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Items: 1 to 50 of 129

1.

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.

Rice CM, Davies LC, Subleski JJ, Maio N, Gonzalez-Cotto M, Andrews C, Patel NL, Palmieri EM, Weiss JM, Lee JM, Annunziata CM, Rouault TA, Durum SK, McVicar DW.

Nat Commun. 2018 Nov 30;9(1):5099. doi: 10.1038/s41467-018-07505-2.

2.

Diversity and environmental adaptation of phagocytic cell metabolism.

Davies LC, Rice CM, McVicar DW, Weiss JM.

J Leukoc Biol. 2019 Jan;105(1):37-48. doi: 10.1002/JLB.4RI0518-195R. Epub 2018 Sep 14. Review.

3.

Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.

Basudhar D, Bharadwaj G, Somasundaram V, Cheng RYS, Ridnour LA, Fujita M, Lockett SJ, Anderson SK, McVicar DW, Wink DA.

Br J Pharmacol. 2019 Jan;176(2):155-176. doi: 10.1111/bph.14488. Epub 2018 Nov 6. Review.

PMID:
30152521
4.

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.

Weiss JM, Davies LC, Karwan M, Ileva L, Ozaki MK, Cheng RY, Ridnour LA, Annunziata CM, Wink DA, McVicar DW.

J Clin Invest. 2018 Aug 31;128(9):3794-3805. doi: 10.1172/JCI99169. Epub 2018 Jul 30.

5.

TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation.

Tong WH, Maio N, Zhang DL, Palmieri EM, Ollivierre H, Ghosh MC, McVicar DW, Rouault TA.

Blood Adv. 2018 May 22;2(10):1146-1156. doi: 10.1182/bloodadvances.2018015669.

6.

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism.

Somasundaram V, Basudhar D, Bharadwaj G, No JH, Ridnour LA, Cheng RYS, Fujita M, Thomas DD, Anderson SK, McVicar DW, Wink DA.

Antioxid Redox Signal. 2019 Mar 10;30(8):1124-1143. doi: 10.1089/ars.2018.7527. Epub 2018 May 2.

PMID:
29634348
7.

Identification of an elaborate NK-specific system regulating HLA-C expression.

Li H, Ivarsson MA, Walker-Sperling VE, Subleski J, Johnson JK, Wright PW, Carrington M, Björkström NK, McVicar DW, Anderson SK.

PLoS Genet. 2018 Jan 12;14(1):e1007163. doi: 10.1371/journal.pgen.1007163. eCollection 2018 Jan.

8.

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.

Davies LC, Rice CM, Palmieri EM, Taylor PR, Kuhns DB, McVicar DW.

Nat Commun. 2017 Dec 12;8(1):2074. doi: 10.1038/s41467-017-02092-0.

9.

Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer.

Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13030-13035. doi: 10.1073/pnas.1709119114. Epub 2017 Oct 27.

10.

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.

Palmieri EM, Menga A, Martín-Pérez R, Quinto A, Riera-Domingo C, De Tullio G, Hooper DC, Lamers WH, Ghesquière B, McVicar DW, Guarini A, Mazzone M, Castegna A.

Cell Rep. 2017 Aug 15;20(7):1654-1666. doi: 10.1016/j.celrep.2017.07.054.

11.

Evaluation of the Effectiveness and Cost-Effectiveness of Personalized Surveillance After Colorectal Adenomatous Polypectomy.

McFerran E, O'Mahony JF, Fallis R, McVicar D, Zauber AG, Kee F.

Epidemiol Rev. 2017 Jan 1;39(1):148-160. doi: 10.1093/epirev/mxx002. Review.

12.

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.

Pymm P, Illing PT, Ramarathinam SH, O'Connor GM, Hughes VA, Hitchen C, Price DA, Ho BK, McVicar DW, Brooks AG, Purcell AW, Rossjohn J, Vivian JP.

Nat Struct Mol Biol. 2017 Apr;24(4):387-394. doi: 10.1038/nsmb.3381. Epub 2017 Feb 20.

PMID:
28218747
13.

Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers.

de Oliveira GA, Cheng RYS, Ridnour LA, Basudhar D, Somasundaram V, McVicar DW, Monteiro HP, Wink DA.

Antioxid Redox Signal. 2017 Jun 20;26(18):1059-1077. doi: 10.1089/ars.2016.6850. Epub 2016 Oct 31. Review.

