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Perfluorooctane Sulfonate (PFOS) Produces Dopaminergic Neuropathology in Caenorhabditis elegans.

Sammi SR, Foguth RM, Nieves CS, De Perre C, Wipf P, McMurray CT, Lee LS, Cannon JR.

Toxicol Sci. 2019 Dec 1;172(2):417-434. doi: 10.1093/toxsci/kfz191.


Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.

Polyzos AA, Lee DY, Datta R, Hauser M, Budworth H, Holt A, Mihalik S, Goldschmidt P, Frankel K, Trego K, Bennett MJ, Vockley J, Xu K, Gratton E, McMurray CT.

Cell Metab. 2019 Jun 4;29(6):1258-1273.e11. doi: 10.1016/j.cmet.2019.03.004. Epub 2019 Mar 28.


Folate deficiency drives mitotic missegregation of the human FRAXA locus.

Bjerregaard VA, Garribba L, McMurray CT, Hickson ID, Liu Y.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13003-13008. doi: 10.1073/pnas.1808377115. Epub 2018 Dec 3.


XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent.

Polyzos AA, Wood NI, Williams P, Wipf P, Morton AJ, McMurray CT.

PLoS One. 2018 Apr 9;13(4):e0194580. doi: 10.1371/journal.pone.0194580. eCollection 2018.


Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.

Polyzos AA, McMurray CT.

DNA Repair (Amst). 2017 Aug;56:144-155. doi: 10.1016/j.dnarep.2017.06.017. Epub 2017 Jun 9. Review.


The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease.

Polyzos AA, McMurray CT.

Mech Ageing Dev. 2017 Jan;161(Pt A):181-197. doi: 10.1016/j.mad.2016.09.003. Epub 2016 Sep 12. Review.


Crosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair.

Lai Y, Budworth H, Beaver JM, Chan NL, Zhang Z, McMurray CT, Liu Y.

Nat Commun. 2016 Aug 22;7:12465. doi: 10.1038/ncomms12465.


Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity.

Budworth H, McMurray CT.

Rare Dis. 2016 Feb 18;4(1):e1131885. doi: 10.1080/21675511.2015.1131885. eCollection 2016.


Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes.

Polyzos A, Holt A, Brown C, Cosme C, Wipf P, Gomez-Marin A, Castro MR, Ayala-Peña S, McMurray CT.

Hum Mol Genet. 2016 May 1;25(9):1792-802. doi: 10.1093/hmg/ddw051. Epub 2016 Feb 21.


Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.

Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT.

PLoS Genet. 2015 Aug 6;11(8):e1005267. doi: 10.1371/journal.pgen.1005267. eCollection 2015 Aug.


Editorial overview: Molecular and genetic bases of disease: the double life of DNA.

McMurray CT, Vijg J.

Curr Opin Genet Dev. 2014 Jun;26:v-vii. doi: 10.1016/j.gde.2014.09.002. Epub 2014 Oct 2.


Trinucleotide expansion in disease: why is there a length threshold?

Lee DY, McMurray CT.

Curr Opin Genet Dev. 2014 Jun;26:131-40. doi: 10.1016/j.gde.2014.07.003. Epub 2014 Oct 1. Review. Erratum in: Curr Opin Genet Dev. 2015 Feb;30:80.


Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo.

Trushina E, Canaria CA, Lee DY, McMurray CT.

Hum Mol Genet. 2014 Jan 1;23(1):129-44. doi: 10.1093/hmg/ddt406. Epub 2013 Sep 10.


Distinct pools of non-glycolytic substrates differentiate brain regions and prime region-specific responses of mitochondria.

Lee DY, Xun Z, Platt V, Budworth H, Canaria CA, McMurray CT.

PLoS One. 2013 Jul 17;8(7):e68831. doi: 10.1371/journal.pone.0068831. Print 2013.


Towards understanding region-specificity of triplet repeat diseases: coupled immunohistology and mass spectrometry imaging.

Platt V, Lee DY, Canaria CA, Frankel K, Bernstein S, McMurray CT.

Methods Mol Biol. 2013;1010:213-30. doi: 10.1007/978-1-62703-411-1_14.


A brief history of triplet repeat diseases.

Budworth H, McMurray CT.

