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Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study.

Vatsalya V, Hassan HZ, Kong M, Stangl BL, Schwandt ML, Schmidt-Teron VY, Verster JC, Ramchandani VA, McClain CJ.

J Clin Med. 2019 Nov 12;8(11). pii: E1943. doi: 10.3390/jcm8111943.


Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice.

Zhao C, Liu L, Liu Q, Li F, Zhang L, Zhu F, Shao T, Barve S, Chen Y, Li X, McClain CJ, Feng W.

Mol Metab. 2019 Nov;29:145-157. doi: 10.1016/j.molmet.2019.08.020. Epub 2019 Sep 3.


Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury.

Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S.

Cell Mol Gastroenterol Hepatol. 2019 Oct 22. pii: S2352-345X(19)30141-9. doi: 10.1016/j.jcmgh.2019.10.005. [Epub ahead of print]


Decreased ω6/ω3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota and liver injury.

Warner DR, Warner JB, Hardesty JE, Song YL, King TN, Kang JX, Chen CY, Xie S, Yuan F, Prodhan MAI, Ma X, Zhang X, Rouchka EC, Maddipati KR, Whitlock J, Li EC, Wang GP, McClain CJ, Kirpich IA.

J Lipid Res. 2019 Oct 4. pii: jlr.RA119000200. doi: 10.1194/jlr.RA119000200. [Epub ahead of print]


Probiotic LGG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice.

Liu Y, Chen K, Li F, Gu Z, Liu Q, He L, Shao T, Song Q, Zhu F, Zhang L, Jiang M, Zhou Y, Barve S, Zhang X, McClain CJ, Feng W.

Hepatology. 2019 Sep 30. doi: 10.1002/hep.30975. [Epub ahead of print]


Integrating comprehensive two-dimensional gas chromatography mass spectrometry and parallel two-dimensional liquid chromatography mass spectrometry for untargeted metabolomics.

Prodhan MAI, Shi B, Song M, He L, Yuan F, Yin X, Bohman P, McClain CJ, Zhang X.

Analyst. 2019 Jul 21;144(14):4331-4341. doi: 10.1039/c9an00560a. Epub 2019 Jun 13.


Profiling of Polar Metabolites in Mouse Feces Using Four Analytical Platforms to Study the Effects Of Cathelicidin-Related Antimicrobial Peptide in Alcoholic Liver Disease.

He L, Li F, Yin X, Bohman P, Kim S, McClain CJ, Feng W, Zhang X.

J Proteome Res. 2019 Jul 5;18(7):2875-2884. doi: 10.1021/acs.jproteome.9b00181. Epub 2019 Jun 12.


Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation.

Kong X, Wu G, Chen S, Zhang L, Li F, Shao T, Ren L, Chen SY, Zhang H, McClain CJ, Feng W.

Alcohol Clin Exp Res. 2019 Aug;43(8):1662-1671. doi: 10.1111/acer.14120. Epub 2019 Jun 30.


Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition: Summary of the ISBRA 2018 Symposium.

Kirpich IA, Warner DR, Feng W, Joshi-Barve S, McClain CJ, Seth D, Zhong W, Zhou Z, Osna NA, Kharbanda KK.

Alcohol. 2019 May 23. pii: S0741-8329(19)30069-2. doi: 10.1016/j.alcohol.2019.05.004. [Epub ahead of print] Review.


Simultaneous Quantification of Nucleosides and Nucleotides from Biological Samples.

He L, Wei X, Ma X, Yin X, Song M, Donninger H, Yaddanapudi K, McClain CJ, Zhang X.

J Am Soc Mass Spectrom. 2019 Jun;30(6):987-1000. doi: 10.1007/s13361-019-02140-7. Epub 2019 Mar 7.


Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis.

Zhou Y, Vatsalya V, Gobejishvili L, Lamont RJ, McClain CJ, Feng W.

Hepatol Commun. 2018 Dec 14;3(2):293-304. doi: 10.1002/hep4.1296. eCollection 2019 Feb.


Introduction to the Virtual Issue "Translational Studies in AUD: Liver Disease".

