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Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes.

Schott MB, Weller SG, Schulze RJ, Krueger EW, Drizyte-Miller K, Casey CA, McNiven MA.

J Cell Biol. 2019 Oct 7;218(10):3320-3335. doi: 10.1083/jcb.201803153. Epub 2019 Aug 7.


RINT1 Bi-allelic Variations Cause Infantile-Onset Recurrent Acute Liver Failure and Skeletal Abnormalities.

Cousin MA, Conboy E, Wang JS, Lenz D, Schwab TL, Williams M, Abraham RS, Barnett S, El-Youssef M, Graham RP, Gutierrez Sanchez LH, Hasadsri L, Hoffmann GF, Hull NC, Kopajtich R, Kovacs-Nagy R, Li JQ, Marx-Berger D, McLin V, McNiven MA, Mounajjed T, Prokisch H, Rymen D, Schulze RJ, Staufner C, Yang Y, Clark KJ, Lanpher BC, Klee EW.

Am J Hum Genet. 2019 Jul 3;105(1):108-121. doi: 10.1016/j.ajhg.2019.05.011. Epub 2019 Jun 13.


The cell biology of the hepatocyte: A membrane trafficking machine.

Schulze RJ, Schott MB, Casey CA, Tuma PL, McNiven MA.

J Cell Biol. 2019 Jul 1;218(7):2096-2112. doi: 10.1083/jcb.201903090. Epub 2019 Jun 14. Review.


Lipophagy and Alcohol-Induced Fatty Liver.

Yang L, Yang C, Thomes PG, Kharbanda KK, Casey CA, McNiven MA, Donohue TM Jr.

Front Pharmacol. 2019 May 9;10:495. doi: 10.3389/fphar.2019.00495. eCollection 2019. Review.


Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.

Inoue J, Ninomiya M, Umetsu T, Nakamura T, Kogure T, Kakazu E, Iwata T, Takai S, Sano A, Fukuda M, Watashi K, Isogawa M, Tanaka Y, Shimosegawa T, McNiven MA, Masamune A.

J Virol. 2019 Jul 17;93(15). pii: e00621-19. doi: 10.1128/JVI.00621-19. Print 2019 Aug 1.


Lipid Droplet Formation and Lipophagy in Fatty Liver Disease.

Schulze RJ, McNiven MA.

Semin Liver Dis. 2019 Jul;39(3):283-290. doi: 10.1055/s-0039-1685524. Epub 2019 Apr 30.


Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism.

Thomes PG, Rasineni K, Yang L, Donohue TM Jr, Kubik JL, McNiven MA, Casey CA.

Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G509-G518. doi: 10.1152/ajpgi.00376.2018. Epub 2019 Feb 4.


Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1.

Qiang L, Cao H, Chen J, Weller SG, Krueger EW, Zhang L, Razidlo GL, McNiven MA.

J Cell Biol. 2019 Jan 7;218(1):317-332. doi: 10.1083/jcb.201802032. Epub 2018 Nov 28.


Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.

Razidlo GL, Burton KM, McNiven MA.

J Biol Chem. 2018 Jul 13;293(28):11143-11153. doi: 10.1074/jbc.RA118.003276. Epub 2018 May 31.


Fasting Inhibits the Recruitment of Kinesin-1 to Lipid Droplets and Stalls Hepatic Triglyceride Secretion.

Schulze RJ, McNiven MA.

Hepatology. 2019 Jan;69(1):444-446. doi: 10.1002/hep.30104. Epub 2018 Dec 12. No abstract available.


Ethanol exposure inhibits hepatocyte lipophagy by inactivating the small guanosine triphosphatase Rab7.

Schulze RJ, Rasineni K, Weller SG, Schott MB, Schroeder B, Casey CA, McNiven MA.

Hepatol Commun. 2017 Mar 10;1(2):140-152. doi: 10.1002/hep4.1021. eCollection 2017 Apr.


Cellular Membrane Trafficking Machineries Used by the Hepatitis Viruses.

Inoue J, Ninomiya M, Shimosegawa T, McNiven MA.

Hepatology. 2018 Aug;68(2):751-762. doi: 10.1002/hep.29785. Review.


Ethanol-induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity.

Rasineni K, Donohue TM Jr, Thomes PG, Yang L, Tuma DJ, McNiven MA, Casey CA.

Hepatol Commun. 2017 Aug;1(6):501-512. doi: 10.1002/hep4.1063. Epub 2017 Jul 10.


Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver.

Schulze RJ, Drižytė K, Casey CA, McNiven MA.

Hepatol Commun. 2017 Jul;1(5):359-369. doi: 10.1002/hep4.1056. Epub 2017 Jun 9.


Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.

Martin C, Leyton L, Hott M, Arancibia Y, Spichiger C, McNiven MA, Court FA, Concha MI, Burgos PV, Otth C.

