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2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia.

Fitzpatrick SF, Lambden S, Macias D, Puthucheary Z, Pietsch S, Mendil L, McPhail MJW, Johnson RS.

Front Physiol. 2020 Mar 3;11:147. doi: 10.3389/fphys.2020.00147. eCollection 2020.


Sequential Cohort Analysis After Liver Transplantation Shows de Novo Extended Release Tacrolimus Is Safe, Efficacious, and Minimizes Renal Dysfunction.

Lim TY, McPhail MJ, Shah A, Mahgoub S, Nayagam J, Cramp M, Bernal W, Menon K, Jassem W, Joshi D, Heneghan MA, Agarwal K, Heaton ND, Suddle A, O'Grady JG, Aluvihare VR.

Transplant Direct. 2020 Jan 17;6(2):e528. doi: 10.1097/TXD.0000000000000970. eCollection 2020 Feb.


Assessing the time-dependent impact of performance status on outcomes after liver transplantation.

Wallace D, Cowling T, McPhail MJ, Brown SE, Aluvihare V, Suddle A, Auzinger G, Heneghan MA, Rowe IA, Walker K, Heaton N, van der Meulen J, Bernal W.

Hepatology. 2020 Jan 22. doi: 10.1002/hep.31124. [Epub ahead of print]


A 'real-world' analysis of risk factors for post liver transplant delirium and the effect on length of stay.

Tavabie OD, Colwill M, Adamson R, McPhail MJW, Bernal W, Jassem W, Prachialias A, Heneghan M, Aluvihare VR, Agarwal K.

Eur J Gastroenterol Hepatol. 2020 Jan 9. doi: 10.1097/MEG.0000000000001661. [Epub ahead of print]


Significant lung injury and its prognostic significance in acute liver failure: A cohort analysis.

Dong V, Sun K, Gottfried M, Cardoso FS, McPhail MJ, Stravitz RT, Lee WM, Karvellas CJ.

Liver Int. 2020 Mar;40(3):654-663. doi: 10.1111/liv.14268. Epub 2019 Oct 13.


Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Cacciottolo TM, Perikari A, van der Klaauw A, Henning E, Stadler LKJ, Keogh J, Farooqi IS, Tenin G, Keavney B, Ryan E, Budd R, Bewley M, Coelho P, Rumsey W, Sanchez Y, McCafferty J, Dockrell D, Walmsley S, Whyte M, Liu Y, Choy MK, Tenin G, Abraham S, Black G, Keavney B, Ford T, Stanley B, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Sidik N, McCartney P, Corcoran D, Collison D, Rush C, McConnachie A, Touyz R, Oldroyd K, Berry C, Gazdagh G, Diver L, Marshall J, McGowan R, Ahmed F; DDD Study, Tobias E, Curtis E, Parsons C, Maslin K, D'Angelo S, Moon R, Crozier S, Gossiel F, Bishop N, Kennedy S, Papageorghiou A, Fraser R, Gandhi S, Prentice A, Inskip H, Godfrey K, Schoenmakers I, Javaid MK, Eastell R, Cooper C, Harvey N, Watt ER, Howden A, Mirchandani A, Coelho P, Hukelmann JL, Sadiku P, Plant TM, Cantrell DA, Whyte MKB, Walmsley SR, Mordi I, Forteath C, Wong A, Mohan M, Palmer C, Doney A, Rena G, Lang C, Gray EH, Azarian S, Riva A, Edwards H, McPhail MJW, Williams R, Chokshi S, Patel VC, Edwards LA, Page D, Miossec M, Williams S, Monaghan R, Fotiou E; CHANGE Study Collaborators, CheartED Study Collaborators, Santibanez-Koref M, Keavney B, Badat M, Mettananda S, Hua P, Schwessinger R, Hughes J, Higgs D, Davies J.

QJM. 2019 Sep 1;112(9):724-729. doi: 10.1093/qjmed/hcz175. No abstract available.


Aeroacoustic source characterization in a physical model of phonation.

McPhail MJ, Campo ET, Krane MH.

J Acoust Soc Am. 2019 Aug;146(2):1230. doi: 10.1121/1.5122787.


