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Items: 1 to 50 of 55

1.

Molecular Networking Reveals Two Distinct Chemotypes in Pyrroloiminoquinone-Producing Tsitsikamma favus Sponges.

Kalinski JJ, Waterworth SC, Noundou XS, Jiwaji M, Parker-Nance S, Krause RWM, McPhail KL, Dorrington RA.

Mar Drugs. 2019 Jan 16;17(1). pii: E60. doi: 10.3390/md17010060.

2.

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):248-249. doi: 10.1039/c8np90041h. Epub 2018 Nov 23.

3.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):35-107. doi: 10.1039/c7np00064b. Epub 2018 Jul 13. Erratum in: Nat Prod Rep. 2018 Nov 23;:.

4.

Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea.

Gallegos DA, Saurí J, Cohen RD, Wan X, Videau P, Vallota-Eastman AO, Shaala LA, Youssef DTA, Williamson RT, Martin GE, Philmus B, Sikora AE, Ishmael JE, McPhail KL.

J Nat Prod. 2018 Jun 22;81(6):1417-1425. doi: 10.1021/acs.jnatprod.8b00117. Epub 2018 May 29.

PMID:
29808677
5.

Ectoine: a compatible solute in radio-halophilic Stenotrophomonas sp. WMA-LM19 strain to prevent ultraviolet-induced protein damage.

Sajjad W, Qadir S, Ahmad M, Rafiq M, Hasan F, Tehan R, McPhail KL, Shah AA.

J Appl Microbiol. 2018 Aug;125(2):457-467. doi: 10.1111/jam.13903. Epub 2018 Jun 6.

PMID:
29729069
6.

ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A.

Wan X, Serrill JD, Humphreys IR, Tan M, McPhail KL, Ganley IG, Ishmael JE.

Mar Drugs. 2018 Mar 1;16(3). pii: E77. doi: 10.3390/md16030077.

7.

Synthetic Access to the Mandelalide Family of Macrolides: Development of an Anion Relay Chemistry Strategy.

Nguyen MH, Imanishi M, Kurogi T, Wan X, Ishmael JE, McPhail KL, Smith AB 3rd.

J Org Chem. 2018 Apr 20;83(8):4287-4306. doi: 10.1021/acs.joc.8b00268. Epub 2018 Feb 26.

8.

Secondary Metabolism and Interspecific Competition Affect Accumulation of Spontaneous Mutants in the GacS-GacA Regulatory System in Pseudomonas protegens.

Yan Q, Lopes LD, Shaffer BT, Kidarsa TA, Vining O, Philmus B, Song C, Stockwell VO, Raaijmakers JM, McPhail KL, Andreote FD, Chang JH, Loper JE.

MBio. 2018 Jan 16;9(1). pii: e01845-17. doi: 10.1128/mBio.01845-17.

9.

Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont.

Lopera J, Miller IJ, McPhail KL, Kwan JC.

mSystems. 2017 Nov 21;2(6). pii: e00096-17. doi: 10.1128/mSystems.00096-17. eCollection 2017 Nov-Dec.

10.

New Mandelalides Expand a Macrolide Series of Mitochondrial Inhibitors.

Nazari M, Serrill JD, Wan X, Nguyen MH, Anklin C, Gallegos DA, Smith AB 3rd, Ishmael JE, McPhail KL.

J Med Chem. 2017 Sep 28;60(18):7850-7862. doi: 10.1021/acs.jmedchem.7b00990. Epub 2017 Sep 7.

11.

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N.

Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.

12.

Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A.

Snyder KM, Sikorska J, Ye T, Fang L, Su W, Carter RG, McPhail KL, Cheong PH.

Org Biomol Chem. 2016 Jun 28;14(24):5826-31. doi: 10.1039/c6ob00707d. Epub 2016 May 6.

PMID:
27152741
13.

Discovery of Mandelalide E and Determinants of Cytotoxicity for the Mandelalide Series.

