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Items: 1 to 50 of 107

1.

HCN3 ion channels: roles in sensory neuronal excitability and pain.

Lainez S, Tsantoulas C, Biel M, McNaughton PA.

J Physiol. 2019 Sep;597(17):4661-4675. doi: 10.1113/JP278211. Epub 2019 Jul 27.

PMID:
31290157
2.

A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial.

Lee MC, Bond S, Wheeler D, Scholtes I, Armstrong G, McNaughton P, Menon D.

Pain. 2019 Nov;160(11):2554-2565. doi: 10.1097/j.pain.0000000000001638.

PMID:
31188268
3.

Two decades of excellent transplant survival for chronic granulomatous disease: a supraregional immunology transplant center report.

Lum SH, Flood T, Hambleton S, McNaughton P, Watson H, Abinun M, Owens S, Cigrovski N, Cant A, Gennery AR, Slatter M.

Blood. 2019 Jun 6;133(23):2546-2549. doi: 10.1182/blood.2019000021. Epub 2019 Apr 5. No abstract available.

PMID:
30952673
4.

TRPM2 and warmth sensation.

Tan CH, McNaughton PA.

Pflugers Arch. 2018 May;470(5):787-798. doi: 10.1007/s00424-018-2139-7. Epub 2018 Mar 19. Review.

5.

Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy.

Tsantoulas C, Laínez S, Wong S, Mehta I, Vilar B, McNaughton PA.

Sci Transl Med. 2017 Sep 27;9(409):eaam6072. doi: 10.1126/scitranslmed.aam6072.

6.

Sensitization of TRPA1 by Protein Kinase A.

Meents JE, Fischer MJ, McNaughton PA.

PLoS One. 2017 Jan 11;12(1):e0170097. doi: 10.1371/journal.pone.0170097. eCollection 2017.

7.

HCN2 ion channels: basic science opens up possibilities for therapeutic intervention in neuropathic pain.

Tsantoulas C, Mooney ER, McNaughton PA.

Biochem J. 2016 Sep 15;473(18):2717-36. doi: 10.1042/BCJ20160287. Review.

PMID:
27621481
8.

The TRPM2 ion channel is required for sensitivity to warmth.

Tan CH, McNaughton PA.

Nature. 2016 Aug 25;536(7617):460-3. Epub 2016 Aug 17.

9.

Agonist-induced sensitisation of the irritant receptor ion channel TRPA1.

Meents JE, Fischer MJ, McNaughton PA.

J Physiol. 2016 Nov 15;594(22):6643-6660. doi: 10.1113/JP272237. Epub 2016 Aug 4.

10.

Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.

Young GT, Emery EC, Mooney ER, Tsantoulas C, McNaughton PA.

Pain. 2014 Sep;155(9):1708-19. doi: 10.1016/j.pain.2014.05.021. Epub 2014 May 23.

PMID:
24861581
11.

How anchoring proteins shape pain.

Fischer MJ, McNaughton PA.

Pharmacol Ther. 2014 Sep;143(3):316-22. doi: 10.1016/j.pharmthera.2014.04.001. Epub 2014 Apr 12. Review.

PMID:
24727631
12.

Direct evidence for functional TRPV1/TRPA1 heteromers.

Fischer MJ, Balasuriya D, Jeggle P, Goetze TA, McNaughton PA, Reeh PW, Edwardson JM.

Pflugers Arch. 2014 Dec;466(12):2229-41. doi: 10.1007/s00424-014-1497-z. Epub 2014 Mar 19.

PMID:
24643480
13.

Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.

Btesh J, Fischer MJM, Stott K, McNaughton PA.

J Neurosci. 2013 May 22;33(21):9184-9193. doi: 10.1523/JNEUROSCI.4991-12.2013. Erratum in: J Neurosci. 2015 May 27;35(21):8377.

14.

Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia.

Fischer MJ, Btesh J, McNaughton PA.

J Neurosci. 2013 Apr 24;33(17):7407-14. doi: 10.1523/JNEUROSCI.3721-12.2013.

15.

Magnetic characterization of isolated candidate vertebrate magnetoreceptor cells.

Eder SH, Cadiou H, Muhamad A, McNaughton PA, Kirschvink JL, Winklhofer M.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12022-7. doi: 10.1073/pnas.1205653109. Epub 2012 Jul 9.

