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An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.

McMillan JM, Krentz HB, Gill MJ, Hogan DB.

Can Geriatr J. 2019 Dec 30;22(4):190-198. doi: 10.5770/cgj.22.387. eCollection 2019 Dec.


Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation.

Ibrahim IM, Bade AN, Lin Z, Soni D, Wojtkiewicz M, Dyavar Shetty BL, Gautam N, McMillan JM, Alnouti Y, Edagwa BJ, Gendelman HE.

Int J Nanomedicine. 2019 Aug 7;14:6231-6247. doi: 10.2147/IJN.S215447. eCollection 2019.


Creation of a long-acting rilpivirine prodrug nanoformulation.

Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE.

J Control Release. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. Epub 2019 Sep 3.


Exploring participation experiences of youth who use AAC in social media settings: impact of an e-mentoring intervention.

Grace E, Raghavendra P, McMillan JM, Gunson JS.

Augment Altern Commun. 2019 Jun;35(2):132-141. doi: 10.1080/07434618.2018.1557250. Epub 2019 Feb 8.


A Care Process Model to Deliver 177Lu-Dotatate Peptide Receptor Radionuclide Therapy for Patients With Neuroendocrine Tumors.

Kasi PM, Maige CL, Shahjehan F, Rodgers JM, Aloszka DL, Ritter A, Andrus ML, Mcmillan JM, Mody K, Sharma A, Jain MK.

Front Oncol. 2019 Jan 9;8:663. doi: 10.3389/fonc.2018.00663. eCollection 2018.


Impact of pharmacological treatment of diabetes mellitus on dementia risk: systematic review and meta-analysis.

McMillan JM, Mele BS, Hogan DB, Leung AA.

BMJ Open Diabetes Res Care. 2018 Nov 16;6(1):e000563. doi: 10.1136/bmjdrc-2018-000563. eCollection 2018.


Effectiveness of video-based modelling to facilitate conversational turn taking of adolescents with autism spectrum disorder who use AAC.

Thirumanickam A, Raghavendra P, McMillan JM, van Steenbrugge W.

Augment Altern Commun. 2018 Dec;34(4):311-322. doi: 10.1080/07434618.2018.1523948. Epub 2018 Nov 20.


Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD.

J Biomed Mater Res A. 2018 Nov;106(11):2881-2890. doi: 10.1002/jbm.a.36477. Epub 2018 Oct 26.


Managing HIV infection in patients older than 50 years.

McMillan JM, Krentz H, Gill MJ, Hogan DB.

CMAJ. 2018 Oct 22;190(42):E1253-E1258. doi: 10.1503/cmaj.171409. Review. No abstract available.


Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities.

Ottemann BM, Helmink AJ, Zhang W, Mukadam I, Woldstad C, Hilaire JR, Liu Y, McMillan JM, Edagwa BJ, Mosley RL, Garrison JC, Kevadiya BD, Gendelman HE.

Biomaterials. 2018 Dec;185:174-193. doi: 10.1016/j.biomaterials.2018.09.018. Epub 2018 Sep 14.


Wolfram Syndrome: A Case Report and Review of Clinical Manifestations, Genetics Pathophysiology, and Potential Therapies.

Toppings NB, McMillan JM, Au PYB, Suchowersky O, Donovan LE.

Case Rep Endocrinol. 2018 Apr 18;2018:9412676. doi: 10.1155/2018/9412676. eCollection 2018.


Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice.

McMillan JM, Cobb DA, Lin Z, Banoub MG, Dagur RS, Branch Woods AA, Wang W, Makarov E, Kocher T, Joshi PS, Quadros RM, Harms DW, Cohen SM, Gendelman HE, Gurumurthy CB, Gorantla S, Poluektova LY.

J Pharmacol Exp Ther. 2018 May;365(2):272-280. doi: 10.1124/jpet.117.247288. Epub 2018 Feb 23.


Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution.

Kevadiya BD, Woldstad C, Ottemann BM, Dash P, Sajja BR, Lamberty B, Morsey B, Kocher T, Dutta R, Bade AN, Liu Y, Callen SE, Fox HS, Byrareddy SN, McMillan JM, Bronich TK, Edagwa BJ, Boska MD, Gendelman HE.

Theranostics. 2018 Jan 1;8(1):256-276. doi: 10.7150/thno.22764. eCollection 2018.


Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging.

Kevadiya BD, Bade AN, Woldstad C, Edagwa BJ, McMillan JM, Sajja BR, Boska MD, Gendelman HE.

