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Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging.

Dempsey GT, Chaudhary KW, Atwater N, Nguyen C, Brown BS, McNeish JD, Cohen AE, Kralj JM.

J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:240-50. doi: 10.1016/j.vascn.2016.05.003. Epub 2016 May 13.


Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke.

Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K.

Stroke. 2016 Apr;47(4):1094-100. doi: 10.1161/STROKEAHA.115.012133. Epub 2016 Mar 10.


Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats.

Liang AC, Mandeville ET, Maki T, Shindo A, Som AT, Egawa N, Itoh K, Chuang TT, McNeish JD, Holder JC, Lok J, Lo EH, Arai K.

Cell Transplant. 2016;25(4):705-14. doi: 10.3727/096368916X690557. Epub 2016 Jan 22.


Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells.

Koh SH, Liang AC, Takahashi Y, Maki T, Shindo A, Osumi N, Zhao J, Lin H, Holder JC, Chuang TT, McNeish JD, Arai K, Lo EH.

PLoS One. 2015 Sep 25;10(9):e0138724. doi: 10.1371/journal.pone.0138724. eCollection 2015.


From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.

McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K.

Cell Stem Cell. 2015 Jul 2;17(1):8-10. doi: 10.1016/j.stem.2015.06.013.


Role of the trochlear nerve in eye abduction and frontal vision of the red-eared slider turtle (Trachemys scripta elegans).

Dearworth JR Jr, Ashworth AL, Kaye JM, Bednarz DT, Blaum JF, Vacca JM, McNeish JE, Higgins KA, Michael CL, Skrobola MG, Jones MS, Ariel M.

J Comp Neurol. 2013 Oct 15;521(15):3464-77. doi: 10.1002/cne.23361.


Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning.

Gutteridge A, Rukstalis JM, Ziemek D, Tié M, Ji L, Ramos-Zayas R, Nardone NA, Norquay LD, Brenner MB, Tang K, McNeish JD, Rowntree RK.

PLoS One. 2013;8(2):e56024. doi: 10.1371/journal.pone.0056024. Epub 2013 Feb 13.


Derivation of high purity neuronal progenitors from human embryonic stem cells.

Nistor G, Siegenthaler MM, Poirier SN, Rossi S, Poole AJ, Charlton ME, McNeish JD, Airriess CN, Keirstead HS.

PLoS One. 2011;6(6):e20692. doi: 10.1371/journal.pone.0020692. Epub 2011 Jun 6.


Induced pluripotent stem cells: opportunities as research and development tools in 21st century drug discovery.

Rowntree RK, McNeish JD.

Regen Med. 2010 Jul;5(4):557-68. doi: 10.2217/rme.10.36.


Pharma's developing interest in stem cells.

McKernan R, McNeish J, Smith D.

Cell Stem Cell. 2010 Jun 4;6(6):517-20. doi: 10.1016/j.stem.2010.05.012.


High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptors.

McNeish J, Roach M, Hambor J, Mather RJ, Weibley L, Lazzaro J, Gazard J, Schwarz J, Volkmann R, Machacek D, Stice S, Zawadzke L, O'Donnell C, Hurst R.

J Biol Chem. 2010 May 28;285(22):17209-17. doi: 10.1074/jbc.M109.098814. Epub 2010 Mar 8.


Genetically engineered mouse models in drug discovery research.

Sacca R, Engle SJ, Qin W, Stock JL, McNeish JD.

Methods Mol Biol. 2010;602:37-54. doi: 10.1007/978-1-60761-058-8_3.


KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE.

Cell Metab. 2009 Nov;10(5):366-78. doi: 10.1016/j.cmet.2009.09.010.


Stem cells as screening tools in drug discovery.

McNeish JD.

Curr Opin Pharmacol. 2007 Oct;7(5):515-20. Epub 2007 Aug 6. Review.


Post-discharge surgical site infection surveillance by automated telephony.

