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Items: 50

1.

Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments.

Horvat S, McWhir J, Rozman D.

Drug Metab Rev. 2011 Feb;43(1):69-90. doi: 10.3109/03602532.2010.540580. Review.

PMID:
21247357
2.

Transcriptome alterations due to physiological normoxic (2% O2) culture of human embryonic stem cells.

Forsyth NR, Kay A, Hampson K, Downing A, Talbot R, McWhir J.

Regen Med. 2008 Nov;3(6):817-33. doi: 10.2217/17460751.3.6.817.

3.

Sequential genetic modification of the hprt locus in human ESCs combining gene targeting and recombinase-mediated cassette exchange.

Di Domenico AI, Christodoulou I, Pells SC, McWhir J, Thomson AJ.

Cloning Stem Cells. 2008 Jun;10(2):217-30. doi: 10.1089/clo.2008.0016.

PMID:
18386992
4.

Bone tissue formation from human embryonic stem cells in vivo.

Tremoleda JL, Forsyth NR, Khan NS, Wojtacha D, Christodoulou I, Tye BJ, Racey SN, Collishaw S, Sottile V, Thomson AJ, Simpson AH, Noble BS, McWhir J.

Cloning Stem Cells. 2008 Mar;10(1):119-32. doi: 10.1089/clo.2007.0R36.

PMID:
18241129
5.

Human embryonic stem cells passaged using enzymatic methods retain a normal karyotype and express CD30.

Thomson A, Wojtacha D, Hewitt Z, Priddle H, Sottile V, Di Domenico A, Fletcher J, Waterfall M, Corrales NL, Ansell R, McWhir J.

Cloning Stem Cells. 2008 Mar;10(1):89-106. doi: 10.1089/clo.2007.0072.

PMID:
18241127
6.
7.

Viable offspring derived from fetal and adult mammalian cells.

Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH.

Cloning Stem Cells. 2007 Spring;9(1):3-7. No abstract available.

PMID:
17386005
8.

Fluorescence-activated single cell sorting of human embryonic stem cells.

Hewitt Z, Forsyth NR, Waterfall M, Wojtacha D, Thomson AJ, McWhir J.

Cloning Stem Cells. 2006 Fall;8(3):225-34.

PMID:
17009898
9.

Nuclear reprogramming of somatic cells by embryonic stem cells is affected by cell cycle stage.

Sullivan S, Pells S, Hooper M, Gallagher E, McWhir J.

Cloning Stem Cells. 2006 Fall;8(3):174-88.

PMID:
17009894
10.

Ablation of undifferentiated human embryonic stem cells: exploiting innate immunity against the Gal alpha1-3Galbeta1-4GlcNAc-R (alpha-Gal) epitope.

Hewitt Z, Priddle H, Thomson AJ, Wojtacha D, McWhir J.

Stem Cells. 2007 Jan;25(1):10-8. Epub 2006 Sep 7.

11.

Routine culture and differentiation of human embryonic stem cells.

McWhir J, Wojtacha D, Thomson A.

Methods Mol Biol. 2006;331:77-90.

PMID:
16881510
12.

Quantification of cell fusion by flow cytometry.

Sullivan S, Waterfall M, Gallagher EJ, McWhir J, Pells S.

Methods Mol Biol. 2006;325:81-97.

PMID:
16761721
13.

Conventional gene targeting protocols lead to loss of targeted cells when applied to a silent gene locus in primary fibroblasts.

Marques MM, Thomson AJ, McCreath KJ, McWhir J.

J Biotechnol. 2006 Sep 1;125(2):185-93. Epub 2006 Apr 18.

PMID:
16621085
14.

Physiologic oxygen enhances human embryonic stem cell clonal recovery and reduces chromosomal abnormalities.

Forsyth NR, Musio A, Vezzoni P, Simpson AH, Noble BS, McWhir J.

Cloning Stem Cells. 2006;8(1):16-23.

PMID:
16571074
15.

Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs', results in higher gene targeting efficiency.

Domínguez-Bendala J, Masutani M, McWhir J.

Cell Biol Int. 2006 Apr;30(4):389-93. Epub 2006 Feb 28.

PMID:
16504547
17.
18.

Immortalized fibroblast-like cells derived from human embryonic stem cells support undifferentiated cell growth.

Xu C, Jiang J, Sottile V, McWhir J, Lebkowski J, Carpenter MK.

Stem Cells. 2004;22(6):972-80.

19.

Biomedical and agricultural applications of animal transgenesis.

Thomson AJ, McWhir J.

Mol Biotechnol. 2004 Jul;27(3):231-44. Review.

PMID:
15247496
20.

Enhanced gene targeting frequency in ES cells with low genomic methylation levels.

Domínguez-Bendala J, McWhir J.

Transgenic Res. 2004 Feb;13(1):69-74.

PMID:
15070077
21.

Studying nuclear reprogramming with cell hybrids.

Pells S, McWhir J.

Methods Mol Biol. 2004;254:301-12. No abstract available.

PMID:
15041770
22.

The derivation of murine embryonic stem and embryonic germ cells by selective ablation.

Gallagher EJ, McWhir J.

Methods Mol Biol. 2004;254:99-112. No abstract available.

PMID:
15041758
23.

Gene targeting in livestock.

Thomson AJ, Marques MM, McWhir J.

Reprod Suppl. 2003;61:495-508. Review.

PMID:
14635957
24.

Effects of donor oocytes and culture conditions on development of cloned mice embryos.

Gao S, McGarry M, Priddle H, Ferrier T, Gasparrini B, Fletcher J, Harkness L, De Sousa P, McWhir J, Wilmut I.

Mol Reprod Dev. 2003 Oct;66(2):126-33.

PMID:
12950099
25.