Front Cell Infect Microbiol. 2017 Aug 22;7:371. doi: 10.3389/fcimb.2017.00371. eCollection 2017.


LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, Lummertz da Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look AT.

Cancer Cell. 2017 Sep 11;32(3):310-323.e5. doi: 10.1016/j.ccell.2017.08.002. Epub 2017 Aug 31.


β-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure.

Schott MB, Rasineni K, Weller SG, Schulze RJ, Sletten AC, Casey CA, McNiven MA.

J Biol Chem. 2017 Jul 14;292(28):11815-11828. doi: 10.1074/jbc.M117.777748. Epub 2017 May 17.


A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets.

Li Z, Schulze RJ, Weller SG, Krueger EW, Schott MB, Zhang X, Casey CA, Liu J, Stöckli J, James DE, McNiven MA.

Sci Adv. 2016 Dec 16;2(12):e1601470. doi: 10.1126/sciadv.1601470. eCollection 2016 Dec.


Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma.

Boddicker RL, Razidlo GL, Dasari S, Zeng Y, Hu G, Knudson RA, Greipp PT, Davila JI, Johnson SH, Porcher JC, Smadbeck JB, Eckloff BW, Billadeau DD, Kurtin PJ, McNiven MA, Link BK, Ansell SM, Cerhan JR, Asmann YW, Vasmatzis G, Feldman AL.

Blood. 2016 Sep 1;128(9):1234-45. doi: 10.1182/blood-2016-03-707141. Epub 2016 Jun 13.


The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase.

Cao H, Schroeder B, Chen J, Schott MB, McNiven MA.

J Biol Chem. 2016 Aug 5;291(32):16424-37. doi: 10.1074/jbc.M116.724997. Epub 2016 May 24.


Alcoholic vs non-alcoholic fatty liver in rats: distinct differences in endocytosis and vesicle trafficking despite similar pathology.

Rasineni K, Penrice DD, Natarajan SK, McNiven MA, McVicker BL, Kharbanda KK, Casey CA, Harris EN.

BMC Gastroenterol. 2016 Feb 29;16:27. doi: 10.1186/s12876-016-0433-4.


Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease.

Natarajan SK, Rasineni K, Ganesan M, Feng D, McVicker BL, McNiven MA, Osna NA, Mott JL, Casey CA, Kharbanda KK.

Curr Mol Pharmacol. 2017;10(3):237-248. doi: 10.2174/1874467208666150817111727. Review.


Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.

McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ.

J Bone Miner Res. 2016 Jan;31(1):116-28. doi: 10.1002/jbmr.2602. Epub 2015 Aug 20.


Stromal fibroblasts facilitate cancer cell invasion by a novel invadopodia-independent matrix degradation process.

Cao H, Eppinga RD, Razidlo GL, Krueger EW, Chen J, Qiang L, McNiven MA.

Oncogene. 2016 Mar 3;35(9):1099-1110. doi: 10.1038/onc.2015.163. Epub 2015 May 18.


Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.

Razidlo GL, Magnine C, Sletten AC, Hurley RM, Almada LL, Fernandez-Zapico ME, Ji B, McNiven MA.

Cancer Res. 2015 Jul 15;75(14):2907-15. doi: 10.1158/0008-5472.CAN-14-3103. Epub 2015 May 14.


HBV secretion is regulated through the activation of endocytic and autophagic compartments mediated by Rab7 stimulation.

Inoue J, Krueger EW, Chen J, Cao H, Ninomiya M, McNiven MA.

J Cell Sci. 2015 May 1;128(9):1696-706. doi: 10.1242/jcs.158097. Epub 2015 Mar 13.


The small GTPase Rab7 as a central regulator of hepatocellular lipophagy.

Schroeder B, Schulze RJ, Weller SG, Sletten AC, Casey CA, McNiven MA.

Hepatology. 2015 Jun;61(6):1896-907. doi: 10.1002/hep.27667. Epub 2015 Apr 23.


Importance of endocytic pathways in liver function and disease.

Schroeder B, McNiven MA.

Compr Physiol. 2014 Oct;4(4):1403-17. doi: 10.1002/cphy.c140001. Review.


Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth.

Wu Q, Kohli M, Bergen HR 3rd, Cheville JC, Karnes RJ, Cao H, Young CY, Tindall DJ, McNiven MA, Donkena KV.

Mol Cancer Ther. 2014 May;13(5):1067-77. doi: 10.1158/1535-7163.MCT-13-0699. Epub 2014 Mar 27.


A well-oiled machine: DNM2/dynamin 2 helps keep hepatocyte lipophagy running smoothly.

Schulze RJ, McNiven MA.

Autophagy. 2014 Feb;10(2):388-9. doi: 10.4161/auto.27486. Epub 2013 Dec 18. Review.


Vav1 as a central regulator of invadopodia assembly.

Razidlo GL, Schroeder B, Chen J, Billadeau DD, McNiven MA.