Acta Biomater. 2017 Feb;49:507-520. doi: 10.1016/j.actbio.2016.11.071. Epub 2016 Dec 1.


Cellular Responses and Tissue Depots for Nanoformulated Antiretroviral Therapy.

Martinez-Skinner AL, Araínga MA, Puligujja P, Palandri DL, Baldridge HM, Edagwa BJ, McMillan JM, Mosley RL, Gendelman HE.

PLoS One. 2015 Dec 30;10(12):e0145966. doi: 10.1371/journal.pone.0145966. eCollection 2015.


The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.

Zhang G, Guo D, Dash PK, Araínga M, Wiederin JL, Haverland NA, Knibbe-Hollinger J, Martinez-Skinner A, Ciborowski P, Goodfellow VS, Wysocki TA, Wysocki BJ, Poluektova LY, Liu XM, McMillan JM, Gorantla S, Gelbard HA, Gendelman HE.

Nanomedicine. 2016 Jan;12(1):109-22. doi: 10.1016/j.nano.2015.09.009. Epub 2015 Oct 22.


Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy.

Li T, Gendelman HE, Zhang G, Puligujja P, McMillan JM, Bronich TK, Edagwa B, Liu XM, Boska MD.

Int J Nanomedicine. 2015 Jun 3;10:3779-90. doi: 10.2147/IJN.S83279. eCollection 2015.


Usability testing of a prototype multi-user telehealth kiosk.

Courtney KL, Matthews JT, McMillan JM, Person Mecca L, Smailagic A, Siewiorek D.

Stud Health Technol Inform. 2015;208:109-13.


Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

Mallapragada SK, Brenza TM, McMillan JM, Narasimhan B, Sakaguchi DS, Sharma AD, Zbarska S, Gendelman HE.

Nanomedicine. 2015 Apr;11(3):715-29. doi: 10.1016/j.nano.2014.12.013. Epub 2015 Jan 31. Review.


Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations.

Puligujja P, Balkundi SS, Kendrick LM, Baldridge HM, Hilaire JR, Bade AN, Dash PK, Zhang G, Poluektova LY, Gorantla S, Liu XM, Ying T, Feng Y, Wang Y, Dimitrov DS, McMillan JM, Gendelman HE.

Biomaterials. 2015 Feb;41:141-50. doi: 10.1016/j.biomaterials.2014.11.012. Epub 2014 Dec 9.


Development of HIV reservoir targeted long acting nanoformulated antiretroviral therapies.

Edagwa BJ, Zhou T, McMillan JM, Liu XM, Gendelman HE.

Curr Med Chem. 2014;21(36):4186-98. Review.


Endosomal trafficking of nanoformulated antiretroviral therapy facilitates drug particle carriage and HIV clearance.

Guo D, Zhang G, Wysocki TA, Wysocki BJ, Gelbard HA, Liu XM, McMillan JM, Gendelman HE.

J Virol. 2014 Sep 1;88(17):9504-13. doi: 10.1128/JVI.01557-14. Epub 2014 Jun 11.


Bench-to-bedside translation of magnetic nanoparticles.

Singh D, McMillan JM, Kabanov AV, Sokolsky-Papkov M, Gendelman HE.

Nanomedicine (Lond). 2014 Apr;9(4):501-16. doi: 10.2217/NMM.14.5. Review.


Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues.

Singh D, McMillan JM, Liu XM, Vishwasrao HM, Kabanov AV, Sokolsky-Papkov M, Gendelman HE.

Nanomedicine (Lond). 2014 Mar;9(3):469-85. doi: 10.2217/nnm.14.4. Epub 2014 Mar 19.


Management of insomnia and long-term use of sedative-hypnotic drugs in older patients.

McMillan JM, Aitken E, Holroyd-Leduc JM.

CMAJ. 2013 Nov 19;185(17):1499-505. doi: 10.1503/cmaj.130025. Epub 2013 Sep 23. Review. No abstract available.


Functional proteome of macrophage carried nanoformulated antiretroviral therapy demonstrates enhanced particle carrying capacity.

Martinez-Skinner AL, Veerubhotla RS, Liu H, Xiong H, Yu F, McMillan JM, Gendelman HE.

J Proteome Res. 2013 May 3;12(5):2282-94. doi: 10.1021/pr400185w. Epub 2013 Apr 17.


Designing the community multi-user health kiosk.

McMillan JM, Courtney KL, Matthews JT, Smailagic A, Siewiorek D.

Stud Health Technol Inform. 2013;183:79-83.


BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice.