14.

CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in Sézary syndrome: the Sézary signature genes, FCRL3, Tox, and miR-214.

Benoit BM, Jariwala N, O'Connor G, Oetjen LK, Whelan TM, Werth A, Troxel AB, Sicard H, Zhu L, Miller C, Takeshita J, McVicar DW, Kim BS, Rook AH, Wysocka M.

Arch Dermatol Res. 2017 Jan;309(1):11-19. doi: 10.1007/s00403-016-1698-8. Epub 2016 Oct 20.

15.

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production.

Baseler WA, Davies LC, Quigley L, Ridnour LA, Weiss JM, Hussain SP, Wink DA, McVicar DW.

Redox Biol. 2016 Dec;10:12-23. doi: 10.1016/j.redox.2016.09.005. Epub 2016 Sep 16.

16.

Analysis of Ly49 gene transcripts in mature NK cells supports a role for the Pro1 element in gene activation, not gene expression.

McCullen MV, Li H, Cam M, Sen SK, McVicar DW, Anderson SK.

Genes Immun. 2016 Sep;17(6):349-57. doi: 10.1038/gene.2016.31. Epub 2016 Jul 28.

17.

Cross-section and panel estimates of peer effects in early adolescent cannabis use: With a little help from my 'friends once removed'.

Moriarty J, McVicar D, Higgins K.

Soc Sci Med. 2016 Aug;163:37-44. doi: 10.1016/j.socscimed.2016.06.032. Epub 2016 Jun 21.

PMID:
27391251
18.

Orally administered β-glucan attenuates the Th2 response in a model of airway hypersensitivity.

Burg AR, Quigley L, Jones AV, O'Connor GM, Boelte K, McVicar DW, Orr SJ.

Springerplus. 2016 Jun 21;5(1):815. doi: 10.1186/s40064-016-2501-1. eCollection 2016.

19.

Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency.

De Ravin SS, Wu X, Moir S, Anaya-O'Brien S, Kwatemaa N, Littel P, Theobald N, Choi U, Su L, Marquesen M, Hilligoss D, Lee J, Buckner CM, Zarember KA, O'Connor G, McVicar D, Kuhns D, Throm RE, Zhou S, Notarangelo LD, Hanson IC, Cowan MJ, Kang E, Hadigan C, Meagher M, Gray JT, Sorrentino BP, Malech HL, Kardava L.

Sci Transl Med. 2016 Apr 20;8(335):335ra57. doi: 10.1126/scitranslmed.aad8856. Erratum in: Sci Transl Med. 2016 Jun 1;8(341):341er5.

20.

Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition.

Saunders PM, Pymm P, Pietra G, Hughes VA, Hitchen C, O'Connor GM, Loiacono F, Widjaja J, Price DA, Falco M, Mingari MC, Moretta L, McVicar DW, Rossjohn J, Brooks AG, Vivian JP.

J Exp Med. 2016 May 2;213(5):791-807. doi: 10.1084/jem.20152023. Epub 2016 Apr 4.

21.

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF.

Nature. 2016 Mar 10;531(7593):253-7. doi: 10.1038/nature16969. Epub 2016 Mar 2.

22.

Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity.

Shanker A, Pellom ST Jr, Dudimah DF, Thounaojam MC, de Kluyver RL, Brooks AD, Yagita H, McVicar DW, Murphy WJ, Longo DL, Sayers TJ.

Cancer Res. 2015 Dec 15;75(24):5260-72. doi: 10.1158/0008-5472.CAN-15-0794. Epub 2015 Oct 22.

23.

Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells.

Townsley E, O'Connor G, Cosgrove C, Woda M, Co M, Thomas SJ, Kalayanarooj S, Yoon IK, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Gostick E, Price DA, Carrington M, Alter G, McVicar DW, Rothman AL, Mathew A.

Clin Exp Immunol. 2016 Mar;183(3):419-30. doi: 10.1111/cei.12722. Epub 2015 Nov 24.

24.

Signaling and stress: The redox landscape in NOS2 biology.

Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD, Glynn S, Fukuto JM, Wink DA, Miranda KM.

Free Radic Biol Med. 2015 Oct;87:204-25. doi: 10.1016/j.freeradbiomed.2015.06.002. Epub 2015 Jun 24. Review.

25.

Erratum for O'Connor et al., Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1.

