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Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine.

Kathuria A, Lopez-Lengowski K, Watmuff B, McPhie D, Cohen BM, Karmacharya R.

Transl Psychiatry. 2019 Nov 28;9(1):321. doi: 10.1038/s41398-019-0660-x.


Correction: iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function.

Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S.

Mol Psychiatry. 2019 Jul 31. doi: 10.1038/s41380-019-0467-4. [Epub ahead of print]


iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function.

Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S.

Mol Psychiatry. 2019 Apr 24. doi: 10.1038/s41380-019-0423-3. [Epub ahead of print] Erratum in: Mol Psychiatry. 2019 Jul 31;:.


Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.

Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S.

Nat Neurosci. 2019 Feb;22(2):229-242. doi: 10.1038/s41593-018-0313-z. Epub 2019 Jan 21.


Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development.

McPhie DL, Nehme R, Ravichandran C, Babb SM, Ghosh SD, Staskus A, Kalinowski A, Kaur R, Douvaras P, Du F, Ongur D, Fossati V, Eggan K, Cohen BM.

Transl Psychiatry. 2018 Oct 23;8(1):230. doi: 10.1038/s41398-018-0284-6.


Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles.

Sonntag KC, Ryu WI, Amirault KM, Healy RA, Siegel AJ, McPhie DL, Forester B, Cohen BM.

Sci Rep. 2017 Oct 25;7(1):14038. doi: 10.1038/s41598-017-14420-x.


Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder.

Robicsek O, Ene HM, Karry R, Ytzhaki O, Asor E, McPhie D, Cohen BM, Ben-Yehuda R, Weiner I, Ben-Shachar D.

Schizophr Bull. 2018 Feb 15;44(2):432-442. doi: 10.1093/schbul/sbx077.


Reproductive Status of Drosophila suzukii (Diptera: Drosophilidae) Females Influences Attraction to Fermentation-Based Baits and Ripe Fruits.

Swoboda-Bhattarai KA, McPhie DR, Burrack HJ.

J Econ Entomol. 2017 Aug 1;110(4):1648-1652. doi: 10.1093/jee/tox150.


Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines.

Huang JH, Park H, Iaconelli J, Berkovitch SS, Watmuff B, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R.

J Proteome Res. 2017 Feb 3;16(2):481-493. doi: 10.1021/acs.jproteome.6b00628. Epub 2016 Nov 28.


Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.

Huang JH, Berkovitch SS, Iaconelli J, Watmuff B, Park H, Chattopadhyay S, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R.

Mol Neuropsychiatry. 2016 Jul;2(2):97-106. doi: 10.1159/000446654. Epub 2016 Jun 24.


Multistate Comparison of Attractants for Monitoring Drosophila suzukii (Diptera: Drosophilidae) in Blueberries and Caneberries.

Burrack HJ, Asplen M, Bahder L, Collins J, Drummond FA, Guédot C, Isaacs R, Johnson D, Blanton A, Lee JC, Loeb G, Rodriguez-Saona C, van Timmeren S, Walsh D, McPhie DR.

Environ Entomol. 2015 Jun;44(3):704-12. doi: 10.1093/ee/nvv022. Epub 2015 Mar 21.


Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats.

Dow AL, Lin TV, Chartoff EH, Potter D, McPhie DL, Van't Veer AV, Knoll AT, Lee KN, Neve RL, Patel TB, Ongur D, Cohen BM, Carlezon WA Jr.

PLoS One. 2015 Mar 30;10(3):e0120693. doi: 10.1371/journal.pone.0120693. eCollection 2015.


Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.

Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH.

Mol Psychiatry. 2015 Feb;20(2):284. doi: 10.1038/mp.2014.181. Epub 2015 Jan 27. No abstract available.


MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.

Kim W, Noh H, Lee Y, Jeon J, Shanmugavadivu A, McPhie DL, Kim KS, Cohen BM, Seo H, Sonntag KC.

Mol Neurobiol. 2016 Jan;53(1):95-108. doi: 10.1007/s12035-014-8989-x. Epub 2014 Nov 19.


Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.

Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH.

Mol Psychiatry. 2015 Feb;20(2):162-9. doi: 10.1038/mp.2014.143. Epub 2014 Nov 18. Erratum in: Mol Psychiatry. 2015 Feb;20(2):284.


Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients.

McCarthy MJ, Wei H, Marnoy Z, Darvish RM, McPhie DL, Cohen BM, Welsh DK.

Transl Psychiatry. 2013 Oct 22;3:e318. doi: 10.1038/tp.2013.90.


Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report.

Chartoff EH, Damez-Werno D, Sonntag KC, Hassinger L, Kaufmann DE, Peterson J, McPhie D, Cataldo AM, Cohen BM.

Stem Cells Int. 2011;2011:586586. doi: 10.4061/2011/586586. Epub 2011 Nov 15.


Abnormalities in mitochondrial structure in cells from patients with bipolar disorder.

Cataldo AM, McPhie DL, Lange NT, Punzell S, Elmiligy S, Ye NZ, Froimowitz MP, Hassinger LC, Menesale EB, Sargent LW, Logan DJ, Carpenter AE, Cohen BM.

Am J Pathol. 2010 Aug;177(2):575-85. doi: 10.2353/ajpath.2010.081068. Epub 2010 Jun 21.


Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.

Laifenfeld D, Patzek LJ, McPhie DL, Chen Y, Levites Y, Cataldo AM, Neve RL.

