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Items: 27

1.

Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.

Costa MDC, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL.

Brain. 2016 Nov 1;139(11):2891-2908. doi: 10.1093/brain/aww228.

2.

Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.

Pang AH, Garzan A, Larsen MJ, McQuade TJ, Garneau-Tsodikova S, Tsodikov OV.

ACS Chem Biol. 2016 Nov 18;11(11):3084-3092. Epub 2016 Sep 26.

PMID:
27622287
3.

Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.

Park SR, Tripathi A, Wu J, Schultz PJ, Yim I, McQuade TJ, Yu F, Arevang CJ, Mensah AY, Tamayo-Castillo G, Xi C, Sherman DH.

Nat Commun. 2016 Feb 16;7:10710. doi: 10.1038/ncomms10710.

4.

Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.

Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE.

Science. 2015 Nov 6;350(6261):674-7. doi: 10.1126/science.aac9145.

5.

Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries.

Lowell AN, Santoro N, Swaney SM, McQuade TJ, Schultz PJ, Larsen MJ, Sherman DH.

Chem Biol Drug Des. 2015 Dec;86(6):1331-8. doi: 10.1111/cbdd.12614. Epub 2015 Jul 25.

6.

Narrow-spectrum inhibitors of Campylobacter jejuni flagellar expression and growth.

Johnson JG, Yuhas C, McQuade TJ, Larsen MJ, DiRita VJ.

Antimicrob Agents Chemother. 2015 Jul;59(7):3880-6. doi: 10.1128/AAC.04926-14. Epub 2015 Apr 13.

7.

High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity.

Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki JE.

Chem Biol Drug Des. 2014 Apr;83(4):440-9. doi: 10.1111/cbdd.12259.

8.

Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism.

Chang L, Miyata Y, Ung PM, Bertelsen EB, McQuade TJ, Carlson HA, Zuiderweg ER, Gestwicki JE.

Chem Biol. 2011 Feb 25;18(2):210-21. doi: 10.1016/j.chembiol.2010.12.010.

9.

Bicinchoninic acid (BCA) assay in low volume.

Bainor A, Chang L, McQuade TJ, Webb B, Gestwicki JE.

Anal Biochem. 2011 Mar 15;410(2):310-2. doi: 10.1016/j.ab.2010.11.015. Epub 2010 Nov 13.

PMID:
21078286
10.

Application of a high-throughput fluorescent acetyltransferase assay to identify inhibitors of homocitrate synthase.

Bulfer SL, McQuade TJ, Larsen MJ, Trievel RC.

Anal Biochem. 2011 Mar 1;410(1):133-40. doi: 10.1016/j.ab.2010.11.004. Epub 2010 Nov 10.

11.

High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.

Miyata Y, Chang L, Bainor A, McQuade TJ, Walczak CP, Zhang Y, Larsen MJ, Kirchhoff P, Gestwicki JE.

J Biomol Screen. 2010 Dec;15(10):1211-9. doi: 10.1177/1087057110380571. Epub 2010 Oct 6.

12.

High-throughput screening of the virulence regulator VirF: a novel antibacterial target for shigellosis.

Hurt JK, McQuade TJ, Emanuele A, Larsen MJ, Garcia GA.

J Biomol Screen. 2010 Apr;15(4):379-87. doi: 10.1177/1087057110362101. Epub 2010 Mar 17.

13.

A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis.

McQuade TJ, Shallop AD, Sheoran A, Delproposto JE, Tsodikov OV, Garneau-Tsodikova S.

Anal Biochem. 2009 Mar 15;386(2):244-50. doi: 10.1016/j.ab.2008.12.014. Epub 2008 Dec 24.

PMID:
19135023
14.

Discovery and optimization of nonpeptide HIV-1 protease inhibitors.

Tummino PJ, Prasad JV, Ferguson D, Nouhan C, Graham N, Domagala JM, Ellsworth E, Gajda C, Hagen SE, Lunney EA, Para KS, Tait BD, Pavlovsky A, Erickson JW, Gracheck S, McQuade TJ, Hupe DJ.