McNeish J, Lyle D, McCowan M, Emmerson S, McAuley S, Reilly J.

J Hosp Infect. 2007 Jul;66(3):232-6. Epub 2007 Jun 4.


The automatic choice for tackling infections. Interview by Victoria Hoban.

McNeish J.

Nurs Times. 2007 Apr 17-23;103(16):20-1. No abstract available.


Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function.

Siuciak JA, McCarthy SA, Chapin DS, Fujiwara RA, James LC, Williams RD, Stock JL, McNeish JD, Strick CA, Menniti FS, Schmidt CJ.

Neuropharmacology. 2006 Aug;51(2):374-85. Epub 2006 Jun 12.


The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice.

Gladue RP, Cole SH, Roach ML, Tylaska LA, Nelson RT, Shepard RM, McNeish JD, Ogborne KT, Neote KS.

J Immunol. 2006 Mar 1;176(5):3141-8.


Embryonic stem cells in predictive cardiotoxicity: laser capture microscopy enables assay development.

Chaudhary KW, Barrezueta NX, Bauchmann MB, Milici AJ, Beckius G, Stedman DB, Hambor JE, Blake WL, McNeish JD, Bahinski A, Cezar GG.

Toxicol Sci. 2006 Mar;90(1):149-58. Epub 2005 Dec 15.


Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment.

Chevalier E, Stock J, Fisher T, Dupont M, Fric M, Fargeau H, Leport M, Soler S, Fabien S, Pruniaux MP, Fink M, Bertrand CP, McNeish J, Li B.

J Immunol. 2005 Aug 15;175(4):2056-60.


Circadian rhythm phenotype of 5-HT7 receptor knockout mice: 5-HT and 8-OH-DPAT-induced phase advances of SCN neuronal firing.

Sprouse J, Li X, Stock J, McNeish J, Reynolds L.

J Biol Rhythms. 2005 Apr;20(2):122-31.


The role of estrogen receptor-beta, in the early age-related bone gain and later age-related bone loss in female mice.

Ke HZ, Brown TA, Qi H, Crawford DT, Simmons HA, Petersen DN, Allen MR, McNeish JD, Thompson DD.

J Musculoskelet Neuronal Interact. 2002 Sep;2(5):479-88.


E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.

Goulet JL, Pace AJ, Key ML, Byrum RS, Nguyen M, Tilley SL, Morham SG, Langenbach R, Stock JL, McNeish JD, Smithies O, Coffman TM, Koller BH.

J Immunol. 2004 Jul 15;173(2):1321-6.


Embryonic stem cells in drug discovery.

McNeish J.

Nat Rev Drug Discov. 2004 Jan;3(1):70-80. Review. No abstract available.


Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.

Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG.

J Clin Invest. 2003 Jul;112(2):197-208. Epub 2003 Jul 3.


Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase.

Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson PJ, Carty TJ, Perez JR, Audoly LP.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9044-9. Epub 2003 Jun 30.


Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine.

Peakman MC, Colby C, Perrotti LI, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen MR, Stock JL, Duman RS, McNeish JD, Barrot M, Self DW, Nestler EJ, Schaeffer E.

Brain Res. 2003 Apr 25;970(1-2):73-86.


Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass.

Gowen LC, Petersen DN, Mansolf AL, Qi H, Stock JL, Tkalcevic GT, Simmons HA, Crawford DT, Chidsey-Frink KL, Ke HZ, McNeish JD, Brown TA.

J Biol Chem. 2003 Jan 17;278(3):1998-2007. Epub 2002 Nov 5.


Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production.

Nguyen M, Solle M, Audoly LP, Tilley SL, Stock JL, McNeish JD, Coffman TM, Dombrowicz D, Koller BH.

J Immunol. 2002 Oct 15;169(8):4586-93.


Trafficking of CD44-deficient murine lymphocytes under normal and inflammatory conditions.

Stoop R, Gál I, Glant TT, McNeish JD, Mikecz K.