Nazari M, Serrill JD, Sikorska J, Ye T, Ishmael JE, McPhail KL.

Org Lett. 2016 Mar 18;18(6):1374-7. doi: 10.1021/acs.orglett.6b00308. Epub 2016 Feb 25.

PMID:
26914981
14.

Enantioselective Total Synthesis of Mandelalide A and Isomandelalide A: Discovery of a Cytotoxic Ring-Expanded Isomer.

Veerasamy N, Ghosh A, Li J, Watanabe K, Serrill JD, Ishmael JE, McPhail KL, Carter RG.

J Am Chem Soc. 2016 Jan 27;138(3):770-3. doi: 10.1021/jacs.5b12318. Epub 2016 Jan 13.

PMID:
26759923
15.

Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts.

Serrill JD, Wan X, Hau AM, Jang HS, Coleman DJ, Indra AK, Alani AW, McPhail KL, Ishmael JE.

Invest New Drugs. 2016 Feb;34(1):24-40. doi: 10.1007/s10637-015-0303-x. Epub 2015 Nov 12.

PMID:
26563191
16.

Phloroglucinol functions as an intracellular and intercellular chemical messenger influencing gene expression in Pseudomonas protegens.

Clifford JC, Buchanan A, Vining O, Kidarsa TA, Chang JH, McPhail KL, Loper JE.

Environ Microbiol. 2016 Oct;18(10):3296-3308. doi: 10.1111/1462-2920.13043. Epub 2015 Oct 14.

PMID:
26337778
17.

Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer.

Vining OB, Medina RA, Mitchell EA, Videau P, Li D, Serrill JD, Kelly JX, Gerwick WH, Proteau PJ, Ishmael JE, McPhail KL.

J Nat Prod. 2015 Mar 27;78(3):413-20. doi: 10.1021/np5007907. Epub 2015 Jan 6.

18.

Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A.

Serrill JD, Tan M, Fotso S, Sikorska J, Kasanah N, Hau AM, McPhail KL, Santosa DA, Zabriskie TM, Mahmud T, Viollet B, Proteau PJ, Ishmael JE.

Biochem Pharmacol. 2015 Feb 1;93(3):251-65. doi: 10.1016/j.bcp.2014.11.015. Epub 2014 Dec 12.

PMID:
25511868
19.

Synthesis and biological evaluation of the [d-MeAla(11)]-epimer of coibamide A.

Nabika R, Suyama TL, Hau AM, Misu R, Ohno H, Ishmael JE, McPhail KL, Oishi S, Fujii N.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):302-6. doi: 10.1016/j.bmcl.2014.11.044. Epub 2014 Nov 22.

20.

2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens.

Youssef DT, Shaala LA, Mohamed GA, Ibrahim SR, Banjar ZM, Badr JM, McPhail KL, Risinger AL, Mooberry SL.

Nat Prod Res. 2015;29(8):703-9. doi: 10.1080/14786419.2014.982647. Epub 2014 Nov 25.

PMID:
25421266
21.

Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.

Pavlik CM, Wong CY, Ononye S, Lopez DD, Engene N, McPhail KL, Gerwick WH, Balunas MJ.

J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Epub 2013 Oct 28.

22.

Apratoxin H and apratoxin A sulfoxide from the Red Sea cyanobacterium Moorea producens.

Thornburg CC, Cowley ES, Sikorska J, Shaala LA, Ishmael JE, Youssef DT, McPhail KL.

J Nat Prod. 2013 Sep 27;76(9):1781-8. doi: 10.1021/np4004992. Epub 2013 Sep 9.

23.

The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster.

Bushley KE, Raja R, Jaiswal P, Cumbie JS, Nonogaki M, Boyd AE, Owensby CA, Knaus BJ, Elser J, Miller D, Di Y, McPhail KL, Spatafora JW.

PLoS Genet. 2013 Jun;9(6):e1003496. doi: 10.1371/journal.pgen.1003496. Epub 2013 Jun 20.

