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Items: 43


Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite.

Filbey KJ, Varyani F, Harcus Y, Hewitson JP, Smyth DJ, McSorley HJ, Ivens A, Nylén S, Rottenberg M, Löser S, Maizels RM.

Front Immunol. 2019 Oct 24;10:2375. doi: 10.3389/fimmu.2019.02375. eCollection 2019.


Interleukin-33 in the developing lung-Roles in asthma and infection.

Johansson K, McSorley HJ.

Pediatr Allergy Immunol. 2019 Aug;30(5):503-510. doi: 10.1111/pai.13040. Epub 2019 Mar 18. Review.


Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules.

Maizels RM, Smits HH, McSorley HJ.

Immunity. 2018 Nov 20;49(5):801-818. doi: 10.1016/j.immuni.2018.10.016. Review.


Basal Instinct: Persistence of Barrier Dysfunction.

Chauché C, McSorley HJ.

Immunity. 2018 Oct 16;49(4):590-592. doi: 10.1016/j.immuni.2018.09.022.


Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion.

Smith KA, Löser S, Varyani F, Harcus Y, McSorley HJ, McKenzie AN, Maizels RM.

Elife. 2018 Sep 21;7. pii: e38269. doi: 10.7554/eLife.38269.


Worms: Pernicious parasites or allies against allergies?

McSorley HJ, Chayé MAM, Smits HH.

Parasite Immunol. 2019 Jun;41(6):e12574. doi: 10.1111/pim.12574. Epub 2018 Aug 29. Review.


TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.

Smyth DJ, Harcus Y, White MPJ, Gregory WF, Nahler J, Stephens I, Toke-Bjolgerud E, Hewitson JP, Ivens A, McSorley HJ, Maizels RM.

Int J Parasitol. 2018 Apr;48(5):379-385. doi: 10.1016/j.ijpara.2017.12.004. Epub 2018 Mar 3.


IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Serrels B, McGivern N, Canel M, Byron A, Johnson SC, McSorley HJ, Quinn N, Taggart D, Von Kreigsheim A, Anderton SM, Serrels A, Frame MC.

Sci Signal. 2017 Dec 5;10(508). pii: eaan8355. doi: 10.1126/scisignal.aan8355.


A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM.

Nat Commun. 2017 Nov 23;8(1):1741. doi: 10.1038/s41467-017-01886-6.


HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.

Osbourn M, Soares DC, Vacca F, Cohen ES, Scott IC, Gregory WF, Smyth DJ, Toivakka M, Kemter AM, le Bihan T, Wear M, Hoving D, Filbey KJ, Hewitson JP, Henderson H, Gonzàlez-Cìscar A, Errington C, Vermeren S, Astier AL, Wallace WA, Schwarze J, Ivens AC, Maizels RM, McSorley HJ.

Immunity. 2017 Oct 17;47(4):739-751.e5. doi: 10.1016/j.immuni.2017.09.015.


Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.

Pastille E, Frede A, McSorley HJ, Gräb J, Adamczyk A, Kollenda S, Hansen W, Epple M, Buer J, Maizels RM, Klopfleisch R, Westendorf AM.

PLoS Pathog. 2017 Sep 22;13(9):e1006649. doi: 10.1371/journal.ppat.1006649. eCollection 2017 Sep.


Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis.

Robb CT, McSorley HJ, Lee J, Aoki T, Yu C, Crittenden S, Astier A, Felton JM, Parkinson N, Ayele A, Breyer RM, Anderton SM, Narumiya S, Rossi AG, Howie SE, Guttman-Yassky E, Weller RB, Yao C.

J Allergy Clin Immunol. 2018 Jan;141(1):152-162. doi: 10.1016/j.jaci.2017.04.045. Epub 2017 Jun 3.


Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity.

Coakley G, McCaskill JL, Borger JG, Simbari F, Robertson E, Millar M, Harcus Y, McSorley HJ, Maizels RM, Buck AH.

Cell Rep. 2017 May 23;19(8):1545-1557. doi: 10.1016/j.celrep.2017.05.001.


Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota.

McFarlane AJ, McSorley HJ, Davidson DJ, Fitch PM, Errington C, Mackenzie KJ, Gollwitzer ES, Johnston CJC, MacDonald AS, Edwards MR, Harris NL, Marsland BJ, Maizels RM, Schwarze J.

J Allergy Clin Immunol. 2017 Oct;140(4):1068-1078.e6. doi: 10.1016/j.jaci.2017.01.016. Epub 2017 Feb 11.


IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha.

Jackson-Jones LH, Rückerl D, Svedberg F, Duncan S, Maizels RM, Sutherland TE, Jenkins SJ, McSorley HJ, Bénézech C, MacDonald AS, Allen JE.

Eur J Immunol. 2016 Oct;46(10):2311-2321. doi: 10.1002/eji.201646442.


Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.

Jackson-Jones LH, Duncan SM, Magalhaes MS, Campbell SM, Maizels RM, McSorley HJ, Allen JE, Bénézech C.

Nat Commun. 2016 Sep 1;7:12651. doi: 10.1038/ncomms12651.


Regulation of the host immune system by helminth parasites.

Maizels RM, McSorley HJ.

J Allergy Clin Immunol. 2016 Sep;138(3):666-675. doi: 10.1016/j.jaci.2016.07.007. Epub 2016 Jul 29. Review.


Stage-specific Proteomes from Onchocerca ochengi, Sister Species of the Human River Blindness Parasite, Uncover Adaptations to a Nodular Lifestyle.

Armstrong SD, Xia D, Bah GS, Krishna R, Ngangyung HF, LaCourse EJ, McSorley HJ, Kengne-Ouafo JA, Chounna-Ndongmo PW, Wanji S, Enyong PA, Taylor DW, Blaxter ML, Wastling JM, Tanya VN, Makepeace BL.

Mol Cell Proteomics. 2016 Aug;15(8):2554-75. doi: 10.1074/mcp.M115.055640. Epub 2016 May 25.


Microbes and asthma: Opportunities for intervention.

Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C.

J Allergy Clin Immunol. 2016 Mar;137(3):690-7. doi: 10.1016/j.jaci.2016.01.004. Review.


Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus.

Hewitson JP, Nguyen DL, van Diepen A, Smit CH, Koeleman CA, McSorley HJ, Murray J, Maizels RM, Hokke CH.

Int J Parasitol. 2016 Mar;46(3):157-170. doi: 10.1016/j.ijpara.2015.10.004. Epub 2015 Dec 12.


Erratum: Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.

Buck AH, Coakley G, Simbari F, McSorley HJ, Quintana JF, Le Bihan T, Kumar S, Abreu-Goodger C, Lear M, Harcus Y, Ceroni A, Babayan SA, Blaxter M, Ivens A, Maizels RM.

Nat Commun. 2015 Oct 22;6:8772. doi: 10.1038/ncomms9772. No abstract available.


Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products.

Johnston CJ, Robertson E, Harcus Y, Grainger JR, Coakley G, Smyth DJ, McSorley HJ, Maizels R.

J Vis Exp. 2015 Apr 6;(98):e52412. doi: 10.3791/52412.


Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.

Buck AH, Coakley G, Simbari F, McSorley HJ, Quintana JF, Le Bihan T, Kumar S, Abreu-Goodger C, Lear M, Harcus Y, Ceroni A, Babayan SA, Blaxter M, Ivens A, Maizels RM.

Nat Commun. 2014 Nov 25;5:5488. doi: 10.1038/ncomms6488. Erratum in: Nat Commun. 2015;6:8772.


Helminths in the hygiene hypothesis: sooner or later?

Maizels RM, McSorley HJ, Smyth DJ.

Clin Exp Immunol. 2014 Jul;177(1):38-46. doi: 10.1111/cei.12353. Review.


Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.

McSorley HJ, Blair NF, Smith KA, McKenzie AN, Maizels RM.

Mucosal Immunol. 2014 Sep;7(5):1068-78. doi: 10.1038/mi.2013.123. Epub 2014 Feb 5.


IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection.

Horsnell WG, Darby MG, Hoving JC, Nieuwenhuizen N, McSorley HJ, Ndlovu H, Bobat S, Kimberg M, Kirstein F, Cutler AJ, Dewals B, Cunningham AF, Brombacher F.

PLoS Pathog. 2013 Oct;9(10):e1003662. doi: 10.1371/journal.ppat.1003662. Epub 2013 Oct 24.


Helminths and immunological tolerance.

Johnston CJ, McSorley HJ, Anderton SM, Wigmore SJ, Maizels RM.

Transplantation. 2014 Jan 27;97(2):127-32. doi: 10.1097/TP.0b013e3182a53f59. Review. Erratum in: Transplantation. 2014 Sep 27;98(6):e67.


Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.