O'Connor GM, Vivian JP, Gostick E, Pymm P, Lafont BA, Price DA, Rossjohn J, Brooks AG, McVicar DW.

J Virol. 2015 Jul;89(14):7442. doi: 10.1128/JVI.01159-15. No abstract available.

26.

From substance use to homelessness or vice versa?

McVicar D, Moschion J, van Ours JC.

Soc Sci Med. 2015 Jul;136-137:89-98. doi: 10.1016/j.socscimed.2015.05.005. Epub 2015 May 2.

PMID:
25989002
27.

Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA-A3 and A11 in vivo.

Augusto DG, O'Connor GM, Lobo-Alves SC, Bass S, Martin MP, Carrington M, McVicar DW, Petzl-Erler ML.

Eur J Immunol. 2015 Jul;45(7):2052-60. doi: 10.1002/eji.201445324. Epub 2015 May 6.

28.

Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1.

O'Connor GM, Vivian JP, Gostick E, Pymm P, Lafont BA, Price DA, Rossjohn J, Brooks AG, McVicar DW.

J Virol. 2015 May;89(10):5213-21. doi: 10.1128/JVI.03586-14. Epub 2015 Mar 4. Erratum in: J Virol. 2015 Jul;89(14):7442.

29.

The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope.

Saunders PM, Vivian JP, Baschuk N, Beddoe T, Widjaja J, O'Connor GM, Hitchen C, Pymm P, Andrews DM, Gras S, McVicar DW, Rossjohn J, Brooks AG.

J Immunol. 2015 Jan 15;194(2):781-789. doi: 10.4049/jimmunol.1402542. Epub 2014 Dec 5.

30.

Interleukin-1 and interferon-γ orchestrate β-glucan-activated human dendritic cell programming via IκB-ζ modulation.

Cardone M, Dzutsev AK, Li H, Riteau N, Gerosa F, Shenderov K, Winkler-Pickett R, Provezza L, Riboldi E, Leighty RM, Orr SJ, Steinhagen F, Wewers MD, Sher A, Anderson SK, Goldszmid R, McVicar DW, Lyakh L, Trinchieri G.

PLoS One. 2014 Dec 4;9(12):e114516. doi: 10.1371/journal.pone.0114516. eCollection 2014.

31.

Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.

Sen SK, Boelte KC, Barb JJ, Joehanes R, Zhao X, Cheng Q, Adams L, Teer JK, Accame DS, Chowdhury S, Singh LN; NISC Comparative Sequencing Program; CHARGE Consortium, Kavousi M, Peyser PA, Quigley L, Priel DL, Lau K, Kuhns DB, Yoshimura T, Johnson AD, Hwang SJ, Chen MY, Arai AE, Green ED, Mullikin JC, Kolodgie FD, O'Donnell CJ, Virmani R, Munson PJ, McVicar DW, Biesecker LG.

Am J Hum Genet. 2014 Jul 3;95(1):66-76. doi: 10.1016/j.ajhg.2014.06.003. Epub 2014 Jun 26.

32.

Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity.

O'Connor GM, Vivian JP, Widjaja JM, Bridgeman JS, Gostick E, Lafont BA, Anderson SK, Price DA, Brooks AG, Rossjohn J, McVicar DW.

J Immunol. 2014 Mar 15;192(6):2875-84. doi: 10.4049/jimmunol.1303142. Epub 2014 Feb 21.

33.

Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes.

Montalvo V, Quigley L, Vistica BP, Boelte KC, Nugent LF, Takai T, McVicar DW, Gery I.

Immunology. 2013 Dec;140(4):475-82. doi: 10.1111/imm.12158.

34.

The yin-yang of KIR3DL1/S1: molecular mechanisms and cellular function.

O'Connor GM, McVicar D.

Crit Rev Immunol. 2013;33(3):203-18. Review.

35.

LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.

Orr SJ, Burg AR, Chan T, Quigley L, Jones GW, Ford JW, Hodge D, Razzook C, Sarhan J, Jones YL, Whittaker GC, Boelte KC, Lyakh L, Cardone M, O'Connor GM, Tan C, Li H, Anderson SK, Jones SA, Zhang W, Taylor PR, Trinchieri G, McVicar DW.

PLoS Pathog. 2013 May;9(5):e1003357. doi: 10.1371/journal.ppat.1003357. Epub 2013 May 9.

36.

In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection.

