Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 245

1.

Regression of Epileptogenesis by Inhibiting Tropomyosin Kinase B Signaling following a Seizure.

Krishnamurthy K, Huang YZ, Harward SC, Sharma KK, Tamayo DL, McNamara JO.

Ann Neurol. 2019 Dec;86(6):939-950. doi: 10.1002/ana.25602. Epub 2019 Oct 9.

PMID:
31525273
2.

Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy.

Lin TW, Harward SC, Huang YZ, McNamara JO.

Neuropharmacology. 2019 Aug 1:107734. doi: 10.1016/j.neuropharm.2019.107734. [Epub ahead of print] Review.

PMID:
31377199
3.

TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.

Huang YZ, He XP, Krishnamurthy K, McNamara JO.

J Neurosci. 2019 Jun 5;39(23):4624-4630. doi: 10.1523/JNEUROSCI.2939-18.2019. Epub 2019 Mar 29.

4.

Small Animal Multivariate Brain Analysis (SAMBA) - a High Throughput Pipeline with a Validation Framework.

Anderson RJ, Cook JJ, Delpratt N, Nouls JC, Gu B, McNamara JO, Avants BB, Johnson GA, Badea A.

Neuroinformatics. 2019 Jul;17(3):451-472. doi: 10.1007/s12021-018-9410-0.

5.

LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.

Pan E, Zhao Z, McNamara JO.

J Neurophysiol. 2019 Feb 1;121(2):609-619. doi: 10.1152/jn.00669.2018. Epub 2018 Dec 5.

PMID:
30517040
6.

Ex Vivo Tracer Efficacy in Optical Imaging of Staphylococcus Aureus Nuclease Activity.

Rosman CWK, Romero Pastrana F, Buist G, Heuker M, van Oosten M, McNamara JO, van Dam GM, van Dijl JM.

Sci Rep. 2018 Jan 22;8(1):1305. doi: 10.1038/s41598-018-19289-y.

7.

Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology.

Kruspe S, Dickey DD, Urak KT, Blanco GN, Miller MJ, Clark KC, Burghardt E, Gutierrez WR, Phadke SD, Kamboj S, Ginader T, Smith BJ, Grimm SK, Schappet J, Ozer H, Thomas A, McNamara JO 2nd, Chan CH, Giangrande PH.

Mol Ther Nucleic Acids. 2017 Sep 15;8:542-557. doi: 10.1016/j.omtn.2017.08.004. Epub 2017 Aug 12.

8.

Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity.

Flenker KS, Burghardt EL, Dutta N, Burns WJ, Grover JM, Kenkel EJ, Weaver TM, Mills J, Kim H, Huang L, Owczarzy R, Musselman CA, Behlke MA, Ford B, McNamara JO 2nd.

Mol Ther. 2017 Jun 7;25(6):1353-1362. doi: 10.1016/j.ymthe.2017.03.015. Epub 2017 Apr 5.

9.

Colorimetric Detection of Staphylococcus aureus Contaminated Solutions without Purification.

Tiet P, Clark KC, McNamara JO 2nd, Berlin JM.

Bioconjug Chem. 2017 Jan 18;28(1):183-193. doi: 10.1021/acs.bioconjchem.6b00571. Epub 2016 Dec 2.

PMID:
28095683
10.

Vagal nerve stimulation modifies neuronal activity and the proteome of excitatory synapses of amygdala/piriform cortex.

Alexander GM, Huang YZ, Soderblom EJ, He XP, Moseley MA, McNamara JO.

J Neurochem. 2017 Feb;140(4):629-644. doi: 10.1111/jnc.13931. Epub 2017 Feb 3.

11.

Is FGF13 a major contributor to genetic epilepsy with febrile seizures plus?

Rigbye KA, van Hasselt PM, Burgess R, Damiano JA, Mullen SA, Petrovski S, Puranam RS, van Gassen KL, Gecz J, Scheffer IE, McNamara JO, Berkovic SF, Hildebrand MS.

Epilepsy Res. 2016 Dec;128:48-51. doi: 10.1016/j.eplepsyres.2016.10.008. Epub 2016 Oct 25.

PMID:
27810516
12.