Hutter-Saunders JA, Kosloski LM, McMillan JM, Yotam N, Rinat T, Mosley RL, Gendelman HE.

Neuroscience. 2011 Apr 28;180:293-304. doi: 10.1016/j.neuroscience.2011.02.015. Epub 2011 Feb 12.


Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS.

Dou H, Grotepas CB, McMillan JM, Destache CJ, Chaubal M, Werling J, Kipp J, Rabinow B, Gendelman HE.

J Immunol. 2009 Jul 1;183(1):661-9. doi: 10.4049/jimmunol.0900274. Epub 2009 Jun 17.


Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid.

Lock EA, Reed CJ, McMillan JM, Oatis JE Jr, Schnellmann RG.

Toxicology. 2007 Feb 12;230(2-3):234-43. Epub 2006 Nov 18.


Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol.

Bronley-DeLancey A, McMillan DC, McMillan JM, Jollow DJ, Mohr LC, Hoel DG.

Environ Health Perspect. 2006 Aug;114(8):1237-42.


S-adenosylmethionine but not glutathione protects against galactosamine-induced cytotoxicity in rat hepatocyte cultures.

McMillan JM, McMillan DC.

Toxicology. 2006 May 15;222(3):175-84. Epub 2006 Feb 28.


Comparative physical mapping links conservation of microsynteny to chromosome structure and recombination in grasses.

Bowers JE, Arias MA, Asher R, Avise JA, Ball RT, Brewer GA, Buss RW, Chen AH, Edwards TM, Estill JC, Exum HE, Goff VH, Herrick KL, Steele CL, Karunakaran S, Lafayette GK, Lemke C, Marler BS, Masters SL, McMillan JM, Nelson LK, Newsome GA, Nwakanma CC, Odeh RN, Phelps CA, Rarick EA, Rogers CJ, Ryan SP, Slaughter KA, Soderlund CA, Tang H, Wing RA, Paterson AH.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13206-11. Epub 2005 Sep 2.


Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.

Walgren JL, Kurtz DT, McMillan JM.

Toxicology. 2005 Aug 1;211(3):220-30. Epub 2005 Apr 21.


S-adenosyl-L-methionine: transcellular transport and uptake by Caco-2 cells and hepatocytes.

McMillan JM, Walle UK, Walle T.

J Pharm Pharmacol. 2005 May;57(5):599-605.


Covalent binding of the flavonoid quercetin to human serum albumin.

Kaldas MI, Walle UK, van der Woude H, McMillan JM, Walle T.

J Agric Food Chem. 2005 May 18;53(10):4194-7.


Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates.

Walgren JL, Jollow DJ, McMillan JM.

Toxicology. 2004 May 3;197(3):189-97.


Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes.

Walgren JL, Amani Z, McMillan JM, Locher M, Buse MG.

Metabolism. 2004 Feb;53(2):165-73.


Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate.

Walgren JE, Kurtz DT, McMillan JM.

Res Commun Mol Pathol Pharmacol. 2000 Jul-Aug;108(1-2):116-32.


Dichloroacetic acid induction of peroxisome proliferation in cultured hepatocytes.

Everhart JL, Kurtz DT, McMillan JM.

J Biochem Mol Toxicol. 1998;12(6):351-9.


Dexamethasone induction of taxol metabolism in the rat.

Anderson CD, Wang J, Kumar GN, McMillan JM, Walle UK, Walle T.

Drug Metab Dispos. 1995 Nov;23(11):1286-90.


Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system.

McMillan JM, Jollow DJ.

Res Commun Mol Pathol Pharmacol. 1995 Jun;88(3):327-38.


Taxol metabolism in rat hepatocytes.

Walle T, Kumar GN, McMillan JM, Thornburg KR, Walle UK.

Biochem Pharmacol. 1993 Nov 2;46(9):1661-4.


Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone.

McMillan JM, Shaddock JG, Casciano DA, Arlotto MP, Leakey JE.

Mutat Res. 1991 Jul;249(1):81-92.


Contribution of 3,4-dichlorophenylhydroxylamine in propanil-induced hemolytic anemia.

McMillan DC, Bradshaw TP, McMillan JM, Hinson JA, Jollow DJ.

Adv Exp Med Biol. 1991;283:343-5. No abstract available.


Metabolism of the arylamide herbicide propanil. II. Effects of propanil and its derivatives on hepatic microsomal drug-metabolizing enzymes in the rat.

McMillan DC, Leakey JE, Arlotto MP, McMillan JM, Hinson JA.

Toxicol Appl Pharmacol. 1990 Mar 15;103(1):102-12.


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