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Antibody and T cell responses against avian and microbial antigens associate with hypersensitivity pneumonitis disease parameters in pigeon breeders.

Hasan SF, Jozwik A, Heaps A, Kakkar N, Donnelly I, Cookson S, Bourke SJ, McSharry C, Todryk SM.

Allergy. 2019 Dec 13. doi: 10.1111/all.14152. [Epub ahead of print] No abstract available.


Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations.

Yang JF, Chaudhuri R, Thomson NC, Ramparsad N, O'Pray H, Barclay S, MacBride-Stewart S, McCallum C, Sharma V, McSharry C, Murray D, Shepherd M, Lee WN.

NPJ Prim Care Respir Med. 2018 Sep 19;28(1):35. doi: 10.1038/s41533-018-0103-9.


MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.

Alivernini S, Gremese E, McSharry C, Tolusso B, Ferraccioli G, McInnes IB, Kurowska-Stolarska M.

Front Immunol. 2018 Jan 5;8:1932. doi: 10.3389/fimmu.2017.01932. eCollection 2017. Review.


MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis.

Kurowska-Stolarska M, Alivernini S, Melchor EG, Elmesmari A, Tolusso B, Tange C, Petricca L, Gilchrist DS, Di Sante G, Keijzer C, Stewart L, Di Mario C, Morrison V, Brewer JM, Porter D, Milling S, Baxter RD, McCarey D, Gremese E, Lemke G, Ferraccioli G, McSharry C, McInnes IB.

Nat Commun. 2017 Jun 22;8:15877. doi: 10.1038/ncomms15877.


Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium.

Skaaby T, Taylor AE, Jacobsen RK, Paternoster L, Thuesen BH, Ahluwalia TS, Larsen SC, Zhou A, Wong A, Gabrielsen ME, Bjørngaard JH, Flexeder C, Männistö S, Hardy R, Kuh D, Barry SJ, Tang Møllehave L, Cerqueira C, Friedrich N, Bonten TN, Noordam R, Mook-Kanamori DO, Taube C, Jessen LE, McConnachie A, Sattar N, Upton MN, McSharry C, Bønnelykke K, Bisgaard H, Schulz H, Strauch K, Meitinger T, Peters A, Grallert H, Nohr EA, Kivimaki M, Kumari M, Völker U, Nauck M, Völzke H, Power C, Hyppönen E, Hansen T, Jørgensen T, Pedersen O, Salomaa V, Grarup N, Langhammer A, Romundstad PR, Skorpen F, Kaprio J, R Munafò M, Linneberg A.

Sci Rep. 2017 May 22;7(1):2224. doi: 10.1038/s41598-017-01977-w.


The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis.

Kurowska-Stolarska M, Hasoo MK, Welsh DJ, Stewart L, McIntyre D, Morton BE, Johnstone S, Miller AM, Asquith DL, Millar NL, Millar AB, Feghali-Bostwick CA, Hirani N, Crick PJ, Wang Y, Griffiths WJ, McInnes IB, McSharry C.

J Allergy Clin Immunol. 2017 Jun;139(6):1946-1956. doi: 10.1016/j.jaci.2016.09.021. Epub 2016 Oct 14.


Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma.

Chaudhuri R, McSharry C, Heaney LG, Niven R, Brightling CE, Menzies-Gow AN, Bucknall C, Mansur AH, Lee W, Shepherd M, Spears M, Cowan DC, Husi H, Thomson NC; BTS Severe Asthma Network.

Respir Med. 2016 Sep;118:46-52. doi: 10.1016/j.rmed.2016.07.005. Epub 2016 Jul 9.


MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis.

Elmesmari A, Fraser AR, Wood C, Gilchrist D, Vaughan D, Stewart L, McSharry C, McInnes IB, Kurowska-Stolarska M.

Rheumatology (Oxford). 2016 Nov;55(11):2056-2065. Epub 2016 Jul 13.


Periostin as a biomarker of airway inflammation.

McSharry C, Johnstone S.

Pol Arch Med Wewn. 2016;126(3):118-20. doi: 10.20452/pamw.3333. Epub 2016 Mar 23. No abstract available.


Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12.

Komai-Koma M, Wang E, Kurowska-Stolarska M, Li D, McSharry C, Xu D.

Immunobiology. 2016 Mar;221(3):412-7. doi: 10.1016/j.imbio.2015.11.013. Epub 2015 Dec 7.


