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Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease.

Diwakarla S, Finkelstein DI, Constable R, Artaiz O, Di Natale M, McQuade RM, Lei E, Chai XY, Ringuet MT, Fothergill LJ, Lawson VA, Ellett LJ, Berger JP, Furness JB.

Neurogastroenterol Motil. 2019 Nov 10:e13755. doi: 10.1111/nmo.13755. [Epub ahead of print]


Efficacy and Safety of Brexpiprazole for the Treatment of Agitation in Alzheimer's Dementia: Two 12-Week, Randomized, Double-Blind, Placebo-Controlled Trials.

Grossberg GT, Kohegyi E, Mergel V, Josiassen MK, Meulien D, Hobart M, Slomkowski M, Baker RA, McQuade RD, Cummings JL.

Am J Geriatr Psychiatry. 2019 Oct 1. pii: S1064-7481(19)30521-4. doi: 10.1016/j.jagp.2019.09.009. [Epub ahead of print]


Quantitation and chemical coding of enteroendocrine cell populations in the human jejunum.

Fazio Coles TE, Fothergill LJ, Hunne B, Nikfarjam M, Testro A, Callaghan B, McQuade RM, Furness JB.

Cell Tissue Res. 2019 Sep 2. doi: 10.1007/s00441-019-03099-3. [Epub ahead of print]


Muscarinic receptor 1 allosteric modulators stimulate colorectal emptying in dog, mouse and rat and resolve constipation.

Pustovit RV, Itomi Y, Ringuet M, Diwakarla S, Chai XY, McQuade RM, Tsukimi Y, Furness JB.

Neurogastroenterol Motil. 2019 Nov;31(11):e13692. doi: 10.1111/nmo.13692. Epub 2019 Aug 2.


Co-treatment With BGP-15 Exacerbates 5-Fluorouracil-Induced Gastrointestinal Dysfunction.

McQuade RM, Al Thaalibi M, Petersen AC, Abalo R, Bornstein JC, Rybalka E, Nurgali K.

Front Neurosci. 2019 May 8;13:449. doi: 10.3389/fnins.2019.00449. eCollection 2019.


Distributions and relationships of chemically defined enteroendocrine cells in the rat gastric mucosa.

Hunne B, Stebbing MJ, McQuade RM, Furness JB.

Cell Tissue Res. 2019 Oct;378(1):33-48. doi: 10.1007/s00441-019-03029-3. Epub 2019 May 2.


A Long-Term, Open-Label Study to Evaluate the Safety and Tolerability of Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder.

Hobart M, Zhang P, Skuban A, Brewer C, Hefting N, Sanchez R, McQuade RD.

J Clin Psychopharmacol. 2019 May/Jun;39(3):203-209. doi: 10.1097/JCP.0000000000001034.


Oxaliplatin Treatment Alters Systemic Immune Responses.

Stojanovska V, Prakash M, McQuade R, Fraser S, Apostolopoulos V, Sakkal S, Nurgali K.

Biomed Res Int. 2019 Feb 18;2019:4650695. doi: 10.1155/2019/4650695. eCollection 2019.


Agonist-dependent development of delta opioid receptor tolerance in the colon.

DiCello JJ, Saito A, Rajasekhar P, Sebastian BW, McQuade RM, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP.

Cell Mol Life Sci. 2019 Aug;76(15):3033-3050. doi: 10.1007/s00018-019-03077-6. Epub 2019 Mar 23.


Relationships of endocrine cells to each other and to other cell types in the human gastric fundus and corpus.

Fakhry J, Stebbing MJ, Hunne B, Bayguinov Y, Ward SM, Sasse KC, Callaghan B, McQuade RM, Furness JB.

Cell Tissue Res. 2019 Apr;376(1):37-49. doi: 10.1007/s00441-018-2957-0. Epub 2018 Nov 22.


PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection.

McQuade RM, Stojanovska V, Bornstein JC, Nurgali K.

Pharmacol Res. 2018 Nov;137:104-113. doi: 10.1016/j.phrs.2018.09.031. Epub 2018 Sep 29. Review.


An Engineered Synthetic Biologic Protects Against Clostridium difficile Infection.

Vedantam G, Kochanowsky J, Lindsey J, Mallozzi M, Roxas JL, Adamson C, Anwar F, Clark A, Claus-Walker R, Mansoor A, McQuade R, Monasky RC, Ramamurthy S, Roxas B, Viswanathan VK.

Front Microbiol. 2018 Sep 5;9:2080. doi: 10.3389/fmicb.2018.02080. eCollection 2018.


