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Items: 1 to 50 of 84

1.

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning.

Johnstone TBC, McCarren HS, Spampanato J, Dudek FE, McDonough JH, Hogenkamp D, Gee KW.

Front Pharmacol. 2019 May 24;10:560. doi: 10.3389/fphar.2019.00560. eCollection 2019.

2.

Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital.

Jackson C, Ardinger C, Winter KM, McDonough JH, McCarren HS.

J Pharmacol Toxicol Methods. 2019 May - Jun;97:1-12. doi: 10.1016/j.vascn.2019.02.006. Epub 2019 Feb 19.

PMID:
30790623
3.

Comparative efficacy of valnoctamide and sec-butylpropylacetamide (SPD) in terminating nerve agent-induced seizures in pediatric rats.

Haines KM, Matson LM, Dunn EN, Ardinger CE, Lee-Stubbs R, Bibi D, McDonough JH, Bialer M.

Epilepsia. 2019 Feb;60(2):315-321. doi: 10.1111/epi.14630. Epub 2019 Jan 7.

PMID:
30615805
4.

Assessment of mouse strain differences in baseline esterase activities and toxic response to sarin.

Matson LM, Lee-Stubbs RB, Cadieux CL, Koenig JA, Ardinger CE, Chandler J, Johnson EA, Hoard-Fruchey HM, Shih TA, Cerasoli DM, McDonough JH.

Toxicology. 2018 Dec 1;410:10-15. doi: 10.1016/j.tox.2018.08.016. Epub 2018 Aug 30.

PMID:
30172647
5.

Behavioral, Pharmacokinetic, and Cardiovascular Evaluation of Candidate Oximes in African Green Monkeys.

Moffett MC, McDonough JH, McMonagle JD, Myers TM.

Int J Toxicol. 2018 Sep/Oct;37(5):352-363. doi: 10.1177/1091581818779362. Epub 2018 Jun 7.

PMID:
29879849
6.

Evaluating mice lacking serum carboxylesterase as a behavioral model for nerve agent intoxication.

Dunn EN, Ferrara-Bowens TM, Chachich ME, Honnold CL, Rothwell CC, Hoard-Fruchey HM, Lesyna CA, Johnson EA, Cerasoli DM, McDonough JH, Cadieux CL.

Toxicol Mech Methods. 2018 Oct;28(8):563-572. doi: 10.1080/15376516.2018.1476637. Epub 2018 Jun 7.

PMID:
29768075
7.

Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats.

Scholl EA, Miller-Smith SM, Bealer SL, Lehmkuhle MJ, Ekstrand JJ, Dudek FE, McDonough JH.

Neurotoxicology. 2018 May;66:10-21. doi: 10.1016/j.neuro.2018.02.018. Epub 2018 Mar 3.

8.

Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus.

McCarren HS, Arbutus JA, Ardinger C, Dunn EN, Jackson CE, McDonough JH.

Epilepsy Res. 2018 Mar;141:1-12. doi: 10.1016/j.eplepsyres.2018.01.010. Epub 2018 Jan 31.

9.

Plasma Concentration of Meloxicam in Pediatric Rats.

Pugh KA, Reitnauer KJ, Lee RB, Wilkins WL, McDonough JH, Pennington MR, Litvin SR.

J Am Assoc Lab Anim Sci. 2017 Nov 1;56(6):762-767.

10.

The role of genetic background in susceptibility to chemical warfare nerve agents across rodent and non-human primate models.

Matson LM, McCarren HS, Cadieux CL, Cerasoli DM, McDonough JH.

Toxicology. 2018 Jan 15;393:51-61. doi: 10.1016/j.tox.2017.11.003. Epub 2017 Nov 4. Review.

PMID:
29113833
11.

The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication.

Althaus AL, McCarren HS, Alqazzaz A, Jackson C, McDonough JH, Smith CD, Hoffman E, Hammond RS, Robichaud AJ, Doherty JJ.

Epilepsy Behav. 2017 Mar;68:22-30. doi: 10.1016/j.yebeh.2016.12.024. Epub 2017 Jan 18.

12.

Anticonvulsant discovery through animal models of status epilepticus induced by organophosphorus nerve agents and pesticides.

McCarren HS, McDonough JH Jr.

Ann N Y Acad Sci. 2016 Jun;1374(1):144-50. doi: 10.1111/nyas.13092. Epub 2016 Jun 3. Review.

PMID:
27258770
13.

Analysis of Nerve Agent Metabolites from Hair for Long-Term Verification of Nerve Agent Exposure.

Appel AS, McDonough JH, McMonagle JD, Logue BA.

Anal Chem. 2016 Jun 21;88(12):6523-30. doi: 10.1021/acs.analchem.6b01274. Epub 2016 May 29.

PMID:
27161086
14.

The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus.

Shekh-Ahmad T, Mawasi H, McDonough JH, Yagen B, Bialer M.

Epilepsy Behav. 2015 Aug;49:298-302. doi: 10.1016/j.yebeh.2015.04.012. Epub 2015 May 13. Review.

PMID:
25979572
15.