Effectiveness of bronchial thermoplasty in severe asthma in 'real life' patients compared with those recruited to clinical trials in the same centre.

Bicknell S, Chaudhuri R, Lee N, Shepherd M, Spears M, Pitman N, Cameron E, Cowan D, Nixon J, Thompson J, McSharry C, Thomson NC.

Ther Adv Respir Dis. 2015 Dec;9(6):267-71. doi: 10.1177/1753465815601332. Epub 2015 Aug 24.



Thomson NC, McSharry C, Chaudhuri R.

Chest. 2015 Jul;148(1):e33-e34. doi: 10.1378/chest.15-0890. No abstract available.


Serum periostin in smokers and never smokers with asthma.

Thomson NC, Chaudhuri R, Spears M, Haughney J, McSharry C.

Respir Med. 2015 Jun;109(6):708-15. doi: 10.1016/j.rmed.2015.03.009. Epub 2015 Apr 3.


Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

Thomson NC, Charron CE, Chaudhuri R, Spears M, Ito K, McSharry C.

Pulm Pharmacol Ther. 2015 Apr;31:1-8. doi: 10.1016/j.pupt.2015.01.001. Epub 2015 Jan 14.


Decreased FEV1 % in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values.

McSharry C, Vesper S, Wymer L, Howieson S, Chaudhuri R, Wright GR, Thomson NC.

Clin Exp Allergy. 2015 May;45(5):902-907. doi: 10.1111/cea.12482.


Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma.

Thomson NC, Chaudhuri R, Spears M, Messow CM, MacNee W, Connell M, Murchison JT, Sproule M, McSharry C.

Chest. 2015 Mar;147(3):735-744. doi: 10.1378/chest.14-1119. Erratum in: Chest. 2015 Aug;148(2):572.


Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients.

McSharry C, Spears M, Chaudhuri R, Cameron EJ, Husi H, Thomson NC.

J Allergy Clin Immunol. 2014 Nov;134(5):1068-75. doi: 10.1016/j.jaci.2014.08.022. Epub 2014 Sep 26.


Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma.

Chaudhuri R, McSharry C, Brady J, Grierson C, Messow CM, Spears M, Miele G, Nocka K, MacNee W, Connell M, Murchison JT, Sproule M, Hilmi OJ, Miller DK, Thomson NC.

Eur Respir J. 2014 Oct;44(4):895-904. doi: 10.1183/09031936.00047014. Epub 2014 Jul 3.


IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice.

Li D, Guabiraba R, Besnard AG, Komai-Koma M, Jabir MS, Zhang L, Graham GJ, Kurowska-Stolarska M, Liew FY, McSharry C, Xu D.

J Allergy Clin Immunol. 2014 Dec;134(6):1422-1432.e11. doi: 10.1016/j.jaci.2014.05.011. Epub 2014 Jun 27.


Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking.

Thomson NC, Chaudhuri R, Spears M, Messow CM, Jelinsky S, Miele G, Nocka K, Takahashi E, Hilmi OJ, Shepherd MC, Miller DK, McSharry C.

Allergy. 2014 Apr;69(4):527-36. doi: 10.1111/all.12376. Epub 2014 Feb 26.


Sputum matrix metalloproteinase-9 is associated with the degree of emphysema on computed tomography in COPD.

Chaudhuri R, McSharry C, Spears M, Brady J, Grierson C, Messow CM, Miele G, Nocka K, MacNee W, Connell M, Murchison JT, Sproule M, Hilmi O, Miller DK, Thomson NC.

Transl Respir Med. 2013 Dec;1(1):11. doi: 10.1186/2213-0802-1-11. Epub 2013 Jun 6.


Randomised controlled trial of azithromycin in smokers with asthma.

Cameron EJ, Chaudhuri R, Mair F, McSharry C, Greenlaw N, Weir CJ, Jolly L, Donnelly I, Gallacher K, Morrison D, Spears M, Evans TJ, Anderson K, Thomson NC.

Eur Respir J. 2013 Nov;42(5):1412-5. doi: 10.1183/09031936.00093913. Epub 2013 Sep 13. No abstract available.


Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines-an exploratory study.

Spears M, McSharry C, Chaudhuri R, Weir CJ, de Wet C, Thomson NC.

