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Items: 38


Functional paralysis of human natural killer cells by alphaherpesviruses.

Campbell TM, McSharry BP, Steain M, Russell TA, Tscharke DC, Kennedy JJ, Slobedman B, Abendroth A.

PLoS Pathog. 2019 Jun 13;15(6):e1007784. doi: 10.1371/journal.ppat.1007784. eCollection 2019 Jun.


Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression.

Ashley CL, Abendroth A, McSharry BP, Slobedman B.

Viruses. 2019 Mar 12;11(3). pii: E246. doi: 10.3390/v11030246.


Gal power: the diverse roles of galectins in regulating viral infections.

Machala EA, McSharry BP, Rouse BT, Abendroth A, Slobedman B.

J Gen Virol. 2019 Mar;100(3):333-349. doi: 10.1099/jgv.0.001208. Epub 2019 Jan 16.


Restriction of Human Cytomegalovirus Infection by Galectin-9.

Machala EA, Avdic S, Stern L, Zajonc DM, Benedict CA, Blyth E, Gottlieb DJ, Abendroth A, McSharry BP, Slobedman B.

J Virol. 2019 Jan 17;93(3). pii: e01746-18. doi: 10.1128/JVI.01746-18. Print 2019 Feb 1.


Varicella zoster virus productively infects human natural killer cells and manipulates phenotype.

Campbell TM, McSharry BP, Steain M, Ashhurst TM, Slobedman B, Abendroth A.

PLoS Pathog. 2018 Apr 30;14(4):e1006999. doi: 10.1371/journal.ppat.1006999. eCollection 2018 Apr.


Varicella-Zoster Virus ORF63 Protects Human Neuronal and Keratinocyte Cell Lines from Apoptosis and Changes Its Localization upon Apoptosis Induction.

Gerada C, Steain M, McSharry BP, Slobedman B, Abendroth A.

J Virol. 2018 May 29;92(12). pii: e00338-18. doi: 10.1128/JVI.00338-18. Print 2018 Jun 15.


Nuclear domain 10 components upregulated via interferon during human cytomegalovirus infection potently regulate viral infection.

Ashley CL, Glass MS, Abendroth A, McSharry BP, Slobedman B.

J Gen Virol. 2017 Jul;98(7):1795-1805. doi: 10.1099/jgv.0.000858.


Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype.

Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM.

Hum Immunol. 2016 Oct;77(10):876-885. doi: 10.1016/j.humimm.2016.06.018. Epub 2016 Jun 24.


Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells.

Low H, Mukhamedova N, Cui HL, McSharry BP, Avdic S, Hoang A, Ditiatkovski M, Liu Y, Fu Y, Meikle PJ, Blomberg M, Polyzos KA, Miller WE, Religa P, Bukrinsky M, Soderberg-Naucler C, Slobedman B, Sviridov D.

Cell Rep. 2016 Jun 28;16(1):186-200. doi: 10.1016/j.celrep.2016.05.070. Epub 2016 Jun 16.


Human Cytomegalovirus-Encoded Human Interleukin-10 (IL-10) Homolog Amplifies Its Immunomodulatory Potential by Upregulating Human IL-10 in Monocytes.

Avdic S, McSharry BP, Steain M, Poole E, Sinclair J, Abendroth A, Slobedman B.

J Virol. 2016 Mar 28;90(8):3819-3827. doi: 10.1128/JVI.03066-15. Print 2016 Apr.


Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection.

Campbell TM, McSharry BP, Steain M, Slobedman B, Abendroth A.

J Virol. 2015 Aug;89(15):7932-43. doi: 10.1128/JVI.00292-15. Epub 2015 May 20.


Abrogation of the interferon response promotes more efficient human cytomegalovirus replication.

McSharry BP, Forbes SK, Avdic S, Randall RE, Wilkinson GW, Abendroth A, Slobedman B.