The safety and tolerability of aripiprazole once-monthly as maintenance treatment for bipolar I disorder: A double-blind, placebo-controlled, randomized withdrawal study.

Calabrese JR, Sanchez R, Jin N, Amatniek J, Cox K, Johnson B, Perry PP, Hertel P, Such P, McQuade RD, Nyilas M, Carson WH.

J Affect Disord. 2018 Dec 1;241:425-432. doi: 10.1016/j.jad.2018.06.043. Epub 2018 Jul 6.


Inflammation-associated changes in DOR expression and function in the mouse colon.

DiCello JJ, Saito A, Rajasekhar P, Eriksson EM, McQuade RM, Nowell CJ, Sebastian BW, Fichna J, Veldhuis NA, Canals M, Bunnett NW, Carbone SE, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G544-G559. doi: 10.1152/ajpgi.00025.2018. Epub 2018 Jun 21.


Secretion Systems and Secreted Proteins in Gram-Negative Entomopathogenic Bacteria: Their Roles in Insect Virulence and Beyond.

McQuade R, Stock SP.

Insects. 2018 Jun 19;9(2). pii: E68. doi: 10.3390/insects9020068. Review.


Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon.

Stojanovska V, McQuade RM, Fraser S, Prakash M, Gondalia S, Stavely R, Palombo E, Apostolopoulos V, Sakkal S, Nurgali K.

PLoS One. 2018 Jun 12;13(6):e0198359. doi: 10.1371/journal.pone.0198359. eCollection 2018.


A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Fixed-Dose Brexpiprazole 2 mg/d as Adjunctive Treatment of Adults With Major Depressive Disorder.

Hobart M, Skuban A, Zhang P, Augustine C, Brewer C, Hefting N, Sanchez R, McQuade RD.

J Clin Psychiatry. 2018 May 22;79(4). pii: 17m12058. doi: 10.4088/JCP.17m12058.


Effects of Oxaliplatin Treatment on the Myenteric Plexus Innervation and Glia in the Murine Distal Colon.

Stojanovska V, McQuade RM, Miller S, Nurgali K.

J Histochem Cytochem. 2018 Oct;66(10):723-736. doi: 10.1369/0022155418774755. Epub 2018 May 9.


The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

Schneider EK, McQuade RM, Carbone VC, Reyes-Ortega F, Wilson JW, Button B, Saito A, Poole DP, Hoyer D, Li J, Velkov T.

ERJ Open Res. 2018 Mar 13;4(1). pii: 00127-2017. doi: 10.1183/23120541.00127-2017. eCollection 2018 Jan. Erratum in: ERJ Open Res. 2018 Dec 21;4(4):.


Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study.

Hobart M, Skuban A, Zhang P, Josiassen MK, Hefting N, Augustine C, Brewer C, Sanchez R, McQuade RD.

Curr Med Res Opin. 2018 Apr;34(4):633-642. doi: 10.1080/03007995.2018.1430220. Epub 2018 Jan 25.


Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15.

McQuade RM, Stojanovska V, Stavely R, Timpani C, Petersen AC, Abalo R, Bornstein JC, Rybalka E, Nurgali K.

Br J Pharmacol. 2018 Feb;175(4):656-677. doi: 10.1111/bph.14114. Epub 2018 Jan 11.


Symptoms and functioning with aripiprazole once-monthly injection as maintenance treatment for bipolar I disorder.

Calabrese JR, Sanchez R, Jin N, Amatniek J, Cox K, Johnson B, Perry P, Hertel P, Such P, McQuade RD, Nyilas M, Carson WH.

J Affect Disord. 2018 Feb;227:649-656. doi: 10.1016/j.jad.2017.10.035. Epub 2017 Oct 24.


Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.

Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Koch G, Ouyang J, McQuade RD, Blais JD, Czerwiec FS, Sergeyeva O; REPRISE Trial Investigators.

N Engl J Med. 2017 Nov 16;377(20):1930-1942. doi: 10.1056/NEJMoa1710030. Epub 2017 Nov 4.


Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain.

Lichtman AH, Lux EA, McQuade R, Rossetti S, Sanchez R, Sun W, Wright S, Kornyeyeva E, Fallon MT.

J Pain Symptom Manage. 2018 Feb;55(2):179-188.e1. doi: 10.1016/j.jpainsymman.2017.09.001. Epub 2017 Sep 18.


Oral Aripiprazole as Maintenance Treatment in Adolescent Schizophrenia: Results From a 52-Week, Randomized, Placebo-Controlled Withdrawal Study.