Modern Outcomes Following Treatment of Hepatocellular Carcinoma in Hereditary Hemochromatosis: A Matched Cohort Study.

McPhail MJW, Khorsandi SE, Abbott L, Al-Kadhimi G, Kane P, Karani J, O'Grady J, Heaton N, Bomford A, Suddle A.

Am J Clin Oncol. 2019 Dec;42(12):918-923. doi: 10.1097/COC.0000000000000583.


Computed Tomography Data to Generate a Reproducible, Anatomically Accurate Hemilaryngeal Model.

Hintze JM, Myers CE, McPhail MJ, Tchoukalova YD, Lott DG.

Otolaryngol Head Neck Surg. 2019 Sep;161(3):472-477. doi: 10.1177/0194599819844974. Epub 2019 Apr 23.


Lactate and number of organ failures predict intensive care unit mortality in patients with acute-on-chronic liver failure.

Cardoso FS, Abraldes JG, Sy E, Ronco JJ, Bagulho L, Mcphail MJ, Karvellas CJ.

Liver Int. 2019 Jul;39(7):1271-1280. doi: 10.1111/liv.14083. Epub 2019 Mar 19.


L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses.

Butterworth RF, McPhail MJW.

Drugs. 2019 Feb;79(Suppl 1):31-37. doi: 10.1007/s40265-018-1024-1. Review.


Update on the management of acute liver failure.

Trovato FM, Rabinowich L, McPhail MJW.

Curr Opin Crit Care. 2019 Apr;25(2):157-164. doi: 10.1097/MCC.0000000000000583. Review.


The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure.

Triantafyllou E, Woollard KJ, McPhail MJW, Antoniades CG, Possamai LA.

Front Immunol. 2018 Dec 14;9:2948. doi: 10.3389/fimmu.2018.02948. eCollection 2018. Review.


Efficacy of l-Ornithine l-Aspartate for the Treatment of Hepatic Encephalopathy and Hyperammonemia in Cirrhosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Butterworth RF, Kircheis G, Hilger N, McPhail MJW.

J Clin Exp Hepatol. 2018 Sep;8(3):301-313. doi: 10.1016/j.jceh.2018.05.004. Epub 2018 May 22.


The authors reply.

McPhail MJW, Harrison D, Rowan K, Bernal W.

Crit Care Med. 2018 Oct;46(10):e1018. doi: 10.1097/CCM.0000000000003329. No abstract available.


Metabolic phenotype of skeletal muscle in early critical illness.

Puthucheary ZA, Astin R, Mcphail MJW, Saeed S, Pasha Y, Bear DE, Constantin D, Velloso C, Manning S, Calvert L, Singer M, Batterham RL, Gomez-Romero M, Holmes E, Steiner MC, Atherton PJ, Greenhaff P, Edwards LM, Smith K, Harridge SD, Hart N, Montgomery HE.

Thorax. 2018 Oct;73(10):926-935. doi: 10.1136/thoraxjnl-2017-211073. Epub 2018 Jul 6.


Incidence and Outcomes for Patients With Cirrhosis Admitted to the United Kingdom Critical Care Units.

McPhail MJW, Parrott F, Wendon JA, Harrison DA, Rowan KA, Bernal W.

Crit Care Med. 2018 May;46(5):705-712. doi: 10.1097/CCM.0000000000002961.


The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis.

Aggarwal N, Donald ND, Malik S, Selvendran SS, McPhail MJ, Monahan KJ.

Clin Transl Gastroenterol. 2017 Jul 27;8(7):e109. doi: 10.1038/ctg.2017.35.


Improving the Diagnostic Criteria for Primary Liver Graft Nonfunction in Adults Utilizing Standard and Transportable Laboratory Parameters: An Outcome-Based Analysis.

Al-Freah MAB, McPhail MJW, Dionigi E, Foxton MR, Auzinger G, Rela M, Wendon JA, O'Grady JG, Heneghan MA, Heaton ND, Bernal W.

Am J Transplant. 2017 May;17(5):1255-1266. doi: 10.1111/ajt.14230. Epub 2017 Apr 5.


High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.