16.

Direct inhibition of the cold-activated TRPM8 ion channel by Gαq.

Zhang X, Mak S, Li L, Parra A, Denlinger B, Belmonte C, McNaughton PA.

Nat Cell Biol. 2012 Aug;14(8):851-8. doi: 10.1038/ncb2529. Epub 2012 Jul 1.

17.

HCN2 ion channels: an emerging role as the pacemakers of pain.

Emery EC, Young GT, McNaughton PA.

Trends Pharmacol Sci. 2012 Aug;33(8):456-63. doi: 10.1016/j.tips.2012.04.004. Epub 2012 May 19. Review.

PMID:
22613784
18.

HCN2 ion channels play a central role in inflammatory and neuropathic pain.

Emery EC, Young GT, Berrocoso EM, Chen L, McNaughton PA.

Science. 2011 Sep 9;333(6048):1462-6. doi: 10.1126/science.1206243.

19.

The thermo-TRP ion channel family: properties and therapeutic implications.

Vay L, Gu C, McNaughton PA.

Br J Pharmacol. 2012 Feb;165(4):787-801. doi: 10.1111/j.1476-5381.2011.01601.x. Review.

20.

Neuroscience cuts will hurt key areas.

McNaughton PA, Robbins TW.

Nature. 2011 Mar 3;471(7336):36-7. doi: 10.1038/471036c. No abstract available.

PMID:
21368808
21.

Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.

Vellani V, Kinsey AM, Prandini M, Hechtfischer SC, Reeh P, Magherini PC, Giacomoni C, McNaughton PA.

Mol Pain. 2010 Sep 27;6:61. doi: 10.1186/1744-8069-6-61.

22.

Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications.

Vay L, Gu C, McNaughton PA.

Expert Rev Clin Pharmacol. 2010 Sep;3(5):687-704. doi: 10.1586/ecp.10.41.

PMID:
22111750
23.

Modulation of single-channel properties of TRPV1 by phosphorylation.

Studer M, McNaughton PA.

J Physiol. 2010 Oct 1;588(Pt 19):3743-56. doi: 10.1113/jphysiol.2010.190611. Epub 2010 Aug 6.

24.

Avian magnetite-based magnetoreception: a physiologist's perspective.

Cadiou H, McNaughton PA.

J R Soc Interface. 2010 Apr 6;7 Suppl 2:S193-205. doi: 10.1098/rsif.2009.0423.focus. Epub 2010 Jan 27.

25.

Activation of the TRPV4 ion channel is enhanced by phosphorylation.

Fan HC, Zhang X, McNaughton PA.

J Biol Chem. 2009 Oct 9;284(41):27884-91. doi: 10.1074/jbc.M109.028803. Epub 2009 Aug 6.

26.

Regulation of firing frequency in nociceptive neurons by pro-inflammatory mediators.

Momin A, McNaughton PA.

Exp Brain Res. 2009 Jun;196(1):45-52. doi: 10.1007/s00221-009-1744-2. Epub 2009 Apr 7. Review.

PMID:
19350231
27.

Role of the hyperpolarization-activated current Ih in somatosensory neurons.

Momin A, Cadiou H, Mason A, McNaughton PA.

J Physiol. 2008 Dec 15;586(24):5911-29. doi: 10.1113/jphysiol.2008.163154. Epub 2008 Oct 20.

28.

Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150.

Zhang X, Li L, McNaughton PA.

Neuron. 2008 Aug 14;59(3):450-61. doi: 10.1016/j.neuron.2008.05.015.

29.

Inflammatory pain: the cellular basis of heat hyperalgesia.

Huang J, Zhang X, McNaughton PA.

Curr Neuropharmacol. 2006 Jul;4(3):197-206.

30.

Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin.

Vellani V, Petrosino S, De Petrocellis L, Valenti M, Prandini M, Magherini PC, McNaughton PA, Di Marzo V.

Neuropharmacology. 2008 Dec;55(8):1274-9. doi: 10.1016/j.neuropharm.2008.01.010. Epub 2008 Feb 6.

PMID:
18329052
31.

Modulation of acid-sensing ion channel activity by nitric oxide.