Autocrine BDNF-TrkB signalling within a single dendritic spine.

Harward SC, Hedrick NG, Hall CE, Parra-Bueno P, Milner TA, Pan E, Laviv T, Hempstead BL, Yasuda R, McNamara JO.

Nature. 2016 Oct 6;538(7623):99-103. doi: 10.1038/nature19766. Epub 2016 Sep 28.

13.

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity.

Hedrick NG, Harward SC, Hall CE, Murakoshi H, McNamara JO, Yasuda R.

Nature. 2016 Oct 6;538(7623):104-108. doi: 10.1038/nature19784. Epub 2016 Sep 28.

14.

Rapid, Culture-Free Detection of Staphylococcus aureus Bacteremia.

Burghardt EL, Flenker KS, Clark KC, Miguel J, Ince D, Winokur P, Ford B, McNamara JO 2nd.

PLoS One. 2016 Jun 15;11(6):e0157234. doi: 10.1371/journal.pone.0157234. eCollection 2016.

15.

Results of the Australasian (Trans-Tasman Oncology Group) radiotherapy benchmarking exercise in preparation for participation in the PORTEC-3 trial.

Jameson MG, McNamara J, Bailey M, Metcalfe PE, Holloway LC, Foo K, Do V, Mileshkin L, Creutzberg CL, Khaw P.

J Med Imaging Radiat Oncol. 2016 Aug;60(4):554-9. doi: 10.1111/1754-9485.12447. Epub 2016 Apr 5.

PMID:
27059658
16.

A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.

Gu B, Huang YZ, He XP, Joshi RB, Jang W, McNamara JO.

Neuron. 2015 Nov 4;88(3):484-91. doi: 10.1016/j.neuron.2015.09.032. Epub 2015 Oct 17.

17.

Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.

Puranam RS, He XP, Yao L, Le T, Jang W, Rehder CW, Lewis DV, McNamara JO.

J Neurosci. 2015 Jun 10;35(23):8866-81. doi: 10.1523/JNEUROSCI.3470-14.2015.

18.

Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells.

Thiel WH, Thiel KW, Flenker KS, Bair T, Dupuy AJ, McNamara JO 2nd, Miller FJ, Giangrande PH.

Methods Mol Biol. 2015;1218:187-99. doi: 10.1007/978-1-4939-1538-5_11.

19.

Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo.

Helgager J, Huang YZ, Mcnamara JO.

J Comp Neurol. 2014 Dec 1;522(17):3885-99. doi: 10.1002/cne.23647. Epub 2014 Aug 25.

20.

Aligning animal models with clinical epilepsy: where to begin?

Harward SC, McNamara JO.

Adv Exp Med Biol. 2014;813:243-51. doi: 10.1007/978-94-017-8914-1_19. Review.

PMID:
25012381
21.

Antiseizure effects of TrkB kinase inhibition.

Liu G, Kotloski RJ, McNamara JO.

Epilepsia. 2014 Aug;55(8):1264-73. doi: 10.1111/epi.12671. Epub 2014 Jun 5.

22.

Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease.

Kiedrowski MR, Crosby HA, Hernandez FJ, Malone CL, McNamara JO 2nd, Horswill AR.

PLoS One. 2014 Apr 21;9(4):e95574. doi: 10.1371/journal.pone.0095574. eCollection 2014.

23.

Impairment of kindling development in phospholipase Cγ1 heterozygous mice.

He XP, Wen R, McNamara JO.

Epilepsia. 2014 Mar;55(3):456-63. doi: 10.1111/epi.12536. Epub 2014 Feb 6.

24.

Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.

Hernandez FJ, Huang L, Olson ME, Powers KM, Hernandez LI, Meyerholz DK, Thedens DR, Behlke MA, Horswill AR, McNamara JO 2nd.

Nat Med. 2014 Mar;20(3):301-6. doi: 10.1038/nm.3460. Epub 2014 Feb 2.

25.

Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.