J Virol. 2015 Jan 15;89(2):1479-83. doi: 10.1128/JVI.02988-14. Epub 2014 Nov 12.


Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus.

Avdic S, McSharry BP, Slobedman B.

Front Microbiol. 2014 Jul 4;5:337. doi: 10.3389/fmicb.2014.00337. eCollection 2014. Review.


Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon.

McSharry BP, Forbes SK, Cao JZ, Avdic S, Machala EA, Gottlieb DJ, Abendroth A, Slobedman B.

J Virol. 2014 Sep;88(18):10990-4. doi: 10.1128/JVI.01259-14. Epub 2014 Jul 9.


Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation.

Fielding CA, Aicheler R, Stanton RJ, Wang EC, Han S, Seirafian S, Davies J, McSharry BP, Weekes MP, Antrobus PR, Prod'homme V, Blanchet FP, Sugrue D, Cuff S, Roberts D, Davison AJ, Lehner PJ, Wilkinson GW, Tomasec P.

PLoS Pathog. 2014 May 1;10(5):e1004058. doi: 10.1371/journal.ppat.1004058. eCollection 2014 May.


Human cytomegalovirus interleukin-10 polarizes monocytes toward a deactivated M2c phenotype to repress host immune responses.

Avdic S, Cao JZ, McSharry BP, Clancy LE, Brown R, Steain M, Gottlieb DJ, Abendroth A, Slobedman B.

J Virol. 2013 Sep;87(18):10273-82. doi: 10.1128/JVI.00912-13. Epub 2013 Jul 17.


Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation.

McSharry BP, Avdic S, Slobedman B.

Viruses. 2012 Oct 25;4(11):2448-70. doi: 10.3390/v4112448. Review.


Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18.

Prod'homme V, Tomasec P, Cunningham C, Lemberg MK, Stanton RJ, McSharry BP, Wang EC, Cuff S, Martoglio B, Davison AJ, Braud VM, Wilkinson GW.

J Immunol. 2012 Mar 15;188(6):2794-804. doi: 10.4049/jimmunol.1102068. Epub 2012 Feb 15.


Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.

Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R; Irish HCV Research Consortium, O'Farrelly C, Gardiner CM.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5736-41. doi: 10.1073/pnas.1016358108. Epub 2011 Mar 14.


Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication.

Stanton RJ, Baluchova K, Dargan DJ, Cunningham C, Sheehy O, Seirafian S, McSharry BP, Neale ML, Davies JA, Tomasec P, Davison AJ, Wilkinson GW.

J Clin Invest. 2010 Sep;120(9):3191-208. doi: 10.1172/JCI42955. Epub 2010 Aug 2.


Differential relocation and stability of PML-body components during productive human cytomegalovirus infection: detailed characterization by live-cell imaging.

Dimitropoulou P, Caswell R, McSharry BP, Greaves RF, Spandidos DA, Wilkinson GW, Sourvinos G.

Eur J Cell Biol. 2010 Oct;89(10):757-68. doi: 10.1016/j.ejcb.2010.05.006.


Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture.

Dargan DJ, Douglas E, Cunningham C, Jamieson F, Stanton RJ, Baluchova K, McSharry BP, Tomasec P, Emery VC, Percivalle E, Sarasini A, Gerna G, Wilkinson GW, Davison AJ.

J Gen Virol. 2010 Jun;91(Pt 6):1535-46. doi: 10.1099/vir.0.018994-0.


The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.

McLaren JE, Calder CJ, McSharry BP, Sexton K, Salter RC, Singh NN, Wilkinson GW, Wang EC, Ramji DP.

J Immunol. 2010 May 15;184(10):5827-34. doi: 10.4049/jimmunol.0903782. Epub 2010 Apr 21.


Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function.

Stanton RJ, McSharry BP, Armstrong M, Tomasec P, Wilkinson GW.

Biotechniques. 2008 Dec;45(6):659-62, 664-8.


Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.

