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Cord Blood Hemopoietic Cell Receptor Expression is Associated with Early Life Atopic Risk and Lung Function.

Akhabir L, Rosenberg E, Tworek D, Heroux D, Balhara J, McNagny KM, Sears MR, Lefebvre DL, Becker AB, Turvey SE, Mandhane PJ, Moraes TJ, Subbarao P, Paré G, Denburg JA.

Allergy. 2020 Jan 22. doi: 10.1111/all.14190. [Epub ahead of print] No abstract available.


The Transcription Factor RORα Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection.

Lo BC, Canals Hernaez D, Scott RW, Hughes MR, Shin SB, Underhill TM, Takei F, McNagny KM.

J Immunol. 2019 Dec 15;203(12):3209-3215. doi: 10.4049/jimmunol.1900781. Epub 2019 Nov 1.


Chronic Salmonella Infection Induced Intestinal Fibrosis.

Lo BC, Shin SB, Messing M, McNagny KM.

J Vis Exp. 2019 Sep 22;(151). doi: 10.3791/60068.


Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease.

Tam A, Hughes M, McNagny KM, Obeidat M, Hackett TL, Leung JM, Shaipanich T, Dorscheid DR, Singhera GK, Yang CWT, Paré PD, Hogg JC, Nickle D, Sin DD.

Sci Rep. 2019 Mar 4;9(1):3353. doi: 10.1038/s41598-019-40045-3.


HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.

Patel N, Wang J, Shiozawa K, Jones KB, Zhang Y, Prokop JW, Davenport GG, Nihira NT, Hao Z, Wong D, Brandsmeier L, Meadows SK, Sampaio AV, Werff RV, Endo M, Capecchi MR, McNagny KM, Mak TW, Nielsen TO, Underhill TM, Myers RM, Kondo T, Su L.

iScience. 2019 Mar 29;13:43-54. doi: 10.1016/j.isci.2019.02.008. Epub 2019 Feb 15.


Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation.

Cait J, Hughes MR, Zeglinski MR, Chan AW, Osterhof S, Scott RW, Canals Hernaez D, Cait A, Vogl AW, Bernatchez P, Underhill TM, Granville DJ, Murphy TH, Roskelley CD, McNagny KM.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4518-4527. doi: 10.1073/pnas.1814766116. Epub 2019 Feb 20.


The first identified heterozygous nonsense mutations in podocalyxin offer new perspectives on the biology of podocytopathies.

Refaeli I, Hughes MR, McNagny KM.

Clin Sci (Lond). 2019 Feb 8;133(3):443-447. doi: 10.1042/CS20181067. Print 2019 Feb 14.


IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection.

Lo BC, Shin SB, Canals Hernaez D, Refaeli I, Yu HB, Goebeler V, Cait A, Mohn WW, Vallance BA, McNagny KM.

J Immunol. 2019 Feb 1;202(3):956-965. doi: 10.4049/jimmunol.1801308. Epub 2019 Jan 7.


Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.

Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1588-1592. doi: 10.1073/pnas.1716804115. Epub 2018 Feb 2.


The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice.

Nesbitt JR, Steves EY, Schonhofer CR, Cait A, Manku SS, Yeung JHF, Bennet AJ, McNagny KM, Choy JC, Hughes MR, Moore MM.

Front Microbiol. 2018 Jan 18;8:2706. doi: 10.3389/fmicb.2017.02706. eCollection 2017.


Loss of podocalyxin causes a novel syndromic type of congenital nephrotic syndrome.

Kang HG, Lee M, Lee KB, Hughes M, Kwon BS, Lee S, McNagny KM, Ahn YH, Ko JM, Ha IS, Choi M, Cheong HI.

Exp Mol Med. 2017 Dec 15;49(12):e414. doi: 10.1038/emm.2017.227.


Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids.