N-acetyl-aspartyl-glutamate and inhibition of glutamate carboxypeptidases protects against soman-induced neuropathology.

Guo H, Liu J, Van Shura K, Chen H, Flora MN, Myers TM, McDonough JH, McCabe JT.

Neurotoxicology. 2015 May;48:180-91. doi: 10.1016/j.neuro.2015.03.010. Epub 2015 Mar 28.

PMID:
25825357
16.

Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.

Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, Bialer M.

Epilepsia. 2014 Dec;55(12):1944-52. doi: 10.1111/epi.12857. Epub 2014 Nov 29.

17.

(-)-Phenserine attenuates soman-induced neuropathology.

Chen J, Pan H, Chen C, Wu W, Iskandar K, He J, Piermartiri T, Jacobowitz DM, Yu QS, McDonough JH, Greig NH, Marini AM.

PLoS One. 2014 Jun 23;9(6):e99818. doi: 10.1371/journal.pone.0099818. eCollection 2014.

18.

Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential.

Shekh-Ahmad T, Hen N, Yagen B, McDonough JH, Finnell RH, Wlodarczyk BJ, Bialer M.

Epilepsia. 2014 Feb;55(2):353-61. doi: 10.1111/epi.12480. Epub 2013 Dec 6.

19.

Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus.

Shekh-Ahmad T, Hen N, McDonough JH, Yagen B, Bialer M.

Epilepsia. 2013 Sep;54 Suppl 6:99-102. doi: 10.1111/epi.12290.

20.

Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus.

Hen N, Shekh-Ahmad T, Yagen B, McDonough JH, Finnell RH, Wlodarczyk B, Bialer M.

J Med Chem. 2013 Aug 22;56(16):6467-77. doi: 10.1021/jm4007565. Epub 2013 Aug 7.

PMID:
23879329
21.

Neuropharmacological specificity of brain structures involved in soman-induced seizures.

Skovira JW, Shih TM, McDonough JH.

Neurotoxicology. 2012 Jun;33(3):463-8. Epub 2012 Mar 20.

PMID:
22774227
22.

A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.

White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M.

Epilepsia. 2012 Jan;53(1):134-46. doi: 10.1111/j.1528-1167.2011.03338.x. Epub 2011 Dec 9. Erratum in: Epilepsia. 2012 Feb;53(2):397.

23.

Immunomodulation by poly-YE reduces organophosphate-induced brain damage.

Finkelstein A, Kunis G, Berkutzki T, Ronen A, Krivoy A, Yoles E, Last D, Mardor Y, Van Shura K, McFarland E, Capacio BA, Eisner C, Gonzales M, Gregorowicz D, Eisenkraft A, McDonough JH, Schwartz M.

Brain Behav Immun. 2012 Jan;26(1):159-69. doi: 10.1016/j.bbi.2011.09.002. Epub 2011 Sep 8.

PMID:
21925261
24.

In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate.

O'Donnell JC, McDonough JH, Shih TM.

Arch Toxicol. 2011 Dec;85(12):1607-16. doi: 10.1007/s00204-011-0724-z. Epub 2011 Jun 22.

PMID:
21695469
25.

The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs.

Shih TM, Guarisco JA, Myers TM, Kan RK, McDonough JH.

Toxicol Mech Methods. 2011 Jan;21(1):53-62. doi: 10.3109/15376516.2010.529190. Epub 2010 Nov 30.

PMID:
21117832
26.

Comparison of extracellular striatal acetylcholine and brain seizure activity following acute exposure to the nerve agents cyclosarin and tabun in freely moving guinea pigs.

O'Donnell JC, Acon-Chen C, McDonough JH, Shih TM.

Toxicol Mech Methods. 2010 Nov;20(9):600-8. doi: 10.3109/15376516.2010.521208. Epub 2010 Oct 4.

PMID:
20919801
27.

Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damage.

Angoa-Pérez M, Kreipke CW, Thomas DM, Van Shura KE, Lyman M, McDonough JH, Kuhn DM.

Neurotoxicology. 2010 Dec;31(6):738-46. doi: 10.1016/j.neuro.2010.06.007. Epub 2010 Jul 1.

28.

Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs.

McDonough JH, McMonagle JD, Shih TM.

Drug Chem Toxicol. 2010 Jul;33(3):279-83. doi: 10.3109/01480540903483417.

PMID:
20429808
29.

Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs.

Skovira JW, O'Donnell JC, Koplovitz I, Kan RK, McDonough JH, Shih TM.

Chem Biol Interact. 2010 Sep 6;187(1-3):318-24. doi: 10.1016/j.cbi.2010.03.010. Epub 2010 Mar 15.

PMID:
20230808
30.

In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Chem Biol Interact. 2010 Sep 6;187(1-3):207-14. doi: 10.1016/j.cbi.2010.03.006. Epub 2010 Mar 9.

PMID:
20223229
31.

Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs.

O'Donnell JC, McDonough JH, Shih TM.

Toxicol Mech Methods. 2010 Mar;20(3):143-52. doi: 10.3109/15376511003657439.

PMID:
20163292
32.

