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Items: 1 to 50 of 101

1.

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.

Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C.

Sci Transl Med. 2019 Sep 18;11(510). pii: eaav5055. doi: 10.1126/scitranslmed.aav5055.

PMID:
31534019
2.

Plasma Apelin Unchanged With Acute Exercise Insulin Sensitization.

Waller JD, McNeill EH, Zhong F, Vervaecke LS, Goldfarb AH.

J Sports Sci Med. 2019 Aug 1;18(3):537-543. eCollection 2019 Sep.

3.

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM.

Nature. 2019 Aug;572(7769):E18. doi: 10.1038/s41586-019-1459-x.

PMID:
31363232
4.

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.

Bailey JD, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, Hale A, Starr A, Nandi M, Stylianou E, McShane H, Davis S, Fischer R, Kessler BM, McCullagh J, Channon KM, Crabtree MJ.

Cell Rep. 2019 Jul 2;28(1):218-230.e7. doi: 10.1016/j.celrep.2019.06.018.

5.

Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.

Allen-Redpath K, Aldrovandi M, Lauder SN, Gketsopoulou A, Tyrrell VJ, Slatter DA, Andrews R, Watkins WJ, Atkinson G, McNeill E, Gilfedder A, Protty M, Burston J, Johnson SRC, Rodrigues PRS, Jones DO, Lee R, Handa A, Channon K, Obaji S, Alvarez-Jarreta J, Krönke G, Ackermann J, Jenkins PV, Collins PW, O'Donnell VB.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8038-8047. doi: 10.1073/pnas.1814409116. Epub 2019 Apr 3.

6.

Correction to 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.

Sarver P, Acker M, Bagdanoff JT, Chen Z, Chen YN, Chan H, Firestone B, Fodor M, Fortanet J, Hao H, Hentemann M, Jouk A, Kato M, Koenig R, LaBonte LR, Liu G, Liu S, Liu C, McNeill E, Mohseni M, Shultz MD, Sendzik M, Stams T, Spence S, Tamez V, Tichkule R, Towler C, Wang H, Wang P, Williams SL, Yu B, LaMarche MJ.

J Med Chem. 2019 Apr 11;62(7):3781. doi: 10.1021/acs.jmedchem.9b00436. Epub 2019 Mar 22. No abstract available.

PMID:
30900883
7.

Taxi Drivers at Risk: Tailoring Nutrition and Exercise Materials.

McNeill E, Hashemi A, Ramirez J, Roberts-Eversley N, Gany F.

J Community Health. 2019 Oct;44(5):888-895. doi: 10.1007/s10900-019-00618-9.

PMID:
30706324
8.

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.

Sarver P, Acker M, Bagdanoff JT, Chen Z, Chen YN, Chan H, Firestone B, Fodor M, Fortanet J, Hao H, Hentemann M, Kato M, Koenig R, LaBonte LR, Liu G, Liu S, Liu C, McNeill E, Mohseni M, Sendzik M, Stams T, Spence S, Tamez V, Tichkule R, Towler C, Wang H, Wang P, Williams SL, Yu B, LaMarche MJ.

J Med Chem. 2019 Feb 28;62(4):1793-1802. doi: 10.1021/acs.jmedchem.8b01726. Epub 2019 Feb 16. Erratum in: J Med Chem. 2019 Apr 11;62(7):3781.

PMID:
30688459
9.

Identifying the Inclusion of National Sexuality Education Standards Utilizing a Systematic Analysis of Teen Dating Violence Prevention Curriculum.

Wilson KL, Szucs LE, Shipley M, Fehr SK, McNeill EB, Wiley DC.

J Sch Health. 2019 Feb;89(2):106-114. doi: 10.1111/josh.12718.

PMID:
30604448
10.

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.

McNeill E, Stylianou E, Crabtree MJ, Harrington-Kandt R, Kolb AL, Diotallevi M, Hale AB, Bettencourt P, Tanner R, O'Shea MK, Matsumiya M, Lockstone H, Müller J, Fletcher HA, Greaves DR, McShane H, Channon KM.

Nat Commun. 2018 Dec 20;9(1):5409. doi: 10.1038/s41467-018-07714-9.

11.

Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition.

