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Items: 1 to 50 of 74

1.

Chronic voluntary ethanol drinking in cynomolgus macaques elicits gene expression changes in prefrontal cortical area 46.

Walter NAR, Zheng CL, Searles RP, McWeeney SK, Grant KA, Hitzemann R.

Alcohol Clin Exp Res. 2019 Dec 16. doi: 10.1111/acer.14259. [Epub ahead of print]

PMID:
31840818
2.

Acute myeloid leukemia-induced T-cell suppression can be reversed by inhibition of the MAPK pathway.

Moshofsky KB, Cho HJ, Wu G, Romine KA, Newman MT, Kosaka Y, McWeeney SK, Lind EF.

Blood Adv. 2019 Oct 22;3(20):3038-3051. doi: 10.1182/bloodadvances.2019000574.

3.

ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.

Luo X, Feurstein S, Mohan S, Porter CC, Jackson SA, Keel S, Chicka M, Brown AL, Kesserwan C, Agarwal A, Luo M, Li Z, Ross JE, Baliakas P, Pineda-Alvarez D, DiNardo CD, Bertuch AA, Mehta N, Vulliamy T, Wang Y, Nichols KE, Malcovati L, Walsh MF, Rawlings LH, McWeeney SK, Soulier J, Raimbault A, Routbort MJ, Zhang L, Ryan G, Speck NA, Plon SE, Wu D, Godley LA.

Blood Adv. 2019 Oct 22;3(20):2962-2979. doi: 10.1182/bloodadvances.2019000644.

4.

Immune predictors of mortality following RNA virus infection.

Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schäfer A, Plante KS, Morrison CR, Voss KM, Green R, Choonoo G, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Heise MT, Baric RS, Lund JM.

J Infect Dis. 2019 Oct 17. pii: jiz531. doi: 10.1093/infdis/jiz531. [Epub ahead of print]

PMID:
31621854
5.

Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma.

Choonoo G, Blucher AS, Higgins S, Boardman M, Jeng S, Zheng C, Jacobs J, Anderson A, Chamberlin S, Evans N, Vigoda M, Cordier B, Tyner JW, Kulesz-Martin M, McWeeney SK, Laderas T.

PLoS One. 2019 Oct 9;14(10):e0223639. doi: 10.1371/journal.pone.0223639. eCollection 2019.

6.

Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance.

Michaelis KA, Norgard MA, Levasseur PR, Olson B, Burfeind KG, Buenafe AC, Zhu X, Jeng S, McWeeney SK, Marks DL.

Brain Behav Immun. 2019 Nov;82:338-353. doi: 10.1016/j.bbi.2019.09.004. Epub 2019 Sep 6.

7.

Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz.

Blucher AS, McWeeney SK, Stein L, Wu G.

F1000Res. 2019 Jun 20;8:908. doi: 10.12688/f1000research.19592.1. eCollection 2019.

8.

Genomic landscape of neutrophilic leukemias of ambiguous diagnosis.

Zhang H, Wilmot B, Bottomly D, Dao KT, Stevens E, Eide CA, Khanna V, Rofelty A, Savage S, Reister Schultz A, Long N, White L, Carlos A, Henson R, Lin C, Searles R, Collins RH, DeAngelo DJ, Deininger MW, Dunn T, Hein T, Luskin MR, Medeiros BC, Oh ST, Pollyea DA, Steensma DP, Stone RM, Druker BJ, McWeeney SK, Maxson JE, Gotlib JR, Tyner JW.

Blood. 2019 Sep 12;134(11):867-879. doi: 10.1182/blood.2019000611. Epub 2019 Jul 31.

PMID:
31366621
9.

The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells.

Nechiporuk T, Kurtz SE, Nikolova O, Liu T, Jones CL, D'Alessandro A, Culp-Hill R, d'Almeida A, Joshi SK, Rosenberg M, Tognon CE, Danilov AV, Druker BJ, Chang BH, McWeeney SK, Tyner JW.

Cancer Discov. 2019 Jul;9(7):910-925. doi: 10.1158/2159-8290.CD-19-0125. Epub 2019 May 2.

PMID:
31048320
10.

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.

Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, Wilmot B, McWeeney SK, Eide CA, Nechiporuk T, Carlos A, Henson R, Lin C, Searles R, Ho H, Lam YL, Sweat R, Follit C, Jain V, Lind E, Borthakur G, Garcia-Manero G, Ravandi F, Kantarjian HM, Cortes J, Collins R, Buelow DR, Baker SD, Druker BJ, Tyner JW.