24.

Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells.

Hau AM, Greenwood JA, Löhr CV, Serrill JD, Proteau PJ, Ganley IG, McPhail KL, Ishmael JE.

PLoS One. 2013 Jun 6;8(6):e65250. doi: 10.1371/journal.pone.0065250. Print 2013.

25.

Development of a quantitative assay amenable for high-throughput screening to target the type II secretion system for new treatments against plant-pathogenic bacteria.

Tran N, Zielke RA, Vining OB, Azevedo MD, Armstrong DJ, Banowetz GM, McPhail KL, Sikora AE.

J Biomol Screen. 2013 Sep;18(8):921-9. doi: 10.1177/1087057113485426. Epub 2013 Apr 11.

PMID:
23580665
26.

Antimicrobial rubrolides from a South African species of Synoicum tunicate.

Sikorska J, Parker-Nance S, Davies-Coleman MT, Vining OB, Sikora AE, McPhail KL.

J Nat Prod. 2012 Oct 26;75(10):1824-7. doi: 10.1021/np300580z. Epub 2012 Oct 2.

27.

Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.

Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH.

Org Lett. 2012 Aug 3;14(15):3878-81. Epub 2012 Jul 13.

28.

Mandelalides A-D, cytotoxic macrolides from a new Lissoclinum species of South African tunicate.

Sikorska J, Hau AM, Anklin C, Parker-Nance S, Davies-Coleman MT, Ishmael JE, McPhail KL.

J Org Chem. 2012 Jul 20;77(14):6066-75. doi: 10.1021/jo3008622. Epub 2012 Jul 3. Erratum in: J Org Chem. 2013 Mar 15;78(6):2812.

29.

Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula.

Han B, Gross H, McPhail KL, Goeger D, Maier CS, Gerwick WH.

J Microbiol Biotechnol. 2011 Sep;21(9):930-6.

30.

Cyclic depsipeptides, grassypeptolides D and E and Ibu-epidemethoxylyngbyastatin 3, from a Red Sea Leptolyngbya cyanobacterium.

Thornburg CC, Thimmaiah M, Shaala LA, Hau AM, Malmo JM, Ishmael JE, Youssef DT, McPhail KL.

J Nat Prod. 2011 Aug 26;74(8):1677-85. doi: 10.1021/np200270d. Epub 2011 Aug 1.

31.

Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis.

Suyama TL, Gerwick WH, McPhail KL.

Bioorg Med Chem. 2011 Nov 15;19(22):6675-701. doi: 10.1016/j.bmc.2011.06.011. Epub 2011 Jun 12. Review.

32.

Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus.

Andrianasolo EH, Haramaty L, McPhail KL, White E, Vetriani C, Falkowski P, Lutz R.

J Nat Prod. 2011 Apr 25;74(4):842-6. doi: 10.1021/np100601w. Epub 2011 Jan 11.

33.

4-Formylaminooxyvinylglycine, an herbicidal germination-arrest factor from Pseudomonas rhizosphere bacteria.

McPhail KL, Armstrong DJ, Azevedo MD, Banowetz GM, Mills DI.

J Nat Prod. 2010 Nov 29;73(11):1853-7. doi: 10.1021/np1004856. Epub 2010 Oct 27.

34.

Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula.

Gross H, McPhail KL, Goeger DE, Valeriote FA, Gerwick WH.

Phytochemistry. 2010 Oct;71(14-15):1729-35. doi: 10.1016/j.phytochem.2010.07.001. Epub 2010 Aug 9.

35.

Deep-sea hydrothermal vents: potential hot spots for natural products discovery?

Thornburg CC, Zabriskie TM, McPhail KL.

J Nat Prod. 2010 Mar 26;73(3):489-99. doi: 10.1021/np900662k. Review.

PMID:
20099811
36.

Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp.

