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Obstructive sleep apnoea and comorbidity - an overview of the association and impact of continuous positive airway pressure therapy.

McNicholas WT.

Expert Rev Respir Med. 2019 Mar;13(3):251-261. doi: 10.1080/17476348.2019.1575204. Epub 2019 Feb 11.


Comorbid obstructive sleep apnoea and chronic obstructive pulmonary disease and the risk of cardiovascular disease.

McNicholas WT.

J Thorac Dis. 2018 Dec;10(Suppl 34):S4253-S4261. doi: 10.21037/jtd.2018.10.117. Review.


Obstructive sleep apnoea and cardiovascular comorbidity-growing evidence of independent association but recent doubts about benefits from therapy.

McNicholas WT.

J Thorac Dis. 2018 Dec;10(Suppl 34):S4186-S4188. doi: 10.21037/jtd.2018.10.118. No abstract available.


Does Associated Chronic Obstructive Pulmonary Disease Increase Morbidity and Mortality in Obstructive Sleep Apnea?

McNicholas WT.

Ann Am Thorac Soc. 2019 Jan;16(1):50-53. doi: 10.1513/AnnalsATS.201809-628ED. No abstract available.


Identifying and treating obstructive sleep apnea in sleepy drivers: Everybody wins.

McNicholas WT.

J Sleep Res. 2018 Dec;27(6):e12787. doi: 10.1111/jsr.12787. No abstract available.



McNicholas WT.

Chest. 2018 Jul;154(1):225-226. doi: 10.1016/j.chest.2018.03.027. No abstract available.


Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort.

Bonsignore MR, Pepin JL, Anttalainen U, Schiza SE, Basoglu OK, Pataka A, Steiropoulos P, Dogas Z, Grote L, Hedner J, McNicholas WT, Marrone O; ESADA Study Group.

J Sleep Res. 2018 Dec;27(6):e12729. doi: 10.1111/jsr.12729. Epub 2018 Jul 11.


Challenges and perspectives in obstructive sleep apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society.

Randerath W, Bassetti CL, Bonsignore MR, Farre R, Ferini-Strambi L, Grote L, Hedner J, Kohler M, Martinez-Garcia MA, Mihaicuta S, Montserrat J, Pepin JL, Pevernagie D, Pizza F, Polo O, Riha R, Ryan S, Verbraecken J, McNicholas WT.

Eur Respir J. 2018 Sep 16;52(3). pii: 1702616. doi: 10.1183/13993003.02616-2017. Print 2018 Sep. Review.


Treatment choice by patients with obstructive sleep apnea: data from two centers in China.

Liao WJ, Song LJ, Yi HL, Guan J, Zou JY, Xu HJ, Wang G, Ma F, Zhou LB, Chen YQ, Yan LB, Deng ZC, McNicholas WT, Yin SK, Zhong NS, Zhang XW.

J Thorac Dis. 2018 Mar;10(3):1941-1950. doi: 10.21037/jtd.2018.03.135.


Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA.

Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR; ESADA Network.

Chest. 2018 Aug;154(2):326-334. doi: 10.1016/j.chest.2018.04.020. Epub 2018 Apr 24.


Diagnostic criteria for obstructive sleep apnea: time for reappraisal.

McNicholas WT.

J Thorac Dis. 2018 Jan;10(1):531-533. doi: 10.21037/jtd.2017.12.91. No abstract available.


Challenges in obstructive sleep apnoea.

McNicholas WT, Bassetti CL, Ferini-Strambi L, Pépin JL, Pevernagie D, Verbraecken J, Randerath W; Baveno Working Group members.

Lancet Respir Med. 2018 Mar;6(3):170-172. doi: 10.1016/S2213-2600(18)30059-6. Epub 2018 Feb 7. No abstract available. Erratum in: Lancet Respir Med. 2018 Apr;6(4):e15.


Obstructive sleep apnoea of mild severity: should it be treated?

McNicholas WT.

Curr Opin Pulm Med. 2017 Nov;23(6):506-511. doi: 10.1097/MCP.0000000000000420. Review.


COPD-OSA Overlap Syndrome: Evolving Evidence Regarding Epidemiology, Clinical Consequences, and Management.