Cait A, Hughes MR, Antignano F, Cait J, Dimitriu PA, Maas KR, Reynolds LA, Hacker L, Mohr J, Finlay BB, Zaph C, McNagny KM, Mohn WW.

Mucosal Immunol. 2018 May;11(3):785-795. doi: 10.1038/mi.2017.75. Epub 2017 Oct 25.


Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.

Kim YK, Refaeli I, Brooks CR, Jing P, Gulieva RE, Hughes MR, Cruz NM, Liu Y, Churchill AJ, Wang Y, Fu H, Pippin JW, Lin LY, Shankland SJ, Vogl AW, McNagny KM, Freedman BS.

Stem Cells. 2017 Dec;35(12):2366-2378. doi: 10.1002/stem.2707. Epub 2017 Sep 29.


The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Lo BC, Gold MJ, Hughes MR, Antignano F, Valdez Y, Zaph C, Harder KW, McNagny KM.

Sci Immunol. 2016 Sep 2;1(3):eaaf8864. doi: 10.1126/sciimmunol.aaf8864. Epub 2016 Sep 2.


Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.

Lo BC, Gold MJ, Scheer S, Hughes MR, Cait J, Debruin E, Chu FSF, Walker DC, Soliman H, Rossi FM, Blanchet MR, Perona-Wright G, Zaph C, McNagny KM.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):651-661. doi: 10.1165/rcmb.2016-0386OC.


The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Lo BC, Gold MJ, Hughes MR, Antignano F, Valdez Y, Zaph C, Harder KW, McNagny KM.

Sci Immunol. 2016 Sep 2;1(3). pii: eaaf8864. doi: 10.1126/sciimmunol.aaf8864.


Methanosphaera stadtmanae induces a type IV hypersensitivity response in a mouse model of airway inflammation.

Bernatchez E, Gold MJ, Langlois A, Blais-Lecours P, Boucher M, Duchaine C, Marsolais D, McNagny KM, Blanchet MR.

Physiol Rep. 2017 Apr;5(7). pii: e13163. doi: 10.14814/phy2.13163.


Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.

de Bock CE, Hughes MR, Snyder K, Alley S, Sadeqzadeh E, Dun MD, McNagny KM, Molloy TJ, Hondermarck H, Thorne RF.

FEBS Lett. 2017 Feb;591(4):667-678. doi: 10.1002/1873-3468.12569. Epub 2017 Feb 16.


Correction: CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.

Siemerink MJ, Hughes MR, Dallinga MG, Gora T, Cait J, Vogels IM, Yetkin-Arik B, Van Noorden CJ, Klaassen I, McNagny KM, Schlingemann RO.

PLoS One. 2016 Dec 21;11(12):e0169061. doi: 10.1371/journal.pone.0169061. eCollection 2016.


Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.

Chenery AL, Antignano F, Hughes MR, Burrows K, McNagny KM, Zaph C.

Eur J Immunol. 2016 Nov;46(11):2587-2596. doi: 10.1002/eji.201646326. Epub 2016 Sep 26.


CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.

Siemerink MJ, Hughes MR, Dallinga MG, Gora T, Cait J, Vogels IM, Yetin-Arik B, Van Noorden CJ, Klaassen I, McNagny KM, Schlingemann RO.

PLoS One. 2016 Jun 28;11(6):e0157902. doi: 10.1371/journal.pone.0157902. eCollection 2016. Erratum in: PLoS One. 2016 Dec 21;11(12 ):e0169061.


G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

Antignano F, Braam M, Hughes MR, Chenery AL, Burrows K, Gold MJ, Oudhoff MJ, Rattray D, Halim TY, Cait A, Takei F, Rossi FM, McNagny KM, Zaph C.

J Exp Med. 2016 Jun 27;213(7):1153-62. doi: 10.1084/jem.20151646. Epub 2016 Jun 13.


SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JH, Owen DR, Brown PJ, Zaph C.

Dev Cell. 2016 Apr 4;37(1):47-57. doi: 10.1016/j.devcel.2016.03.002.


DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis.

Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, Hughes MR, Lee L, Jia W, Adomat HH, Guns ES, McNagny KM, Samudio I, Krystal G.

PLoS One. 2016 Mar 31;11(3):e0152538. doi: 10.1371/journal.pone.0152538. eCollection 2016.


Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice.

Chow LN, Schreiner P, Ng BY, Lo B, Hughes MR, Scott RW, Gusti V, Lecour S, Simonson E, Manisali I, Barta I, McNagny KM, Crawford J, Webb M, Underhill TM.

PLoS One. 2016 Mar 21;11(3):e0151765. doi: 10.1371/journal.pone.0151765. eCollection 2016.


The cell surface mucin podocalyxin regulates collective breast tumor budding.

Graves ML, Cipollone JA, Austin P, Bell EM, Nielsen JS, Gilks CB, McNagny KM, Roskelley CD.

Breast Cancer Res. 2016 Jan 22;18(1):11. doi: 10.1186/s13058-015-0670-4.


Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects.

Hosseini A, Hirota JA, Hackett TL, McNagny KM, Wilson SJ, Carlsten C.

Part Fibre Toxicol. 2016 Jan 13;13:2. doi: 10.1186/s12989-016-0114-z.


Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice.

Gold MJ, Antignano F, Hughes MR, Zaph C, McNagny KM.

Eur J Immunol. 2016 Jan;46(1):122-30. doi: 10.1002/eji.201545628. Epub 2015 Nov 30. Erratum in: Eur J Immunol. 2016 Mar;46(3):782.


Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.

Gold MJ, Hiebert PR, Park HY, Stefanowicz D, Le A, Starkey MR, Deane A, Brown AC, Liu G, Horvat JC, Ibrahim ZA, Sukkar MB, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA, Hirota JA.

Mucosal Immunol. 2016 May;9(3):809-20. doi: 10.1038/mi.2015.104. Epub 2015 Oct 28.


Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.

Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV.

Nat Commun. 2015 Oct 23;6:8715. doi: 10.1038/ncomms9715.


Early infancy microbial and metabolic alterations affect risk of childhood asthma.

Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears MR, Kollmann T; CHILD Study Investigators, Mohn WW, Turvey SE, Finlay BB.

Sci Transl Med. 2015 Sep 30;7(307):307ra152. doi: 10.1126/scitranslmed.aab2271.


Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy.

Snyder KA, Hughes MR, Hedberg B, Brandon J, Hernaez DC, Bergqvist P, Cruz F, Po K, Graves ML, Turvey ME, Nielsen JS, Wilkins JA, McColl SR, Babcook JS, Roskelley CD, McNagny KM.

Breast Cancer Res. 2015 Mar 27;17:46. doi: 10.1186/s13058-015-0562-7.


In situ hematopoiesis: a regulator of TH2 cytokine-mediated immunity and inflammation at mucosal surfaces.

Hui CC, McNagny KM, Denburg JA, Siracusa MC.

Mucosal Immunol. 2015 Jul;8(4):701-11. doi: 10.1038/mi.2015.17. Epub 2015 Mar 18. Review.


Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1).

Gold MJ, Hughes MR, Antignano F, Hirota JA, Zaph C, McNagny KM.

J Allergy Clin Immunol. 2015 Sep;136(3):725-736.e2. doi: 10.1016/j.jaci.2015.01.019. Epub 2015 Mar 5.


Pulmonary CD103 expression regulates airway inflammation in asthma.

Bernatchez E, Gold MJ, Langlois A, Lemay AM, Brassard J, Flamand N, Marsolais D, McNagny KM, Blanchet MR.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L816-26. doi: 10.1152/ajplung.00319.2014. Epub 2015 Feb 13.


Preface. Mast cells.

Hughes MR, McNagny KM.

Methods Mol Biol. 2015;1220:vii-viii. No abstract available.


Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT).

Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ.