Kirpich IA, McClain CJ.

Alcohol Clin Exp Res. 2019 Apr;43(4):593-596. doi: 10.1111/acer.13967. Epub 2019 Feb 27. No abstract available.


Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD.

Song M, Vos MB, McClain CJ.

Nutrients. 2018 Nov 21;10(11). pii: E1815. doi: 10.3390/nu10111815. Review.


Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota.

Teng Y, Ren Y, Sayed M, Hu X, Lei C, Kumar A, Hutchins E, Mu J, Deng Z, Luo C, Sundaram K, Sriwastva MK, Zhang L, Hsieh M, Reiman R, Haribabu B, Yan J, Jala VR, Miller DM, Van Keuren-Jensen K, Merchant ML, McClain CJ, Park JW, Egilmez NK, Zhang HG.

Cell Host Microbe. 2018 Nov 14;24(5):637-652.e8. doi: 10.1016/j.chom.2018.10.001. Epub 2018 Oct 25.


Alterations in Serum Zinc and Polyunsaturated Fatty Acid Concentrations in Treatment-Naive HIV-Diagnosed Alcohol-Dependent Subjects with Liver Injury.

Vatsalya V, Cave MC, Kumar R, Srivastava S, Khanal S, Jenson AB, Schwandt ML, Barve SS, Ramchandani VA, McClain CJ.

AIDS Res Hum Retroviruses. 2019 Jan;35(1):92-99. doi: 10.1089/AID.2018.0124. Epub 2018 Dec 11.


Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease.

Warner DR, Liu H, Ghosh Dastidar S, Warner JB, Prodhan MAI, Yin X, Zhang X, Feldstein AE, Gao B, Prough RA, McClain CJ, Kirpich IA.

PLoS One. 2018 Sep 26;13(9):e0204119. doi: 10.1371/journal.pone.0204119. eCollection 2018.


Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice.

Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE.

J Lipid Res. 2018 Sep;59(9):1597-1609. doi: 10.1194/jlr.M083741. Epub 2018 Jul 3.


Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice.

Ramsden CE, Hennebelle M, Schuster S, Keyes GS, Johnson CD, Kirpich IA, Dahlen JE, Horowitz MS, Zamora D, Feldstein AE, McClain CJ, Muhlhausler BS, Makrides M, Gibson RA, Taha AY.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1206-1213. doi: 10.1016/j.bbalip.2018.07.007. Epub 2018 Jul 25.


Association of serum zinc with markers of liver injury in very heavy drinking alcohol-dependent patients.

Vatsalya V, Kong M, Cave MC, Liu N, Schwandt ML, George DT, Ramchandani VA, McClain CJ.

J Nutr Biochem. 2018 Sep;59:49-55. doi: 10.1016/j.jnutbio.2018.05.003. Epub 2018 May 12.


Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction.

Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W.

J Hepatol. 2018 Oct;69(4):886-895. doi: 10.1016/j.jhep.2018.05.021. Epub 2018 May 25.


Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV.

Moghe A, Barve SS, McClain CJ, Joshi-Barve S.

Cell Mol Gastroenterol Hepatol. 2017 Dec 9;5(2):163-164. doi: 10.1016/j.jcmgh.2017.11.009. eCollection 2018. No abstract available.


Liver Disease in a Residential Cohort With Elevated Polychlorinated Biphenyl Exposures.

Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC.

Toxicol Sci. 2018 Jul 1;164(1):39-49. doi: 10.1093/toxsci/kfy076.


Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.

Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA.

Biomolecules. 2018 Mar 26;8(2). pii: E16. doi: 10.3390/biom8020016.


Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration.

Ghosh Dastidar S, Warner JB, Warner DR, McClain CJ, Kirpich IA.

Biomolecules. 2018 Jan 13;8(1). pii: E3. doi: 10.3390/biom8010003. Review.


Dietary copper-fructose interactions alter gut microbial activity in male rats.