Nat Commun. 2019 Jan 16;10(1):244. doi: 10.1038/s41467-018-08263-x.

11.

Predicting response to BET inhibitors using computational modeling: A BEAT AML project study.

Drusbosky LM, Vidva R, Gera S, Lakshminarayana AV, Shyamasundar VP, Agrawal AK, Talawdekar A, Abbasi T, Vali S, Tognon CE, Kurtz SE, Tyner JW, McWeeney SK, Druker BJ, Cogle CR.

Leuk Res. 2019 Feb;77:42-50. doi: 10.1016/j.leukres.2018.11.010. Epub 2019 Jan 7.

12.

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.

Edwards DK 5th, Watanabe-Smith K, Rofelty A, Damnernsawad A, Laderas T, Lamble A, Lind EF, Kaempf A, Mori M, Rosenberg M, d'Almeida A, Long N, Agarwal A, Sweeney DT, Loriaux M, McWeeney SK, Tyner JW.

Blood. 2019 Feb 7;133(6):588-599. doi: 10.1182/blood-2018-03-838946. Epub 2018 Nov 13.

PMID:
30425048
13.

Functional genomic landscape of acute myeloid leukaemia.

Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DK 5th, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, McWeeney SK, Druker BJ.

Nature. 2018 Oct;562(7728):526-531. doi: 10.1038/s41586-018-0623-z. Epub 2018 Oct 17.

14.

Community profiling of the urinary microbiota: considerations for low-biomass samples.

Karstens L, Asquith M, Caruso V, Rosenbaum JT, Fair DA, Braun J, Gregory WT, Nardos R, McWeeney SK.

Nat Rev Urol. 2018 Dec;15(12):735-749. doi: 10.1038/s41585-018-0104-z. Review.

15.

Cross-species molecular dissection across alcohol behavioral domains.

Farris SP, Riley BP, Williams RW, Mulligan MK, Miles MF, Lopez MF, Hitzemann R, Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Mayfield RD.

Alcohol. 2018 Nov;72:19-31. doi: 10.1016/j.alcohol.2017.11.036. Epub 2017 Dec 6. Review.

16.

Regional Differences and Similarities in the Brain Transcriptome for Mice Selected for Ethanol Preference From HS-CC Founders.

Colville AM, Iancu OD, Lockwood DR, Darakjian P, McWeeney SK, Searles R, Zheng C, Hitzemann R.

Front Genet. 2018 Aug 28;9:300. doi: 10.3389/fgene.2018.00300. eCollection 2018.

17.

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.

Jenkins C, Luty SB, Maxson JE, Eide CA, Abel ML, Togiai C, Nemecek ER, Bottomly D, McWeeney SK, Wilmot B, Loriaux M, Chang BH, Tyner JW.

Sci Signal. 2018 Jul 17;11(539). pii: eaao5617. doi: 10.1126/scisignal.aao5617.

18.

Network-Based Predictors of Progression in Head and Neck Squamous Cell Carcinoma.

Sanati N, Iancu OD, Wu G, Jacobs JE, McWeeney SK.

Front Genet. 2018 May 29;9:183. doi: 10.3389/fgene.2018.00183. eCollection 2018.

19.

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples.

Edwards V DK, Sweeney DT, Ho H, Eide CA, Rofelty A, Agarwal A, Liu SQ, Danilov AV, Lee P, Chantry D, McWeeney SK, Druker BJ, Tyner JW, Spurgeon SE, Loriaux MM.

Oncotarget. 2018 May 15;9(37):24576-24589. doi: 10.18632/oncotarget.25191. eCollection 2018 May 15.

20.

Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models.

Ouyang X, Barling A, Lesch A, Tyner JW, Choonoo G, Zheng C, Jeng S, West TM, Clayburgh D, Courtneidge SA, McWeeney SK, Kulesz-Martin M.

Cancer Biol Ther. 2018;19(10):921-933. doi: 10.1080/15384047.2018.1451285. Epub 2018 Aug 17.

21.

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.

Sehrawat A, Gao L, Wang Y, Bankhead A 3rd, McWeeney SK, King CJ, Schwartzman J, Urrutia J, Bisson WH, Coleman DJ, Joshi SK, Kim DH, Sampson DA, Weinmann S, Kallakury BVS, Berry DL, Haque R, Van Den Eeden SK, Sharma S, Bearss J, Beer TM, Thomas GV, Heiser LM, Alumkal JJ.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188. doi: 10.1073/pnas.1719168115. Epub 2018 Mar 26.

