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The atlastin membrane anchor forms an intramembrane hairpin that does not span the phospholipid bilayer.

Betancourt-Solis MA, Desai T, McNew JA.

J Biol Chem. 2018 Nov 30;293(48):18514-18524. doi: 10.1074/jbc.RA118.003812. Epub 2018 Oct 4.


Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association.

Zhang W, Zheng W, Toh Y, Betancourt-Solis MA, Tu J, Fan Y, Vakharia VN, Liu J, McNew JA, Jin M, Tao YJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8550-8555. doi: 10.1073/pnas.1701747114. Epub 2017 Jul 24.


Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.

Wangler MF, Chao YH, Bayat V, Giagtzoglou N, Shinde AB, Putluri N, Coarfa C, Donti T, Graham BH, Faust JE, McNew JA, Moser A, Sardiello M, Baes M, Bellen HJ.

PLoS Genet. 2017 Jun 22;13(6):e1006825. doi: 10.1371/journal.pgen.1006825. eCollection 2017 Jun.


Beneficial effects of rapamycin in a Drosophila model for hereditary spastic paraplegia.

Xu S, Stern M, McNew JA.

J Cell Sci. 2017 Jan 15;130(2):453-465. doi: 10.1242/jcs.196741. Epub 2016 Dec 1.


The effects of ER morphology on synaptic structure and function in Drosophila melanogaster.

Summerville JB, Faust JF, Fan E, Pendin D, Daga A, Formella J, Stern M, McNew JA.

J Cell Sci. 2016 Apr 15;129(8):1635-48. doi: 10.1242/jcs.184929. Epub 2016 Feb 23.


The Atlastin C-terminal tail is an amphipathic helix that perturbs the bilayer structure during endoplasmic reticulum homotypic fusion.

Faust JE, Desai T, Verma A, Ulengin I, Sun TL, Moss TJ, Betancourt-Solis MA, Huang HW, Lee T, McNew JA.

J Biol Chem. 2015 Feb 20;290(8):4772-83. doi: 10.1074/jbc.M114.601823. Epub 2015 Jan 2.


Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum.

Chen S, Desai T, McNew JA, Gerard P, Novick PJ, Ferro-Novick S.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):418-23. doi: 10.1073/pnas.1423026112. Epub 2014 Dec 29.


Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster.

Faust JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler M, Stern M, McNew JA.

PLoS One. 2014 Jun 19;9(6):e100213. doi: 10.1371/journal.pone.0100213. eCollection 2014.


The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p.

Shen D, Yuan H, Hutagalung A, Verma A, Kümmel D, Wu X, Reinisch K, McNew JA, Novick P.

J Cell Biol. 2013 Aug 5;202(3):509-26. doi: 10.1083/jcb.201211148. Epub 2013 Jul 29.


GTP-dependent membrane fusion.

McNew JA, Sondermann H, Lee T, Stern M, Brandizzi F.

Annu Rev Cell Dev Biol. 2013;29:529-50. doi: 10.1146/annurev-cellbio-101512-122328. Epub 2013 Jul 15. Review.


An inventory of peroxisomal proteins and pathways in Drosophila melanogaster.

Faust JE, Verma A, Peng C, McNew JA.

Traffic. 2012 Oct;13(10):1378-92. doi: 10.1111/j.1600-0854.2012.01393.x. Epub 2012 Jul 25.


Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells.

Kim K, Petrova YM, Scott BL, Nigam R, Agrawal A, Evans CM, Azzegagh Z, Gomez A, Rodarte EM, Olkkonen VM, Bagirzadeh R, Piccotti L, Ren B, Yoon JH, McNew JA, Adachi R, Tuvim MJ, Dickey BF.

Biochem J. 2012 Sep 15;446(3):383-94. doi: 10.1042/BJ20120057.


In Arabidopsis, the spatial and dynamic organization of the endoplasmic reticulum and Golgi apparatus is influenced by the integrity of the C-terminal domain of RHD3, a non-essential GTPase.

Stefano G, Renna L, Moss T, McNew JA, Brandizzi F.

Plant J. 2012 Mar;69(6):957-66. doi: 10.1111/j.1365-313X.2011.04846.x. Epub 2011 Dec 19.


GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion.

Pendin D, Tosetto J, Moss TJ, Andreazza C, Moro S, McNew JA, Daga A.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16283-8. doi: 10.1073/pnas.1106421108. Epub 2011 Sep 19.