Cadiou H, Studer M, Jones NG, Smith ES, Ballard A, McMahon SB, McNaughton PA.

J Neurosci. 2007 Nov 28;27(48):13251-60.

32.

Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a.

Smith ES, Zhang X, Cadiou H, McNaughton PA.

Neurosci Lett. 2007 Oct 9;426(1):12-7. Epub 2007 Aug 8.

PMID:
17881127
33.

Sensitisation of TRPV1 in rat sensory neurones by activation of SNSRs.

Honan SA, McNaughton PA.

Neurosci Lett. 2007 Jul 5;422(1):1-6. Epub 2007 Jun 2.

PMID:
17601667
34.

Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action.

Smith ES, Cadiou H, McNaughton PA.

Neuroscience. 2007 Mar 16;145(2):686-98. Epub 2007 Jan 29.

PMID:
17258862
35.

Modulation of temperature-sensitive TRP channels.

Huang J, Zhang X, McNaughton PA.

Semin Cell Dev Biol. 2006 Dec;17(6):638-45. Epub 2006 Nov 11. Review.

PMID:
17185012
36.

Why pain gets worse: the mechanism of heat hyperalgesia.

Zhang X, McNaughton PA.

J Gen Physiol. 2006 Nov;128(5):491-3. No abstract available.

37.

Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8.

Vellani V, Colucci M, Lattanzi R, Giannini E, Negri L, Melchiorri P, McNaughton PA.

J Neurosci. 2006 May 10;26(19):5109-16.

38.

NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.

Zhang X, Huang J, McNaughton PA.

EMBO J. 2005 Dec 21;24(24):4211-23. Epub 2005 Dec 1.

39.

Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels.

van der Stelt M, Trevisani M, Vellani V, De Petrocellis L, Schiano Moriello A, Campi B, McNaughton P, Geppetti P, Di Marzo V.

EMBO J. 2005 Sep 7;24(17):3026-37. Epub 2005 Aug 18. Erratum in: EMBO J. 2005 Oct 5;24(19):3517-8.

40.

Acid-induced pain and its modulation in humans.

Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB.

J Neurosci. 2004 Dec 1;24(48):10974-9.

41.

Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF.

Vellani V, Zachrisson O, McNaughton PA.

J Physiol. 2004 Oct 15;560(Pt 2):391-401. Epub 2004 Aug 19.

42.

Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling.

Robinson DR, McNaughton PA, Evans ML, Hicks GA.

Neurogastroenterol Motil. 2004 Feb;16(1):113-24.

PMID:
14764211
43.

Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor.

Bonnington JK, McNaughton PA.

J Physiol. 2003 Sep 1;551(Pt 2):433-46. Epub 2003 Jun 18.

44.

Upregulation of bradykinin B2 receptor expression by neurotrophic factors and nerve injury in mouse sensory neurons.

Lee YJ, Zachrisson O, Tonge DA, McNaughton PA.

Mol Cell Neurosci. 2002 Feb;19(2):186-200.

PMID:
11860272
45.

Glial cell responses to lipids bound to albumin in serum and plasma.

Nadal A, Fuentes E, McNaughton PA.

Prog Brain Res. 2001;132:367-74. Review. No abstract available.

PMID:
11545003
46.

Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide.

Vellani V, Mapplebeck S, Moriondo A, Davis JB, McNaughton PA.

J Physiol. 2001 Aug 1;534(Pt 3):813-25.

47.

Multidrug transporters in prokaryotic and eukaryotic cells: physiological functions and transport mechanisms.

Blackmore CG, McNaughton PA, van Veen HW.

Mol Membr Biol. 2001 Jan-Mar;18(1):97-103. Review.

PMID:
11396617
48.
49.

Manipulation of synaptic sign and strength with divalent cations in the vertebrate retina: pushing the limits of tonic, chemical neurotransmission.

Piccolino M, Vellani V, Rakotobe LA, Pignatelli A, Barnes S, McNaughton P.

Eur J Neurosci. 1999 Nov;11(11):4134-8.

PMID:
10583501
50.

Lysophospholipids trigger calcium signals but not DNA synthesis in cortical astrocytes.

Fuentes E, Nadal A, McNaughton PA.

Glia. 1999 Dec;28(3):272-6.

PMID:
10559786

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