Gray N, Zia R, King A, Patel VC, Wendon J, McPhail MJ, Coen M, Plumb RS, Wilson ID, Nicholson JK.

Anal Chem. 2017 Feb 21;89(4):2478-2487. doi: 10.1021/acs.analchem.6b04623. Epub 2017 Feb 7.


Predicting Fluid Responsiveness in Acute Liver Failure: A Prospective Study.

Audimoolam VK, McPhail MJ, Willars C, Bernal W, Wendon JA, Cecconi M, Auzinger G.

Anesth Analg. 2017 Feb;124(2):480-486. doi: 10.1213/ANE.0000000000001585.


Urinary metabolic profiling by 1H NMR spectroscopy in patients with cirrhosis may discriminate overt but not covert hepatic encephalopathy.

McPhail MJ, Montagnese S, Villanova M, El Hadi H, Amodio P, Crossey MM, Williams R, Cox IJ, Taylor-Robinson SD.

Metab Brain Dis. 2017 Apr;32(2):331-341. doi: 10.1007/s11011-016-9904-0. Epub 2016 Sep 17.


A longitudinal study of patients with cirrhosis treated with L-ornithine L-aspartate, examined with magnetization transfer, diffusion-weighted imaging and magnetic resonance spectroscopy.

Grover VP, McPhail MJ, Wylezinska-Arridge M, Crossey MM, Fitzpatrick JA, Southern L, Saxby BK, Cook NA, Cox IJ, Waldman AD, Dhanjal NS, Bak-Bol A, Williams R, Morgan MY, Taylor-Robinson SD.

Metab Brain Dis. 2017 Feb;32(1):77-86. doi: 10.1007/s11011-016-9881-3. Epub 2016 Aug 3.


Changes in Liver Volume in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy.

Fitzpatrick JA, Kim JU, Cobbold JF, McPhail MJ, Crossey MM, Bak-Bol AA, Zaky A, Taylor-Robinson SD.

J Clin Exp Hepatol. 2016 Mar;6(1):15-20. doi: 10.1016/j.jceh.2015.11.004. Epub 2015 Dec 6.


Decisions on futility in patients with cirrhosis and organ failure.

McPhail MJ, Auzinger G, Bernal W, Wendon JA.

Hepatology. 2016 Sep;64(3):986. doi: 10.1002/hep.28539. Epub 2016 Apr 30. No abstract available.


Magnetic Resonance Spectroscopy: Principles and Techniques: Lessons for Clinicians.

Tognarelli JM, Dawood M, Shariff MI, Grover VP, Crossey MM, Cox IJ, Taylor-Robinson SD, McPhail MJ.

J Clin Exp Hepatol. 2015 Dec;5(4):320-8. doi: 10.1016/j.jceh.2015.10.006. Epub 2015 Nov 12. Review.


LiFe: a liver injury score to predict outcome in critically ill patients.

Edmark C, McPhail MJW, Bell M, Whitehouse T, Wendon J, Christopher KB.

Intensive Care Med. 2016 Mar;42(3):361-369. doi: 10.1007/s00134-015-4203-5. Epub 2016 Jan 28.


Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis.

McPhail MJW, Shawcross DL, Lewis MR, Coltart I, Want EJ, Antoniades CG, Veselkov K, Triantafyllou E, Patel V, Pop O, Gomez-Romero M, Kyriakides M, Zia R, Abeles RD, Crossey MME, Jassem W, O'Grady J, Heaton N, Auzinger G, Bernal W, Quaglia A, Coen M, Nicholson JK, Wendon JA, Holmes E, Taylor-Robinson SD.

J Hepatol. 2016 May;64(5):1058-1067. doi: 10.1016/j.jhep.2016.01.003. Epub 2016 Jan 18.


Magnetic Resonance Imaging: Principles and Techniques: Lessons for Clinicians.

Grover VP, Tognarelli JM, Crossey MM, Cox IJ, Taylor-Robinson SD, McPhail MJ.

J Clin Exp Hepatol. 2015 Sep;5(3):246-55. doi: 10.1016/j.jceh.2015.08.001. Epub 2015 Aug 20. Review.


Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis.

McPhail MJ, Farne H, Senvar N, Wendon JA, Bernal W.