Bioorg Med Chem. 1996 Sep;4(9):1401-10.

PMID:
8894098
15.

Nonpeptidic HIV protease inhibitors: 4-hydroxy-pyran-2-one inhibitors with functional tethers to P1 phenyl ring to reach S3 pocket of the enzyme.

Vara Prasad J, Tummino PJ, Ferguson D, Saunders J, Vander Roest S, McQuade TJ, Heldsinger A, Reyner EL, Stewart BH, Guttendorf RJ, Para KS, Lunney EA, Gracheck SJ, Domagala JM.

Biochem Biophys Res Commun. 1996 Apr 25;221(3):815-20.

PMID:
8630044
16.

Nonpeptidic potent HIV-1 protease inhibitors: (4-hydroxy-6-phenyl-2-oxo-2H- pyran-3-yl)thiomethanes that span P1-P2' subsites in a unique mode of active site binding.

Prasad JV, Para KS, Tummino PJ, Ferguson D, McQuade TJ, Lunney EA, Rapundalo ST, Batley BL, Hingorani G, Domagala JM, et al.

J Med Chem. 1995 Mar 17;38(6):898-905.

PMID:
7699705
17.

Evaluation of a vitamin-cloaking strategy for oligopeptide therapeutics: biotinylated HIV-1 protease inhibitors.

Islam I, Ng KY, Chong KT, McQuade TJ, Hui JO, Wilkinson KF, Rush BD, Ruwart MJ, Borchardt RT, Fisher JF.

J Med Chem. 1994 Jan 21;37(2):293-304.

PMID:
8295217
18.

Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere.

Thaisrivongs S, Turner SR, Strohbach JW, TenBrink RE, Tarpley WG, McQuade TJ, Heinrikson RL, Tomasselli AG, Hui JO, Howe WJ.

J Med Chem. 1993 Apr 16;36(8):941-52.

PMID:
8478908
20.

Purification of an active monomeric recombinant HIV-1 trans-activator.

Waszak GA, Hasler JM, McQuade TJ, Tarpley WG, Deibel MR Jr.

Protein Expr Purif. 1992 Apr;3(2):126-33.

PMID:
1422216
21.
22.

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity.

Thaisrivongs S, Tomasselli AG, Moon JB, Hui J, McQuade TJ, Turner SR, Strohbach JW, Howe WJ, Tarpley WG, Heinrikson RL.

J Med Chem. 1991 Aug;34(8):2344-56.

PMID:
1875334
23.

Metal affinity chromatography of recombinant HIV-1 reverse transcriptase containing a human renin cleavable metal binding domain.

Sharma SK, Evans DB, Vosters AF, McQuade TJ, Tarpley WG.

Biotechnol Appl Biochem. 1991 Aug;14(1):69-81.

PMID:
1716913
24.

An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

Ashorn P, McQuade TJ, Thaisrivongs S, Tomasselli AG, Tarpley WG, Moss B.

Proc Natl Acad Sci U S A. 1990 Oct;87(19):7472-6.

25.

Denaturation/refolding of purified recombinant HIV reverse transcriptase yields monomeric enzyme with high enzymatic activity.

Deibel MR Jr, McQuade TJ, Brunner DP, Tarpley WG.

AIDS Res Hum Retroviruses. 1990 Mar;6(3):329-40.

PMID:
1692723
26.

A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation.

McQuade TJ, Tomasselli AG, Liu L, Karacostas V, Moss B, Sawyer TK, Heinrikson RL, Tarpley WG.

Science. 1990 Jan 26;247(4941):454-6.

PMID:
2405486
27.

A rapid solution immunoassay to quantify binding of the human immunodeficiency virus envelope glycoprotein to soluble CD4.

McQuade TJ, Pitts TW, Tarpley WG.

Biochem Biophys Res Commun. 1989 Aug 30;163(1):172-6.

PMID:
2549987

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