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Items: 29

1.

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.

Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ.

Nat Commun. 2019 Oct 28;10(1):4910. doi: 10.1038/s41467-019-12711-7.

2.

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.

McNeill LA, Brown TJN, Sami M, Clifton IJ, Burzlaff NI, Claridge TDW, Adlington RM, Baldwin JE, Rutledge PJ, Schofield CJ.

Chemistry. 2017 Sep 18;23(52):12815-12824. doi: 10.1002/chem.201701592. Epub 2017 Aug 21.

3.

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon ECY, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ.

Org Biomol Chem. 2013 Feb 7;11(5):732-745. doi: 10.1039/c2ob26648b. Epub 2012 Nov 15.

4.

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6125-8. doi: 10.1016/j.bmcl.2010.08.032. Epub 2010 Aug 10.

PMID:
20822901
5.

Evidence for a stereoelectronic effect in human oxygen sensing.

Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ.

Angew Chem Int Ed Engl. 2009;48(10):1784-7. doi: 10.1002/anie.200805427.

PMID:
19180614
6.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.

7.

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.

Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ.

J Biol Chem. 2007 Feb 2;282(5):3293-301. Epub 2006 Nov 29.

8.

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

McNeill LA, Flashman E, Buck MR, Hewitson KS, Clifton IJ, Jeschke G, Claridge TD, Ehrismann D, Oldham NJ, Schofield CJ.

Mol Biosyst. 2005 Oct;1(4):321-4. Epub 2005 Aug 22.

PMID:
16880998
9.

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. Epub 2006 Jun 16.

10.

Another student reflects: Sarah's story of nursing artistry.

McNeill LA.

J Holist Nurs. 2006 Jun;24(2):145-6.

PMID:
16740908
11.

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.

Banerji B, Conejo-Garcia A, McNeill LA, McDonough MA, Buck MR, Hewitson KS, Oldham NJ, Schofield CJ.

Chem Commun (Camb). 2005 Nov 21;(43):5438-40. Epub 2005 Oct 4.

PMID:
16261239
12.

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans.

Welford RW, Kirkpatrick JM, McNeill LA, Puri M, Oldham NJ, Schofield CJ.

FEBS Lett. 2005 Sep 26;579(23):5170-4. Erratum in: FEBS Lett. 2005 Dec 5;579(29):6688.

13.

Selective inhibition of factor inhibiting hypoxia-inducible factor.

McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ.

J Am Chem Soc. 2005 Jun 1;127(21):7680-1.

PMID:
15913349
14.

Glyco- and peptidomimetics from three-component Joullié-Ugi coupling show selective antiviral activity.

Chapman TM, Davies IG, Gu B, Block TM, Scopes DI, Hay PA, Courtney SM, McNeill LA, Schofield CJ, Davis BG.

J Am Chem Soc. 2005 Jan 19;127(2):506-7.

PMID:
15643858
15.

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases.

McNeill LA, Bethge L, Hewitson KS, Schofield CJ.

Anal Biochem. 2005 Jan 1;336(1):125-31.

PMID:
15582567
16.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ.

Biochem J. 2004 Nov 1;383(Pt. 3):429-37.

17.

Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.

Hewitson KS, McNeill LA, Schofield CJ.

Curr Pharm Des. 2004;10(8):821-33. Review.

PMID:
15032687
18.

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.

Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80.

PMID:
12873492
19.

Human porphobilinogen deaminase mutations in the investigation of the mechanism of dipyrromethane cofactor assembly and tetrapyrrole formation.

Shoolingin-Jordan PM, Al-Dbass A, McNeill LA, Sarwar M, Butler D.

Biochem Soc Trans. 2003 Jun;31(Pt 3):731-5.

PMID:
12773194
20.

The role of iron and 2-oxoglutarate oxygenases in signalling.

Hewitson KS, McNeill LA, Elkins JM, Schofield CJ.

Biochem Soc Trans. 2003 Jun;31(Pt 3):510-5. Review.

PMID:
12773146
21.

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.

Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ.

Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4.

PMID:
12668010
22.

The selectivity and inhibition of AlkB.

Welford RW, Schlemminger I, McNeill LA, Hewitson KS, Schofield CJ.

J Biol Chem. 2003 Mar 21;278(12):10157-61. Epub 2003 Jan 6.

23.

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.

Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ.

J Biol Chem. 2003 Jan 17;278(3):1802-6. Epub 2002 Nov 21.

24.

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ.

Biochem J. 2002 Nov 1;367(Pt 3):571-5.

25.

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.

Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ.

J Biol Chem. 2002 Jul 19;277(29):26351-5. Epub 2002 May 31.

26.

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ.

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50.

PMID:
12039559
27.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ.

Cell. 2001 Oct 5;107(1):43-54.

29.

Dipyrromethane cofactor assembly in porphobilinogen deaminase.

McNeill LA, Shoolingin-Jordan PM.

Biochem Soc Trans. 1998 Aug;26(3):S286. No abstract available.

PMID:
9766005

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