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Items: 33

1.

A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.

McNulty DE, Bonnette WG, Qi H, Wang L, Ho TF, Waszkiewicz A, Kallal LA, Nagarajan RP, Stern M, Quinn AM, Creasy CL, Su DS, Graves AP, Annan RS, Sweitzer SM, Holbert MA.

SLAS Discov. 2018 Jan;23(1):34-46. doi: 10.1177/2472555217732014. Epub 2017 Sep 28.

PMID:
28957646
2.

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.

Harris PA, King BW, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Finger JN, Grady LC, Hoffman SJ, Jeong JU, Kang J, Kasparcova V, Lakdawala AS, Lehr R, McNulty DE, Nagilla R, Ouellette MT, Pao CS, Rendina AR, Schaeffer MC, Summerfield JD, Swift BA, Totoritis RD, Ward P, Zhang A, Zhang D, Marquis RW, Bertin J, Gough PJ.

J Med Chem. 2016 Mar 10;59(5):2163-78. doi: 10.1021/acs.jmedchem.5b01898. Epub 2016 Feb 23.

PMID:
26854747
3.

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.

Gilmartin AG, Faitg TH, Richter M, Groy A, Seefeld MA, Darcy MG, Peng X, Federowicz K, Yang J, Zhang SY, Minthorn E, Jaworski JP, Schaber M, Martens S, McNulty DE, Sinnamon RH, Zhang H, Kirkpatrick RB, Nevins N, Cui G, Pietrak B, Diaz E, Jones A, Brandt M, Schwartz B, Heerding DA, Kumar R.

Nat Chem Biol. 2014 Mar;10(3):181-7. doi: 10.1038/nchembio.1427. Epub 2014 Jan 5.

PMID:
24390428
4.

Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration.

Ochoa-Alvarez JA, Krishnan H, Shen Y, Acharya NK, Han M, McNulty DE, Hasegawa H, Hyodo T, Senga T, Geng JG, Kosciuk M, Shin SS, Goydos JS, Temiakov D, Nagele RG, Goldberg GS.

PLoS One. 2012;7(7):e41845. doi: 10.1371/journal.pone.0041845. Epub 2012 Jul 23.

5.

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Pappalardi MB, McNulty DE, Martin JD, Fisher KE, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Schwartz B, Annan RS, Copeland RA, Tummino PJ, Luo L.

Biochem J. 2011 Jun 1;436(2):363-9. doi: 10.1042/BJ20101201.

PMID:
21410436
6.

MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation.

McNulty DE, Li Z, White CD, Sacks DB, Annan RS.

J Biol Chem. 2011 Apr 29;286(17):15010-21. doi: 10.1074/jbc.M111.227694. Epub 2011 Feb 24.

7.

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.

Wood KW, Lad L, Luo L, Qian X, Knight SD, Nevins N, Brejc K, Sutton D, Gilmartin AG, Chua PR, Desai R, Schauer SP, McNulty DE, Annan RS, Belmont LD, Garcia C, Lee Y, Diamond MA, Faucette LF, Giardiniere M, Zhang S, Sun CM, Vidal JD, Lichtsteiner S, Cornwell WD, Greshock JD, Wooster RF, Finer JT, Copeland RA, Huang PS, Morgans DJ Jr, Dhanak D, Bergnes G, Sakowicz R, Jackson JR.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44. doi: 10.1073/pnas.0915068107. Epub 2010 Feb 18.

8.

Hydrophilic interaction chromatography for fractionation and enrichment of the phosphoproteome.

McNulty DE, Annan RS.

Methods Mol Biol. 2009;527:93-105, x. doi: 10.1007/978-1-60327-834-8_8. Review.

PMID:
19241008
9.

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.

Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA, Sha D, Suarez DP, Murphy DJ, Harpel MR, Manas ES, McNulty DE, Annan RS, Matico RE, Schwartz BK, Trill JJ, Sweitzer TD, Wang DY, Keller PM, Krawiec JA, Jaye MC.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):27-30. doi: 10.1016/j.bmcl.2008.11.033. Epub 2008 Nov 14.

PMID:
19058966
10.

Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system.

Ramos L, Kopec LA, Sweitzer SM, Fornwald JA, Zhao H, McAllister P, McNulty DE, Trill JJ, Kane JF.

Cytotechnology. 2002 Jan;38(1-3):37-41. doi: 10.1023/A:1021189628274.

11.

Frameshift events associated with the lysyl-tRNA and the rare arginine codon, AGA, in Escherichia coli: a case study involving the human Relaxin 2 protein.

Kerrigan JJ, McNulty DE, Burns M, Allen KE, Tang X, Lu Q, Trulli JM, Johanson KO, Kane JF.

Protein Expr Purif. 2008 Aug;60(2):110-6. doi: 10.1016/j.pep.2008.02.016. Epub 2008 Mar 5.

PMID:
18474430
12.

Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection.

McNulty DE, Annan RS.