McNicholas WT.

Chest. 2017 Dec;152(6):1318-1326. doi: 10.1016/j.chest.2017.04.160. Epub 2017 Apr 23. Review.


Diagnostic accuracy of carotid intima media thickness in predicting coronary plaque burden on coronary computed tomography angiography in patients with obstructive sleep apnoea.

Murphy DJ, Crinion SJ, Redmond CE, Healy GM, McNicholas WT, Ryan S, Dodd JD.

J Cardiovasc Comput Tomogr. 2017 May - Jun;11(3):227-233. doi: 10.1016/j.jcct.2017.02.004. Epub 2017 Feb 11.


Continuous positive airway pressure therapy and cardiovascular outcomes in obstructive sleep apnoea syndrome: where are we now?

McNicholas WT.

J Thorac Dis. 2016 Dec;8(12):E1644-E1646. doi: 10.21037/jtd.2016.12.36. No abstract available.


Obstructive sleep apnoea as a cause of nocturnal nondipping blood pressure: recent evidence regarding clinical importance and underlying mechanisms.

Crinion SJ, Ryan S, McNicholas WT.

Eur Respir J. 2017 Jan 11;49(1). pii: 1601818. doi: 10.1183/13993003.01818-2016. Print 2017 Jan. No abstract available.


Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep.

Randerath W, Verbraecken J, Andreas S, Arzt M, Bloch KE, Brack T, Buyse B, De Backer W, Eckert DJ, Grote L, Hagmeyer L, Hedner J, Jennum P, La Rovere MT, Miltz C, McNicholas WT, Montserrat J, Naughton M, Pepin JL, Pevernagie D, Sanner B, Testelmans D, Tonia T, Vrijsen B, Wijkstra P, Levy P.

Eur Respir J. 2017 Jan 18;49(1). pii: 1600959. doi: 10.1183/13993003.00959-2016. Print 2017 Jan.


Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients.

Saaresranta T, Hedner J, Bonsignore MR, Riha RL, McNicholas WT, Penzel T, Anttalainen U, Kvamme JA, Pretl M, Sliwinski P, Verbraecken J, Grote L; ESADA Study Group.

PLoS One. 2016 Oct 4;11(10):e0163439. doi: 10.1371/journal.pone.0163439. eCollection 2016.


Rebuttal from Alexandros N. Vgontzas, Jordan Gaines, Silke Ryan and Walter T. McNicholas.

Vgontzas AN, Gaines J, Ryan S, McNicholas WT.

J Physiol. 2016 Sep 1;594(17):4695. doi: 10.1113/JP272615. Epub 2016 Jun 30. No abstract available.


CrossTalk proposal: Metabolic syndrome causes sleep apnoea.

Vgontzas AN, Gaines J, Ryan S, McNicholas WT.

J Physiol. 2016 Sep 1;594(17):4687-90. doi: 10.1113/JP272114. Epub 2016 Jun 30. No abstract available.


Screening for sleep-disordered breathing: the continuing search for a reliable predictive questionnaire.

McNicholas WT.

Lancet Respir Med. 2016 Sep;4(9):683-685. doi: 10.1016/S2213-2600(16)30119-9. Epub 2016 Jun 16. No abstract available.


Mild obstructive sleep apnoea: clinical relevance and approaches to management.

McNicholas WT, Bonsignore MR, Lévy P, Ryan S.

Lancet Respir Med. 2016 Oct;4(10):826-834. doi: 10.1016/S2213-2600(16)30146-1. Epub 2016 May 27. Review.


Driving risk in obstructive sleep apnoea: Do new European regulations contribute to safer roads?

McNicholas WT.

Expert Rev Respir Med. 2016;10(5):473-5. doi: 10.1586/17476348.2016.1159134. Epub 2016 Mar 16. No abstract available.


New rules on driver licensing for patients with obstructive sleep apnea: European Union Directive 2014/85/EU.

Bonsignore MR, Randerath W, Riha R, Smyth D, Gratziou C, Gonçalves M, McNicholas WT.

J Sleep Res. 2016 Feb;25(1):3-4. doi: 10.1111/jsr.12379. No abstract available.


