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Items: 1 to 50 of 83

1.

Systemic Delivery of CRISPR/Cas9 Targeting HPV Oncogenes Is Effective at Eliminating Established Tumors.

Jubair L, Fallaha S, McMillan NAJ.

Mol Ther. 2019 Aug 29. pii: S1525-0016(19)30395-8. doi: 10.1016/j.ymthe.2019.08.012. [Epub ahead of print]

PMID:
31537455
2.

High serum levels of CD178 (soluble FasL) predict for inferior progression free survival in chronic lymphocytic leukemia treated with fludarabine-based chemotherapy.

Tate C, Burgess M, McMillan NA, Saunders NA, Cheung C, Gill D, Mollee P.

Leuk Lymphoma. 2019 Jun 25:1-5. doi: 10.1080/10428194.2019.1581936. [Epub ahead of print] No abstract available.

PMID:
31237178
3.

cGAS-STING responses are dampened in high-risk HPV type 16 positive head and neck squamous cell carcinoma cells.

Shaikh MH, Bortnik V, McMillan NA, Idris A.

Microb Pathog. 2019 Jul;132:162-165. doi: 10.1016/j.micpath.2019.05.004. Epub 2019 May 2.

PMID:
31054871
4.

Development of novel lipidic particles for siRNA delivery that are highly effective after 12 months storage.

Clarke D, Idris A, McMillan NAJ.

PLoS One. 2019 Feb 8;14(2):e0211954. doi: 10.1371/journal.pone.0211954. eCollection 2019.

5.

Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma.

Maroof H, Islam F, Dong L, Ajjikuttira P, Gopalan V, McMillan NAJ, Lam AK.

Cells. 2018 Dec 11;7(12). pii: E265. doi: 10.3390/cells7120265.

6.

Targeting of high mobility group A2 by small interfering RNA-loaded nanoliposome-induced apoptosis and migration inhibition in gastrointestinal cancer cells.

Mohammadi A, Mansoori B, Savadi P, Khaze V, Minouei M, McMillan NAJ, Hallaj-Nezhadi S, Baradaran B.

J Cell Biochem. 2019 Jun;120(6):9203-9212. doi: 10.1002/jcb.28196. Epub 2018 Dec 2.

PMID:
30507008
7.

Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers.

Shaikh MH, Idris A, Johnson NW, Fallaha S, Clarke DTW, Martin D, Morgan IM, Gabrielli B, McMillan NAJ.

Oral Oncol. 2018 Nov;86:105-112. doi: 10.1016/j.oraloncology.2018.09.006. Epub 2018 Sep 19.

PMID:
30409290
8.

RNAi Targeting of Human Metapneumovirus P and N Genes Inhibits Viral Growth.

Nitschinsk KM, Clarke DT, Idris A, McMillan NA.

Intervirology. 2018;61(3):149-154. doi: 10.1159/000491927. Epub 2018 Aug 24.

9.

Patient derived xenografts as models for head and neck cancer.

Nitschinsk K, Idris A, McMillan N.

Cancer Lett. 2018 Oct 10;434:114-119. doi: 10.1016/j.canlet.2018.07.023. Epub 2018 Jul 18.

PMID:
30031118
10.

Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients.

Li X, Tian R, Gao H, Yang Y, Williams BRG, Gantier MP, McMillan NAJ, Xu D, Hu Y, Gao Y.

Sci Rep. 2017 Nov 28;7(1):16495. doi: 10.1038/s41598-017-16472-5.

11.

Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh.

Shaikh MH, Khan AI, Sadat A, Chowdhury AH, Jinnah SA, Gopalan V, Lam AK, Clarke DTW, McMillan NAJ, Johnson NW.

BMC Cancer. 2017 Nov 25;17(1):792. doi: 10.1186/s12885-017-3789-0.

12.

Critical risk-benefit assessment of the novel anti-cancer aurora a kinase inhibitor alisertib (MLN8237): A comprehensive review of the clinical data.

Tayyar Y, Jubair L, Fallaha S, McMillan NAJ.

Crit Rev Oncol Hematol. 2017 Nov;119:59-65. doi: 10.1016/j.critrevonc.2017.09.006. Epub 2017 Sep 18. Review.

PMID:
29065986
13.

