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Macropinosome formation by tent pole ruffling in macrophages.

Condon ND, Heddleston JM, Chew TL, Luo L, McPherson PS, Ioannou MS, Hodgson L, Stow JL, Wall AA.

J Cell Biol. 2018 Nov 5;217(11):3873-3885. doi: 10.1083/jcb.201804137. Epub 2018 Aug 27.


Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations.

Ménade M, Kozlov G, Trempe JF, Pande H, Shenker S, Wickremasinghe S, Li X, Hojjat H, Dicaire MJ, Brais B, McPherson PS, Wong MJH, Young JC, Gehring K.

J Biol Chem. 2018 Aug 17;293(33):12832-12842. doi: 10.1074/jbc.RA118.003939. Epub 2018 Jun 26.


Light, space, and time in cancer signaling.

McPherson PS, Wu M.

Mol Biol Cell. 2018 Mar 15;29(6):688. doi: 10.1091/mbc.E17-11-0675. No abstract available.


A lentiviral system for efficient knockdown of proteins in neuronal cultures [version 1; referees: 2 approved].

Ritter B, Ferguson SM, De Camilli P, McPherson PS.

MNI Open Res. 2017;1(2). doi: 10.12688/mniopenres.12766.1. Epub 2017 Dec 5.


A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy.

Xu J, Kozlov G, McPherson PS, Gehring K.

J Biol Chem. 2018 Mar 23;293(12):4566-4574. doi: 10.1074/jbc.RA117.001446. Epub 2018 Jan 19.


Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.

Ioannou MS, Kulasekaran G, Fotouhi M, Morein JJ, Han C, Tse S, Nossova N, Han T, Mannard E, McPherson PS.

EMBO Rep. 2017 Dec;18(12):2119-2130. doi: 10.15252/embr.201744034. Epub 2017 Oct 13.


Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo.

Deng J, Koutras C, Donnelier J, Alshehri M, Fotouhi M, Girard M, Casha S, McPherson PS, Robbins SM, Braun JEA.

Sci Rep. 2017 Apr 19;7(1):956. doi: 10.1038/s41598-017-01115-6.


Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.

Xu J, McPherson PS.

J Biol Chem. 2017 Apr 28;292(17):7274-7282. doi: 10.1074/jbc.M116.772434. Epub 2017 Mar 1.


Epileptic Encephalopathy Caused by Mutations in the Guanine Nucleotide Exchange Factor DENND5A.

Han C, Alkhater R, Froukh T, Minassian AG, Galati M, Liu RH, Fotouhi M, Sommerfeld J, Alfrook AJ, Marshall C, Walker S, Bauer P, Scherer SW, Riess O, Buchert R, Minassian BA, McPherson PS.

Am J Hum Genet. 2016 Dec 1;99(6):1359-1367. doi: 10.1016/j.ajhg.2016.10.006. Epub 2016 Nov 17.


Rab-mediated membrane trafficking and the control of epithelial cell polarity.

Ioannou MS, McPherson PS.

J Cell Biol. 2016 May 9;213(3):301-3. doi: 10.1083/jcb.201604076. Epub 2016 May 2.


Regulation of Cancer Cell Behavior by the Small GTPase Rab13.

Ioannou MS, McPherson PS.

J Biol Chem. 2016 May 6;291(19):9929-37. doi: 10.1074/jbc.R116.715193. Epub 2016 Apr 4. Review.


Rab13 Traffics on Vesicles Independent of Prenylation.

Ioannou MS, Girard M, McPherson PS.

J Biol Chem. 2016 May 13;291(20):10726-35. doi: 10.1074/jbc.M116.722298. Epub 2016 Mar 11.


Endocytic membrane trafficking and neurodegenerative disease.

Schreij AM, Fon EA, McPherson PS.

Cell Mol Life Sci. 2016 Apr;73(8):1529-45. doi: 10.1007/s00018-015-2105-x. Epub 2015 Dec 31. Review.


Eating Locally: Microautophagy and Protein Turnover at the Synapse.

McPherson PS.

Neuron. 2015 Nov 18;88(4):619-21. doi: 10.1016/j.neuron.2015.11.008.


High-Throughput Screening for Ligands of the HEPN Domain of Sacsin.

Li X, Ménade M, Kozlov G, Hu Z, Dai Z, McPherson PS, Brais B, Gehring K.

PLoS One. 2015 Sep 14;10(9):e0137298. doi: 10.1371/journal.pone.0137298. eCollection 2015.


DENND3: a signaling/trafficking interface in autophagy.

Xu J, McPherson PS.

Cell Cycle. 2015;14(17):2717-8. doi: 10.1080/15384101.2015.1071136. Epub 2015 Jul 15. No abstract available.


Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors.

Kulasekaran G, Nossova N, Marat AL, Lund I, Cremer C, Ioannou MS, McPherson PS.

J Biol Chem. 2015 Jul 17;290(29):17999-8008. doi: 10.1074/jbc.M115.636712. Epub 2015 Jun 8.