Hewitson JP, Ivens AC, Harcus Y, Filbey KJ, McSorley HJ, Murray J, Bridgett S, Ashford D, Dowle AA, Maizels RM.

PLoS Pathog. 2013 Aug;9(8):e1003492. doi: 10.1371/journal.ppat.1003492. Epub 2013 Aug 15.


Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis.

Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, Artis D, Laha T, Navarro S, Loukas A, McSorley HJ.

Infect Immun. 2013 Jun;81(6):2104-11. doi: 10.1128/IAI.00563-12. Epub 2013 Apr 1.


Immunomodulation by helminth parasites: defining mechanisms and mediators.

McSorley HJ, Hewitson JP, Maizels RM.

Int J Parasitol. 2013 Mar;43(3-4):301-10. doi: 10.1016/j.ijpara.2012.11.011. Epub 2013 Jan 3. Review.


Helminth infections and host immune regulation.

McSorley HJ, Maizels RM.

Clin Microbiol Rev. 2012 Oct;25(4):585-608. doi: 10.1128/CMR.05040-11. Review.


Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus.

McSorley HJ, O'Gorman MT, Blair N, Sutherland TE, Filbey KJ, Maizels RM.

Eur J Immunol. 2012 Oct;42(10):2667-82. doi: 10.1002/eji.201142161. Epub 2012 Aug 8.


Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2.

Pearson MS, Pickering DA, McSorley HJ, Bethony JM, Tribolet L, Dougall AM, Hotez PJ, Loukas A.

PLoS Negl Trop Dis. 2012;6(3):e1564. doi: 10.1371/journal.pntd.0001564. Epub 2012 Mar 13.


Characterising the mucosal and systemic immune responses to experimental human hookworm infection.

Gaze S, McSorley HJ, Daveson J, Jones D, Bethony JM, Oliveira LM, Speare R, McCarthy JS, Engwerda CR, Croese J, Loukas A.

PLoS Pathog. 2012 Feb;8(2):e1002520. doi: 10.1371/journal.ppat.1002520. Epub 2012 Feb 9.


Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection.

McSorley HJ, Gaze S, Daveson J, Jones D, Anderson RP, Clouston A, Ruyssers NE, Speare R, McCarthy JS, Engwerda CR, Croese J, Loukas A.

PLoS One. 2011;6(9):e24092. doi: 10.1371/journal.pone.0024092. Epub 2011 Sep 16.


Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung.

Burke ML, McGarvey L, McSorley HJ, Bielefeldt-Ohmann H, McManus DP, Gobert GN.

Mol Immunol. 2011 Oct;49(1-2):191-200. doi: 10.1016/j.molimm.2011.08.014. Epub 2011 Sep 13.


Immune modulation and modulators in Heligmosomoides polygyrus infection.

Maizels RM, Hewitson JP, Murray J, Harcus YM, Dayer B, Filbey KJ, Grainger JR, McSorley HJ, Reynolds LA, Smith KA.

Exp Parasitol. 2012 Sep;132(1):76-89. doi: 10.1016/j.exppara.2011.08.011. Epub 2011 Aug 22. Review.


Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.

Grainger JR, Smith KA, Hewitson JP, McSorley HJ, Harcus Y, Filbey KJ, Finney CA, Greenwood EJ, Knox DP, Wilson MS, Belkaid Y, Rudensky AY, Maizels RM.

J Exp Med. 2010 Oct 25;207(11):2331-41. doi: 10.1084/jem.20101074. Epub 2010 Sep 27.


The immunology of human hookworm infections.

McSorley HJ, Loukas A.

Parasite Immunol. 2010 Aug;32(8):549-59. doi: 10.1111/j.1365-3024.2010.01224.x. Review.


daf-7-related TGF-beta homologues from Trichostrongyloid nematodes show contrasting life-cycle expression patterns.

McSorley HJ, Grainger JR, Harcus Y, Murray J, Nisbet AJ, Knox DP, Maizels RM.

Parasitology. 2010 Jan;137(1):159-71. doi: 10.1017/S0031182009990321. Epub 2009 Aug 28.


A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.

Perona-Wright G, Jenkins SJ, O'Connor RA, Zienkiewicz D, McSorley HJ, Maizels RM, Anderton SM, MacDonald AS.

J Immunol. 2009 Mar 1;182(5):2808-15. doi: 10.4049/jimmunol.0803553.


Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi.

McSorley HJ, Harcus YM, Murray J, Taylor MD, Maizels RM.

J Immunol. 2008 Nov 1;181(9):6456-66.

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