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Items: 12

1.

Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors.

Qi J, McTigue MA, Rogers A, Lifshits E, Christensen JG, Jänne PA, Engelman JA.

Cancer Res. 2011 Feb 1;71(3):1081-91. doi: 10.1158/0008-5472.CAN-10-1623. Epub 2011 Jan 25.

2.

Characterizing the effects of the juxtamembrane domain on vascular endothelial growth factor receptor-2 enzymatic activity, autophosphorylation, and inhibition by axitinib.

Solowiej J, Bergqvist S, McTigue MA, Marrone T, Quenzer T, Cobbs M, Ryan K, Kania RS, Diehl W, Murray BW.

Biochemistry. 2009 Jul 28;48(29):7019-31. doi: 10.1021/bi900522y.

PMID:
19526984
3.

Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.

Timofeevski SL, McTigue MA, Ryan K, Cui J, Zou HY, Zhu JX, Chau F, Alton G, Karlicek S, Christensen JG, Murray BW.

Biochemistry. 2009 Jun 16;48(23):5339-49. doi: 10.1021/bi900438w.

PMID:
19459657
4.

Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3.

Hu-Lowe DD, Zou HY, Grazzini ML, Hallin ME, Wickman GR, Amundson K, Chen JH, Rewolinski DA, Yamazaki S, Wu EY, McTigue MA, Murray BW, Kania RS, O'Connor P, Shalinsky DR, Bender SL.

Clin Cancer Res. 2008 Nov 15;14(22):7272-83. doi: 10.1158/1078-0432.CCR-08-0652.

5.

Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2.

Murray BW, Padrique ES, Pinko C, McTigue MA.

Biochemistry. 2001 Aug 28;40(34):10243-53.

PMID:
11513602
6.

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.

Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN.

Nat Genet. 2000 Jun;25(2):153-9.

PMID:
10835628
7.

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.

McTigue MA, Wickersham JA, Pinko C, Showalter RE, Parast CV, Tempczyk-Russell A, Gehring MR, Mroczkowski B, Kan CC, Villafranca JE, Appelt K.

Structure. 1999 Mar 15;7(3):319-30.

8.

Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily.

Bruns CM, Nowalk AJ, Arvai AS, McTigue MA, Vaughan KG, Mietzner TA, McRee DE.

Nat Struct Biol. 1997 Nov;4(11):919-24.

PMID:
9360608
9.

Purification and crystallization of a schistosomal glutathione S-transferase.

McTigue MA, Bernstein SL, Williams DR, Tainer JA.

Proteins. 1995 May;22(1):55-7.

PMID:
7675787
11.

Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.

McTigue MA, Davies JF 2nd, Kaufman BT, Kraut J.

Biochemistry. 1993 Jul 13;32(27):6855-62.

PMID:
8334118
12.

Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.

McTigue MA, Davies JF 2nd, Kaufman BT, Kraut J.

Biochemistry. 1992 Aug 18;31(32):7264-73.

PMID:
1510919

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