The Therapeutic Potential of CRISPR/Cas9 Systems in Oncogene-Addicted Cancer Types: Virally Driven Cancers as a Model System.

Jubair L, McMillan NAJ.

Mol Ther Nucleic Acids. 2017 Sep 15;8:56-63. doi: 10.1016/j.omtn.2017.06.006. Epub 2017 Jun 12. Review.

14.

Can gene editing and silencing technologies play a role in the treatment of head and neck cancer?

Shaikh MH, Clarke DTW, Johnson NW, McMillan NAJ.

Oral Oncol. 2017 May;68:9-19. doi: 10.1016/j.oraloncology.2017.02.016. Epub 2017 Mar 10. Review.

PMID:
28438299
15.

Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.

Gytz H, Hansen MF, Skovbjerg S, Kristensen AC, Hørlyck S, Jensen MB, Fredborg M, Markert LD, McMillan NA, Christensen EI, Martensen PM.

Biol Cell. 2017 Feb;109(2):94-112. doi: 10.1111/boc.201600034. Epub 2016 Oct 26.

PMID:
27673746
16.

Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer.

Hussein WM, Liu TY, Jia Z, McMillan NAJ, Monteiro MJ, Toth I, Skwarczynski M.

Bioorg Med Chem. 2016 Sep 15;24(18):4372-4380. doi: 10.1016/j.bmc.2016.07.036. Epub 2016 Jul 18.

PMID:
27475535
17.

MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target.

Sheng YH, He Y, Hasnain SZ, Wang R, Tong H, Clarke DT, Lourie R, Oancea I, Wong KY, Lumley JW, Florin TH, Sutton P, Hooper JD, McMillan NA, McGuckin MA.

Oncogene. 2017 Feb 2;36(5):700-713. doi: 10.1038/onc.2016.241. Epub 2016 Jul 11.

18.

Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates.

Singhania R, Pavey S, Payne E, Gu W, Clancy J, Jubair L, Preiss T, Saunders N, McMillan NA.

Biochim Biophys Acta. 2016 Aug;1859(8):1034-42. doi: 10.1016/j.bbagrm.2016.06.005. Epub 2016 Jun 16.

PMID:
27321990
19.

Impact of Reimbursement Cuts on the Sustainability and Accessibility of Dopamine Transporter Imaging.

Covington MF, McMillan NA, Kuo PH.

J Am Coll Radiol. 2016 Sep;13(9):1039-43. doi: 10.1016/j.jacr.2016.04.002. Epub 2016 May 25.

PMID:
27233911
20.

HPV-associated head and neck cancers in the Asia Pacific: A critical literature review & meta-analysis.

Shaikh MH, McMillan NA, Johnson NW.

Cancer Epidemiol. 2015 Dec;39(6):923-38. doi: 10.1016/j.canep.2015.09.013. Epub 2015 Nov 9. Review.

PMID:
26523982
21.

Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.

Gabrielli B, Bokhari F, Ranall MV, Oo ZY, Stevenson AJ, Wang W, Murrell M, Shaikh M, Fallaha S, Clarke D, Kelly M, Sedelies K, Christensen M, McKee S, Leggatt G, Leo P, Skalamera D, Soyer HP, Gonda TJ, McMillan NA.

Mol Cancer Ther. 2015 Dec;14(12):2753-61. doi: 10.1158/1535-7163.MCT-15-0506. Epub 2015 Oct 29.

22.

Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors.

Moyle PM, Dai W, Liu TY, Hussein WM, Maruthayanar P, Wells JW, McMillan NA, Skwarczynski M, Toth I.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5570-5. doi: 10.1016/j.bmcl.2015.10.049. Epub 2015 Oct 19.

PMID:
26514746
23.

Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine.

Liu TY, Hussein WM, Giddam AK, Jia Z, Reiman JM, Zaman M, McMillan NA, Good MF, Monteiro MJ, Toth I, Skwarczynski M.

J Med Chem. 2015 Jan 22;58(2):888-96. doi: 10.1021/jm501514h. Epub 2014 Dec 22.

PMID:
25489968
24.

Self-adjuvanting therapeutic peptide-based vaccine induce CD8+ cytotoxic T lymphocyte responses in a murine human papillomavirus tumor model.

Liu TY, Giddam AK, Hussein WM, Jia Z, McMillan NA, Monteiro MJ, Toth I, Skwarczynski M.