22.

Working Memory and Vigilance as Multivariate Endophenotypes Related to Common Genetic Risk for Attention-Deficit/Hyperactivity Disorder.

Nigg JT, Gustafsson HC, Karalunas SL, Ryabinin P, McWeeney SK, Faraone SV, Mooney MA, Fair DA, Wilmot B.

J Am Acad Child Adolesc Psychiatry. 2018 Mar;57(3):175-182. doi: 10.1016/j.jaac.2017.12.013. Epub 2018 Jan 9.

23.

Integration of genomic, transcriptomic and functional profiles of aggressive osteosarcomas across multiple species.

Davis LE, Jeng S, Svalina MN, Huang E, Pittsenbarger J, Cantor EL, Berlow N, Seguin B, Mansoor A, McWeeney SK, Keller C.

Oncotarget. 2017 Jul 25;8(44):76241-76256. doi: 10.18632/oncotarget.19532. eCollection 2017 Sep 29.

24.

Evidence-Based Precision Oncology with the Cancer Targetome.

Blucher AS, Choonoo G, Kulesz-Martin M, Wu G, McWeeney SK.

Trends Pharmacol Sci. 2017 Dec;38(12):1085-1099. doi: 10.1016/j.tips.2017.08.006. Epub 2017 Sep 27. Review.

25.

Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function.

Zhang H, Means S, Schultz AR, Watanabe-Smith K, Medeiros BC, Bottomly D, Wilmot B, McWeeney SK, Kükenshöner T, Hantschel O, Tyner JW.

Cancer Res. 2017 Aug 15;77(16):4258-4267. doi: 10.1158/0008-5472.CAN-17-1052. Epub 2017 Jun 26.

26.

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations.

Zhang H, Reister Schultz A, Luty S, Rofelty A, Su Y, Means S, Bottomly D, Wilmot B, McWeeney SK, Tyner JW.

Leukemia. 2017 Dec;31(12):2752-2760. doi: 10.1038/leu.2017.126. Epub 2017 Apr 25.

27.

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia.

Carey A, Edwards DK 5th, Eide CA, Newell L, Traer E, Medeiros BC, Pollyea DA, Deininger MW, Collins RH, Tyner JW, Druker BJ, Bagby GC, McWeeney SK, Agarwal A.

Cell Rep. 2017 Mar 28;18(13):3204-3218. doi: 10.1016/j.celrep.2017.03.018.

28.

On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome.

Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Hitzemann R.

Addict Biol. 2018 Jan;23(1):196-205. doi: 10.1111/adb.12501. Epub 2017 Feb 28.

29.

A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection.

Smith JL, Jeng S, McWeeney SK, Hirsch AJ.

J Virol. 2017 Mar 29;91(8). pii: e02388-16. doi: 10.1128/JVI.02388-16. Print 2017 Apr 15.

30.

REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.

Monaghan CE, Nechiporuk T, Jeng S, McWeeney SK, Wang J, Rosenfeld MG, Mandel G.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E406-E415. doi: 10.1073/pnas.1620230114. Epub 2017 Jan 3.

31.

Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity?

Karstens L, Asquith M, Davin S, Stauffer P, Fair D, Gregory WT, Rosenbaum JT, McWeeney SK, Nardos R.

Front Cell Infect Microbiol. 2016 Jul 27;6:78. doi: 10.3389/fcimb.2016.00078. eCollection 2016.

32.

Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach.

Mooney MA, McWeeney SK, Faraone SV, Hinney A, Hebebrand J; IMAGE2 Consortium; German ADHD GWAS Group, Nigg JT, Wilmot B.

Am J Med Genet B Neuropsychiatr Genet. 2016 Sep;171(6):815-26. doi: 10.1002/ajmg.b.32446. Epub 2016 Mar 22.

33.

HitWalker2: visual analytics for precision medicine and beyond.

Bottomly D, McWeeney SK, Wilmot B.

Bioinformatics. 2016 Apr 15;32(8):1253-5. doi: 10.1093/bioinformatics/btv739. Epub 2015 Dec 26.

34.

Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.

Maxson JE, Abel ML, Wang J, Deng X, Reckel S, Luty SB, Sun H, Gorenstein J, Hughes SB, Bottomly D, Wilmot B, McWeeney SK, Radich J, Hantschel O, Middleton RE, Gray NS, Druker BJ, Tyner JW.

Cancer Res. 2016 Jan 1;76(1):127-38. doi: 10.1158/0008-5472.CAN-15-0817. Epub 2015 Dec 17.

