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Items: 25


A global reference for human genetic variation.

1000 Genomes Project Consortium, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, Abecasis GR.

Nature. 2015 Oct 1;526(7571):68-74. doi: 10.1038/nature15393.


Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.

Colonna V, Ayub Q, Chen Y, Pagani L, Luisi P, Pybus M, Garrison E, Xue Y, Tyler-Smith C; 1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA.

Genome Biol. 2014 Jun 30;15(6):R88. doi: 10.1186/gb-2014-15-6-r88.


Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I.

Babbs C, Roberts NA, Sanchez-Pulido L, McGowan SJ, Ahmed MR, Brown JM, Sabry MA; WGS500 Consortium, Bentley DR, McVean GA, Donnelly P, Gileadi O, Ponting CP, Higgs DR, Buckle VJ.

Haematologica. 2013 Sep;98(9):1383-7. doi: 10.3324/haematol.2013.089490. Epub 2013 May 28.


An integrated map of genetic variation from 1,092 human genomes.

1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA.

Nature. 2012 Nov 1;491(7422):56-65. doi: 10.1038/nature11632.


A map of human genome variation from population-scale sequencing.

1000 Genomes Project Consortium, Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM, Gibbs RA, Hurles ME, McVean GA.

Nature. 2010 Oct 28;467(7319):1061-73. doi: 10.1038/nature09534. Erratum in: Nature. 2011 May 26;473(7348):544. Xue, Yali [added]; Cartwright, Reed A [added]; Altshuler, David L [corrected to Altshuler, David]; Kebbel, Andrew [corrected to Keebler, Jonathan]; Koko-Gonzales, Paula [corrected to Kokko-Gonzales, Paula]; Nickerson, Debbie A [corrected to Nickerson, Debo.


Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors.

Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Rajpert-De Meyts E, Wilkie AO.

Nat Genet. 2009 Nov;41(11):1247-52. doi: 10.1038/ng.470. Epub 2009 Oct 25.


Evidence for widespread cryptic sexual generations in apparently purely asexual Andricus gallwasps.

Stone GN, Atkinson RJ, Rokas A, Aldrey JL, Melika G, Acs Z, Csóka G, Hayward A, Bailey R, Buckee C, McVean GA.

Mol Ecol. 2008 Jan;17(2):652-65. Epub 2007 Dec 12.


Population genomics of the immune evasion (var) genes of Plasmodium falciparum.

Barry AE, Leliwa-Sytek A, Tavul L, Imrie H, Migot-Nabias F, Brown SM, McVean GA, Day KP.

PLoS Pathog. 2007 Mar;3(3):e34.


Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome.

Mu J, Awadalla P, Duan J, McGee KM, Keebler J, Seydel K, McVean GA, Su XZ.

Nat Genet. 2007 Jan;39(1):126-30. Epub 2006 Dec 10.


Recombination hotspots and population structure in Plasmodium falciparum.

Mu J, Awadalla P, Duan J, McGee KM, Joy DA, McVean GA, Su XZ.

PLoS Biol. 2005 Oct;3(10):e335. Epub 2005 Sep 13.


Approximating the coalescent with recombination.

McVean GA, Cardin NJ.

Philos Trans R Soc Lond B Biol Sci. 2005 Jul 29;360(1459):1387-93.


Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia.

Goriely A, McVean GA, van Pelt AM, O'Rourke AW, Wall SA, de Rooij DG, Wilkie AO.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6051-6. Epub 2005 Apr 19.


Comparison of fine-scale recombination rates in humans and chimpanzees.

Winckler W, Myers SR, Richter DJ, Onofrio RC, McDonald GJ, Bontrop RE, McVean GA, Gabriel SB, Reich D, Donnelly P, Altshuler D.

Science. 2005 Apr 1;308(5718):107-11. Epub 2005 Feb 10.


The fine-scale structure of recombination rate variation in the human genome.

McVean GA, Myers SR, Hunt S, Deloukas P, Bentley DR, Donnelly P.

Science. 2004 Apr 23;304(5670):581-4.


Estimating recombination rates from population-genetic data.

Stumpf MP, McVean GA.

Nat Rev Genet. 2003 Dec;4(12):959-68. Review.


Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line.

Goriely A, McVean GA, Röjmyr M, Ingemarsson B, Wilkie AO.

Science. 2003 Aug 1;301(5633):643-6.


A genealogical interpretation of linkage disequilibrium.

McVean GA.

Genetics. 2002 Oct;162(2):987-91.


What do patterns of genetic variability reveal about mitochondrial recombination?

McVean GA.

Heredity (Edinb). 2001 Dec;87(Pt 6):613-20. Review.


Genome sequences and evolutionary biology, a two-way interaction.

Charlesworth D, Charlesworth B, McVean GA.

Trends Ecol Evol. 2001 May 1;16(5):235-242.


Evolutionary lability of context-dependent codon bias in bacteria.

McVean GA, Hurst GD.

J Mol Evol. 2000 Mar;50(3):264-75.


Neutral evolution of the sex-determining gene transformer in Drosophila.

McAllister BF, McVean GA.

Genetics. 2000 Apr;154(4):1711-20.

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