Curr Drug Deliv. 2015;12(1):3-8.

PMID:
25269453
25.

Targeted drug delivery to the virus-infected airway; complications and remedies.

Clarke DT, McMillan NA.

Curr Drug Deliv. 2015;12(1):86-97. Review.

PMID:
25233122
26.

CXCL1 gene silencing in skin using liposome-encapsulated siRNA delivered by microprojection array.

Haigh O, Depelsenaire AC, Meliga SC, Yukiko SR, McMillan NA, Frazer IH, Kendall MA.

J Control Release. 2014 Nov 28;194:148-56. doi: 10.1016/j.jconrel.2014.08.021. Epub 2014 Sep 1.

PMID:
25192942
27.

Gene delivery: cell-specific therapy on target.

Clarke DT, McMillan NA.

Nat Nanotechnol. 2014 Aug;9(8):568-9. doi: 10.1038/nnano.2014.155. No abstract available.

PMID:
25091443
28.

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK.

Nat Commun. 2014 Mar 12;5:3459. doi: 10.1038/ncomms4459.

29.

In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours.

Khairuddin N, Blake SJ, Firdaus F, Steptoe RJ, Behlke MA, Hertzog PJ, McMillan NA.

Immunol Cell Biol. 2014 Feb;92(2):156-63. doi: 10.1038/icb.2013.75. Epub 2013 Nov 12.

PMID:
24217808
30.

CD62L as a therapeutic target in chronic lymphocytic leukemia.

Burgess M, Gill D, Singhania R, Cheung C, Chambers L, Renyolds BA, Smith L, Mollee P, Saunders N, McMillan NA.

Clin Cancer Res. 2013 Oct 15;19(20):5675-85. doi: 10.1158/1078-0432.CCR-13-1037. Epub 2013 Aug 15.

31.

Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer.

Liu TY, Hussein WM, Jia Z, Ziora ZM, McMillan NA, Monteiro MJ, Toth I, Skwarczynski M.

Biomacromolecules. 2013 Aug 12;14(8):2798-806. doi: 10.1021/bm400626w. Epub 2013 Jul 22.

PMID:
23837675
32.

Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA.

McCaskill J, Singhania R, Burgess M, Allavena R, Wu S, Blumenthal A, McMillan NA.

Mol Ther Nucleic Acids. 2013 Jun 4;2:e96. doi: 10.1038/mtna.2013.22.

33.

Potent inhibition of Hendra virus infection via RNA interference and poly I:C immune activation.

McCaskill JL, Marsh GA, Monaghan P, Wang LF, Doran T, McMillan NA.

PLoS One. 2013 May 14;8(5):e64360. doi: 10.1371/journal.pone.0064360. Print 2013.

34.

The semicolon sign: dopamine transporter imaging artifact from head tilt.

Covington MF, McMillan NA, Avery RJ, Kuo PH.

J Nucl Med Technol. 2013 Jun;41(2):105-7. doi: 10.2967/jnmt.112.117184. Epub 2013 Mar 21.

35.

RNA interference for the treatment of papillomavirus disease.

Singhania R, Khairuddin N, Clarke D, McMillan NA.

Open Virol J. 2012;6:204-15. doi: 10.2174/1874357901206010204. Epub 2012 Dec 28.

36.

MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells.

Plummer PN, Freeman R, Taft RJ, Vider J, Sax M, Umer BA, Gao D, Johns C, Mattick JS, Wilton SD, Ferro V, McMillan NA, Swarbrick A, Mittal V, Mellick AS.

Cancer Res. 2013 Jan 1;73(1):341-52. doi: 10.1158/0008-5472.CAN-12-0271. Epub 2012 Jul 25.

37.

Morphological and molecular analysis of a breast cancer cluster at the ABC Studio in Toowong.

Waddell N, Stein SR, Wagner SA, Bennett I, Djougarian A, Melana S, Jaffer S, Holland JF, Pogo BG, Gonda TJ, Brown MA, Leo P, Saunders NA, McMillan NA, Cocciardi S, Vargas AC, Lakhani SR, Chenevix-Trench G, Newman B, Francis GD.

Pathology. 2012 Aug;44(5):469-72. doi: 10.1097/PAT.0b013e3283559e67. No abstract available.