Clin Gastroenterol Hepatol. 2016 Apr;14(4):516-525.e5; quiz e43-e45. doi: 10.1016/j.cgh.2015.10.007. Epub 2015 Oct 20. Review.


Neutrophil Toll-Like Receptor 9 Expression and the Systemic Inflammatory Response in Acetaminophen-Induced Acute Liver Failure.

Manakkat Vijay GK, Ryan JM, Abeles RD, Ramage S, Patel V, Bernsmeier C, Riva A, McPhail MJ, Tranah TH, Markwick LJ, Taylor NJ, Bernal W, Auzinger G, Willars C, Chokshi S, Wendon JA, Ma Y, Shawcross DL.

Crit Care Med. 2016 Jan;44(1):43-53. doi: 10.1097/CCM.0000000000001309.


Bile acid profiling and quantification in biofluids using ultra-performance liquid chromatography tandem mass spectrometry.

Sarafian MH, Lewis MR, Pechlivanis A, Ralphs S, McPhail MJ, Patel VC, Dumas ME, Holmes E, Nicholson JK.

Anal Chem. 2015 Oct 6;87(19):9662-70. doi: 10.1021/acs.analchem.5b01556. Epub 2015 Sep 30.


A pilot study of change in fracture risk in patients with acute respiratory distress syndrome.

Rawal J, McPhail MJ, Ratnayake G, Chan P, Moxham J, Harridge SD, Hart N, Montgomery HE, Puthucheary ZA.

Crit Care. 2015 Apr 14;19:165. doi: 10.1186/s13054-015-0892-y.


Qualitative Ultrasound in Acute Critical Illness Muscle Wasting.

Puthucheary ZA, Phadke R, Rawal J, McPhail MJ, Sidhu PS, Rowlerson A, Moxham J, Harridge S, Hart N, Montgomery HE.

Crit Care Med. 2015 Aug;43(8):1603-11. doi: 10.1097/CCM.0000000000001016.


Current management of acute liver failure.

McPhail MJ, Kriese S, Heneghan MA.

Curr Opin Gastroenterol. 2015 May;31(3):209-14. doi: 10.1097/MOG.0000000000000174. Review.


Multicolor particle shadow accelerometry.

McPhail MJ, Krane MH, Fontaine AA, Goss L, Crafton J.

Meas Sci Technol. 2015 Apr;26(4). pii: 045301. doi: 10.1088/0957-0233/26/4/045301. Epub 2015 Feb 27.


Correcting for color crosstalk and chromatic aberration in multicolor particle shadow velocimetry.

McPhail MJ, Fontaine AA, Krane MH, Goss L, Crafton J.

Meas Sci Technol. 2015 Feb;26(2). pii: 025302. doi: 10.1088/0957-0233/26/2/025302. Epub 2015 Jan 7.


The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity.

Possamai LA, McPhail MJ, Khamri W, Wu B, Concas D, Harrison M, Williams R, Cox RD, Cox IJ, Anstee QM, Thursz MR.

Liver Int. 2015 Mar;35(3):764-73. doi: 10.1111/liv.12689. Epub 2014 Oct 8.


Increased Survival for Patients With Cirrhosis and Organ Failure in Liver Intensive Care and Validation of the Chronic Liver Failure-Sequential Organ Failure Scoring System.

McPhail MJ, Shawcross DL, Abeles RD, Chang A, Patel V, Lee GH, Abdulla M, Sizer E, Willars C, Auzinger G, Bernal W, Wendon JA.

Clin Gastroenterol Hepatol. 2015 Jul;13(7):1353-1360.e8. doi: 10.1016/j.cgh.2014.08.041. Epub 2014 Sep 21.


Letter: comparing of scoring systems and outcome of patients admitted to a liver intensive care unit of a tertiary referral centre with severe variceal bleeding--authors' reply.

McPhail MJ, Al-Freah MA, Wendon JA.

Aliment Pharmacol Ther. 2014 Oct;40(7):857. doi: 10.1111/apt.12924. No abstract available.


Assessment of bone mineral density in tenofovir-treated patients with chronic hepatitis B: can the fracture risk assessment tool identify those at greatest risk?