J Neurosci. 2007 Jul 4;27(27):7141-53.


APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.

Chen Y, Bodles AM, McPhie DL, Neve RL, Mrak RE, Griffin WS.

Mol Neurodegener. 2007 Feb 7;2:3.


Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis.

Neve RL, McPhie DL.

Biochim Biophys Acta. 2007 Apr;1772(4):430-7. Epub 2006 Oct 18. Review.


Biological Bulletin Virtual Symposium: Marine Invertebrate Models of Learning and Memory.

McPhie DL, Miller MW.

Biol Bull. 2006 Jun;210(3):171-173. No abstract available.


The cell cycle as a therapeutic target for Alzheimer's disease.

Neve RL, McPhie DL.

Pharmacol Ther. 2006 Jul;111(1):99-113. Epub 2005 Nov 7. Review.


Old drugs, new uses: solving a Hatch-Waxman patent predicament.

McPhie DC.

Food Drug Law J. 2004;59(1):155-68. No abstract available.


APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.

Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL.

J Cell Biol. 2003 Oct 13;163(1):27-33.


DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.

McPhie DL, Coopersmith R, Hines-Peralta A, Chen Y, Ivins KJ, Manly SP, Kozlowski MR, Neve KA, Neve RL.

J Neurosci. 2003 Jul 30;23(17):6914-27.


Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism.

Suhara T, Magrané J, Rosen K, Christensen R, Kim HS, Zheng B, McPhie DL, Walsh K, Querfurth H.

Neurobiol Aging. 2003 May-Jun;24(3):437-51.


beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.

McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL.

Brain Res Mol Brain Res. 2001 Dec 16;97(1):103-13.


Alzheimer's disease: dysfunction of a signalling pathway mediated by the amyloid precursor protein?

Neve RL, McPhie DL, Chen Y.

Biochem Soc Symp. 2001;(67):37-50. Review.


Repeated exposure to rewarding brain stimulation downregulates GluR1 expression in the ventral tegmental area.

Carlezon WA Jr, Todtenkopf MS, McPhie DL, Pimentel P, Pliakas AM, Stellar JR, Trzcinska M.

Neuropsychopharmacology. 2001 Aug;25(2):234-41.


Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy.

Querfurth HW, Suhara T, Rosen KM, McPhie DL, Fujio Y, Tejada G, Neve RL, Adelman LS, Walsh K.

Mol Cell Neurosci. 2001 May;17(5):793-810.


Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

Neve RL, McPhie DL, Chen Y.

Brain Res. 2000 Dec 15;886(1-2):54-66. Review.


Enhanced BK-induced calcium responsiveness in PC12 cells expressing the C100 fragment of the amyloid precursor protein.

Pascale A, Bhagavan S, Nelson TJ, Neve RL, McPhie DL, Etcheberrigaray R.

Brain Res Mol Brain Res. 1999 Oct 1;72(2):205-13.


Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.

Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL.

Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):150-62.


Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

Bursztajn S, DeSouza R, McPhie DL, Berman SA, Shioi J, Robakis NK, Neve RL.

J Neurosci. 1998 Dec 1;18(23):9790-9.


The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis.

Neve RL, Coopersmith R, McPhie DL, Santeufemio C, Pratt KG, Murphy CJ, Lynn SD.

J Neurosci. 1998 Oct 1;18(19):7757-67.


Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

McPhie DL, Lee RK, Eckman CB, Olstein DH, Durham SP, Yager D, Younkin SG, Wurtman RJ, Neve RL.

J Biol Chem. 1997 Oct 3;272(40):24743-6.


Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability.

Nelson TJ, Cavallaro S, Yi CL, McPhie D, Schreurs BG, Gusev PA, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon DL.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13808-13.


Transgenic mice expressing APP-C100 in the brain.

Neve RL, Boyce FM, McPhie DL, Greenan J, Oster-Granite ML.

Neurobiol Aging. 1996 Mar-Apr;17(2):191-203.


Incorporation of fluorescent lipids into living rabbit hippocampal and cerebellar slices.

Lester DS, Olds JL, Schreurs BG, McPhie D, Bramham CR, Alkon DL.

Neuroimage. 1994 Nov;1(4):264-75.


Lateralization of membrane-associated protein kinase C in rat piriform cortex: specific to operant training cues in the olfactory modality.

Olds JL, Bhalla US, McPhie DL, Lester DS, Bower JM, Alkon DL.

Behav Brain Res. 1994 Mar 31;61(1):37-46.


Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

Ito E, Oka K, Etcheberrigaray R, Nelson TJ, McPhie DL, Tofel-Grehl B, Gibson GE, Alkon DL.

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):534-8.


Cell specificity of molecular changes during memory storage.

McPhie DL, Matzel LD, Olds JL, Lester DS, Kuzirian AM, Alkon DL.

J Neurochem. 1993 Feb;60(2):646-51.


Heterogenous Distribution of Fluorescent Phorbol Ester Signal in Living Sea Urchin Embryos.

Connor JH, Olds JL, Lester DS, McPhie DL, Senft SL, Johnston JA, Alkon DL.

Biol Bull. 1992 Oct;183(2):365-366. doi: 10.1086/BBLv183n2p365. No abstract available.


Discrimination learning alters the distribution of protein kinase C in the hippocampus of rats.

Olds JL, Golski S, McPhie DL, Olton D, Mishkin M, Alkon DL.

J Neurosci. 1990 Nov;10(11):3707-13.

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