Ruzzo EK, Capo-Chichi JM, Ben-Zeev B, Chitayat D, Mao H, Pappas AL, Hitomi Y, Lu YF, Yao X, Hamdan FF, Pelak K, Reznik-Wolf H, Bar-Joseph I, Oz-Levi D, Lev D, Lerman-Sagie T, Leshinsky-Silver E, Anikster Y, Ben-Asher E, Olender T, Colleaux L, Décarie JC, Blaser S, Banwell B, Joshi RB, He XP, Patry L, Silver RJ, Dobrzeniecka S, Islam MS, Hasnat A, Samuels ME, Aryal DK, Rodriguiz RM, Jiang YH, Wetsel WC, McNamara JO, Rouleau GA, Silver DL, Lancet D, Pras E, Mitchell GA, Michaud JL, Goldstein DB.

Neuron. 2013 Oct 16;80(2):429-41. doi: 10.1016/j.neuron.2013.08.013.

26.

Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers.

Hernandez LI, Flenker KS, Hernandez FJ, Klingelhutz AJ, McNamara JO 2nd, Giangrande PH.

Pharmaceuticals (Basel). 2013 Mar 14;6(3):295-319.

27.

Morphological changes among hippocampal dentate granule cells exposed to early kindling-epileptogenesis.

Singh SP, He X, McNamara JO, Danzer SC.

Hippocampus. 2013 Dec;23(12):1309-20. doi: 10.1002/hipo.22169. Epub 2013 Aug 26.

28.

In search of the ever-elusive positive endozepine.

Harward SC, McNamara JO.

Neuron. 2013 Jun 19;78(6):951-2. doi: 10.1016/j.neuron.2013.06.004.

29.

Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy.

Liu G, Gu B, He XP, Joshi RB, Wackerle HD, Rodriguiz RM, Wetsel WC, McNamara JO.

Neuron. 2013 Jul 10;79(1):31-8. doi: 10.1016/j.neuron.2013.04.027. Epub 2013 Jun 20.

30.

The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.

Wang HG, He XP, Li Q, Madison RD, Moore SD, McNamara JO, Pitt GS.

J Biol Chem. 2013 May 10;288(19):13258-68. doi: 10.1074/jbc.M112.434548. Epub 2013 Mar 27.

31.

Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB.

Huang YZ, McNamara JO.

J Neurosci. 2012 Oct 31;32(44):15521-32. doi: 10.1523/JNEUROSCI.0755-12.2012.

32.

The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis.

Helgager J, Liu G, McNamara JO.

J Comp Neurol. 2013 Feb 15;521(3):499-521, Spc1. doi: 10.1002/cne.23225.

33.

Conditional deletion of TrkC does not modify limbic epileptogenesis.

Soren Leonard A, Puranam RS, Helgager J, Liu G, McNamara JO.

Epilepsy Res. 2012 Nov;102(1-2):126-30. doi: 10.1016/j.eplepsyres.2012.07.019. Epub 2012 Sep 12.

34.

Vagus nerve stimulation elevates seizure threshold in the kindling model.

Alexander GM, McNamara JO.

Epilepsia. 2012 Nov;53(11):2043-52. doi: 10.1111/j.1528-1167.2012.03646.x. Epub 2012 Sep 7.

35.

Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.

Heinzen EL, Depondt C, Cavalleri GL, Ruzzo EK, Walley NM, Need AC, Ge D, He M, Cirulli ET, Zhao Q, Cronin KD, Gumbs CE, Campbell CR, Hong LK, Maia JM, Shianna KV, McCormack M, Radtke RA, O'Conner GD, Mikati MA, Gallentine WB, Husain AM, Sinha SR, Chinthapalli K, Puranam RS, McNamara JO, Ottman R, Sisodiya SM, Delanty N, Goldstein DB.

Am J Hum Genet. 2012 Aug 10;91(2):293-302. doi: 10.1016/j.ajhg.2012.06.016. Epub 2012 Aug 2.

36.

Temporal Lobe Epilepsy and the BDNF Receptor, TrkB.

McNamara JO, Scharfman HE.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

37.

RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB.

Huang YZ, Hernandez FJ, Gu B, Stockdale KR, Nanapaneni K, Scheetz TE, Behlke MA, Peek AS, Bair T, Giangrande PH, McNamara JO 2nd.

Mol Pharmacol. 2012 Oct;82(4):623-35. Epub 2012 Jun 29.