Methods Mol Biol. 2015;1220:381-400. doi: 10.1007/978-1-4939-1568-2_24.


Mast cells in human health and disease.

DeBruin EJ, Gold M, Lo BC, Snyder K, Cait A, Lasic N, Lopez M, McNagny KM, Hughes MR.

Methods Mol Biol. 2015;1220:93-119. doi: 10.1007/978-1-4939-1568-2_7. Review.


Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion.

Debruin EJ, Hughes MR, Sina C, Lu A, Cait J, Jian Z, Lopez M, Lo B, Abraham T, McNagny KM.

PLoS One. 2014 Oct 10;9(10):e108881. doi: 10.1371/journal.pone.0108881. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e116613. Liu, Alex [corrected to Lu, Alex].


Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases.

Russell SL, Gold MJ, Reynolds LA, Willing BP, Dimitriu P, Thorson L, Redpath SA, Perona-Wright G, Blanchet MR, Mohn WW, Finlay BB, McNagny KM.

J Allergy Clin Immunol. 2015 Jan;135(1):100-9. doi: 10.1016/j.jaci.2014.06.027. Epub 2014 Aug 18.


Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation.

Aloyouni SY, Segeritz CP, Sherrid AM, Gold MJ, Loeffler DI, Blanchet MR, Cai B, Hirota J, McNagny KM, Kollmann TR.

Allergy Asthma Immunol Res. 2014 Jul;6(4):341-9. doi: 10.4168/aair.2014.6.4.341. Epub 2014 Mar 21.


The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 μm.

Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):96-105. doi: 10.1165/rcmb.2014-0158OC.


Mutant mice and animal models of airway allergic disease.

Blanchet MR, Gold M, McNagny KM.

Methods Mol Biol. 2014;1178:295-308. doi: 10.1007/978-1-4939-1016-8_25.


Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.

Gold MJ, Antignano F, Halim TY, Hirota JA, Blanchet MR, Zaph C, Takei F, McNagny KM.

J Allergy Clin Immunol. 2014 Apr;133(4):1142-8. doi: 10.1016/j.jaci.2014.02.033.


Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, Arrowsmith CH, Lupien M, Levings MK, Zaph C.

J Clin Invest. 2014 May;124(5):1945-55. doi: 10.1172/JCI69592. Epub 2014 Mar 25.


Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.

Halim TY, Steer CA, Mathä L, Gold MJ, Martinez-Gonzalez I, McNagny KM, McKenzie AN, Takei F.

Immunity. 2014 Mar 20;40(3):425-35. doi: 10.1016/j.immuni.2014.01.011. Epub 2014 Mar 6.


Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.

Anderson NM, Javadi M, Berndl E, Berberovic Z, Bailey ML, Huang K, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Carter-Su C, Wang C, McNagny KM, Paulson RF, Minden MD, Stanford WL, Barber DL.

PLoS One. 2013 Sep 25;8(9):e75472. doi: 10.1371/journal.pone.0075472. eCollection 2013.


SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.

Sham HP, Yu EY, Gulen MF, Bhinder G, Stahl M, Chan JM, Brewster L, Morampudi V, Gibson DL, Hughes MR, McNagny KM, Li X, Vallance BA.

PLoS Pathog. 2013;9(8):e1003539. doi: 10.1371/journal.ppat.1003539. Epub 2013 Aug 8.


Requirement for core 2 O-glycans for optimal resistance to helminth infection.

Mullaly SC, Oudhoff MJ, Min PH, Burrows K, Antignano F, Rattray DG, Chenery A, McNagny KM, Ziltener HJ, Zaph C.

PLoS One. 2013;8(3):e60124. doi: 10.1371/journal.pone.0060124. Epub 2013 Mar 29.


A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue.

Scherberich A, Di Maggio ND, McNagny KM.

World J Stem Cells. 2013 Jan 26;5(1):1-8. doi: 10.4252/wjsc.v5.i1.1.

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