McNeill EP, Reese RW, Tondon A, Clough BH, Pan S, Froese J, Palmer D, Krause U, Loeb DM, Kaunas R, Gregory CA.

Cell Death Dis. 2018 Nov 26;9(12):1161. doi: 10.1038/s41419-018-1203-8.

12.

Improved cellular uptake of perfluorocarbon nanoparticles for in vivo murine cardiac 19F MRS/MRI and temporal tracking of progenitor cells.

Constantinides C, McNeill E, Carnicer R, Al Haj Zen A, Sainz-Urruela R, Shaw A, Patel J, Swider E, Alonaizan R, Potamiti L, Hadjisavvas A, Padilla-Parra S, Kyriacou K, Srinivas M, Carr CA.

Nanomedicine. 2019 Jun;18:391-401. doi: 10.1016/j.nano.2018.10.014. Epub 2018 Nov 16.

PMID:
30448526
13.

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM.

Nature. 2018 Nov;563(7732):564-568. doi: 10.1038/s41586-018-0701-2. Epub 2018 Nov 7. Erratum in: Nature. 2019 Aug;572(7769):E18.

14.

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.

Chuaiphichai S, Rashbrook VS, Hale AB, Trelfa L, Patel J, McNeill E, Lygate CA, Channon KM, Douglas G.

Hypertension. 2018 Jul;72(1):128-138. doi: 10.1161/HYPERTENSIONAHA.118.11144. Epub 2018 May 29.

15.

A brief look at the history of the Deaconess Hospital, Edinburgh, 1894-1990.

McNeill ER, Wright D, Demetriades AK.

J R Coll Physicians Edinb. 2018 Mar;48(1):78-84. doi: 10.4997/JRCPE.2018.118.

PMID:
29741534
16.

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.

Douglas G, Hale AB, Patel J, Chuaiphichai S, Al Haj Zen A, Rashbrook VS, Trelfa L, Crabtree MJ, McNeill E, Channon KM.

Cardiovasc Res. 2018 Aug 1;114(10):1385-1399. doi: 10.1093/cvr/cvy078.

17.

Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T.

Constantinides C, Maguire M, McNeill E, Carnicer R, Swider E, Srinivas M, Carr CA, Schneider JE.

PLoS One. 2018 Jan 11;13(1):e0190558. doi: 10.1371/journal.pone.0190558. eCollection 2018.

18.

Dual Allosteric Inhibition of SHP2 Phosphatase.

Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, Perez LB, Paris G, Quinn CM, Ramsey T, Sendzik M, Shultz MD, Williams SL, Stams T, Blacklow SC, Acker MG, LaMarche MJ.

ACS Chem Biol. 2018 Mar 16;13(3):647-656. doi: 10.1021/acschembio.7b00980. Epub 2018 Jan 18.

PMID:
29304282
19.

Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.

Akbar N, Digby JE, Cahill TJ, Tavare AN, Corbin AL, Saluja S, Dawkins S, Edgar L, Rawlings N, Ziberna K, McNeill E; Oxford Acute Myocardial Infarction (OxAMI) Study, Johnson E, Aljabali AA, Dragovic RA, Rohling M, Belgard TG, Udalova IA, Greaves DR, Channon KM, Riley PR, Anthony DC, Choudhury RP.

JCI Insight. 2017 Sep 7;2(17). pii: 93344. doi: 10.1172/jci.insight.93344. eCollection 2017 Sep 7.

20.

Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes.

Appari M, Channon KM, McNeill E.

Antioxid Redox Signal. 2018 Jul 20;29(3):297-312. doi: 10.1089/ars.2017.7060. Epub 2017 Oct 13. Review.

21.

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.

Chuaiphichai S, Crabtree MJ, Mcneill E, Hale AB, Trelfa L, Channon KM, Douglas G.

Br J Pharmacol. 2017 Apr;174(8):657-671. doi: 10.1111/bph.13728. Epub 2017 Mar 13.

22.

Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats.

Clough BH, Ylostalo J, Browder E, McNeill EP, Bartosh TJ, Rawls HR, Nakamoto T, Gregory CA.

Calcif Tissue Int. 2017 Mar;100(3):298-310. doi: 10.1007/s00223-016-0215-6. Epub 2016 Dec 2.

