heterogeneity in myeloproliferative neoplasms: Causes and consequences.

O'Sullivan J, Mead AJ.

Adv Biol Regul. 2019 Jan;71:55-68. doi: 10.1016/j.jbior.2018.11.007. Epub 2018 Nov 22. Review.


From Pioneer to Repressor: Bimodal foxd3 Activity Dynamically Remodels Neural Crest Regulatory Landscape In Vivo.

Lukoseviciute M, Gavriouchkina D, Williams RM, Hochgreb-Hagele T, Senanayake U, Chong-Morrison V, Thongjuea S, Repapi E, Mead A, Sauka-Spengler T.

Dev Cell. 2018 Dec 3;47(5):608-628.e6. doi: 10.1016/j.devcel.2018.11.009.


A guideline for the diagnosis and management of polycythaemia vera. A British Society for Haematology Guideline.

McMullin MF, Harrison CN, Ali S, Cargo C, Chen F, Ewing J, Garg M, Godfrey A, S SK, McLornan DP, Nangalia J, Sekhar M, Wadelin F, Mead AJ; BSH Committee.

Br J Haematol. 2019 Jan;184(2):176-191. doi: 10.1111/bjh.15648. Epub 2018 Nov 27. No abstract available. Erratum in: Br J Haematol. 2019 Apr;185(1):198.


A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis: A British Society for Haematology Guideline.

McMullin MFF, Mead AJ, Ali S, Cargo C, Chen F, Ewing J, Garg M, Godfrey A, Knapper S, McLornan DP, Nangalia J, Sekhar M, Wadelin F, Harrison CN; British Society for Haematology Guideline.

Br J Haematol. 2019 Jan;184(2):161-175. doi: 10.1111/bjh.15647. Epub 2018 Nov 13. No abstract available.


The transformative journey of chronic myeloid leukemia.

Neelakantan P, Mead A.

Int J Hematol Oncol. 2018 Aug 28;7(1):IJH07. doi: 10.2217/ijh-2018-0008. eCollection 2018 Mar. No abstract available.


Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media.

Mead A, Lees P, Mitchell J, Rycroft A, Standing JF, Toutain PL, Pelligand L.

J Vet Pharmacol Ther. 2019 Jan;42(1):52-59. doi: 10.1111/jvp.12719. Epub 2018 Sep 28.


Ruxolitinib Therapy Followed by Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation for Myelofibrosis: Myeloproliferative Disorders Research Consortium 114 Study.

Gupta V, Kosiorek HE, Mead A, Klisovic RB, Galvin JP, Berenzon D, Yacoub A, Viswabandya A, Mesa RA, Goldberg J, Price L, Salama ME, Weinberg RS, Rampal R, Farnoud N, Dueck AC, Mascarenhas JO, Hoffman R.

Biol Blood Marrow Transplant. 2019 Feb;25(2):256-264. doi: 10.1016/j.bbmt.2018.09.001. Epub 2018 Sep 8.


Consensus on BCR-ABL1 reporting in chronic myeloid leukaemia in the UK.

Cross NCP, White HE, Evans PAS, Hancock J, Copland M, Milojkovic D, Mason J, Craine S, Mead AJ.

Br J Haematol. 2018 Sep;182(6):777-788. doi: 10.1111/bjh.15542. Epub 2018 Aug 20. Review.


Beyond the one-way ANOVA for 'omics data.

Hassall KL, Mead A.

BMC Bioinformatics. 2018 Jul 9;19(Suppl 7):199. doi: 10.1186/s12859-018-2173-7.


Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy.

Dahal LN, Huang CY, Stopforth RJ, Mead A, Chan K, Bowater JX, Taylor MC, Narang P, Chan HTC, Kim JH, Vaughan AT, Forconi F, Beers SA.

J Immunol. 2018 Aug 15;201(4):1211-1221. doi: 10.4049/jimmunol.1701122. Epub 2018 Jul 11.


Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Neo WH, Booth CAG, Azzoni E, Chi L, Delgado-Olguín P, de Bruijn MFTR, Jacobsen SEW, Mead AJ.

Blood. 2018 May 17;131(20):2223-2234. doi: 10.1182/blood-2017-10-811455. Epub 2018 Mar 19.


Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Booth CAG, Barkas N, Neo WH, Boukarabila H, Soilleux EJ, Giotopoulos G, Farnoud N, Giustacchini A, Ashley N, Carrelha J, Jamieson L, Atkinson D, Bouriez-Jones T, Prinjha RK, Milne TA, Teachey DT, Papaemmanuil E, Huntly BJP, Jacobsen SEW, Mead AJ.