O'Connor GM, Seich Al Basatena NK, Olavarria V, MacNamara A, Vine A, Ying Q, Hisada M, Galvão-Castro B, Asquith B, McVicar DW.

Hum Immunol. 2012 Aug;73(8):783-7. doi: 10.1016/j.humimm.2012.05.006. Epub 2012 May 17.

37.

Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis.

Derive M, Bouazza Y, Sennoun N, Marchionni S, Quigley L, Washington V, Massin F, Max JP, Ford J, Alauzet C, Levy B, McVicar DW, Gibot S.

J Immunol. 2012 Jun 1;188(11):5585-92. doi: 10.4049/jimmunol.1102674. Epub 2012 May 2.

38.

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B.

Vivian JP, Duncan RC, Berry R, O'Connor GM, Reid HH, Beddoe T, Gras S, Saunders PM, Olshina MA, Widjaja JM, Harpur CM, Lin J, Maloveste SM, Price DA, Lafont BA, McVicar DW, Clements CS, Brooks AG, Rossjohn J.

Nature. 2011 Oct 23;479(7373):401-5. doi: 10.1038/nature10517.

39.

Estimates of peer effects in adolescent smoking across twenty six European countries.

McVicar D.

Soc Sci Med. 2011 Oct;73(8):1186-93. doi: 10.1016/j.socscimed.2011.08.006. Epub 2011 Aug 26.

PMID:
21890257
40.

Analysis of binding of KIR3DS1*014 to HLA suggests distinct evolutionary history of KIR3DS1.

O'Connor GM, Yamada E, Rampersaud A, Thomas R, Carrington M, McVicar DW.

J Immunol. 2011 Sep 1;187(5):2162-71. doi: 10.4049/jimmunol.1002906. Epub 2011 Jul 29.

41.

Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 molecules.

Fadda L, O'Connor GM, Kumar S, Piechocka-Trocha A, Gardiner CM, Carrington M, McVicar DW, Altfeld M.

J Virol. 2011 Jun;85(12):5970-4. doi: 10.1128/JVI.00412-11. Epub 2011 Apr 6.

42.

TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release.

Smrz D, Iwaki S, McVicar DW, Metcalfe DD, Gilfillan AM.

Eur J Immunol. 2010 Dec;40(12):3557-69. doi: 10.1002/eji.201040573. Epub 2010 Nov 11.

43.

LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?

Orr SJ, McVicar DW.

J Leukoc Biol. 2011 Jan;89(1):11-9. doi: 10.1189/jlb.0410221. Epub 2010 Jul 19. Review.

44.

Implications for gene therapy-limiting expression of IL-2R gamma c delineate differences in signaling thresholds required for lymphocyte development and maintenance.

Orr SJ, Roessler S, Quigley L, Chan T, Ford JW, O'Connor GM, McVicar DW.

J Immunol. 2010 Aug 1;185(3):1393-403. doi: 10.4049/jimmunol.0903528. Epub 2010 Jun 30.

45.
46.

HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.

Thomas R, Apps R, Qi Y, Gao X, Male V, O'hUigin C, O'Connor G, Ge D, Fellay J, Martin JN, Margolick J, Goedert JJ, Buchbinder S, Kirk GD, Martin MP, Telenti A, Deeks SG, Walker BD, Goldstein D, McVicar DW, Moffett A, Carrington M.

Nat Genet. 2009 Dec;41(12):1290-4. doi: 10.1038/ng.486.

47.

Visualization and identification of IL-7 producing cells in reporter mice.

Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Jenkins NA, Copeland NG, Durum SK.

PLoS One. 2009 Nov 10;4(11):e7637. doi: 10.1371/journal.pone.0007637.

48.

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.

Ranatunga D, Hedrich CM, Wang F, McVicar DW, Nowak N, Joshi T, Feigenbaum L, Grant LR, Stäger S, Bream JH.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17123-8. doi: 10.1073/pnas.0904955106. Epub 2009 Sep 9.

49.

CSF-1R, DAP12 and beta-catenin: a ménage à trois.

McVicar DW, Trinchieri G.

Nat Immunol. 2009 Jul;10(7):681-3. doi: 10.1038/ni0709-681.

PMID:
19536190
50.

TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.

Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW.

J Clin Invest. 2009 Jun;119(6):1489-501. doi: 10.1172/JCI36175. Epub 2009 May 11.

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