PLoS One. 2013 Aug 9;8(8):e71460. doi: 10.1371/journal.pone.0071460. eCollection 2013.


Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum.

Albarbarawi O, Barton A, Miller D, McSharry C, Chaudhuri R, Thomson NC, Palmer CN, Devereux G, Huang JT.

Bioanalysis. 2013 Aug;5(16):1991-2001. doi: 10.4155/bio.13.164.


Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma.

Thomson NC, Chaudhuri R, Messow CM, Spears M, MacNee W, Connell M, Murchison JT, Sproule M, McSharry C.

Respir Med. 2013 Oct;107(10):1501-8. doi: 10.1016/j.rmed.2013.07.017. Epub 2013 Aug 6.


Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09.

Bradley-Stewart A, Jolly L, Adamson W, Gunson R, Frew-Gillespie C, Templeton K, Aitken C, Carman W, Cameron S, McSharry C.

J Clin Virol. 2013 Sep;58(1):100-7. doi: 10.1016/j.jcv.2013.05.011. Epub 2013 Jun 20.


Interleukin-33 exacerbates acute colitis via interleukin-4 in mice.

Pushparaj PN, Li D, Komai-Koma M, Guabiraba R, Alexander J, McSharry C, Xu D.

Immunology. 2013 Sep;140(1):70-7. doi: 10.1111/imm.12111.


Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma.

Thomson NC, Chaudhuri R, Heaney LG, Bucknall C, Niven RM, Brightling CE, Menzies-Gow AN, Mansur AH, McSharry C.

J Allergy Clin Immunol. 2013 Apr;131(4):1008-16. doi: 10.1016/j.jaci.2012.12.1574. Epub 2013 Feb 16.


The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype.

Rzepecka J, Siebeke I, Coltherd JC, Kean DE, Steiger CN, Al-Riyami L, McSharry C, Harnett MM, Harnett W.

Int J Parasitol. 2013 Mar;43(3-4):211-23. doi: 10.1016/j.ijpara.2012.12.001. Epub 2013 Jan 3.


Anti-interleukin-33 inhibits cigarette smoke-induced lung inflammation in mice.

Qiu C, Li Y, Li M, Li M, Liu X, McSharry C, Xu D.

Immunology. 2013 Jan;138(1):76-82. doi: 10.1111/imm.12020. Erratum in: Immunology. 2013 Jan;138(1):83.


Long-term macrolide treatment of chronic inflammatory airway diseases: risks, benefits and future developments.

Cameron EJ, McSharry C, Chaudhuri R, Farrow S, Thomson NC.

Clin Exp Allergy. 2012 Sep;42(9):1302-12. doi: 10.1111/j.1365-2222.2012.03979.x. Review.


Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice.

Komai-Koma M, Brombacher F, Pushparaj PN, Arendse B, McSharry C, Alexander J, Chaudhuri R, Thomson NC, McKenzie AN, McInnes I, Liew FY, Xu D.

Allergy. 2012 Sep;67(9):1118-26. doi: 10.1111/j.1398-9995.2012.02859.x. Epub 2012 Jun 15.


Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity.

Chaudhuri R, McSharry C, Brady J, Donnelly I, Grierson C, McGuinness S, Jolly L, Weir CJ, Messow CM, Spears M, Miele G, Nocka K, Crowther D, Thompson J, Brannigan M, Lafferty J, Sproule M, Macnee W, Connell M, Murchison JT, Shepherd MC, Feuerstein G, Miller DK, Thomson NC.

J Allergy Clin Immunol. 2012 Mar;129(3):655-663.e8. doi: 10.1016/j.jaci.2011.12.996. Epub 2012 Feb 2. Erratum in: J Allergy Clin Immunol. 2013 Jun;131(6):1716.


Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease.

Huang JT, Chaudhuri R, Albarbarawi O, Barton A, Grierson C, Rauchhaus P, Weir CJ, Messow M, Stevens N, McSharry C, Feuerstein G, Mukhopadhyay S, Brady J, Palmer CN, Miller D, Thomson NC.

Thorax. 2012 Jun;67(6):502-8. doi: 10.1136/thoraxjnl-2011-200279. Epub 2012 Jan 16.


Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function.

Xuzhu G, Komai-Koma M, Leung BP, Howe HS, McSharry C, McInnes IB, Xu D.