Cancer Cell. 2018 Feb 12;33(2):274-291.e8. doi: 10.1016/j.ccell.2018.01.006.


Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.

Duarte S, Woll PS, Buza-Vidas N, Chin DWL, Boukarabila H, Luís TC, Stenson L, Bouriez-Jones T, Ferry H, Mead AJ, Atkinson D, Jin S, Clark SA, Wu B, Repapi E, Gray N, Taylor S, Mutvei AP, Tsoi YL, Nerlov C, Lendahl U, Jacobsen SEW.

Blood. 2018 Apr 12;131(15):1712-1719. doi: 10.1182/blood-2017-06-788505. Epub 2018 Jan 16.


Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.

Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, Morris ED, Feng G, Whitlock M, Gorman D, van Gerven J, Reynolds DS, Dua P, Butt RP.

Br J Pharmacol. 2018 Feb;175(4):708-725. doi: 10.1111/bph.14119. Epub 2018 Jan 18. Erratum in: Br J Pharmacol. 2019 Jan;176(1):127.


Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates.

Mead AF, Osinalde N, Ørtenblad N, Nielsen J, Brewer J, Vellema M, Adam I, Scharff C, Song Y, Frandsen U, Blagoev B, Kratchmarova I, Elemans CP.

Elife. 2017 Nov 22;6. pii: e29425. doi: 10.7554/eLife.29425.


Tasigna (nilotinib) in chronic myeloid leukemia treatment-free remission after nearly 2 years: an interview with Adam Mead.

Mead A.

Future Oncol. 2017 Nov;13(27):2401-2404. doi: 10.2217/fon-2017-0460. Epub 2017 Nov 10.


Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide.

Harrison CN, Mead AJ, Panchal A, Fox S, Yap C, Gbandi E, Houlton A, Alimam S, Ewing J, Wood M, Chen F, Coppell J, Panoskaltsis N, Knapper S, Ali S, Hamblin A, Scherber R, Dueck AC, Cross NCP, Mesa R, McMullin MF.

Blood. 2017 Oct 26;130(17):1889-1897. doi: 10.1182/blood-2017-05-785790. Epub 2017 Aug 9.


Barriers and facilitators to implementing addiction medicine fellowships: a qualitative study with fellows, medical students, residents and preceptors.

Klimas J, Small W, Ahamad K, Cullen W, Mead A, Rieb L, Wood E, McNeil R.

Addict Sci Clin Pract. 2017 Sep 20;12(1):21. doi: 10.1186/s13722-017-0086-9.


Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

Loughran SJ, Comoglio F, Hamey FK, Giustacchini A, Errami Y, Earp E, Göttgens B, Jacobsen SEW, Mead AJ, Hendrich B, Green AR.

J Exp Med. 2017 Oct 2;214(10):3085-3104. doi: 10.1084/jem.20161827. Epub 2017 Sep 12.


Single cell analysis of normal and leukemic hematopoiesis.

Povinelli BJ, Rodriguez-Meira A, Mead AJ.

Mol Aspects Med. 2018 Feb;59:85-94. doi: 10.1016/j.mam.2017.08.006. Epub 2017 Sep 8. Review.


Phenotyping of field-grown wheat in the UK highlights contribution of light response of photosynthesis and flag leaf longevity to grain yield.

Carmo-Silva E, Andralojc PJ, Scales JC, Driever SM, Mead A, Lawson T, Raines CA, Parry MAJ.

J Exp Bot. 2017 Jun 15;68(13):3473-3486. doi: 10.1093/jxb/erx169.


Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential.

Brock AJ, Goody SMG, Mead AN, Sudwarts A, Parker MO, Brennan CH.

J Pharmacol Exp Ther. 2017 Oct;363(1):66-79. doi: 10.1124/jpet.117.242628. Epub 2017 Aug 8.


Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

Mead AJ, Neo WH, Barkas N, Matsuoka S, Giustacchini A, Facchini R, Thongjuea S, Jamieson L, Booth CAG, Fordham N, Di Genua C, Atkinson D, Chowdhury O, Repapi E, Gray N, Kharazi S, Clark SA, Bouriez T, Woll P, Suda T, Nerlov C, Jacobsen SEW.

J Exp Med. 2017 Jul 3;214(7):2005-2021. doi: 10.1084/jem.20161418. Epub 2017 Jun 21.


Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.

Giustacchini A, Thongjuea S, Barkas N, Woll PS, Povinelli BJ, Booth CAG, Sopp P, Norfo R, Rodriguez-Meira A, Ashley N, Jamieson L, Vyas P, Anderson K, Segerstolpe Å, Qian H, Olsson-Strömberg U, Mustjoki S, Sandberg R, Jacobsen SEW, Mead AJ.