A liquid chromatographic-mass spectrometric (LC-MS) method for the analysis of the bis-pyridinium oxime ICD-585 in plasma: application in a guinea pig model.

Capacio BR, Dusick B, Smith JR, McDonough JH, Shih TM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 15;878(17-18):1420-5. doi: 10.1016/j.jchromb.2009.12.011. Epub 2009 Dec 16.

PMID:
20044318
33.

Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Toxicol Mech Methods. 2009 Sep;19(6-7):386-400. doi: 10.1080/15376510903213892.

PMID:
19778239
34.

In vivo oxime administration does not influence Ellman acetylcholinesterase assay results.

Guarisco JA, O'Donnell JC, Skovira JW, McDonough JH, Shih TM.

Toxicol Mech Methods. 2009 Sep;19(6-7):379-85. doi: 10.1080/15376510903234773.

PMID:
19778238
35.

Effects of 4-pyridine aldoxime on nerve agent-inhibited acetylcholinesterase activity in guinea pigs.

Shih TM, Skovira JW, McDonough JH.

Arch Toxicol. 2009 Dec;83(12):1083-9. doi: 10.1007/s00204-009-0465-4. Epub 2009 Sep 10.

PMID:
19763542
36.

Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801.

Skovira JW, McDonough JH, Shih TM.

J Mol Neurosci. 2010 Jan;40(1-2):56-62. doi: 10.1007/s12031-009-9253-0. Epub 2009 Aug 19.

PMID:
19690985
37.

Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

J Mol Neurosci. 2010 Jan;40(1-2):63-9. doi: 10.1007/s12031-009-9259-7. Epub 2009 Aug 13.

PMID:
19680820
38.

Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures.

McDonough JH, Van Shura KE, LaMont JC, McMonagle JD, Shih TM.

Basic Clin Pharmacol Toxicol. 2009 Jan;104(1):27-34. doi: 10.1111/j.1742-7843.2008.00326.x.

39.

Kinetics of sarin (GB) following a single sublethal inhalation exposure in the guinea pig.

Whalley CE, McGuire JM, Miller DB, Jakubowski EM, Mioduszewski RJ, Thomson SA, Lumley LA, McDonough JH, Shih TM.

Inhal Toxicol. 2007 Jun;19(8):667-81.

PMID:
17510839
40.

The Toxicity of Soman in the African Green Monkey (Chlorocebus aethiops).

Despain KE, McDonough JH, McMonagle JD, McGinley MJ, Evans J.

Toxicol Mech Methods. 2007;17(5):255-64. doi: 10.1080/15376510600972733.

PMID:
20020948
41.

Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine.

Shih TM, Rowland TC, McDonough JH.

J Pharmacol Exp Ther. 2007 Jan;320(1):154-61. Epub 2006 Oct 2.

PMID:
17015638
42.

The effects of repeated low-dose sarin exposure.

Shih TM, Hulet SW, McDonough JH.

Toxicol Appl Pharmacol. 2006 Sep 1;215(2):119-34. Epub 2006 Mar 23.

PMID:
16556454
43.

In vivo cholinesterase inhibitory specificity of organophosphorus nerve agents.

Shih TM, Kan RK, McDonough JH.

Chem Biol Interact. 2005 Dec 15;157-158:293-303. Epub 2005 Oct 26.

PMID:
16256093
44.

Pharmacokinetic studies of intramuscular midazolam in guinea pigs challenged with soman.

Capacio BR, Byers CE, Merk KA, Smith JR, McDonough JH.

Drug Chem Toxicol. 2004 May;27(2):95-110.

PMID:
15198070
45.

Effects of fosphenytoin on nerve agent-induced status epilepticus.

McDonough JH, Benjamin A, McMonagle JD, Rowland T, Shih TM.

Drug Chem Toxicol. 2004 Feb;27(1):27-39.

PMID:
15038246
46.

Control of nerve agent-induced seizures is critical for neuroprotection and survival.

Shih TM, Duniho SM, McDonough JH.

Toxicol Appl Pharmacol. 2003 Apr 15;188(2):69-80.

PMID:
12691725
47.

Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman.

Capacio BR, Byers CE, Caro ST, McDonough JH.

Drug Chem Toxicol. 2003 Feb;26(1):1-13.

PMID:
12643036
48.

The dose-response effects of repeated subacute sarin exposure on guinea pigs.

Hulet SW, McDonough JH, Shih TM.

Pharmacol Biochem Behav. 2002 Jul;72(4):835-45.

PMID:
12062573
49.

Intramuscular diazepam pharmacokinetics in soman-exposed guinea pigs.

Capacio BR, Whalley CE, Byers CE, McDonough JH.

J Appl Toxicol. 2001 Dec;21 Suppl 1:S67-74.

PMID:
11920923
50.

Isoflurane anesthesia for guinea pigs (Cavia porcella) in a stereotaxic surgical apparatus.

Ross MC, Zoeffel LD, McMonagle JD, McDonough JH.

Contemp Top Lab Anim Sci. 2000 Mar;39(2):43-6.

PMID:
11487240

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