PMID:
22744170
38.

RNA interference for viral infections.

Blake SJ, Bokhari FF, McMillan NA.

Curr Drug Targets. 2012 Oct;13(11):1411-20. Review.

PMID:
22664094
39.

CCL2 and CXCL2 enhance survival of primary chronic lymphocytic leukemia cells in vitro.

Burgess M, Cheung C, Chambers L, Ravindranath K, Minhas G, Knop L, Mollee P, McMillan NA, Gill D.

Leuk Lymphoma. 2012 Oct;53(10):1988-98. doi: 10.3109/10428194.2012.672735. Epub 2012 Apr 19.

PMID:
22397722
40.

Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity.

Lane S, Gill D, McMillan NA, Saunders N, Murphy R, Spurr T, Keane C, Fan HM, Mollee P.

Leuk Lymphoma. 2012 Jun;53(6):1077-83. doi: 10.3109/10428194.2011.642302. Epub 2012 Jan 11.

PMID:
22098405
41.

High prevalence of human papillomaviruses in fresh frozen breast cancer samples.

Antonsson A, Spurr TP, Chen AC, Francis GD, McMillan NA, Saunders NA, Law M, Bennett IC.

J Med Virol. 2011 Dec;83(12):2157-63. doi: 10.1002/jmv.22223.

PMID:
22012724
42.

Self-catalyzed degradable cationic polymer for release of DNA.

Truong NP, Jia Z, Burgess M, Payne L, McMillan NA, Monteiro MJ.

Biomacromolecules. 2011 Oct 10;12(10):3540-8. doi: 10.1021/bm2007423. Epub 2011 Aug 31.

PMID:
21838265
43.

Effective Delivery of PEGylated siRNA-Containing Lipoplexes to Extraperitoneal Tumours following Intraperitoneal Administration.

Singhania A, Wu SY, McMillan NA.

J Drug Deliv. 2011;2011:192562. doi: 10.1155/2011/192562. Epub 2011 Jun 7.

44.

Self-catalyzed degradation of linear cationic poly(2-dimethylaminoethyl acrylate) in water.

Truong NP, Jia Z, Burges M, McMillan NA, Monteiro MJ.

Biomacromolecules. 2011 May 9;12(5):1876-82. doi: 10.1021/bm200219e. Epub 2011 Apr 25.

PMID:
21476544
45.

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo.

Khairuddin N, Gantier MP, Blake SJ, Wu SY, Behlke MA, Williams BR, McMillan NA.

Immunol Cell Biol. 2012 Feb;90(2):187-96. doi: 10.1038/icb.2011.19. Epub 2011 Mar 22.

PMID:
21423261
46.

Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system.

Wu SY, Chang HI, Burgess M, McMillan NA.

J Control Release. 2011 Nov 7;155(3):418-26. doi: 10.1016/j.jconrel.2011.02.002. Epub 2011 Feb 18.

PMID:
21315117
47.

Human papillomavirus in benign prostatic hyperplasia and prostatic adenocarcinoma patients.

Chen AC, Waterboer T, Keleher A, Morrison B, Jindal S, McMillan D, Nicol D, Gardiner RA, McMillan NA, Antonsson A.

Pathol Oncol Res. 2011 Sep;17(3):613-7. doi: 10.1007/s12253-010-9357-4. Epub 2011 Jan 16.

PMID:
21240663
48.

Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs.

Gu W, Payne E, Sun S, Burgess M, McMillan NA.

Cancer Gene Ther. 2011 Mar;18(3):219-27. doi: 10.1038/cgt.2010.72. Epub 2010 Nov 19.

PMID:
21102424
49.

Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models.

Wu SY, Singhania A, Burgess M, Putral LN, Kirkpatrick C, Davies NM, McMillan NA.

Gene Ther. 2011 Jan;18(1):14-22. doi: 10.1038/gt.2010.113. Epub 2010 Aug 12.

PMID:
20703312
50.

Rational design of immunostimulatory siRNAs.

Gantier MP, Tong S, Behlke MA, Irving AT, Lappas M, Nilsson UW, Latz E, McMillan NA, Williams BR.

Mol Ther. 2010 Apr;18(4):785-95. doi: 10.1038/mt.2010.4. Epub 2010 Feb 2.

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