Methods Mol Biol. 2013;1010:3-17. doi: 10.1007/978-1-62703-411-1_1. Review.


Bidirectional transcription of trinucleotide repeats: roles for excision repair.

Budworth H, McMurray CT.

DNA Repair (Amst). 2013 Aug;12(8):672-84. doi: 10.1016/j.dnarep.2013.04.019. Epub 2013 May 11. Review.


Comprehensive macromolecular conformations mapped by quantitative SAXS analyses.

Hura GL, Budworth H, Dyer KN, Rambo RP, Hammel M, McMurray CT, Tainer JA.

Nat Methods. 2013 Jun;10(6):453-4. doi: 10.1038/nmeth.2453. No abstract available.


Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2.

Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrøm RJ, McMurray CT, Alseth I, Tainer JA, Bjørås M.

Structure. 2013 Jan 8;21(1):154-166. doi: 10.1016/j.str.2012.11.004. Epub 2012 Dec 13.


Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease.

Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT.

Cell Rep. 2012 Nov 29;2(5):1137-42. doi: 10.1016/j.celrep.2012.10.001. Epub 2012 Nov 1.


Resolving brain regions using nanostructure initiator mass spectrometry imaging of phospholipids.

Lee DY, Platt V, Bowen B, Louie K, Canaria CA, McMurray CT, Northen T.

Integr Biol (Camb). 2012 Jun;4(6):693-9. doi: 10.1039/c2ib20043k. Epub 2012 Apr 27.


Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells.

Xun Z, Lee DY, Lim J, Canaria CA, Barnebey A, Yanonne SM, McMurray CT.

Mech Ageing Dev. 2012 Apr;133(4):176-85. doi: 10.1016/j.mad.2012.01.008. Epub 2012 Feb 8.


ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.

Majka J, Alford B, Ausio J, Finn RM, McMurray CT.

J Biol Chem. 2012 Jan 20;287(4):2328-41. doi: 10.1074/jbc.M111.307041. Epub 2011 Nov 18.


Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops.

Lang WH, Coats JE, Majka J, Hura GL, Lin Y, Rasnik I, McMurray CT.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E837-44. doi: 10.1073/pnas.1105461108. Epub 2011 Sep 29.


Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo.

Kovtun IV, Johnson KO, McMurray CT.

Aging (Albany NY). 2011 May;3(5):509-14.


Mechanisms of trinucleotide repeat instability during human development.

McMurray CT.

Nat Rev Genet. 2010 Nov;11(11):786-99. doi: 10.1038/nrg2828. Review. Erratum in: Nat Rev Genet. 2010 Dec;11(12):886.


Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion.

Liu Y, Prasad R, Beard WA, Hou EW, Horton JK, McMurray CT, Wilson SH.

J Biol Chem. 2009 Oct 9;284(41):28352-66. doi: 10.1074/jbc.M109.050286. Epub 2009 Aug 11.


The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent.

Owen BA, H Lang W, McMurray CT.

Nat Struct Mol Biol. 2009 May;16(5):550-7. doi: 10.1038/nsmb.1596. Epub 2009 Apr 19. Erratum in: Nat Struct Mol Biol. 2009 Aug;16(8):897.


DNA packaging motor assembly intermediate of bacteriophage phi29.

Koti JS, Morais MC, Rajagopal R, Owen BA, McMurray CT, Anderson DL.

J Mol Biol. 2008 Sep 19;381(5):1114-32. doi: 10.1016/j.jmb.2008.04.034. Epub 2008 Apr 20.


Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease.

McMurray CT.

DNA Repair (Amst). 2008 Jul 1;7(7):1121-34. doi: 10.1016/j.dnarep.2008.03.013. Epub 2008 May 9. Review.


Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats.

Delagoutte E, Goellner GM, Guo J, Baldacci G, McMurray CT.

J Biol Chem. 2008 May 9;283(19):13341-56. doi: 10.1074/jbc.M800153200. Epub 2008 Feb 8.


Features of trinucleotide repeat instability in vivo.

Kovtun IV, McMurray CT.

Cell Res. 2008 Jan;18(1):198-213. doi: 10.1038/cr.2008.5. Review.


OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.

Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT.