Mol Cell Proteomics. 2008 May;7(5):971-80. doi: 10.1074/mcp.M700543-MCP200. Epub 2008 Jan 22.

13.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, Huang PS, Jackson JR, Dhanak D, Copeland RA, Auger KR.

Nat Chem Biol. 2007 Nov;3(11):722-6. Epub 2007 Oct 7.

PMID:
17922005
14.

A simple assay for detection of small-molecule redox activity.

Lor LA, Schneck J, McNulty DE, Diaz E, Brandt M, Thrall SH, Schwartz B.

J Biomol Screen. 2007 Sep;12(6):881-90. Epub 2007 Jun 19.

PMID:
17579124
15.

IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.

Li Z, McNulty DE, Marler KJ, Lim L, Hall C, Annan RS, Sacks DB.

J Biol Chem. 2005 Apr 8;280(14):13871-8. Epub 2005 Jan 28.

16.

Peptide proteomics.

McNulty DE, Slemmon JR.

Methods Mol Biol. 2004;244:411-23. No abstract available.

PMID:
14970576
17.

Mistranslational errors associated with the rare arginine codon CGG in Escherichia coli.

McNulty DE, Claffee BA, Huddleston MJ, Porter ML, Cavnar KM, Kane JF.

Protein Expr Purif. 2003 Feb;27(2):365-74. Erratum in: Protein Expr Purif. 2004 Sep;37(1):264. Porter, M Lauren [added]; Cavnar, Katie M [added].

PMID:
12597898
18.

The influence of sterilization method on wear performance of the low contact stress total knee system.

McNulty DE, Liao YS, Haas BD.

Orthopedics. 2002 Feb;25(2 Suppl):s243-6.

PMID:
11866160
19.

Evaluating energetics of erythropoietin ligand binding to homodimerized receptor extracellular domains.

Hensley P, Doyle ML, Myszka DG, Woody RW, Brigham-Burke MR, Erickson-Miller CL, Griffin CA, Jones CS, McNulty DE, O'Brien SP, Amegadzie BY, MacKenzie L, Ryan MD, Young PR.

Methods Enzymol. 2000;323:177-207. No abstract available.

PMID:
10944753
20.

Expression, purification, and crystallization of the Escherichia coli selenomethionyl beta-ketoacyl-acyl carrier protein synthase III.

Khandekar SS, Konstantinidis AK, Silverman C, Janson CA, McNulty DE, Nwagwu S, Van Aller GS, Doyle ML, Kane JF, Qiu X, Lonsdale J.

Biochem Biophys Res Commun. 2000 Apr 2;270(1):100-7.

PMID:
10733911
21.

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA.

Nature. 1999 Sep 16;401(6750):282-6. Erratum in: Nature 1999 Dec 23-30;402(6764):898.

PMID:
10499587
22.

Analysis of prosthetic femoral heads retrieved at autopsy.

Sychterz CJ, Engh CA Jr, Swope SW, McNulty DE, Engh CA.

Clin Orthop Relat Res. 1999 Jan;(358):223-34.

PMID:
9973995
23.

Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis.

Erdjument-Bromage H, Lui M, Lacomis L, Grewal A, Annan RS, McNulty DE, Carr SA, Tempst P.

J Chromatogr A. 1998 Nov 27;826(2):167-81.

PMID:
9871337
24.

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Mar 6;92(5):1 page following 696. No abstract available.

25.

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Feb 20;92(4):573-85.

26.

Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function.

Li J, Cook R, Doyle ML, Hensley P, McNulty DE, Chaiken I.

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6694-9.

27.

Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.

Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA.

J Biol Chem. 1996 May 24;271(21):12517-24.

28.
29.

Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase.

Ladner RD, McNulty DE, Carr SA, Roberts GD, Caradonna SJ.

J Biol Chem. 1996 Mar 29;271(13):7745-51.

30.

Biological and biophysical characterization of recombinant soluble human E-selectin purified at large scale by reversed-phase high-performance liquid chromatography.

Burrows SD, Franklin SG, Brigham-Burke MR, Brooks IS, McNulty DE, Feild JA, Anumula KR, O'Shannessy DJ.

J Chromatogr B Biomed Appl. 1995 Jun 23;668(2):219-31.

PMID:
7581857
31.
32.

Determination of the monomer-dimer equilibrium of interleukin-8 reveals it is a monomer at physiological concentrations.

Burrows SD, Doyle ML, Murphy KP, Franklin SG, White JR, Brooks I, McNulty DE, Scott MO, Knutson JR, Porter D, et al.

Biochemistry. 1994 Nov 1;33(43):12741-5.

PMID:
7947677
33.

The soluble form of E-selectin is an asymmetric monomer. Expression, purification, and characterization of the recombinant protein.

Hensley P, McDevitt PJ, Brooks I, Trill JJ, Feild JA, McNulty DE, Connor JR, Griswold DE, Kumar NV, Kopple KD, et al.

J Biol Chem. 1994 Sep 30;269(39):23949-58.

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