Chronic obstructive pulmonary disease and obstructive sleep apnoea-the overlap syndrome.

McNicholas WT.

J Thorac Dis. 2016 Feb;8(2):236-42. doi: 10.3978/j.issn.2072-1439.2016.01.52. Review.


Biomechanical evaluation of a non-locking pre-manufactured loop suture technique compared to a three-loop pulley suture in a canine calcaneus tendon avulsion model.

Dunlap AE, Kim SE, McNicholas WT Jr.

Vet Comp Orthop Traumatol. 2016;29(2):131-5. doi: 10.3415/VCOT-15-04-0061. Epub 2016 Jan 25.


New rules on driver licensing for patients with obstructive sleep apnoea: EU Directive 2014/85/EU.

Bonsignore MR, Randerath W, Riha R, Smyth D, Gratziou C, Goncalves M, McNicholas WT.

Eur Respir J. 2016 Jan;47(1):39-41. doi: 10.1183/13993003.01894-2015. No abstract available.


Sleep apnoea and driving risk: the need for regulation.

McNicholas WT, Rodenstein D.

Eur Respir Rev. 2015 Dec;24(138):602-6. doi: 10.1183/16000617.0049-2015. Review.


The diagnostic method has a strong influence on classification of obstructive sleep apnea.

Escourrou P, Grote L, Penzel T, Mcnicholas WT, Verbraecken J, Tkacova R, Riha RL, Hedner J; ESADA Study Group.

J Sleep Res. 2015 Dec;24(6):730-8. doi: 10.1111/jsr.12318. Epub 2015 Aug 14.


Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity.

Gaoatswe G, Kent BD, Corrigan MA, Nolan G, Hogan AE, McNicholas WT, O'Shea D.

Sleep. 2015 Oct 1;38(10):1629-34. doi: 10.5665/sleep.5062.


Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea.

Kent BD, McNicholas WT, Ryan S.

J Thorac Dis. 2015 Aug;7(8):1343-57. doi: 10.3978/j.issn.2072-1439.2015.08.11. Review.


Sleep apnoea: a major and under-recognised public health concern.

McNicholas WT, Luo Y, Zhong N.

J Thorac Dis. 2015 Aug;7(8):1269-72. doi: 10.3978/j.issn.2072-1439.2015.07.29. No abstract available.


Variability in recording and scoring of respiratory events during sleep in Europe: a need for uniform standards.

Arnardottir ES, Verbraecken J, Gonçalves M, Gjerstad MD, Grote L, Puertas FJ, Mihaicuta S, McNicholas WT, Parrino L; The National Representatives as Study Collaborators.

J Sleep Res. 2016 Apr;25(2):144-57. doi: 10.1111/jsr.12353. Epub 2015 Sep 14.


Disordered breathing during sleep and exercise in idiopathic pulmonary fibrosis.

Lee RN, Kelly E, Nolan G, Eigenheer S, Boylan D, Murphy D, Dodd J, Keane MP, McNicholas WT.

QJM. 2016 Feb;109(2):142. doi: 10.1093/qjmed/hcv159. Epub 2015 Sep 9. No abstract available.


Introducing a core curriculum for respiratory sleep practitioners.

Mitchell S, Simonds A, Andreas S, Bonsignore MR, Cooper B, Donic V, McNicholas WT, Morrell M, Palange P, Prest G, Riha R, Trang H, Randerath W, van der Grinten C, Verbraecken J, de Backer W.

Breathe (Sheff). 2015 Mar;11(1):50-6. doi: 10.1183/20734735.020414. Review.


Sleepiness at the wheel across Europe: a survey of 19 countries.

Gonçalves M, Amici R, Lucas R, Åkerstedt T, Cirignotta F, Horne J, Léger D, McNicholas WT, Partinen M, Téran-Santos J, Peigneux P, Grote L; National Representatives as Study Collaborators.

J Sleep Res. 2015 Jun;24(3):242-53.


Obstructive sleep apnoea syndrome.

Lévy P, Kohler M, McNicholas WT, Barbé F, McEvoy RD, Somers VK, Lavie L, Pépin JL.