23.

Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report.

McNeill E, Iqbal AJ, Jones D, Patel J, Coutinho P, Taylor L, Greaves DR, Channon KM.

Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):258-263. doi: 10.1161/ATVBAHA.116.308367. Epub 2016 Dec 1.

24.

An allograft generated from adult stem cells and their secreted products efficiently fuses vertebrae in immunocompromised athymic rats and inhibits local immune responses.

Clough BH, McNeill EP, Palmer D, Krause U, Bartosh TJ, Chaput CD, Gregory CA.

Spine J. 2017 Mar;17(3):418-430. doi: 10.1016/j.spinee.2016.10.009. Epub 2016 Oct 17.

25.

Factors Associated With Intentions to Engage in Vaginal Intercourse Among Sexually Abstinent Missouri High School Freshmen.

Watts T, Wilson KL, McNeill EB, Rosen BL, Moore ND, Smith ML.

J Sch Health. 2016 Oct;86(10):751-8. doi: 10.1111/josh.12431.

PMID:
27619766
26.

Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo.

Iqbal AJ, Barrett TJ, Taylor L, McNeill E, Manmadhan A, Recio C, Carmineri A, Brodermann MH, White GE, Cooper D, DiDonato JA, Zamanian-Daryoush M, Hazen SL, Channon KM, Greaves DR, Fisher EA.

Elife. 2016 Aug 30;5. pii: e15190. doi: 10.7554/eLife.15190.

27.

Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo.

McNeill E, Iqbal AJ, White GE, Patel J, Greaves DR, Channon KM.

Sci Rep. 2015 Dec 1;5:17404. doi: 10.1038/srep17404.

28.

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension.

Chuaiphichai S, Starr A, Nandi M, Channon KM, McNeill E.

Vascul Pharmacol. 2016 Feb;77:69-79. doi: 10.1016/j.vph.2015.08.009. Epub 2015 Aug 11.

29.

1,4-Functionalization of 1,3-dienes with low-valent iron catalysts.

McNeill E, Ritter T.

Acc Chem Res. 2015 Aug 18;48(8):2330-43. doi: 10.1021/acs.accounts.5b00050. Epub 2015 Jul 27.

PMID:
26214092
30.

Freshman College Students' Reasons for Enrolling in and Anticipated Benefits from a Basic College Physical Education Activity Course.

Lackman J, Smith ML, McNeill EB.

Front Public Health. 2015 Jun 24;3:162. doi: 10.3389/fpubh.2015.00162. eCollection 2015.

31.

A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs.

Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, Van Vactor D.

Nat Commun. 2015 Jun 17;6:7279. doi: 10.1038/ncomms8279.

32.

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.

Hussein D, Starr A, Heikal L, McNeill E, Channon KM, Brown PR, Sutton BJ, McDonnell JM, Nandi M.

Br J Pharmacol. 2015 Aug;172(16):4146-57. doi: 10.1111/bph.13202. Epub 2015 Jul 14.

33.

QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.

Guarani V, McNeill EM, Paulo JA, Huttlin EL, Fröhlich F, Gygi SP, Van Vactor D, Harper JW.

Elife. 2015 May 21;4. doi: 10.7554/eLife.06265.

34.

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.

Patel J, McNeill E, Douglas G, Hale AB, de Bono J, Lee R, Iqbal AJ, Regan-Komito D, Stylianou E, Greaves DR, Channon KM.

Nat Commun. 2015 Mar 18;6:6614. doi: 10.1038/ncomms7614.

35.

Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.

Watschinger K, Keller MA, McNeill E, Alam MT, Lai S, Sailer S, Rauch V, Patel J, Hermetter A, Golderer G, Geley S, Werner-Felmayer G, Plumb RS, Astarita G, Ralser M, Channon KM, Werner ER.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2431-6. doi: 10.1073/pnas.1414887112. Epub 2015 Feb 9.

36.

Condensed-phase, halogen-bonded CF3I and C2F5I adducts for perfluoroalkylation reactions.

Sladojevich F, McNeill E, Börgel J, Zheng SL, Ritter T.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3712-6. doi: 10.1002/anie.201410954. Epub 2015 Feb 4.

PMID:
25651531
37.

MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs.

Zhao Q, Gregory CA, Lee RH, Reger RL, Qin L, Hai B, Park MS, Yoon N, Clough B, McNeill E, Prockop DJ, Liu F.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):530-5. doi: 10.1073/pnas.1423008112. Epub 2014 Dec 29.

38.

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.

McNeill E, Crabtree MJ, Sahgal N, Patel J, Chuaiphichai S, Iqbal AJ, Hale AB, Greaves DR, Channon KM.

Free Radic Biol Med. 2015 Feb;79:206-16. doi: 10.1016/j.freeradbiomed.2014.10.575. Epub 2014 Nov 6.

39.

Fractalkine promotes human monocyte survival via a reduction in oxidative stress.

White GE, McNeill E, Channon KM, Greaves DR.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2554-62. doi: 10.1161/ATVBAHA.114.304717. Epub 2014 Oct 30.

40.

Bone regeneration with osteogenically enhanced mesenchymal stem cells and their extracellular matrix proteins.

Clough BH, McCarley MR, Krause U, Zeitouni S, Froese JJ, McNeill EP, Chaput CD, Sampson HW, Gregory CA.

J Bone Miner Res. 2015 Jan;30(1):83-94. doi: 10.1002/jbmr.2320.

41.

Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.

McNeill E, Iqbal AJ, Patel J, White GE, Regan-Komito D, Greaves DR, Channon KM.

J Mol Med (Berl). 2014 Nov;92(11):1169-78. doi: 10.1007/s00109-014-1194-6. Epub 2014 Aug 1.

42.

Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.

Iqbal AJ, McNeill E, Kapellos TS, Regan-Komito D, Norman S, Burd S, Smart N, Machemer DE, Stylianou E, McShane H, Channon KM, Chawla A, Greaves DR.

Blood. 2014 Oct 9;124(15):e33-44. doi: 10.1182/blood-2014-04-568691. Epub 2014 Jul 16.

43.

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.

Fan LM, Douglas G, Bendall JK, McNeill E, Crabtree MJ, Hale AB, Mai A, Li JM, McAteer MA, Schneider JE, Choudhury RP, Channon KM.

Circulation. 2014 Jun 24;129(25):2661-72. doi: 10.1161/CIRCULATIONAHA.113.005062. Epub 2014 May 7.

44.

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM.

Hypertension. 2014 Sep;64(3):530-40. doi: 10.1161/HYPERTENSIONAHA.114.03089. Epub 2014 Apr 28.

45.

A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia.

De Filippo K, Neill DR, Mathies M, Bangert M, McNeill E, Kadioglu A, Hogg N.

FASEB J. 2014 Aug;28(8):3600-8. doi: 10.1096/fj.13-247460. Epub 2014 Apr 28.

PMID:
24776746
46.

miR-8 controls synapse structure by repression of the actin regulator enabled.

Loya CM, McNeill EM, Bao H, Zhang B, Van Vactor D.

Development. 2014 May;141(9):1864-74. doi: 10.1242/dev.105791. Epub 2014 Apr 9.

47.

S100A9 has a protective role in inflammation-induced skin carcinogenesis.

McNeill E, Hogg N.

Int J Cancer. 2014 Aug 15;135(4):798-808. doi: 10.1002/ijc.28725. Epub 2014 Jan 28.

48.

Tetrahydrobiopterin in cardiovascular health and disease.

Bendall JK, Douglas G, McNeill E, Channon KM, Crabtree MJ.

Antioxid Redox Signal. 2014 Jun 20;20(18):3040-77. doi: 10.1089/ars.2013.5566. Epub 2014 Mar 14. Review.

49.

Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity.

Berke B, Wittnam J, McNeill E, Van Vactor DL, Keshishian H.

J Neurosci. 2013 Nov 6;33(45):17937-50. doi: 10.1523/JNEUROSCI.6075-11.2013.

50.

Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.

Ali ZA, Rinze R, Douglas G, Hu Y, Xiao Q, Qi W, McNeill E, Bursill C, George I, Greaves DR, Xu Q, Channon KM.

Circulation. 2013 Sep 10;128(11 Suppl 1):S50-S58. doi: 10.1161/CIRCULATIONAHA.112.000249.

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