SNARE proteins are required for macroautophagy.

Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen WL, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia TJ, Klionsky DJ.

Cell. 2011 Jul 22;146(2):290-302. doi: 10.1016/j.cell.2011.06.022.


Membrane fusion by the GTPase atlastin requires a conserved C-terminal cytoplasmic tail and dimerization through the middle domain.

Moss TJ, Andreazza C, Verma A, Daga A, McNew JA.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11133-8. doi: 10.1073/pnas.1105056108. Epub 2011 Jun 20.


Balancing ER dynamics: shaping, bending, severing, and mending membranes.

Pendin D, McNew JA, Daga A.

Curr Opin Cell Biol. 2011 Aug;23(4):435-42. doi: 10.1016/ Review.


Fusing a lasting relationship between ER tubules.

Moss TJ, Daga A, McNew JA.

Trends Cell Biol. 2011 Jul;21(7):416-23. doi: 10.1016/j.tcb.2011.03.009. Epub 2011 May 6. Review.


Homotypic fusion of ER membranes requires the dynamin-like GTPase atlastin.

Orso G, Pendin D, Liu S, Tosetto J, Moss TJ, Faust JE, Micaroni M, Egorova A, Martinuzzi A, McNew JA, Daga A.

Nature. 2009 Aug 20;460(7258):978-83. doi: 10.1038/nature08280. Epub 2009 Jul 26. Erratum in: Nature.2010 Apr 8;464(7290):942.


Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitro.

Brandie FM, Aran V, Verma A, McNew JA, Bryant NJ, Gould GW.

PLoS One. 2008;3(12):e4074. doi: 10.1371/journal.pone.0004074. Epub 2008 Dec 31.


Binding interactions control SNARE specificity in vivo.

Yang HJ, Nakanishi H, Liu S, McNew JA, Neiman AM.

J Cell Biol. 2008 Dec 15;183(6):1089-100. doi: 10.1083/jcb.200809178. Epub 2008 Dec 8.


Munc18a scaffolds SNARE assembly to promote membrane fusion.

Rodkey TL, Liu S, Barry M, McNew JA.

Mol Biol Cell. 2008 Dec;19(12):5422-34. doi: 10.1091/mbc.E08-05-0538. Epub 2008 Oct 1.


Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina.

Curtis LB, Doneske B, Liu X, Thaller C, McNew JA, Janz R.

J Comp Neurol. 2008 Oct 10;510(5):550-9. doi: 10.1002/cne.21806.


Regulation of SNARE-mediated membrane fusion during exocytosis.

McNew JA.

Chem Rev. 2008 May;108(5):1669-86. doi: 10.1021/cr0782325. Epub 2008 Apr 18. Review. No abstract available.


In vitro fusion catalyzed by the sporulation-specific t-SNARE light-chain Spo20p is stimulated by phosphatidic acid.

Liu S, Wilson KA, Rice-Stitt T, Neiman AM, McNew JA.

Traffic. 2007 Nov;8(11):1630-43. Epub 2007 Aug 14.


Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.

Schaub JR, Lu X, Doneske B, Shin YK, McNew JA.

Nat Struct Mol Biol. 2006 Aug;13(8):748-50. Epub 2006 Jul 16.


An intramolecular t-SNARE complex functions in vivo without the syntaxin NH2-terminal regulatory domain.

Van Komen JS, Bai X, Scott BL, McNew JA.

J Cell Biol. 2006 Jan 16;172(2):295-307. Epub 2006 Jan 9.


The polybasic juxtamembrane region of Sso1p is required for SNARE function in vivo.

Van Komen JS, Bai X, Rodkey TL, Schaub J, McNew JA.

Eukaryot Cell. 2005 Dec;4(12):2017-28.


Membrane fusion induced by neuronal SNAREs transits through hemifusion.

Lu X, Zhang F, McNew JA, Shin YK.

J Biol Chem. 2005 Aug 26;280(34):30538-41. Epub 2005 Jun 24.


Hemifusion in SNARE-mediated membrane fusion.

Xu Y, Zhang F, Su Z, McNew JA, Shin YK.

Nat Struct Mol Biol. 2005 May;12(5):417-22. Epub 2005 Apr 10.


Sec1p directly stimulates SNARE-mediated membrane fusion in vitro.

Scott BL, Van Komen JS, Irshad H, Liu S, Wilson KA, McNew JA.