Medina RA, Goeger DE, Hills P, Mooberry SL, Huang N, Romero LI, Ortega-Barría E, Gerwick WH, McPhail KL.

J Am Chem Soc. 2008 May 21;130(20):6324-5. doi: 10.1021/ja801383f. Epub 2008 Apr 29.

37.

Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp.

Linington RG, Edwards DJ, Shuman CF, McPhail KL, Matainaho T, Gerwick WH.

J Nat Prod. 2008 Jan;71(1):22-7. doi: 10.1021/np070280x. Epub 2007 Dec 29.

38.

Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: jasmonate signaling dependence.

Kourtchenko O, Andersson MX, Hamberg M, Brunnström A, Göbel C, McPhail KL, Gerwick WH, Feussner I, Ellerström M.

Plant Physiol. 2007 Dec;145(4):1658-69. Epub 2007 Oct 19.

39.

Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones.

Whibley CE, McPhail KL, Keyzers RA, Maritz MF, Leaner VD, Birrer MJ, Davies-Coleman MT, Hendricks DT.

Mol Cancer Ther. 2007 Sep;6(9):2535-43.

40.

Hydroxyalkenylresorcinols from Stylogyne turbacensis.

Jiménez-Romero C, Torres-Mendoza D, Ureña González LD, Ortega-Barría E, McPhail KL, Gerwick WH, Cubilla-Rios L.

J Nat Prod. 2007 Aug;70(8):1249-52. Epub 2007 Jul 13.

PMID:
17629327
41.

Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula.

McPhail KL, Correa J, Linington RG, Gonzalez J, Ortega-Barría E, Capson TL, Gerwick WH.

J Nat Prod. 2007 Jun;70(6):984-8. Epub 2007 Apr 19.

42.

Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E.

Andersson MX, Hamberg M, Kourtchenko O, Brunnström A, McPhail KL, Gerwick WH, Göbel C, Feussner I, Ellerström M.

J Biol Chem. 2006 Oct 20;281(42):31528-37. Epub 2006 Aug 21.

43.

Characterization of the initial enzymatic steps of barbamide biosynthesis.

Flatt PM, O'Connell SJ, McPhail KL, Zeller G, Willis CL, Sherman DH, Gerwick WH.

J Nat Prod. 2006 Jun;69(6):938-44.

PMID:
16792414
44.

3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.

Zhen Y, Slanar O, Krausz KW, Chen C, Slavík J, McPhail KL, Zabriskie TM, Perlík F, Gonzalez FJ, Idle JR.

Drug Metab Dispos. 2006 Sep;34(9):1563-74. Epub 2006 Jun 16.

45.

Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.

Gafner S, Dietz BM, McPhail KL, Scott IM, Glinski JA, Russell FE, McCollom MM, Budzinski JW, Foster BC, Bergeron C, Rhyu MR, Bolton JL.

J Nat Prod. 2006 Mar;69(3):432-5.

PMID:
16562853
46.

Analysis of macamides in samples of Maca (Lepidium meyenii) by HPLC-UV-MS/MS.

McCollom MM, Villinski JR, McPhail KL, Craker LE, Gafner S.

Phytochem Anal. 2005 Nov-Dec;16(6):463-9.

PMID:
16315492
47.

Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme.

Sabry OM, Andrews S, McPhail KL, Goeger DE, Yokochi A, LePage KT, Murray TF, Gerwick WH.

J Nat Prod. 2005 Jul;68(7):1022-30.

PMID:
16038542
48.

(3Z)-Bromofucin from a South African sea hare.

McPhail KL, Davies-Coleman MT.

Nat Prod Res. 2005 Jul;19(5):449-52.

PMID:
15938190
49.

Formation of the nonproteinogenic amino acid 2S,3R-capreomycidine by VioD from the viomycin biosynthesis pathway.

Yin X, McPhail KL, Kim KJ, Zabriskie TM.

Chembiochem. 2004 Sep 6;5(9):1278-81. No abstract available.

PMID:
15368581
50.

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