Nat Med. 2017 Jun;23(6):692-702. doi: 10.1038/nm.4336. Epub 2017 May 15.


Equivalence of BCSH and WHO diagnostic criteria for ET.

Harrison CN, McMullin MF, Green AR, Mead AJ.

Leukemia. 2017 Jul;31(7):1660. doi: 10.1038/leu.2017.119. Epub 2017 May 5.


A spatial temporal analysis of the Fusarium graminearum transcriptome during symptomless and symptomatic wheat infection.

Brown NA, Evans J, Mead A, Hammond-Kosack KE.

Mol Plant Pathol. 2017 Dec;18(9):1295-1312. doi: 10.1111/mpp.12564. Epub 2017 Aug 8.


Impact of a brief addiction medicine training experience on knowledge self-assessment among medical learners.

Klimas J, Ahamad K, Fairgrieve C, McLean M, Mead A, Nolan S, Wood E.

Subst Abus. 2017 Apr-Jun;38(2):141-144. doi: 10.1080/08897077.2017.1296055. Epub 2017 Feb 21.


Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial.

Mesa RA, Vannucchi AM, Mead A, Egyed M, Szoke A, Suvorov A, Jakucs J, Perkins A, Prasad R, Mayer J, Demeter J, Ganly P, Singer JW, Zhou H, Dean JP, Te Boekhorst PA, Nangalia J, Kiladjian JJ, Harrison CN.

Lancet Haematol. 2017 May;4(5):e225-e236. doi: 10.1016/S2352-3026(17)30027-3. Epub 2017 Mar 20.


The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law.

Mead A.

Epilepsy Behav. 2017 May;70(Pt B):288-291. doi: 10.1016/j.yebeh.2016.11.021. Epub 2017 Feb 4. Review.


Myeloproliferative neoplasm stem cells.

Mead AJ, Mullally A.

Blood. 2017 Mar 23;129(12):1607-1616. doi: 10.1182/blood-2016-10-696005. Epub 2017 Feb 3. Review.


Two birds with one stone: experiences of combining clinical and research training in addiction medicine.

Klimas J, McNeil R, Ahamad K, Mead A, Rieb L, Cullen W, Wood E, Small W.

BMC Med Educ. 2017 Jan 23;17(1):22. doi: 10.1186/s12909-017-0862-y.


Guideline for the investigation and management of eosinophilia.

Butt NM, Lambert J, Ali S, Beer PA, Cross NC, Duncombe A, Ewing J, Harrison CN, Knapper S, McLornan D, Mead AJ, Radia D, Bain BJ; British Committee for Standards in Haematology.

Br J Haematol. 2017 Feb;176(4):553-572. doi: 10.1111/bjh.14488. Epub 2017 Jan 23. No abstract available.


Towards new sources of resistance to the currant-lettuce aphid (Nasonovia ribisnigri).

Walley PG, Hough G, Moore JD, Carder J, Elliott M, Mead A, Jones J, Teakle G, Barker G, Buchanan-Wollaston V, Hand P, Pink D, Collier R.

Mol Breed. 2017;37(1):4. doi: 10.1007/s11032-016-0606-4. Epub 2017 Jan 3.


Equivalence of BCSH and WHO diagnostic criteria for ET.

Harrison CN, McMullin MF, Green AR, Mead AJ.

Leukemia. 2017 Feb;31(2):527-528. doi: 10.1038/leu.2016.318. Epub 2016 Nov 29. No abstract available. Erratum in: Leukemia. 2017 Jul;31(7):1660.


Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.

Luis TC, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll PS, Azzoni E, Giustacchini A, Lutteropp M, Bouriez-Jones T, Vaidya H, Mead AJ, Atkinson D, Böiers C, Carrelha J, Macaulay IC, Patient R, Geissmann F, Nerlov C, Sandberg R, de Bruijn MFTR, Blackburn CC, Godin I, Jacobsen SEW.

Nat Immunol. 2016 Dec;17(12):1424-1435. doi: 10.1038/ni.3576. Epub 2016 Oct 3.


Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects.

Wager TT, Chappie T, Horton D, Chandrasekaran RY, Samas B, Dunn-Sims ER, Hsu C, Nawreen N, Vanase-Frawley MA, O'Connor RE, Schmidt CJ, Dlugolenski K, Stratman NC, Majchrzak MJ, Kormos BL, Nguyen DP, Sawant-Basak A, Mead AN.

ACS Chem Neurosci. 2017 Jan 18;8(1):165-177. doi: 10.1021/acschemneuro.6b00297. Epub 2016 Oct 21.


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