In vitro osteogenic differentiation of human ES cells.

Sottile V, Thomson A, McWhir J.

Cloning Stem Cells. 2003;5(2):149-55.

PMID:
12930627
26.

Challenges and prospects for targeted transgenesis in livestock. Practical applications of gene targeting.

Marques MM, Thomson AJ, McWhir J.

Adv Exp Med Biol. 2003;534:265-78. No abstract available.

PMID:
12903726
27.

Human embryonic stem cells--realising the potential.

McWhir J, Thomson A, Sottile V.

Adv Exp Med Biol. 2003;534:11-25. No abstract available.

PMID:
12903708
28.

Isolation of murine embryonic stem and embryonic germ cells by selective ablation.

Gallagher EJ, Lodge P, Ansell R, McWhir J.

Transgenic Res. 2003 Aug;12(4):451-60.

PMID:
12885166
29.
30.

Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors.

Smith-Arica JR, Thomson AJ, Ansell R, Chiorini J, Davidson B, McWhir J.

Cloning Stem Cells. 2003;5(1):51-62.

PMID:
12713701
31.

Multipotentiality of neuronal cells after spontaneous fusion with embryonic stem cells and nuclear reprogramming in vitro.

Pells S, Di Domenico AI, Gallagher EJ, McWhir J.

Cloning Stem Cells. 2002;4(4):331-8.

PMID:
12630412
32.

Effect of cell confluence on production of cloned mice using an inbred embryonic stem cell line.

Gao S, McGarry M, Ferrier T, Pallante B, Priddle H, Gasparrini B, Fletcher J, Harkness L, De Sousa P, McWhir J, Wilmut I.

Biol Reprod. 2003 Feb;68(2):595-603. Erratum in: Biol Reprod. 2003 Mar;68(3):1078.

PMID:
12533424
33.

Biomedical and agricultural applications of animal transgenesis.

McWhir J.

Methods Mol Biol. 2002;180:3-23. Review. No abstract available.

PMID:
11873657
34.

Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland.

Clark AJ, Neil C, Gusterson B, McWhir J, Binas B.

Transgenic Res. 2000 Dec;9(6):439-44.

PMID:
11206972
35.

Pre-selection of integration sites imparts repeatable transgene expression.

Wallace H, Ansell R, Clark J, McWhir J.

Nucleic Acids Res. 2000 Mar 15;28(6):1455-64.

36.

Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization.

Binas B, Danneberg H, McWhir J, Mullins L, Clark AJ.

FASEB J. 1999 May;13(8):805-12.

PMID:
10224224
37.

Insertion of a foreign gene into the beta-casein locus by Cre-mediated site-specific recombination.

Kolb AF, Ansell R, McWhir J, Siddell SG.

Gene. 1999 Feb 4;227(1):21-31.

PMID:
9931414
38.

DNA microsatellite analysis of Dolly.

Ashworth D, Bishop M, Campbell K, Colman A, Kind A, Schnieke A, Blott S, Griffin H, Haley C, McWhir J, Wilmut I.

Nature. 1998 Jul 23;394(6691):329. No abstract available.

PMID:
9690467
39.

Viable offspring derived from fetal and adult mammalian cells.

Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH.

Nature. 1997 Feb 27;385(6619):810-3. Erratum in: Nature 1997 Mar 13;386(6621):200.

PMID:
9039911
40.

Selective ablation of differentiated cells permits isolation of embryonic stem cell lines from murine embryos with a non-permissive genetic background.

McWhir J, Schnieke AE, Ansell R, Wallace H, Colman A, Scott AR, Kind AJ.

Nat Genet. 1996 Oct;14(2):223-6.

PMID:
8841201
41.

Implications of cloning.

Campbell KH, McWhir J, Ritchie WA, Wilmut I.

Nature. 1996 Apr 4;380(6573):383. No abstract available.

PMID:
8602231
42.

Sheep cloned by nuclear transfer from a cultured cell line.

Campbell KH, McWhir J, Ritchie WA, Wilmut I.

Nature. 1996 Mar 7;380(6569):64-6.

PMID:
8598906
43.
44.

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning.

McWhir J, Selfridge J, Harrison DJ, Squires S, Melton DW.

Nat Genet. 1993 Nov;5(3):217-24.

PMID:
8275084
45.

In vivo analysis of Pim-1 deficiency.

Laird PW, van der Lugt NM, Clarke A, Domen J, Linders K, McWhir J, Berns A, Hooper M.

Nucleic Acids Res. 1993 Oct 11;21(20):4750-5.

46.

Isolation and cultivation of blastocyst-derived stem cell lines from American mink (Mustela vison).

Sukoyan MA, Golubitsa AN, Zhelezova AI, Shilov AG, Vatolin SY, Maximovsky LP, Andreeva LE, McWhir J, Pack SD, Bayborodin SI, et al.

Mol Reprod Dev. 1992 Dec;33(4):418-31.

PMID:
1282024
47.

A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency.

Magin TM, McWhir J, Melton DW.

Nucleic Acids Res. 1992 Jul 25;20(14):3795-6. No abstract available.

48.

Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: inactivation of the mouse ERCC-1 gene.

Selfridge J, Pow AM, McWhir J, Magin TM, Melton DW.

Somat Cell Mol Genet. 1992 Jul;18(4):325-36.

PMID:
1440055
49.

Incidence and inheritance of the 1/29 and 14/20 Robertsonian translocations in Canadian beef cattle.

McWhir J, Church RB, Coulter GH, Lin CC.

Genome. 1987 Jun;29(3):504-9.

PMID:
3609742
50.

Prediction of traits at constant finish for performance-tested beef cattle.

McWhir J, Wilton JW.

J Anim Sci. 1986 Oct;63(4):1108-18.

PMID:
3771394

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