The juxtamembrane region of synaptotagmin 1 interacts with dynamin 1 and regulates vesicle fission during compensatory endocytosis in endocrine cells.

McAdam RL, Varga KT, Jiang Z, Young FB, Blandford V, McPherson PS, Gong LW, Sossin WS.

J Cell Sci. 2015 Jun 15;128(12):2229-35. doi: 10.1242/jcs.161505. Epub 2015 May 11.


Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.

Xu J, Fotouhi M, McPherson PS.

EMBO Rep. 2015 Jun;16(6):709-18. doi: 10.15252/embr.201440006. Epub 2015 Apr 29.


Analysis of connecdenn 1-3 (DENN1A-C) GEF activity for Rab35.

Allaire PD, McPherson PS, Ritter B.

Methods Mol Biol. 2015;1298:217-31. doi: 10.1007/978-1-4939-2569-8_19.


DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.

Ioannou MS, Bell ES, Girard M, Chaineau M, Hamlin JN, Daubaras M, Monast A, Park M, Hodgson L, McPherson PS.

J Cell Biol. 2015 Mar 2;208(5):629-48. doi: 10.1083/jcb.201407068. Epub 2015 Feb 23.


LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation.

Schreij AM, Chaineau M, Ruan W, Lin S, Barker PA, Fon EA, McPherson PS.

EMBO Rep. 2015 Jan;16(1):79-86. doi: 10.15252/embr.201438714. Epub 2014 Nov 26.


Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay.

Larivière R, Gaudet R, Gentil BJ, Girard M, Conte TC, Minotti S, Leclerc-Desaulniers K, Gehring K, McKinney RA, Shoubridge EA, McPherson PS, Durham HD, Brais B.

Hum Mol Genet. 2015 Feb 1;24(3):727-39. doi: 10.1093/hmg/ddu491. Epub 2014 Sep 26.


A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.

Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P.

Elife. 2014 Jun 24;3:e01621. doi: 10.7554/eLife.01621.


Scyl1 scaffolds class II Arfs to specific subcomplexes of coatomer through the γ-COP appendage domain.

Hamlin JN, Schroeder LK, Fotouhi M, Dokainish H, Ioannou MS, Girard M, Summerfeldt N, Melançon P, McPherson PS.

J Cell Sci. 2014 Apr 1;127(Pt 7):1454-63. doi: 10.1242/jcs.136481. Epub 2014 Jan 30.


DNAJC13 mutations in Parkinson disease.

Vilariño-Güell C, Rajput A, Milnerwood AJ, Shah B, Szu-Tu C, Trinh J, Yu I, Encarnacion M, Munsie LN, Tapia L, Gustavsson EK, Chou P, Tatarnikov I, Evans DM, Pishotta FT, Volta M, Beccano-Kelly D, Thompson C, Lin MK, Sherman HE, Han HJ, Guenther BL, Wasserman WW, Bernard V, Ross CJ, Appel-Cresswell S, Stoessl AJ, Robinson CA, Dickson DW, Ross OA, Wszolek ZK, Aasly JO, Wu RM, Hentati F, Gibson RA, McPherson PS, Girard M, Rajput M, Rajput AH, Farrer MJ.

Hum Mol Genet. 2014 Apr 1;23(7):1794-801. doi: 10.1093/hmg/ddt570. Epub 2013 Nov 11.


NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis.

Ritter B, Murphy S, Dokainish H, Girard M, Gudheti MV, Kozlov G, Halin M, Philie J, Jorgensen EM, Gehring K, McPherson PS.

PLoS Biol. 2013 Oct;11(10):e1001670. doi: 10.1371/journal.pbio.1001670. Epub 2013 Oct 1.


Rab35: GEFs, GAPs and effectors.

Chaineau M, Ioannou MS, McPherson PS.

Traffic. 2013 Nov;14(11):1109-17. doi: 10.1111/tra.12096. Epub 2013 Aug 21. Review.


Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration.

Allaire PD, Seyed Sadr M, Chaineau M, Seyed Sadr E, Konefal S, Fotouhi M, Maret D, Ritter B, Del Maestro RF, McPherson PS.

J Cell Sci. 2013 Feb 1;126(Pt 3):722-31. doi: 10.1242/jcs.112375. Epub 2012 Dec 21.


Diversity of ARSACS mutations in French-Canadians.

Thiffault I, Dicaire MJ, Tetreault M, Huang KN, Demers-Lamarche J, Bernard G, Duquette A, Larivière R, Gehring K, Montpetit A, McPherson PS, Richter A, Montermini L, Mercier J, Mitchell GA, Dupré N, Prévost C, Bouchard JP, Mathieu J, Brais B.

Can J Neurol Sci. 2013 Jan;40(1):61-6.


Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).

Girard M, Larivière R, Parfitt DA, Deane EC, Gaudet R, Nossova N, Blondeau F, Prenosil G, Vermeulen EG, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, Chapple JP, McPherson PS.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1661-6. doi: 10.1073/pnas.1113166109. Epub 2012 Jan 17.


Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton.

Marat AL, Ioannou MS, McPherson PS.