38.

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers.

Thiel KW, Hernandez LI, Dassie JP, Thiel WH, Liu X, Stockdale KR, Rothman AM, Hernandez FJ, McNamara JO 2nd, Giangrande PH.

Nucleic Acids Res. 2012 Jul;40(13):6319-37. doi: 10.1093/nar/gks294. Epub 2012 Mar 30.

39.

Isolation and optimization of murine IL-10 receptor blocking oligonucleotide aptamers using high-throughput sequencing.

Berezhnoy A, Stewart CA, Mcnamara JO 2nd, Thiel W, Giangrande P, Trinchieri G, Gilboa E.

Mol Ther. 2012 Jun;20(6):1242-50. doi: 10.1038/mt.2012.18. Epub 2012 Mar 20.

40.

Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media.

Hernandez FJ, Stockdale KR, Huang L, Horswill AR, Behlke MA, McNamara JO 2nd.

Nucleic Acid Ther. 2012 Feb;22(1):58-68. doi: 10.1089/nat.2011.0316. Epub 2012 Jan 9.

41.

Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling.

Rockey WM, Hernandez FJ, Huang SY, Cao S, Howell CA, Thomas GS, Liu XY, Lapteva N, Spencer DM, McNamara JO, Zou X, Chen SJ, Giangrande PH.

Nucleic Acid Ther. 2011 Oct;21(5):299-314. doi: 10.1089/nat.2011.0313.

42.

Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse.

Pan E, Zhang XA, Huang Z, Krezel A, Zhao M, Tinberg CE, Lippard SJ, McNamara JO.

Neuron. 2011 Sep 22;71(6):1116-26. doi: 10.1016/j.neuron.2011.07.019. Epub 2011 Sep 21.

43.

Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers.

Pastor F, Kolonias D, McNamara JO 2nd, Gilboa E.

Mol Ther. 2011 Oct;19(10):1878-86. doi: 10.1038/mt.2011.145. Epub 2011 Aug 9.

44.

Nucleotide bias observed with a short SELEX RNA aptamer library.

Thiel WH, Bair T, Wyatt Thiel K, Dassie JP, Rockey WM, Howell CA, Liu XY, Dupuy AJ, Huang L, Owczarzy R, Behlke MA, McNamara JO, Giangrande PH.

Nucleic Acid Ther. 2011 Aug;21(4):253-63. doi: 10.1089/nat.2011.0288. Epub 2011 Jun 28.

45.

Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.

He XP, Pan E, Sciarretta C, Minichiello L, McNamara JO.

J Neurosci. 2010 May 5;30(18):6188-96. doi: 10.1523/JNEUROSCI.5821-09.2010.

46.

TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine.

Crooks KR, Kleven DT, Rodriguiz RM, Wetsel WC, McNamara JO.

Neuropharmacology. 2010 Jun;58(7):1067-77. doi: 10.1016/j.neuropharm.2010.01.014. Epub 2010 Feb 20.

47.

Mutual regulation of Src family kinases and the neurotrophin receptor TrkB.

Huang YZ, McNamara JO.

J Biol Chem. 2010 Mar 12;285(11):8207-17. doi: 10.1074/jbc.M109.091041. Epub 2010 Jan 11.

48.

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.

Dassie JP, Liu XY, Thomas GS, Whitaker RM, Thiel KW, Stockdale KR, Meyerholz DK, McCaffrey AP, McNamara JO 2nd, Giangrande PH.

Nat Biotechnol. 2009 Sep;27(9):839-49. doi: 10.1038/nbt.1560. Epub 2009 Aug 23.

49.

Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.

Alexander GM, Rogan SC, Abbas AI, Armbruster BN, Pei Y, Allen JA, Nonneman RJ, Hartmann J, Moy SS, Nicolelis MA, McNamara JO, Roth BL.

Neuron. 2009 Jul 16;63(1):27-39. doi: 10.1016/j.neuron.2009.06.014.

50.

Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model.

Kotloski R, McNamara JO.

Hippocampus. 2010 Jun;20(6):713-23. doi: 10.1002/hipo.20673.

Supplemental Content

Loading ...
Support Center