Curr Biol. 2014 Jan 6;24(1):86-93. doi: 10.1016/j.cub.2013.11.013. Epub 2013 Dec 12.


Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.

Schulze RJ, Weller SG, Schroeder B, Krueger EW, Chi S, Casey CA, McNiven MA.

J Cell Biol. 2013 Oct 28;203(2):315-26. doi: 10.1083/jcb.201306140. Epub 2013 Oct 21.


Rab GTPases associate with isolated lipid droplets (LDs) and show altered content after ethanol administration: potential role in alcohol-impaired LD metabolism.

Rasineni K, McVicker BL, Tuma DJ, McNiven MA, Casey CA.

Alcohol Clin Exp Res. 2014 Feb;38(2):327-35. doi: 10.1111/acer.12271. Epub 2013 Oct 11.


Effects of selenium source on measures of selenium status and immune function in horses.

Montgomery JB, Wichtel JJ, Wichtel MG, McNiven MA, McClure JT, Markham F, Horohov DW.

Can J Vet Res. 2012 Oct;76(4):281-91.


Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1.

Razidlo GL, Wang Y, Chen J, Krueger EW, Billadeau DD, McNiven MA.

Dev Cell. 2013 Mar 25;24(6):573-85. doi: 10.1016/j.devcel.2013.02.010.


Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and Δ5-, Δ6-desaturase protein expression in steer muscles.

Turner TD, Mitchell A, Duynisveld J, Pickova J, Doran O, McNiven MA.

Animal. 2012 Dec;6(12):1973-84. doi: 10.1017/S1751731112000985. Epub 2012 May 10.


Breaking away: matrix remodeling from the leading edge.

McNiven MA.

Trends Cell Biol. 2013 Jan;23(1):16-21. doi: 10.1016/j.tcb.2012.08.009. Epub 2012 Sep 19. Review.


CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies.

Schroeder B, Srivatsan S, Shaw A, Billadeau D, McNiven MA.

Mol Biol Cell. 2012 Sep;23(18):3602-11. doi: 10.1091/mbc.E11-08-0666. Epub 2012 Jul 25.


Lipid droplet accumulation and impaired fat efflux in polarized hepatic cells: consequences of ethanol metabolism.

McVicker BL, Rasineni K, Tuma DJ, McNiven MA, Casey CA.

Int J Hepatol. 2012;2012:978136. doi: 10.1155/2012/978136. Epub 2012 Mar 11.


Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex.

Wang Y, McNiven MA.

J Cell Biol. 2012 Feb 6;196(3):375-85. doi: 10.1083/jcb.201105153. Epub 2012 Jan 30.


Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion.

Feng H, Liu KW, Guo P, Zhang P, Cheng T, McNiven MA, Johnson GR, Hu B, Cheng SY.

Oncogene. 2012 May 24;31(21):2691-702. doi: 10.1038/onc.2011.436. Epub 2011 Sep 26.


Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma.

Eppinga RD, Krueger EW, Weller SG, Zhang L, Cao H, McNiven MA.

Oncogene. 2012 Mar 8;31(10):1228-41. doi: 10.1038/onc.2011.329. Epub 2011 Aug 15.


Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15.

Chi S, Cao H, Wang Y, McNiven MA.

J Biol Chem. 2011 Oct 7;286(40):35196-208. doi: 10.1074/jbc.M111.247577. Epub 2011 Aug 8.


Hepatocytes internalize trophic receptors at large endocytic "Hot Spots".

Cao H, Krueger EW, McNiven MA.

Hepatology. 2011 Nov;54(5):1819-29. doi: 10.1002/hep.24572.


Calcineurin selectively docks with the dynamin Ixb splice variant to regulate activity-dependent bulk endocytosis.

Xue J, Graham ME, Novelle AE, Sue N, Gray N, McNiven MA, Smillie KJ, Cousin MA, Robinson PJ.

J Biol Chem. 2011 Sep 2;286(35):30295-303. doi: 10.1074/jbc.M111.273110. Epub 2011 Jul 5.


A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src.

Wang Y, Cao H, Chen J, McNiven MA.

Mol Biol Cell. 2011 May;22(9):1529-38. doi: 10.1091/mbc.E10-09-0785. Epub 2011 Mar 16.


Alcohol and lipid traffic don't mix.

McNiven MA, Casey CA.

Hepatology. 2011 Apr;53(4):1073-5. doi: 10.1002/hep.24277. No abstract available.


Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons.

Kurklinsky S, Chen J, McNiven MA.

J Neurochem. 2011 Apr;117(1):48-60. doi: 10.1111/j.1471-4159.2011.07169.x. Epub 2011 Feb 9.


A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding.

Schroeder B, Weller SG, Chen J, Billadeau D, McNiven MA.

EMBO J. 2010 Sep 15;29(18):3039-53. doi: 10.1038/emboj.2010.190. Epub 2010 Aug 13.

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