Ann Rheum Dis. 2012 Jan;71(1):129-35. doi: 10.1136/ard.2011.149831. Epub 2011 Sep 27.


Bronchial nitric oxide flux (J'aw) is sensitive to oral corticosteroids in smokers with asthma.

Spears M, Weir CJ, Smith AD, McSharry C, Chaudhuri R, Johnson M, Cameron E, Thomson NC.

Respir Med. 2011 Dec;105(12):1823-30. doi: 10.1016/j.rmed.2011.06.014. Epub 2011 Aug 12.


MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis.

Kurowska-Stolarska M, Alivernini S, Ballantine LE, Asquith DL, Millar NL, Gilchrist DS, Reilly J, Ierna M, Fraser AR, Stolarski B, McSharry C, Hueber AJ, Baxter D, Hunter J, Gay S, Liew FY, McInnes IB.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11193-8. doi: 10.1073/pnas.1019536108. Epub 2011 Jun 20.


Parkinson disease: Could over-the-counter treatment protect against Parkinson disease?

McSharry C.

Nat Rev Neurol. 2011 May;7(5):244. doi: 10.1038/nrneurol.2011.49. No abstract available.


Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial.

Braganza G, Chaudhuri R, McSharry C, Weir CJ, Donnelly I, Jolly L, Lafferty J, Lloyd SM, Spears M, Mair F, Thomson NC.

BMC Pulm Med. 2011 Apr 7;11:16. doi: 10.1186/1471-2466-11-16.


Multiple sclerosis: Noradrenaline deficits suggest novel MS treatments.

McSharry C.

Nat Rev Neurol. 2011 Apr;7(4):184. doi: 10.1038/nrneurol.2011.28. No abstract available.


Parkinson disease: Skin patch improves sleep in PD.

McSharry C.

Nat Rev Neurol. 2011 Feb;7(2):64. No abstract available.


Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma.

Spears M, McSharry C, Donnelly I, Jolly L, Brannigan M, Thomson J, Lafferty J, Chaudhuri R, Shepherd M, Cameron E, Thomson NC.

Clin Exp Allergy. 2011 May;41(5):665-72. doi: 10.1111/j.1365-2222.2010.03692.x. Epub 2011 Feb 21.


Preventing epilepsy in malaria survivors.

McSharry C.

Nat Rev Neurol. 2011 Jan;7(1):2. doi: 10.1038/nrneurol.2010.185. No abstract available.


Epilepsy: A new therapeutic strategy in epileptic seizure suppression.

McSharry C.

Nat Rev Neurol. 2010 Dec;6(12):644. doi: 10.1038/nrneurol.2010.168. No abstract available.


Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy?

Sandilands GP, Wilson M, Huser C, Jolly L, Sands WA, McSharry C.

Clin Exp Immunol. 2010 Dec;162(3):516-27. doi: 10.1111/j.1365-2249.2010.04264.x. Epub 2010 Oct 21.


Parkinson disease: Could sunlight offer protection from Parkinson disease?

McSharry C.

Nat Rev Neurol. 2010 Sep;6(9):468. doi: 10.1038/nrneurol.2010.120. No abstract available.


Stroke: embolus detection could predict risk of stroke.

McSharry C.

Nat Rev Neurol. 2010 Aug;6(8):412. doi: 10.1038/nrneurol.2010.96. No abstract available.


Chronic kidney disease: Early CKD increases the risk of adverse outcomes in pregnancy.

McSharry C.

Nat Rev Nephrol. 2010 Jul;6(7):385. doi: 10.1038/nrneph.2010.76. No abstract available.


IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.

Kurowska-Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan CJ, Ying S, Pitman N, Mirchandani A, Rana B, van Rooijen N, Shepherd M, McSharry C, McInnes IB, Xu D, Liew FY.

J Immunol. 2009 Nov 15;183(10):6469-77. doi: 10.4049/jimmunol.0901575. Epub 2009 Oct 19.


Effect of improved home ventilation on asthma control and house dust mite allergen levels.

Wright GR, Howieson S, McSharry C, McMahon AD, Chaudhuri R, Thompson J, Donnelly I, Brooks RG, Lawson A, Jolly L, McAlpine L, King EM, Chapman MD, Wood S, Thomson NC.

Allergy. 2009 Nov;64(11):1671-80. doi: 10.1111/j.1398-9995.2009.02098.x. Epub 2009 Jul 24.

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