Nat Rev Dis Primers. 2015 Jun 25;1:15015. doi: 10.1038/nrdp.2015.15. Review.


A pilot study of the nocturnal respiration rates in COPD patients in the home environment using a non-contact biomotion sensor.

Ballal T, Heneghan C, Zaffaroni A, Boyle P, de Chazal P, Shouldice R, McNicholas WT, Donnelly SC.

Physiol Meas. 2014 Dec;35(12):2513-27. doi: 10.1088/0967-3334/35/12/2513. Epub 2014 Nov 17.


Disordered breathing during sleep and exercise in idiopathic pulmonary fibrosis and the role of biomarkers.

Lee RN, Kelly E, Nolan G, Eigenheer S, Boylan D, Murphy D, Dodd JD, Keane MP, McNicholas WT.

QJM. 2015 Apr;108(4):315-23. doi: 10.1093/qjmed/hcu175. Epub 2014 Sep 23.


Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study.

Tkacova R, McNicholas WT, Javorsky M, Fietze I, Sliwinski P, Parati G, Grote L, Hedner J; European Sleep Apnoea Database study collaborators.

Eur Respir J. 2014 Oct;44(4):931-41. doi: 10.1183/09031936.00225113. Epub 2014 Aug 7.


Driving habits and risk factors for traffic accidents among sleep apnea patients--a European multi-centre cohort study.

Karimi M, Hedner J, Lombardi C, Mcnicholas WT, Penzel T, Riha RL, Rodenstein D, Grote L; Esada Study Group.

J Sleep Res. 2014 Dec;23(6):689-699. doi: 10.1111/jsr.12171. Epub 2014 Jul 7.


Diabetes mellitus prevalence and control in sleep-disordered breathing: the European Sleep Apnea Cohort (ESADA) study.

Kent BD, Grote L, Ryan S, Pépin JL, Bonsignore MR, Tkacova R, Saaresranta T, Verbraecken J, Lévy P, Hedner J, McNicholas WT.

Chest. 2014 Oct;146(4):982-990. doi: 10.1378/chest.13-2403.


Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression.

Taylor CT, Kent BD, Crinion SJ, McNicholas WT, Ryan S.

Biochem Biophys Res Commun. 2014 May 16;447(4):660-5. doi: 10.1016/j.bbrc.2014.04.062. Epub 2014 Apr 19.


Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study.

Kent BD, Grote L, Bonsignore MR, Saaresranta T, Verbraecken J, Lévy P, Sliwinski P, Tkacova R, Kvamme JA, Fietze I, Hedner J, McNicholas WT; European Sleep Apnoea Database collaborators.

Eur Respir J. 2014 Jul;44(1):130-9. doi: 10.1183/09031936.00162713. Epub 2014 Apr 2.


Obesity and sleep-disordered breathing--when two 'bad guys' meet.

Ryan S, Crinion SJ, McNicholas WT.

QJM. 2014 Dec;107(12):949-54. doi: 10.1093/qjmed/hcu029. Epub 2014 Feb 6. Review.


Comparison of a novel non-contact biomotion sensor with wrist actigraphy in estimating sleep quality in patients with obstructive sleep apnoea.

Pallin M, O'Hare E, Zaffaroni A, Boyle P, Fagan C, Kent B, Heneghan C, de Chazal P, McNicholas WT.

J Sleep Res. 2014 Aug;23(4):475-84. doi: 10.1111/jsr.12126. Epub 2014 Feb 3.


Sleep-related disorders in chronic obstructive pulmonary disease.

Crinion SJ, McNicholas WT.

Expert Rev Respir Med. 2014 Feb;8(1):79-88. doi: 10.1586/17476348.2014.860357. Epub 2013 Dec 30. Review.


Respiratory mechanics and ventilatory control in overlap syndrome and obesity hypoventilation.

Verbraecken J, McNicholas WT.

Respir Res. 2013 Nov 20;14:132. doi: 10.1186/1465-9921-14-132. Review.


Sleep disorders in COPD: the forgotten dimension.

McNicholas WT, Verbraecken J, Marin JM.

Eur Respir Rev. 2013 Sep 1;22(129):365-75. doi: 10.1183/09059180.00003213. Review.

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