J Cell Biol. 2004 Oct 11;167(1):75-85. Epub 2004 Oct 4.


Ca2+ and N-ethylmaleimide-sensitive factor differentially regulate disassembly of SNARE complexes on early endosomes.

Yan Q, Sun W, McNew JA, Vida TA, Bean AJ.

J Biol Chem. 2004 Apr 30;279(18):18270-6. Epub 2004 Feb 9.


Membrane-bound fatty acid desaturases are inserted co-translationally into the ER and contain different ER retrieval motifs at their carboxy termini.

McCartney AW, Dyer JM, Dhanoa PK, Kim PK, Andrews DW, McNew JA, Mullen RT.

Plant J. 2004 Jan;37(2):156-73.


Liposome fusion assay to monitor intracellular membrane fusion machines.

Scott BL, Van Komen JS, Liu S, Weber T, Melia TJ, McNew JA.

Methods Enzymol. 2003;372:274-300. No abstract available.


Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins.

Melia TJ, Weber T, McNew JA, Fisher LE, Johnston RJ, Parlati F, Mahal LK, Sollner TH, Rothman JE.

J Cell Biol. 2002 Sep 2;158(5):929-40. Epub 2002 Sep 3.


Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity.

Parlati F, Varlamov O, Paz K, McNew JA, Hurtado D, Söllner TH, Rothman JE.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5424-9.


A t-SNARE of the endocytic pathway must be activated for fusion.

Paumet F, Brügger B, Parlati F, McNew JA, Söllner TH, Rothman JE.

J Cell Biol. 2001 Dec 10;155(6):961-8. Epub 2001 Dec 10.


Functional architecture of an intracellular membrane t-SNARE.

Fukuda R, McNew JA, Weber T, Parlati F, Engel T, Nickel W, Rothman JE, Söllner TH.

Nature. 2000 Sep 14;407(6801):198-202.


Topological restriction of SNARE-dependent membrane fusion.

Parlati F, McNew JA, Fukuda R, Miller R, Söllner TH, Rothman JE.

Nature. 2000 Sep 14;407(6801):194-8.


Compartmental specificity of cellular membrane fusion encoded in SNARE proteins.

McNew JA, Parlati F, Fukuda R, Johnston RJ, Paz K, Paumet F, Söllner TH, Rothman JE.

Nature. 2000 Sep 14;407(6801):153-9.


Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors.

McNew JA, Weber T, Parlati F, Johnston RJ, Melia TJ, Söllner TH, Rothman JE.

J Cell Biol. 2000 Jul 10;150(1):105-17.


SNAREpins are functionally resistant to disruption by NSF and alphaSNAP.

Weber T, Parlati F, McNew JA, Johnston RJ, Westermann B, Söllner TH, Rothman JE.

J Cell Biol. 2000 May 29;149(5):1063-72.


Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors.

Brügger B, Nickel W, Weber T, Parlati F, McNew JA, Rothman JE, Söllner T.

EMBO J. 2000 Mar 15;19(6):1272-8.


Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs.

Nickel W, Weber T, McNew JA, Parlati F, Söllner TH, Rothman JE.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12571-6.


Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain.

Parlati F, Weber T, McNew JA, Westermann B, Söllner TH, Rothman JE.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12565-70.


The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion.

McNew JA, Weber T, Engelman DM, Söllner TH, Rothman JE.

Mol Cell. 1999 Sep;4(3):415-21.


Gos1p, a Saccharomyces cerevisiae SNARE protein involved in Golgi transport.

McNew JA, Coe JG, Søgaard M, Zemelman BV, Wimmer C, Hong W, Söllner TH.

FEBS Lett. 1998 Sep 11;435(1):89-95.


SNAREpins: minimal machinery for membrane fusion.

Weber T, Zemelman BV, McNew JA, Westermann B, Gmachl M, Parlati F, Söllner TH, Rothman JE.

Cell. 1998 Mar 20;92(6):759-72.


Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic.

Lupashin VV, Pokrovskaya ID, McNew JA, Waters MG.

Mol Biol Cell. 1997 Dec;8(12):2659-76.


Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport.

McNew JA, Sogaard M, Lampen NM, Machida S, Ye RR, Lacomis L, Tempst P, Rothman JE, Söllner TH.

J Biol Chem. 1997 Jul 11;272(28):17776-83.

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