Correll CU, Kohegyi E, Zhao C, Baker RA, McQuade R, Salzman PM, Sanchez R, Nyilas M, Carson W.

J Am Acad Child Adolesc Psychiatry. 2017 Sep;56(9):784-792. doi: 10.1016/j.jaac.2017.06.013. Epub 2017 Jul 8.


Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies.

Fallon MT, Albert Lux E, McQuade R, Rossetti S, Sanchez R, Sun W, Wright S, Lichtman AH, Kornyeyeva E.

Br J Pain. 2017 Aug;11(3):119-133. doi: 10.1177/2049463717710042. Epub 2017 May 17.


Randomized, Double-Blind, Placebo-Controlled Trial Demonstrates the Efficacy and Safety of Oral Aripiprazole for the Treatment of Tourette's Disorder in Children and Adolescents.

Sallee F, Kohegyi E, Zhao J, McQuade R, Cox K, Sanchez R, van Beek A, Nyilas M, Carson W, Kurlan R.

J Child Adolesc Psychopharmacol. 2017 Nov;27(9):771-781. doi: 10.1089/cap.2016.0026. Epub 2017 Jul 7.


Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons.

McQuade RM, Stojanovska V, Donald EL, Rahman AA, Campelj DG, Abalo R, Rybalka E, Bornstein JC, Nurgali K.

Front Physiol. 2017 Jun 8;8:391. doi: 10.3389/fphys.2017.00391. eCollection 2017.


Impact of chemotherapy on gastrointestinal functions and the enteric nervous system.

Escalante J, McQuade RM, Stojanovska V, Nurgali K.

Maturitas. 2017 Nov;105:23-29. doi: 10.1016/j.maturitas.2017.04.021. Epub 2017 May 10. Review.


Variable virulence phenotype of Xenorhabdus bovienii (γ-Proteobacteria: Enterobacteriaceae) in the absence of their vector hosts.

McMullen JG, McQuade R, Ogier JC, Pagès S, Gaudriault S, Patricia Stock S.

Microbiology. 2017 Apr;163(4):510-522. doi: 10.1099/mic.0.000449. Epub 2017 Apr 22.


Aripiprazole Once-Monthly in the Treatment of Acute Psychotic Episodes in Schizophrenia: Post Hoc Analysis of Positive and Negative Syndrome Scale Marder Factor Scores.

Ismail Z, Peters-Strickland T, Miguelez M, Baker RA, Hertel P, Eramo A, Jin N, Perry P, Sanchez R, McQuade RD, Kane JM.

J Clin Psychopharmacol. 2017 Jun;37(3):347-350. doi: 10.1097/JCP.0000000000000710.


Aripiprazole Once-Monthly 400 mg: Comparison of Pharmacokinetics, Tolerability, and Safety of Deltoid Versus Gluteal Administration.

Raoufinia A, Peters-Strickland T, Nylander AG, Baker RA, Eramo A, Jin N, Bricmont P, Repella J, McQuade RD, Hertel P, Larsen F.

Int J Neuropsychopharmacol. 2017 Apr 1;20(4):295-304. doi: 10.1093/ijnp/pyw116.


Segregated fronto-cortical and midbrain connections in the mouse and their relation to approach and avoidance orienting behaviors.

Savage MA, McQuade R, Thiele A.

J Comp Neurol. 2017 Jun 1;525(8):1980-1999. doi: 10.1002/cne.24186. Epub 2017 Mar 20.


Efficacy and Safety of Aripiprazole Once-Monthly in the Maintenance Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled, 52-Week Randomized Withdrawal Study.

Calabrese JR, Sanchez R, Jin N, Amatniek J, Cox K, Johnson B, Perry P, Hertel P, Such P, Salzman PM, McQuade RD, Nyilas M, Carson WH.

J Clin Psychiatry. 2017 Mar;78(3):324-331. doi: 10.4088/JCP.16m11201.


Colorectal Cancer Chemotherapy: The Evolution of Treatment and New Approaches.

McQuade RM, Stojanovska V, Bornstein JC, Nurgali K.

Curr Med Chem. 2017;24(15):1537-1557. doi: 10.2174/0929867324666170111152436. Review.


Neurotoxicity Associated with Platinum-Based Anti-Cancer Agents: What are the Implications of Copper Transporters?

Stojanovska V, McQuade R, Rybalka E, Nurgali K.

Curr Med Chem. 2017;24(15):1520-1536. doi: 10.2174/0929867324666170112095428. Review.


Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments.

McQuade RM, Stojanovska V, Abalo R, Bornstein JC, Nurgali K.

Front Pharmacol. 2016 Nov 3;7:414. eCollection 2016. Review.


Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice.

McQuade RM, Carbone SE, Stojanovska V, Rahman A, Gwynne RM, Robinson AM, Goodman CA, Bornstein JC, Nurgali K.

Br J Pharmacol. 2016 Dec;173(24):3502-3521. doi: 10.1111/bph.13646. Epub 2016 Nov 16.


Efficacy and Safety of Brexpiprazole (OPC-34712) as Maintenance Treatment in Adults with Schizophrenia: a Randomized, Double-Blind, Placebo-Controlled Study.

Fleischhacker WW, Hobart M, Ouyang J, Forbes A, Pfister S, McQuade RD, Carson WH, Sanchez R, Nyilas M, Weiller E.

Int J Neuropsychopharmacol. 2017 Jan 1;20(1):11-21. doi: 10.1093/ijnp/pyw076.


Effects of aripiprazole once-monthly on symptoms of schizophrenia in patients switched from oral antipsychotics.

Peters-Strickland T, Zhao C, Perry PP, Eramo A, Salzman PM, McQuade RD, Johnson BR, Sanchez R.

CNS Spectr. 2016 Dec;21(6):460-465. Epub 2016 Aug 17.


Effects of Oxaliplatin Treatment on the Enteric Glial Cells and Neurons in the Mouse Ileum.

Robinson AM, Stojanovska V, Rahman AA, McQuade RM, Senior PV, Nurgali K.

J Histochem Cytochem. 2016 Sep;64(9):530-45. doi: 10.1369/0022155416656842. Epub 2016 Jul 7.


Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil.

McQuade RM, Stojanovska V, Donald E, Abalo R, Bornstein JC, Nurgali K.

Neurogastroenterol Motil. 2016 Dec;28(12):1861-1875. doi: 10.1111/nmo.12890. Epub 2016 Jun 28.


Stepping Back From Crisis Points: The Provision and Acknowledgment of Support in an Online Suicide Discussion Forum.

Wiggins S, McQuade R, Rasmussen S.

Qual Health Res. 2016 Jul;26(9):1240-51. doi: 10.1177/1049732316633130. Epub 2016 Mar 1.


Adjunctive brexpiprazole 1 and 3 mg for patients with major depressive disorder following inadequate response to antidepressants: a phase 3, randomized, double-blind study.

Thase ME, Youakim JM, Skuban A, Hobart M, Zhang P, McQuade RD, Nyilas M, Carson WH, Sanchez R, Eriksson H.

J Clin Psychiatry. 2015 Sep;76(9):1232-40. doi: 10.4088/JCP.14m09689.


Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants.

Thase ME, Youakim JM, Skuban A, Hobart M, Augustine C, Zhang P, McQuade RD, Carson WH, Nyilas M, Sanchez R, Eriksson H.

J Clin Psychiatry. 2015 Sep;76(9):1224-31. doi: 10.4088/JCP.14m09688.


Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour.

Savy CY, Fitchett AE, McQuade R, Gartside SE, Morris CM, Blain PG, Judge SJ.

Neurotoxicology. 2015 Sep;50:149-56. doi: 10.1016/j.neuro.2015.08.010. Epub 2015 Aug 19.


Efficacy and Safety of Brexpiprazole for the Treatment of Acute Schizophrenia: A 6-Week Randomized, Double-Blind, Placebo-Controlled Trial.

Correll CU, Skuban A, Ouyang J, Hobart M, Pfister S, McQuade RD, Nyilas M, Carson WH, Sanchez R, Eriksson H.

Am J Psychiatry. 2015 Sep 1;172(9):870-80. doi: 10.1176/appi.ajp.2015.14101275. Epub 2015 Apr 16.


Patient-Centered Outcomes with Aripiprazole Once-Monthly for Maintenance Treatment in Patients with Schizophrenia: Results From Two Multicenter, Randomized, Double-Blind Studies.

Kane JM, Sanchez R, Baker RA, Eramo A, Peters-Strickland T, Perry PP, Johnson BR, Tsai LF, Carson WH, McQuade RD, Fleischhacker WW.

Clin Schizophr Relat Psychoses. 2015 Summer;9(2):79-87. doi: 10.3371/CSRP.KASA.022015. Epub 2015 Feb 24.


A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia.

Kane JM, Skuban A, Ouyang J, Hobart M, Pfister S, McQuade RD, Nyilas M, Carson WH, Sanchez R, Eriksson H.

Schizophr Res. 2015 May;164(1-3):127-35. doi: 10.1016/j.schres.2015.01.038. Epub 2015 Feb 12.


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