Song M, Li X, Zhang X, Shi H, Vos MB, Wei X, Wang Y, Gao H, Rouchka EC, Yin X, Zhou Z, Prough RA, Cave MC, McClain CJ.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G119-G130. doi: 10.1152/ajpgi.00378.2016. Epub 2017 Oct 12.


Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability.

Chen WY, Wang M, Zhang J, Barve SS, McClain CJ, Joshi-Barve S.

Am J Pathol. 2017 Dec;187(12):2686-2697. doi: 10.1016/j.ajpath.2017.08.015. Epub 2017 Sep 19.


Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.

Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA.

Am J Pathol. 2017 Oct;187(10):2232-2245. doi: 10.1016/j.ajpath.2017.06.008.


Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling.

Kong X, Yang Y, Ren L, Shao T, Li F, Zhao C, Liu L, Zhang H, McClain CJ, Feng W.

Sci Rep. 2017 Aug 24;7(1):9292. doi: 10.1038/s41598-017-09045-z.


Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation.

Avila DV, Myers SA, Zhang J, Kharebava G, McClain CJ, Kim HY, Whittemore SR, Gobejishvili L, Barve S.

Neuropharmacology. 2017 Oct;125:376-385. doi: 10.1016/j.neuropharm.2017.08.011. Epub 2017 Aug 12.


Rate of hepatitis C viral clearance by human livers in human patients: Liver transplantation modeling primary infection and implications for studying entry inhibition.

Hughes MG Jr, Tucker WW, Reddy S, Brier ME, Koch D, McClain CJ, Jonsson CB, Matoba N, Chung D.

PLoS One. 2017 Jul 21;12(7):e0180719. doi: 10.1371/journal.pone.0180719. eCollection 2017.


Analysis of Stable Isotope Assisted Metabolomics Data Acquired by High Resolution Mass Spectrometry.

Wei X, Lorkiewicz PK, Shi B, Salabei JK, Hill BG, Kim S, McClain CJ, Zhang X.

Anal Methods. 2017 Apr 21;9(15):2275-2283. doi: 10.1039/C7AY00291B. Epub 2017 Mar 10.


Low Hepatic Tissue Copper in Pediatric Nonalcoholic Fatty Liver Disease.

Mendoza M, Caltharp S, Song M, Collin L, Konomi JV, McClain CJ, Vos MB.

J Pediatr Gastroenterol Nutr. 2017 Jul;65(1):89-92. doi: 10.1097/MPG.0000000000001571.


Analysis of stable isotope assisted metabolomics data acquired by GC-MS.

Wei X, Shi B, Koo I, Yin X, Lorkiewicz P, Suhail H, Rattan R, Giri S, McClain CJ, Zhang X.

Anal Chim Acta. 2017 Aug 8;980:25-32. doi: 10.1016/j.aca.2017.05.002. Epub 2017 May 13.


Summary Points and Consensus Recommendations From the International Protein Summit.

Hurt RT, McClave SA, Martindale RG, Ochoa Gautier JB, Coss-Bu JA, Dickerson RN, Heyland DK, Hoffer LJ, Moore FA, Morris CR, Paddon-Jones D, Patel JJ, Phillips SM, Rugeles SJ, Sarav Md M, Weijs PJ, Wernerman J, Hamilton-Reeves J, McClain CJ, Taylor B.

Nutr Clin Pract. 2017 Apr;32(1_suppl):142S-151S. doi: 10.1177/0884533617693610.


Protein and Calorie Requirements Associated With the Presence of Obesity.

Dickerson RN, Patel JJ, McClain CJ.

Nutr Clin Pract. 2017 Apr;32(1_suppl):86S-93S. doi: 10.1177/0884533617691745. Epub 2017 Feb 1. Review.


Protein Requirements for Critically Ill Patients With Renal and Liver Failure.

Patel JJ, McClain CJ, Sarav M, Hamilton-Reeves J, Hurt RT.

Nutr Clin Pract. 2017 Apr;32(1_suppl):101S-111S. doi: 10.1177/0884533616687501. Epub 2017 Feb 16.


Nutrition Support for Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.

Moore FA, Phillips SM, McClain CJ, Patel JJ, Martindale RG.