Eur J Immunol. 2002 Sep;32(9):2532-42.


Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.

Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS.

Mol Cell Biol. 2002 May;22(9):3035-45.


Glycemic control in mice with targeted disruption of the glucagon receptor gene.

Parker JC, Andrews KM, Allen MR, Stock JL, McNeish JD.

Biochem Biophys Res Commun. 2002 Jan 18;290(2):839-43.


Methods for the isolation and maintenance of murine embryonic stem cells.

Roach ML, McNeish JD.

Methods Mol Biol. 2002;185:1-16. Review. No abstract available.


Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 mice.

Stoop R, Kotani H, McNeish JD, Otterness IG, Mikecz K.

Arthritis Rheum. 2001 Dec;44(12):2922-31.


Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.

Beierschmitt WP, McNeish JD, Griffiths RJ, Nagahisa A, Nakane M, Amacher DE.

Toxicol Sci. 2001 Sep;63(1):15-21.


Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.

Fabre JE, Nguyen M, Athirakul K, Coggins K, McNeish JD, Austin S, Parise LK, FitzGerald GA, Coffman TM, Koller BH.

J Clin Invest. 2001 Mar;107(5):603-10.


The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.

Stock JL, Shinjo K, Burkhardt J, Roach M, Taniguchi K, Ishikawa T, Kim HS, Flannery PJ, Coffman TM, McNeish JD, Audoly LP.

J Clin Invest. 2001 Feb;107(3):325-31.


The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines.

Bortnick AE, Rothblat GH, Stoudt G, Hoppe KL, Royer LJ, McNeish J, Francone OL.

J Biol Chem. 2000 Sep 15;275(37):28634-40.


ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.

Hamon Y, Broccardo C, Chambenoit O, Luciani MF, Toti F, Chaslin S, Freyssinet JM, Devaux PF, McNeish J, Marguet D, Chimini G.

Nat Cell Biol. 2000 Jul;2(7):399-406.


High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.

McNeish J, Aiello RJ, Guyot D, Turi T, Gabel C, Aldinger C, Hoppe KL, Roach ML, Royer LJ, de Wet J, Broccardo C, Chimini G, Francone OL.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4245-50.


Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5.

Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A, Kowsz KP, McCarthy S, Coskran T, Carlo A, Seymour PA, Burkhardt JE, Nelson RB, McNeish JD.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2910-5.


Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.

Audoly LP, Tilley SL, Goulet J, Key M, Nguyen M, Stock JL, McNeish JD, Koller BH, Coffman TM.

Am J Physiol. 1999 Sep;277(3):H924-30. doi: 10.1152/ajpheart.1999.277.3.H924.


Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.

Nakagawa TY, Brissette WH, Lira PD, Griffiths RJ, Petrushova N, Stock J, McNeish JD, Eastman SE, Howard ED, Clarke SR, Rosloniec EF, Elliott EA, Rudensky AY.

Immunity. 1999 Feb;10(2):207-17.


Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene.

Bennett JA, Clancy YC, McNeish JD.

Mamm Genome. 1998 Dec;9(12):1069-71. No abstract available.


Phenotypic characterization and analysis of allogeneic T cell responses in ZAP-70 dominant negative transgenic mice.

Gladue RP, Allen M, Cunningham A, Gardner J, Laquerre AM, Connelly PA, Shaw AS, Mcneish J.

Clin Exp Immunol. 1997 Dec;110(3):397-402.


Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice.

Griffiths RJ, Smith MA, Roach ML, Stock JL, Stam EJ, Milici AJ, Scampoli DN, Eskra JD, Byrum RS, Koller BH, McNeish JD.

J Exp Med. 1997 Mar 17;185(6):1123-9.


Human CD8 alpha expression in NK cells but not cytotoxic T cells of transgenic mice.

Kieffer LJ, Bennett JA, Cunningham AC, Gladue RP, McNeish J, Kavathas PB, Hanke JH.

Int Immunol. 1996 Oct;8(10):1617-26.


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