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PGCA: An algorithm to link protein groups created from MS/MS data.

Kepplinger D, Takhar M, Sasaki M, Hollander Z, Smith D, McManus B, McMaster WR, Ng RT, Cohen Freue GV.

PLoS One. 2017 May 31;12(5):e0177569. doi: 10.1371/journal.pone.0177569. eCollection 2017.


Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression.

Casgrain PA, Martel C, McMaster WR, Mottram JC, Olivier M, Descoteaux A.

PLoS Pathog. 2016 May 18;12(5):e1005658. doi: 10.1371/journal.ppat.1005658. eCollection 2016 May.


Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity.

Marr AK, Cen S, Hancock RE, McMaster WR.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2484-91. doi: 10.1128/AAC.02328-15. Print 2016 Apr.


Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity.

Isnard A, Christian JG, Kodiha M, Stochaj U, McMaster WR, Olivier M.

PLoS Pathog. 2015 Mar 31;11(3):e1004776. doi: 10.1371/journal.ppat.1004776. eCollection 2015 Mar.


Anti-leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from Tibouchina paratropica.

Tracanna MI, Fortuna AM, Cárdenas AV, Marr AK, McMaster WR, Gómez-Velasco A, Sánchez-Arreola E, Hernández LR, Bach H.

Phytother Res. 2015 Mar;29(3):393-7. doi: 10.1002/ptr.5263. Epub 2014 Nov 24.


Novel multivariate methods for integration of genomics and proteomics data: applications in a kidney transplant rejection study.

Günther OP, Shin H, Ng RT, McMaster WR, McManus BM, Keown PA, Tebbutt SJ, Lê Cao KA.

OMICS. 2014 Nov;18(11):682-95. doi: 10.1089/omi.2014.0062.


Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages.

Marr AK, MacIsaac JL, Jiang R, Airo AM, Kobor MS, McMaster WR.

PLoS Pathog. 2014 Oct 9;10(10):e1004419. doi: 10.1371/journal.ppat.1004419. eCollection 2014 Oct.


A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice.

Davoudi N, Khamesipour A, Mahboudi F, McMaster WR.

PLoS Negl Trop Dis. 2014 May 29;8(5):e2785. doi: 10.1371/journal.pntd.0002785. eCollection 2014.


Alteration of human blood cell transcriptome in uremia.

Scherer A, Günther OP, Balshaw RF, Hollander Z, Wilson-McManus J, Ng R, McMaster WR, McManus BM, Keown PA.

BMC Med Genomics. 2013 Jun 28;6:23. doi: 10.1186/1755-8794-6-23.


Computational biomarker pipeline from discovery to clinical implementation: plasma proteomic biomarkers for cardiac transplantation.

Cohen Freue GV, Meredith A, Smith D, Bergman A, Sasaki M, Lam KK, Hollander Z, Opushneva N, Takhar M, Lin D, Wilson-McManus J, Balshaw R, Keown PA, Borchers CH, McManus B, Ng RT, McMaster WR; Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams.

PLoS Comput Biol. 2013 Apr;9(4):e1002963. doi: 10.1371/journal.pcbi.1002963. Epub 2013 Apr 4.


Differential quantitative proteomic profiling of Leishmania infantum and Leishmania mexicana density gradient separated membranous fractions.

Lynn MA, Marr AK, McMaster WR.

J Proteomics. 2013 Apr 26;82:179-92. doi: 10.1016/j.jprot.2013.02.010. Epub 2013 Mar 5.


A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers.

Günther OP, Chen V, Freue GC, Balshaw RF, Tebbutt SJ, Hollander Z, Takhar M, McMaster WR, McManus BM, Keown PA, Ng RT.

BMC Bioinformatics. 2012 Dec 8;13:326. doi: 10.1186/1471-2105-13-326.


Modes of action of Leishmanicidal antimicrobial peptides.

Marr AK, McGwire BS, McMaster WR.

Future Microbiol. 2012 Sep;7(9):1047-59. doi: 10.2217/fmb.12.85. Review.


Secreted virulence factors and immune evasion in visceral leishmaniasis.

Lambertz U, Silverman JM, Nandan D, McMaster WR, Clos J, Foster LJ, Reiner NE.

J Leukoc Biol. 2012 Jun;91(6):887-99. doi: 10.1189/jlb.0611326. Epub 2012 Mar 21. Review.


Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.

Axerio-Cilies P, See RH, Zoraghi R, Worral L, Lian T, Stoynov N, Jiang J, Kaur S, Jackson L, Gong H, Swayze R, Amandoron E, Kumar NS, Moreau A, Hsing M, Strynadka NC, McMaster WR, Finlay BB, Foster LJ, Young RN, Reiner NE, Cherkasov A.

ACS Chem Biol. 2012 Feb 17;7(2):350-9. doi: 10.1021/cb2003576. Epub 2011 Nov 21.


Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

Zoraghi R, Worrall L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, Andersen RJ, Reiner NE.

J Biol Chem. 2011 Dec 30;286(52):44716-25. doi: 10.1074/jbc.M111.289033. Epub 2011 Oct 26.


Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival.

Lynn MA, Kindrachuk J, Marr AK, Jenssen H, Panté N, Elliott MR, Napper S, Hancock RE, McMaster WR.

PLoS Negl Trop Dis. 2011;5(5):e1141. doi: 10.1371/journal.pntd.0001141. Epub 2011 May 31.


Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection.

Kulkarni MM, Barbi J, McMaster WR, Gallo RL, Satoskar AR, McGwire BS.

Cell Microbiol. 2011 Jun;13(6):913-23. doi: 10.1111/j.1462-5822.2011.01589.x. Epub 2011 Apr 28.


Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.

Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L, Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE.

Antimicrob Agents Chemother. 2011 May;55(5):2042-53. doi: 10.1128/AAC.01250-10. Epub 2011 Feb 28.


Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.

Cherkasov A, Hsing M, Zoraghi R, Foster LJ, See RH, Stoynov N, Jiang J, Kaur S, Lian T, Jackson L, Gong H, Swayze R, Amandoron E, Hormozdiari F, Dao P, Sahinalp C, Santos-Filho O, Axerio-Cilies P, Byler K, McMaster WR, Brunham RC, Finlay BB, Reiner NE.

J Proteome Res. 2011 Mar 4;10(3):1139-50. doi: 10.1021/pr100918u. Epub 2011 Jan 28.


Effects of sample timing and treatment on gene expression in early acute renal allograft rejection.

Günther OP, Lin D, Balshaw RF, Ng RT, Hollander Z, Wilson-McManus J, McMaster WR, McManus BM, Keown PA; Biomarkers in Transplantation Team.

Transplantation. 2011 Feb 15;91(3):323-9. doi: 10.1097/TP.0b013e3182029b16.


Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells.

Silverman JM, Clos J, Horakova E, Wang AY, Wiesgigl M, Kelly I, Lynn MA, McMaster WR, Foster LJ, Levings MK, Reiner NE.

J Immunol. 2010 Nov 1;185(9):5011-22. doi: 10.4049/jimmunol.1000541. Epub 2010 Sep 29.


Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps.

Gabriel C, McMaster WR, Girard D, Descoteaux A.

J Immunol. 2010 Oct 1;185(7):4319-27. doi: 10.4049/jimmunol.1000893. Epub 2010 Sep 8.


Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from methicillin-resistant Staphylococcus aureus.

Zoraghi R, See RH, Gong H, Lian T, Swayze R, Finlay BB, Brunham RC, McMaster WR, Reiner NE.

Biochemistry. 2010 Sep 7;49(35):7733-47. doi: 10.1021/bi100780t.


Proteomic signatures in plasma during early acute renal allograft rejection.

Freue GV, Sasaki M, Meredith A, Günther OP, Bergman A, Takhar M, Mui A, Balshaw RF, Ng RT, Opushneva N, Hollander Z, Li G, Borchers CH, Wilson-McManus J, McManus BM, Keown PA, McMaster WR; Genome Canada Biomarkers in Transplantation Group.

Mol Cell Proteomics. 2010 Sep;9(9):1954-67. doi: 10.1074/mcp.M110.000554. Epub 2010 May 25.


Tools to identify organ rejection and immune quiescence for biological understanding and personalized medical care.

Keown PA, McMaster WR, McManus BM.

Biomark Med. 2010 Feb;4(1):115-21. Review. No abstract available.


The Leishmania mexicana A600 genes are functionally required for amastigote replication.

Murray AS, Lynn MA, McMaster WR.

Mol Biochem Parasitol. 2010 Aug;172(2):80-9. doi: 10.1016/j.molbiopara.2010.03.008. Epub 2010 Mar 20.


Functional genomic analysis of peripheral blood during early acute renal allograft rejection.

Günther OP, Balshaw RF, Scherer A, Hollander Z, Mui A, Triche TJ, Freue GC, Li G, Ng RT, Wilson-McManus J, McMaster WR, McManus BM, Keown PA; Biomarkers in Transplantation Team.

Transplantation. 2009 Oct 15;88(7):942-51. doi: 10.1097/TP.0b013e3181b7ccc6.


Enhancement of immune response and protection in BALB/c mice immunized with liposomal recombinant major surface glycoprotein of Leishmania (rgp63): the role of bilayer composition.

Badiee A, Jaafari MR, Khamesipour A, Samiei A, Soroush D, Kheiri MT, Barkhordari F, McMaster WR, Mahboudi F.

Colloids Surf B Biointerfaces. 2009 Nov 1;74(1):37-44. doi: 10.1016/j.colsurfb.2009.06.025. Epub 2009 Jun 23.


Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicity.

Kulkarni MM, McMaster WR, Kamysz W, McGwire BS.

J Biol Chem. 2009 Jun 5;284(23):15496-504. doi: 10.1074/jbc.M809079200. Epub 2009 Apr 8.


The role of liposome charge on immune response generated in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63).

Badiee A, Jaafari MR, Khamesipour A, Samiei A, Soroush D, Kheiri MT, Barkhordari F, McMaster WR, Mahboudi F.

Exp Parasitol. 2009 Apr;121(4):362-9. doi: 10.1016/j.exppara.2008.12.015. Epub 2009 Jan 1.


The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation.

Hallé M, Gomez MA, Stuible M, Shimizu H, McMaster WR, Olivier M, Tremblay ML.

J Biol Chem. 2009 Mar 13;284(11):6893-908. doi: 10.1074/jbc.M805861200. Epub 2008 Dec 8.


Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation.

Lieke T, Nylén S, Eidsmo L, McMaster WR, Mohammadi AM, Khamesipour A, Berg L, Akuffo H.

Clin Exp Immunol. 2008 Aug;153(2):221-30. doi: 10.1111/j.1365-2249.2008.03687.x.


Leishmania: conserved evolution--diverse diseases.

Lynn MA, McMaster WR.

Trends Parasitol. 2008 Mar;24(3):103-5. doi: 10.1016/ Epub 2008 Feb 5.


Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation.

Kulkarni MM, Jones EA, McMaster WR, McGwire BS.

Infect Immun. 2008 Apr;76(4):1738-47. doi: 10.1128/IAI.01274-07. Epub 2008 Jan 22.


MDQC: a new quality assessment method for microarrays based on quality control reports.

Cohen Freue GV, Hollander Z, Shen E, Zamar RH, Balshaw R, Scherer A, McManus B, Keown P, McMaster WR, Ng RT.

Bioinformatics. 2007 Dec 1;23(23):3162-9. Epub 2007 Oct 12.


The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome.

Jaafari MR, Badiee A, Khamesipour A, Samiei A, Soroush D, Kheiri MT, Barkhordari F, McMaster WR, Mahboudi F.

Vaccine. 2007 Aug 10;25(32):6107-17. Epub 2007 Jun 4.


Global gene expression in Leishmania.

Cohen-Freue G, Holzer TR, Forney JD, McMaster WR.

Int J Parasitol. 2007 Aug;37(10):1077-86. Epub 2007 May 6. Review.


Leishmania major abrogates gamma interferon-induced gene expression in human macrophages from a global perspective.

Dogra N, Warburton C, McMaster WR.

Infect Immun. 2007 Jul;75(7):3506-15. Epub 2007 Apr 30.


Regions in the 3' untranslated region confer stage-specific expression to the Leishmania mexicana a600-4 gene.

Murray A, Fu C, Habibi G, McMaster WR.

Mol Biochem Parasitol. 2007 Jun;153(2):125-32. Epub 2007 Mar 1.


Genomic and proteomic expression analysis of Leishmania promastigote and amastigote life stages: the Leishmania genome is constitutively expressed.

Leifso K, Cohen-Freue G, Dogra N, Murray A, McMaster WR.

Mol Biochem Parasitol. 2007 Mar;152(1):35-46. Epub 2006 Dec 8.


The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing.

Kulkarni MM, McMaster WR, Kamysz E, Kamysz W, Engman DM, McGwire BS.

Mol Microbiol. 2006 Dec;62(5):1484-97. Epub 2006 Oct 27.


Immune response and protection assay of recombinant major surface glycoprotein of Leishmania (rgp63) reconstituted with liposomes in BALB/c mice.

Jaafari MR, Ghafarian A, Farrokh-Gisour A, Samiei A, Kheiri MT, Mahboudi F, Barkhordari F, Khamesipour A, McMaster WR.

Vaccine. 2006 Jul 17;24(29-30):5708-17. Epub 2006 May 11.


Predictive value of lymph node and tumor matrix metalloproteinase expression in the analysis of metastatic periampullary tumors.

McKenna GJ, Meneghetti A, Chen YL, Mui AL, Ong C, Scudamore CH, McMaster WR, Owen DA, Chung SW.

J Surg Oncol. 2005 Jun 15;90(4):239-46.


Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials.

Davoudi N, Tate CA, Warburton C, Murray A, Mahboudi F, McMaster WR.

Vaccine. 2005 Jan 19;23(9):1170-7.


Leishmania mexicana: identification of genes that are preferentially expressed in amastigotes.

Bellatin JA, Murray AS, Zhao M, McMaster WR.

Exp Parasitol. 2002 Jan;100(1):44-53.


Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor.

Joshi PB, Kelly BL, Kamhawi S, Sacks DL, McMaster WR.

Mol Biochem Parasitol. 2002 Mar;120(1):33-40.


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