35.

Use of semantic workflows to enhance transparency and reproducibility in clinical omics.

Zheng CL, Ratnakar V, Gil Y, McWeeney SK.

Genome Med. 2015 Jul 25;7:73. doi: 10.1186/s13073-015-0202-y.

36.

Therapeutically Targetable ALK Mutations in Leukemia.

Maxson JE, Davare MA, Luty SB, Eide CA, Chang BH, Loriaux MM, Tognon CE, Bottomly D, Wilmot B, McWeeney SK, Druker BJ, Tyner JW.

Cancer Res. 2015 Jun 1;75(11):2146-50. doi: 10.1158/0008-5472.CAN-14-1576.

37.

Cosplicing network analysis of mammalian brain RNA-Seq data utilizing WGCNA and Mantel correlations.

Iancu OD, Colville A, Oberbeck D, Darakjian P, McWeeney SK, Hitzemann R.

Front Genet. 2015 May 13;6:174. doi: 10.3389/fgene.2015.00174. eCollection 2015.

38.

plethy: management of whole body plethysmography data in R.

Bottomly D, Wilmot B, McWeeney SK.

BMC Bioinformatics. 2015 Apr 29;16:134. doi: 10.1186/s12859-015-0547-7.

39.

Maternal high-fat diet and obesity compromise fetal hematopoiesis.

Kamimae-Lanning AN, Krasnow SM, Goloviznina NA, Zhu X, Roth-Carter QR, Levasseur PR, Jeng S, McWeeney SK, Kurre P, Marks DL.

Mol Metab. 2014 Nov 18;4(1):25-38. doi: 10.1016/j.molmet.2014.11.001. eCollection 2015 Jan.

40.

Splicing landscape of the eight collaborative cross founder strains.

Zheng CL, Wilmot B, Walter NA, Oberbeck D, Kawane S, Searles RP, McWeeney SK, Hitzemann R.

BMC Genomics. 2015 Feb 5;16:52. doi: 10.1186/s12864-015-1267-0.

41.

‘Pitfalls in the application of gene set analysis to genetics studies’: a response.

Mooney MA, Nigg JT, McWeeney SK, Wilmot B.

Trends Genet. 2014 Dec;30(12):514-5. No abstract available.

42.

Functional and genomic context in pathway analysis of GWAS data.

Mooney MA, Nigg JT, McWeeney SK, Wilmot B.

Trends Genet. 2014 Sep;30(9):390-400. doi: 10.1016/j.tig.2014.07.004. Epub 2014 Aug 22. Review.

43.

Corepressor Rcor1 is essential for murine erythropoiesis.

Yao H, Goldman DC, Nechiporuk T, Kawane S, McWeeney SK, Tyner JW, Fan G, Kerenyi MA, Orkin SH, Fleming WH, Mandel G.

Blood. 2014 May 15;123(20):3175-84. doi: 10.1182/blood-2013-11-538678. Epub 2014 Mar 20.

44.

Multi-omic network signatures of disease.

Gibbs DL, Gralinski L, Baric RS, McWeeney SK.

Front Genet. 2014 Jan 7;4:309. doi: 10.3389/fgene.2013.00309. eCollection 2014 Jan 7.

45.

Challenges in secondary analysis of high throughput screening data.

Blucher AS, McWeeney SK.

Pac Symp Biocomput. 2014:114-24.

46.

Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine.

Bottomly D, Ryabinin PA, Tyner JW, Chang BH, Loriaux MM, Druker BJ, McWeeney SK, Wilmot B.

Genome Med. 2013 Nov 29;5(11):103. doi: 10.1186/gm509. eCollection 2013.

47.

Protein co-expression network analysis (ProCoNA).

Gibbs DL, Baratt A, Baric RS, Kawaoka Y, Smith RD, Orwoll ES, Katze MG, McWeeney SK.

J Clin Bioinforma. 2013 Jun 1;3(1):11. doi: 10.1186/2043-9113-3-11.

48.

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.

Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW.

N Engl J Med. 2013 May 9;368(19):1781-90. doi: 10.1056/NEJMoa1214514.

49.

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Villena F, Baric RS, Heise MT.

PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.

50.

HitWalker: variant prioritization for personalized functional cancer genomics.

Bottomly D, Wilmot B, Tyner JW, Eide CA, Loriaux MM, Druker BJ, McWeeney SK.

Bioinformatics. 2013 Feb 15;29(4):509-10. doi: 10.1093/bioinformatics/btt003. Epub 2013 Jan 9.

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