Mol Biol Cell. 2012 Jan;23(1):163-75. doi: 10.1091/mbc.E11-05-0474. Epub 2011 Nov 9.


Liquid facets-related (lqfR) is required for egg chamber morphogenesis during Drosophila oogenesis.

Leventis PA, Da Sylva TR, Rajwans N, Wasiak S, McPherson PS, Boulianne GL.

PLoS One. 2011;6(10):e25466. doi: 10.1371/journal.pone.0025466. Epub 2011 Oct 17.


Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).

Kozlov G, Denisov AY, Girard M, Dicaire MJ, Hamlin J, McPherson PS, Brais B, Gehring K.

J Biol Chem. 2011 Jun 10;286(23):20407-12. doi: 10.1074/jbc.M111.232884. Epub 2011 Apr 20.


DENN domain proteins: regulators of Rab GTPases.

Marat AL, Dokainish H, McPherson PS.

J Biol Chem. 2011 Apr 22;286(16):13791-800. doi: 10.1074/jbc.R110.217067. Epub 2011 Feb 17. Review.


Proteomic analysis of clathrin-coated vesicles.

McPherson PS.

Proteomics. 2010 Nov;10(22):4025-39. doi: 10.1002/pmic.201000253. Review.


14-3-3 proteins regulate protein kinase a activity to modulate growth cone turning responses.

Kent CB, Shimada T, Ferraro GB, Ritter B, Yam PT, McPherson PS, Charron F, Kennedy TE, Fournier AE.

J Neurosci. 2010 Oct 20;30(42):14059-67. doi: 10.1523/JNEUROSCI.3883-10.2010.


Variants of DENND1B associated with asthma in children.

Marat AL, McPherson PS.

N Engl J Med. 2010 Sep 2;363(10):988-9; author reply 989. doi: 10.1056/NEJMc1002262. No abstract available.


The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

Ceni C, Kommaddi RP, Thomas R, Vereker E, Liu X, McPherson PS, Ritter B, Barker PA.

J Cell Sci. 2010 Jul 1;123(Pt 13):2299-307. doi: 10.1242/jcs.062612. Epub 2010 Jun 8.


Cell biology through proteomics--ad astra per alia porci.

Bergeron JJ, Au CE, Desjardins M, McPherson PS, Nilsson T.

Trends Cell Biol. 2010 Jun;20(6):337-45. doi: 10.1016/j.tcb.2010.02.005. Epub 2010 Mar 12. Review.


Scyl1 regulates Golgi morphology.

Burman JL, Hamlin JN, McPherson PS.

PLoS One. 2010 Mar 4;5(3):e9537. doi: 10.1371/journal.pone.0009537.


The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes.

Allaire PD, Marat AL, Dall'Armi C, Di Paolo G, McPherson PS, Ritter B.

Mol Cell. 2010 Feb 12;37(3):370-82. doi: 10.1016/j.molcel.2009.12.037.


The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.

Marat AL, McPherson PS.

J Biol Chem. 2010 Apr 2;285(14):10627-37. doi: 10.1074/jbc.M109.050930. Epub 2010 Feb 12.


EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain.

Bouvier D, Tremblay ME, Riad M, Corera AT, Gingras D, Horn KE, Fotouhi M, Girard M, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G.

J Neurochem. 2010 Apr;113(1):153-65. doi: 10.1111/j.1471-4159.2010.06582.x. Epub 2010 Jan 12.


SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.

Trempe JF, Chen CX, Grenier K, Camacho EM, Kozlov G, McPherson PS, Gehring K, Fon EA.

Mol Cell. 2009 Dec 25;36(6):1034-47. doi: 10.1016/j.molcel.2009.11.021.


The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology.

Katoh Y, Ritter B, Gaffry T, Blondeau F, Höning S, McPherson PS.

J Biol Chem. 2009 Oct 2;284(40):27646-54. doi: 10.1074/jbc.M109.034884. Epub 2009 Aug 3.


Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.

Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K, Asselin MC, Day R, Duclos FJ, Witmer M, Parker R, Prat A, Seidah NG.

J Biol Chem. 2009 Oct 16;284(42):28856-64. doi: 10.1074/jbc.M109.037085. Epub 2009 Jul 27.


Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons.

Thomas S, Ritter B, Verbich D, Sanson C, Bourbonnière L, McKinney RA, McPherson PS.

J Biol Chem. 2009 May 1;284(18):12410-9. doi: 10.1074/jbc.M809746200. Epub 2009 Mar 3.


Membrane trafficking heats up in Pavia. Golgi Meeting on Membrane Trafficking in Global Cellular Responses.

Donaldson JG, McPherson PS.

EMBO Rep. 2009 Feb;10(2):132-6. doi: 10.1038/embor.2008.248. Epub 2009 Jan 23. No abstract available.


Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.

Burman JL, Bourbonniere L, Philie J, Stroh T, Dejgaard SY, Presley JF, McPherson PS.

J Biol Chem. 2008 Aug 15;283(33):22774-86. doi: 10.1074/jbc.M801869200. Epub 2008 Jun 13.

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