Lakdawala SS, Schwartz RA, Ferenchak K, Carson CT, McSharry BP, Wilkinson GW, Weitzman MD.

J Virol. 2008 Sep;82(17):8362-72. doi: 10.1128/JVI.00900-08. Epub 2008 Jun 18.


Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B.

McSharry BP, Burgert HG, Owen DP, Stanton RJ, Prod'homme V, Sester M, Koebernick K, Groh V, Spies T, Cox S, Little AM, Wang EC, Tomasec P, Wilkinson GW.

J Virol. 2008 May;82(9):4585-94. doi: 10.1128/JVI.02251-07. Epub 2008 Feb 20.


Modulation of natural killer cells by human cytomegalovirus.

Wilkinson GW, Tomasec P, Stanton RJ, Armstrong M, Prod'homme V, Aicheler R, McSharry BP, Rickards CR, Cochrane D, Llewellyn-Lacey S, Wang EC, Griffin CA, Davison AJ.

J Clin Virol. 2008 Mar;41(3):206-12. Review.


Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death.

Reeves MB, Davies AA, McSharry BP, Wilkinson GW, Sinclair JH.

Science. 2007 Jun 1;316(5829):1345-8.


Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression.

Stanton RJ, McSharry BP, Rickards CR, Wang EC, Tomasec P, Wilkinson GW.

J Virol. 2007 Aug;81(15):7860-72. Epub 2007 May 23.


Adenovirus vector delivery stimulates natural killer cell recognition.

Tomasec P, Wang EC, Groh V, Spies T, McSharry BP, Aicheler RJ, Stanton RJ, Wilkinson GW.

J Gen Virol. 2007 Apr;88(Pt 4):1103-8.


The human cytomegalovirus MHC class I homolog UL18 inhibits LIR-1+ but activates LIR-1- NK cells.

Prod'homme V, Griffin C, Aicheler RJ, Wang EC, McSharry BP, Rickards CR, Stanton RJ, Borysiewicz LK, López-Botet M, Wilkinson GW, Tomasec P.

J Immunol. 2007 Apr 1;178(7):4473-81.


Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18.

Griffin C, Wang EC, McSharry BP, Rickards C, Browne H, Wilkinson GW, Tomasec P.

J Gen Virol. 2005 Nov;86(Pt 11):2999-3008.


Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.

Tomasec P, Wang EC, Davison AJ, Vojtesek B, Armstrong M, Griffin C, McSharry BP, Morris RJ, Llewellyn-Lacey S, Rickards C, Nomoto A, Sinzger C, Wilkinson GW.

Nat Immunol. 2005 Feb;6(2):181-8. Epub 2005 Jan 9.


Genetic content of wild-type human cytomegalovirus.

Dolan A, Cunningham C, Hector RD, Hassan-Walker AF, Lee L, Addison C, Dargan DJ, McGeoch DJ, Gatherer D, Emery VC, Griffiths PD, Sinzger C, McSharry BP, Wilkinson GW, Davison AJ.

J Gen Virol. 2004 May;85(Pt 5):1301-12.


The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro.

McSharry BP, Tomasec P, Neale ML, Wilkinson GW.

J Gen Virol. 2003 Sep;84(Pt 9):2511-6.


Two novel spliced genes in human cytomegalovirus.

Akter P, Cunningham C, McSharry BP, Dolan A, Addison C, Dargan DJ, Hassan-Walker AF, Emery VC, Griffiths PD, Wilkinson GW, Davison AJ.

J Gen Virol. 2003 May;84(Pt 5):1117-22.


Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus.

McSharry BP, Jones CJ, Skinner JW, Kipling D, Wilkinson GW.

J Gen Virol. 2001 Apr;82(Pt 4):855-63.


Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

Tomasec P, Braud VM, Rickards C, Powell MB, McSharry BP, Gadola S, Cerundolo V, Borysiewicz LK, McMichael AJ, Wilkinson GW.

Science. 2000 Feb 11;287(5455):1031.

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