Gill US, Zissimopoulos A, Al-Shamma S, Burke K, McPhail MJ, Barr DA, Kallis YN, Marley RT, Kooner P, Foster GR, Kennedy PT.

J Infect Dis. 2015 Feb 1;211(3):374-82. doi: 10.1093/infdis/jiu471. Epub 2014 Aug 25.


Comparison of scoring systems and outcome of patients admitted to a liver intensive care unit of a tertiary referral centre with severe variceal bleeding.

Al-Freah MA, Gera A, Martini S, McPhail MJ, Devlin J, Harrison PM, Shawcross D, Abeles RD, Taylor NJ, Auzinger G, Bernal W, Heneghan MA, Wendon JA.

Aliment Pharmacol Ther. 2014 Jun;39(11):1286-300. doi: 10.1111/apt.12744. Epub 2014 Apr 16.


Acute muscle wasting among critically ill patients--reply.

Puthucheary ZA, McPhail MJ, Hart N.

JAMA. 2014 Feb 12;311(6):622-3. doi: 10.1001/jama.2013.285426. No abstract available.


Lung injury and its prognostic significance in acute liver failure.

Audimoolam VK, McPhail MJ, Wendon JA, Willars C, Bernal W, Desai SR, Auzinger G.

Crit Care Med. 2014 Mar;42(3):592-600. doi: 10.1097/01.ccm.0000435666.15070.d5.


Aerobic capacity during cardiopulmonary exercise testing and survival with and without liver transplantation for patients with chronic liver disease.

Bernal W, Martin-Mateos R, Lipcsey M, Tallis C, Woodsford K, McPhail MJ, Willars C, Auzinger G, Sizer E, Heneghan M, Cottam S, Heaton N, Wendon J.

Liver Transpl. 2014 Jan;20(1):54-62. doi: 10.1002/lt.23766. Epub 2013 Nov 29.


Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.

Possamai LA, McPhail MJ, Quaglia A, Zingarelli V, Abeles RD, Tidswell R, Puthucheary Z, Rawal J, Karvellas CJ, Leslie EM, Hughes RD, Ma Y, Jassem W, Shawcross DL, Bernal W, Dharwan A, Heaton ND, Thursz M, Wendon JA, Mitry RR, Antoniades CG.

Crit Care Med. 2013 Nov;41(11):2543-50. doi: 10.1097/CCM.0b013e31829791a2.


Predicting the development of acute kidney injury in liver cirrhosis--an analysis of glomerular filtration rate, proteinuria and kidney injury biomarkers.

Slack AJ, McPhail MJ, Ostermann M, Bruce M, Sherwood R, Musto R, Dew T, Auzinger G, Bernal W, O'Grady J, Heneghan MA, Moore K, Wendon JA.

Aliment Pharmacol Ther. 2013 May;37(10):989-97. doi: 10.1111/apt.12299. Epub 2013 Apr 12.


Lessons from look-back in acute liver failure? A single centre experience of 3300 patients.

Bernal W, Hyyrylainen A, Gera A, Audimoolam VK, McPhail MJ, Auzinger G, Rela M, Heaton N, O'Grady JG, Wendon J, Williams R.

J Hepatol. 2013 Jul;59(1):74-80. doi: 10.1016/j.jhep.2013.02.010. Epub 2013 Feb 22.


Modulation of neural activation following treatment of hepatic encephalopathy.

McPhail MJ, Leech R, Grover VP, Fitzpatrick JA, Dhanjal NS, Crossey MM, Pflugrad H, Saxby BK, Wesnes K, Dresner MA, Waldman AD, Thomas HC, Taylor-Robinson SD.

Neurology. 2013 Mar 12;80(11):1041-7. doi: 10.1212/WNL.0b013e31828726e1. Epub 2013 Feb 20.


Endoscopic ultrasound guided fine needle aspiration for the diagnosis of pancreatic cystic neoplasms: a meta-analysis.

Thornton GD, McPhail MJ, Nayagam S, Hewitt MJ, Vlavianos P, Monahan KJ.

Pancreatology. 2013 Jan-Feb;13(1):48-57. doi: 10.1016/j.pan.2012.11.313. Epub 2012 Dec 4.


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