Nutr Clin Pract. 2017 Apr;32(1_suppl):121S-127S. doi: 10.1177/0884533616687502. Epub 2017 Feb 6.


Liver Injury and Endotoxemia in Male and Female Alcohol-Dependent Individuals Admitted to an Alcohol Treatment Program.

Kirpich IA, McClain CJ, Vatsalya V, Schwandt M, Phillips M, Falkner KC, Zhang L, Harwell C, George DT, Umhau JC.

Alcohol Clin Exp Res. 2017 Apr;41(4):747-757. doi: 10.1111/acer.13346. Epub 2017 Mar 2.


A Review on the Sex Differences in Organ and System Pathology with Alcohol Drinking.

Vatsalya V, Liaquat HB, Ghosh K, Mokshagundam SP, McClain CJ.

Curr Drug Abuse Rev. 2016;9(2):87-92. doi: 10.2174/1874473710666170125151410. Review.


Medical Management of Severe Alcoholic Hepatitis: Expert Review from the Clinical Practice Updates Committee of the AGA Institute.

Mitchell MC, Friedman LS, McClain CJ.

Clin Gastroenterol Hepatol. 2017 Jan;15(1):5-12. doi: 10.1016/j.cgh.2016.08.047. Review.


Nutrition in Patients With Cirrhosis.

McClain CJ.

Gastroenterol Hepatol (N Y). 2016 Aug;12(8):507-510. No abstract available.


Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome.

Guardiola JJ, Beier JI, Falkner KC, Wheeler B, McClain CJ, Cave M.

Toxicol Appl Pharmacol. 2016 Dec 15;313:47-56. doi: 10.1016/j.taap.2016.10.001. Epub 2016 Oct 17.


Role of dietary fatty acids in liver injury caused by vinyl chloride metabolites in mice.

Anders LC, Yeo H, Kaelin BR, Lang AL, Bushau AM, Douglas AN, Cave M, Arteel GE, McClain CJ, Beier JI.

Toxicol Appl Pharmacol. 2016 Nov 15;311:34-41. doi: 10.1016/j.taap.2016.09.026. Epub 2016 Sep 28.


Safety Assessment of Liver Injury with Quetiapine Fumarate XR Management in Very Heavy Drinking Alcohol-Dependent Patients.

Vatsalya V, Pandey A, Schwandt ML, Cave MC, Barve SS, Ramchandani VA, McClain CJ.

Clin Drug Investig. 2016 Nov;36(11):935-944.


Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients.

Vatsalya V, Song M, Schwandt ML, Cave MC, Barve SS, George DT, Ramchandani VA, McClain CJ.

Alcohol Clin Exp Res. 2016 Oct;40(10):2085-2093. doi: 10.1111/acer.13197. Epub 2016 Sep 2.


Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.

Osna NA, Carter WG, Ganesan M, Kirpich IA, McClain CJ, Petersen DR, Shearn CT, Tomasi ML, Kharbanda KK.

World J Gastroenterol. 2016 Jul 21;22(27):6192-200. doi: 10.3748/wjg.v22.i27.6192. Review.


Direct Peritoneal Resuscitation Alters Hepatic miRNA Expression after Hemorrhagic Shock.

Weaver JL, Matheson PJ, Hurt RT, Downard CD, McClain CJ, Garrison RN, Smith JW.

J Am Coll Surg. 2016 Jul;223(1):68-75. doi: 10.1016/j.jamcollsurg.2016.03.024. Epub 2016 Mar 26.


Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.

Avila DV, Barker DF, Zhang J, McClain CJ, Barve S, Gobejishvili L.

J Pathol. 2016 Sep;240(1):96-107. doi: 10.1002/path.4760.


Liver Injury Assessment by Vetscan VS2 Analyzer and Most Frequently Used ALT/GTP Reagent.

Vatsalya V, Avila D, Frimodig JC, Barve SS, McClain CJ, Gobejishvili L.

Gastroenterol Hepatol (Bartlesville). 2016;4(4). pii: 107. Epub 2016 Apr 13.

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