Nature. 2007 May 24;447(7143):447-52. Epub 2007 Apr 22.


Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases.

Trushina E, McMurray CT.

Neuroscience. 2007 Apr 14;145(4):1233-48. Epub 2007 Feb 14. Review.


Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo.

Trushina E, Singh RD, Dyer RB, Cao S, Shah VH, Parton RG, Pagano RE, McMurray CT.

Hum Mol Genet. 2006 Dec 15;15(24):3578-91.


Crosstalk of DNA glycosylases with pathways other than base excision repair.

Kovtun IV, McMurray CT.

DNA Repair (Amst). 2007 Apr 1;6(4):517-29. Epub 2006 Nov 28. Review.


Neurological abnormalities in caveolin-1 knock out mice.

Trushina E, Du Charme J, Parisi J, McMurray CT.

Behav Brain Res. 2006 Sep 15;172(1):24-32. Epub 2006 Jun 5.


(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition.

Owen BA, Yang Z, Lai M, Gajec M, Badger JD 2nd, Hayes JJ, Edelmann W, Kucherlapati R, Wilson TM, McMurray CT.

Nat Struct Mol Biol. 2005 Aug;12(8):663-70. Epub 2005 Jul 17. Erratum in: Nat Struct Mol Biol. 2005 Sep;12(9):824. Gajek, Maciez [corrected to Gajec, Maciej].


To die or not to die: DNA repair in neurons.

McMurray CT.

Mutat Res. 2005 Sep 4;577(1-2):260-74. Review.


Dynamics of hydrogen-deuterium exchange in Chlamydomonas centrin.

Ortiz M, Sanoguet Z, Hu H, Chazin WJ, McMurray CT, Salisbury JL, Pastrana-Rios B.

Biochemistry. 2005 Feb 22;44(7):2409-18. Erratum in: Biochemistry. 2005 Nov 22;44(46):15422. McMurray, Cynthia [corrected to McMurray, Cynthia T].


Culture of adult mouse neurons.

Eide L, McMurray CT.

Biotechniques. 2005 Jan;38(1):99-104.


IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis.

Kantarci OH, Goris A, Hebrink DD, Heggarty S, Cunningham S, Alloza I, Atkinson EJ, de Andrade M, McMurray CT, Graham CA, Hawkins SA, Billiau A, Dubois B, Weinshenker BG, Vandenbroeck K.

Genes Immun. 2005 Mar;6(2):153-61.


Somatic deletion events occur during early embryonic development and modify the extent of CAG expansion in subsequent generations.

Kovtun IV, Thornhill AR, McMurray CT.

Hum Mol Genet. 2004 Dec 15;13(24):3057-68. Epub 2004 Oct 20.


Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.

Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT.

Mol Cell Biol. 2004 Sep;24(18):8195-209.


Triplet repeats and DNA repair: germ cell and somatic cell instability in transgenic mice.

Kovtun IV, Spiro C, McMurray CT.

Methods Mol Biol. 2004;277:309-19.


Association of APOE polymorphisms with disease severity in MS is limited to women.

Kantarci OH, Hebrink DD, Achenbach SJ, Pittock SJ, Altintas A, Schaefer-Klein JL, Atkinson EJ, De Andrade M, McMurray CT, Rodriguez M, Weinshenker BG.

Neurology. 2004 Mar 9;62(5):811-4.


CD95 polymorphisms are associated with susceptibility to MS in women. A population-based study of CD95 and CD95L in MS.

Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, de Andrade M, McMurray CT, Weinshenker BG.

J Neuroimmunol. 2004 Jan;146(1-2):162-70.


CAG repeat lengths in X- and Y-bearing sperm indicate that gender bias during transmission of Huntington's disease gene is determined in the embryo.

Kovtun IV, Welch G, Guthrie HD, Hafner KL, McMurray CT.

J Biol Chem. 2004 Mar 5;279(10):9389-91. Epub 2003 Dec 19.


Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease.

Trushina E, Heldebrant MP, Perez-Terzic CM, Bortolon R, Kovtun IV, Badger JD 2nd, Terzic A, Estévez A, Windebank AJ, Dyer RB, Yao J, McMurray CT.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12171-6. Epub 2003 Oct 3.

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